Development and evaluation of a mucoadhesive nasal gel of midazolam prepared with Linum usitatissimum L. seed mucilage

Scientia Pharmaceutica

Volumn 77, Issue 4, 2009, Pages 899-910

  Basu, Shyamoshree ^a   Chakrabatorty, Subrata ^b   Bandyopadhyay, Amal K ^a  

^a JADAVPUR UNIVERSITY   (India)

^b Dr B C Roy College of Pharmacy and Allied Health Sciences   (India)

Author keywords

Enhancers; Midazolam hydrochloride; Mucoadhesive; Nasal

Indexed keywords

ADHESIVE AGENT; CARBOPOL 934; HERBACEOUS AGENT; HYDROXYPROPYLMETHYLCELLULOSE; MIDAZOLAM; POLYMER;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; GEL; GOAT; HISTOLOGY; LINSEED; MICROPHOTOGRAPHY; MUCILAGE; MUCOADHESIVE NASAL GEL; NONHUMAN; NOSE MUCOSA; PH MEASUREMENT; PLANT SEED; SWELLING; TENSILE STRENGTH; VISCOSITY;

EID: 74549143108     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: 10.3797/scipharm.0807-10     Document Type: Article

References (23)

1. Ugwoke MI, Agu RU, Verbeke N, Kinget R. Nasal mucoadhesive drug delivery: Background, applications, trends and future perspectives. Adv Drug Del Rev. 2005; 57: 1640-1665. doi:10.1016/j.addr.2005.07.009
2. Datta R, Bandyopadhyay AK. A new nasal drug delivery system for diazepam using natural mucoadhesive polysaccharide obtained from tamarind seeds. Saudi Pharm J. 2006; 14: 115-119.
3. Martin E, Schipper NGM, Verhoef JC, Merkus FWHM. Nasal mucociliary clearance as a factor in nasal drug delivery. Adv Drug Del Rev. 1998; 29: 13-38. doi:10.1016/S0169-409X(97)00059-8
4. Illum L. Nasal drug delivery: new developments and strategies. Drug Discov Today. 2002; 7: 1184-1189. doi:10.1016/S1359-6446(02)02529-1
5. Türker S, Onur E, Özer Y. Nasal route and drug delivery systems. Pharm World Sci. 2004; 26: 137-142. doi:10.1023/B:PHAR.0000026823. 82950.ff
6. Ugwoke MI, Verbeke N, Kinget R. The biopharmaceutical aspects of nasal mucoadhesive drug delivery. J Pharm Pharmacol. 2001; 53: 3-22. doi:10.1211/0022357011775145
7. Goldman RD. Intranasal Drug Delivery for Children with Acute Illness. Curr Drug Ther. 2006; 1: 127-130. doi:10.2174/157488506775268470
8. Wikipedia. The free encyclopedia. http://en.wikipedia.org/wiki/.
9. Erskine AJ, Jones JKN. The structure of linseed mucilage (Part I). Can J Chem. 1957; 35: 1174-1182. doi:10.1139/v57-158
10. Hunt K, Jones JKN. The structure of linseed mucilage. Can J Chem. 1962; 40: 1266-1279. doi:10.1139/v62-195
11. Muralikrishna G, Salimath PV, Tharanathan RN. Structural features of an arabinoxylan and a rhamnogalacturonan derived from linseed mucilage. Carbohydr Res. 1987; 161: 265-271. doi:10.1016/S0008-6215(00)90083-1
12. Cui W, Mazza G, Biliaderiss CG. Chemical structure, molecular size distributions, and rheological properties of flaxseed gum. J Agric Food Chem. 1994; 42: 1891-1895. doi:10.1021/jf00045a012
13. Chen HH, Xu SY, Wang Z. Separation and purification of acidic polysaccharides and neutral polysaccharides in flaxseed gum. Journal of Food and Fermentation Industry. 2004; 1: 96-100
14. Chen HH, Xu SY, Wang Z. Study of rheological properties of flaxseed gum. Journal of Wuxi University of Light Industry 2004; 1: 30-35
15. Fedeniuk RK, Biliaderis CG. Composition and physicochemical properties of linseed mucilage. J Agric Food Chem. 1994; 42: 240-247. doi:10.1021/jf00038a003
16. Harding SE. Mucoadhesive interactions. Biochem Soc Trans. 2003; 31: 1036 -1041. doi:10.1042/BST0311036
17. Rao YM, Vani G, Bala Ramesha Chary R. Design and evaluation of mucoadhesive drug delivery systems. Ind Drugs. 1998; 35: 558-565.
18. Park H, Robinson JR. Mechanisms of mucoadhesion of poly (acrylic acid) hydrogels. Pharm Res. 1987; 4: 457-464. doi:10.1023/A:1016467219657
19. Lee JW, Park JH, Robinson JR. Bioadhesive based dosage forms: the next generation. J Pharm Sci.2000; 89: 850-866. doi:10.1002/1520-6017(200007)89: 7〈850::AID-JPS2〉3.0.CO;2-G
20. Sudhakar Y, Kuotsu K, Bandyopadhyay AK. Buccal bioadhesive drug delivery: A promising option for orally less efficient drugs. J Control Rel. 2006; 14: 15-40. doi:10.1016/S0048-721X(84)80026-3
21. Loyd V, Allen JR. Compounding Nasal Preparations. Current and Practical Compounding Information for the Pharmacist in Secundum Artem, (www.paddocklabs.com) vol 7, no.1
22. Schmidt MC, Simmen D, Hilbe M, Boderke P, Ditzinger GN, Sandow JR, Lang S, Rubas W, Merkle HP. Validation of excised bovine nasal mucosa as in vitro model to study drug transport and metabolic pathways in nasal epithelium. J Pharm Sci. 2000; 89: 396-407. doi:10.1002/(SICI)1520-6017(200003) 89:3〈396::AID-JPS10〉3.0.CO;2-F
23. Metia PK, Bandyopadhyay AK. In vitro and in vivo evaluation of a novel mucoadhesive buccal oxytocin tablet prepared with Dillenia indica fruit mucilage. Pharmazie. 2008; 63: 1-5. doi:10.1691/ph.2008.7248