Phenotypic characterisation of intestinal lymphocytes in ovine paratuberculosis by immunohistochemistry

Veterinary Immunology and Immunopathology

Volumn 55, Issue 1-3, 1996, Pages 175-187

  Little, David ^a   Alzuherri, Hadi M ^a   Clarke, Christopher J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

immunohistochemistry; intestinal lymphocytes; Mycobacterium avium subspecies paratuberculosis; sheep

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; INTESTINE MUCOSA; MYCOBACTERIUM AVIUM; NONHUMAN; PARATUBERCULOSIS; PHENOTYPE; SHEEP; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CD4-CD8 RATIO; EPITHELIUM; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; INTESTINAL MUCOSA; LYMPHOCYTE COUNT; MYCOBACTERIUM PARATUBERCULOSIS; ORGAN SPECIFICITY; PARATUBERCULOSIS; SHEEP; T-LYMPHOCYTE SUBSETS;

EID: 0030452220     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(96)05716-9     Document Type: Article

References (33)

1. Andrew, E.M. and Jasani, B., 1987. An improved method for the inhibition of endogenous peroxidase non-deleterious to lymphocyte surface markers. Application to immunoperoxidase studies on eosinophil rich tissue preparations. Histochem. J., 19: 426-430.
2. + T-cell clones activated in vitro. Infect. Immun., 61: 3273-3281.
3. + T-cell clones obtained from cattle chronically infected with Fasciola hepatica and specific for adult worm antigen express both unrestricted and Th2 cytokine profiles. Infect. Immun., 62: 818-827.
4. Carrigan, M.J. and Seaman, J.T., 1990. The pathology of Jonne's disease in sheep. Aust. Vet. J., 67; 47-50.
5. + activity. Microb. Pathogen., 13: 447-463.
6. + immunoregulatory T lymphocytes which down-regulate gamma/delta positive T-cell cytotoxicity. Microb. Pathogen., 14: 355-367.
7. Chiodini, R.J., Van Kruiningen, H.J. and Merkal, R.S., 1984. Ruminant paratuberculosis (Johne's disease): The current status and future prospects. Cornell Vet., 74: 218-262.
8. Clarke, C.J. and Little, D., 1996. The pathology of ovine paratuberculosis: gross and histological changes in the intestine and other tissues. J. Comp. Path., 114: 419-437.
9. Clarke, C.J., Patterson, I.A.P., Armstrong, K.E. and Low, J.C., 1996. Comparison of the absorbed ELISA and AGID tests with clinicopathological findings in ovine clinical paratuberculosis. Vet. Rec. (in press).
10. Flynn, J.L., Goldstein, M.M., Triebold, K.J., Koller, B. and Bloom B.R., 1992. Major histocompatibility complex class I restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc. Natl. Acad. Sci. USA, 89: 12013-12017.
11. Hein, W.R. and Mackay, C.R., 1991. Prominence of γδ T cells in the ruminant immune system. Immunol. Today, 12: 30-34.
12. Janis, E.M., Kaufmann, S.H.E., Schwartz, R.H. and Pardoll, D.M., 1989. Activation of γδ T cells in the primary immune response to Mycobacterium tuberculosis. Science, 244: 713.
13. Kreeger, J.M. and Snider, T.G., 1992. Measurement of lymphoblast proliferative capacity of stimulated blood mononuclear cells from cattle with chronic paratuberculosis. Am. J. Vet. Res., 53: 392-395.
14. Kreeger, J.M., Snider, T.G. and Olcott, B.M., 1992. Effects of dialyzable lymph node extracts on lymphoblast proliferative capacity of blood mononuclear cells in cattle with chronic paratuberculosis. Am. J. Vet. Res., 53: 1225-1230.
15. Mackay, C.R., Beya, M.F. and Matzinger, P., 1989. Gamma-delta T cells express a unique surface molecule appearing late during thymic development. Eur. J. Immunol., 19: 1477-1483.
16. Maddox, J.F., Mackay, C.R. and Brandon, M.R., 1985. Surface antigens, SBU-T4 and SBU-T8, of sheep T lymphocyte subsets defined by monoclonal antibodies. Immunology, 55: 739-748.
17. Modlin, R.L., Mehra, V., Wong, L., Fujimiya, Y., Chang, W-C., Horwitz, D.A., Bloom, B.R., Rea, T.H. and Pattengale, P.K., 1986. Suppressor T lymphocytes from lepromatous leprosy skin lesions. J. Immunol., 137: 2831-2834.
18. Modlin R.L., Melancon-Kaplan, J., Young, S.M.M., Pirmez, C., Kino, H., Convit, J., Rea, T.H. and Bloom, B.R., 1988. Learning from lesions: Patterns of tissue inflammation in leprosy. Proc. Natl. Acad. Sci. USA, 85: 1213-1217.
19. Modlin, R.L., Pirmez, C., Hofman, P.M., Torigian, V., Uyemura, K., Rea, T.H., Bloom, B.R. and Brenner, M.B., 1989. Lymphocytes bearing antigen-specific γδ T cell receptors accumulate in disease lesions. Nature, 399: 544.
20. Mombaerts, P., Amoldi, J., Russ, F., Tonegawa, S. and Kaufmann, S.H.E., 1993. Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogen. Nature, 365: 53-56.
21. Mosmann, T.R., Cherwinski, H., Bond, M.W., Giedlin, M.A. and Coffman, L., 1986. Two types of murine helper T cell clones. I. Definition according to profile of lymphokine activities and secreted proteins. J. Immunol., 136: 2348-2357.
22. Nathan, C.F., Murray, H.W., Wiebe, M.E. and Rubin, B.Y., 1983. Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J. Exp. Med., 158: 670-689.
23. Pérez, V., Garcia Marin, J.F. and Badiola, J.J., 1996. Description and classification of different types of lesion associated with natural paratuberculosis infection in sheep. J. Comp. Path., 114: 107-122.
24. Rajya, B.S. and Singh, C.M., 1961. Studies on the pathology of Johne's disease in sheep III. Pathologic changes in sheep with naturally occurring infections. Am. J. Vet. Res., 22: 189-203.
25. Reddy, K.P., Sriraman, P.K., Gopal Naidu, N.R. and Rama Rao, P., 1984. Pathology of Johne's disease in Sheep. Indian. Vet. J., 61: 179-184.
26. Ridley, D.S. and Jopling, W.H., 1966. Classification of leprosy according to immunity. A five group system. Int. J. Lepr., 34: 255.
27. Rust, C.J.J. and Koning, F., 1993. Gamma-delta T-cell reactivity towards bacterial superantigens. Seminars in Immunol., 5: 41-46.
28. Salgame, P., Abrams, J.S., Clayberger, C., Goldstein, H., Convit, J., Modlin, R.L. and Bloom, B.R., 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science, 254: 279-282.
29. Sherman, D.M., Markham, R.J.F. and Bates, F., 1984. Agar gel immimodiffusion test for diagnosis of clinical paratuberculosis in cattle. J. Am. Vet. Med. Assoc., 185: 179-182.
30. Stamp, J.T. and Watt, J.A., 1954. Johne's disease in sheep. J. Comp. Path., 64: 26-40.
31. Thorel, M.F., Krichevsky, M. and Levy-Frebault, V.V., 1990. Numerical taxonomy of mycobactin-dependent mycobacteria, emended description of Mycobacterium avium, and description of Mycobacterium avium subsp. avium subsp. nov., Mycobacterium avium subsp. paratuberculosis subsp. nov., Mycobacterium avium subsp. silvaticum subsp. nov. Int. J. Syst. Bacteriol., 40: 254-260.
32. Van Voorhis, W.C., Kaplan, G., Samo, E.N., Honvitz, M.A., Steinman, R.H., Levis, W.R., Nogeuira, N., Hair, L.S., Gattass, C.R., Arrick, B.A. and Cohn, Z.A., 1982. The cutaneous infiltrates of leprosy. Cellular characteristics and the predominant T-cell phenotypes. N. Engl. J. Med., 307: 1593-1597.
33. Yamamura, M., Uyemura, K., Deans, R.J., Weinberg, K., Rea, T.H., Bloom, B.R. and Modlin, R.L., 1991. Defining protective responses to pathogens: Cytokine profiles in leprosy lesions. Science, 254: 277-279.