Prospective phase II study of preoperative short-course radiotherapy for rectal cancer with twice daily fractions of 2.9 Gy to a total dose of 29 Gy - Long-term results

Radiation Oncology

Volumn 4, Issue 1, 2009, Pages

  Guckenberger, Matthias ^a   Wulf, Joern ^b   Thalheimer, Andreas ^a   Wehner, Daniel ^a   Thiede, Arnulf ^a   Müller, Gottfried ^c   Sailer, Marco ^b   Flentje, Michael ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Lindenhofspital ^*  (Germany)

^c CARITAS KRANKENHAUS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID; OXALIPLATIN; ANTINEOPLASTIC AGENT;

ADULT; AGE DISTRIBUTION; AGED; ANASTOMOSIS LEAKAGE; ARTICLE; CANCER MORTALITY; CANCER STAGING; CHRONIC DIARRHEA; CLINICAL TRIAL; COLON FISTULA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FECES INCONTINENCE; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; ILEUS; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PERIOPERATIVE PERIOD; PHASE 2 CLINICAL TRIAL; POSTOPERATIVE HEMORRHAGE; PREOPERATIVE PERIOD; PROSPECTIVE STUDY; RADIATION DOSE FRACTIONATION; RECTUM ABDOMINOPERINEAL RESECTION; RECTUM ANTERIOR RESECTION; RECTUM CANCER; SEX RATIO; TREATMENT PLANNING; WOUND DEHISCENCE; WOUND INFECTION; ABDOMINAL SURGERY; ADJUVANT THERAPY; KAPLAN MEIER METHOD; METHODOLOGY; MIDDLE AGED; MORTALITY; MULTIMODALITY CANCER THERAPY; PATHOLOGY; RADIATION DOSE; RADIOTHERAPY; RECTUM TUMOR;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; COMBINED MODALITY THERAPY; DIGESTIVE SYSTEM SURGICAL PROCEDURES; FEMALE; HUMANS; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; RADIOTHERAPY; RADIOTHERAPY DOSAGE; RECTAL NEOPLASMS;

EID: 74549137819     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-4-67     Document Type: Article

References (30)

1. NIH consensus conference. Adjuvant therapy for patients with colon and rectal cancer. Jama 1990, 264:1444-1450. 10.1001/jama.264.11.1444, 2202842.
2. Heald RJ, Moran BJ, Ryall RD, Sexton R, MacFarlane JK. Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978-1997. Arch Surg 1998, 133:894-899. 10.1001/archsurg.133.8.894, 9711965.
3. Sauer R, Becker H, Hohenberger W, Rodel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004, 351:1731-1740. 10.1056/NEJMoa040694, 15496622.
4. Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Trial. N Engl J Med 1997, 336:980-987. 10.1056/NEJM199704033361402, 9091798.
5. Kapiteijn E, Marijnen CA, Nagtegaal ID, Putter H, Steup WH, Wiggers T, Rutten HJ, Pahlman L, Glimelius B, van Krieken JH, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001, 345:638-646. 10.1056/NEJMoa010580, 11547717.
6. Bujko K, Nowacki MP, Nasierowska-Guttmejer A, Michalski W, Bebenek M, Kryj M. Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. The British journal of surgery 2006, 93:1215-1223. 10.1002/bjs.5506, 16983741.
7. Pietrzak L, Bujko K, Nowacki MP, Kepka L, Oledzki J, Rutkowski A, Szmeja J, Kladny J, Dymecki D, Wieczorek A, et al. Quality of life, anorectal and sexual functions after preoperative radiotherapy for rectal cancer: report of a randomised trial. Radiother Oncol 2007, 84:217-225. 10.1016/j.radonc.2007.07.007, 17692977.
8. Peeters KC, Marijnen CA, Nagtegaal ID, Kranenbarg EK, Putter H, Wiggers T, Rutten H, Pahlman L, Glimelius B, Leer JW, Velde CJ. The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Annals of surgery 2007, 246:693-701. 10.1097/01.sla.0000257358.56863.ce, 17968156.
9. Sebag-Montefiore D, Stephens RJ, Steele R, Monson J, Grieve R, Khanna S, Quirke P, Couture J, de Metz C, Myint AS, et al. Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial. Lancet 2009, 373:811-820. 10.1016/S0140-6736(09)60484-0, 2668947, 19269519.
10. Folkesson J, Birgisson H, Pahlman L, Cedermark B, Glimelius B, Gunnarsson U. Swedish Rectal Cancer Trial: long lasting benefits from radiotherapy on survival and local recurrence rate. J Clin Oncol 2005, 23:5644-5650. 10.1200/JCO.2005.08.144, 16110023.
11. Andre T, Boni C, Mounedji-Boudiaf L, Navarro M, Tabernero J, Hickish T, Topham C, Zaninelli M, Clingan P, Bridgewater J, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 2004, 350:2343-2351. 10.1056/NEJMoa032709, 15175436.
12. Herzog U, von Flue M, Tondelli P, Schuppisser JP. How accurate is endorectal ultrasound in the preoperative staging of rectal cancer?. Diseases of the colon and rectum 1993, 36:127-134. 10.1007/BF02051167, 8425415.
13. Sailer M, Leppert R, Kraemer M, Fuchs KH, Thiede A. The value of endorectal ultrasound in the assessment of adenomas, T1- and T2-carcinomas. International journal of colorectal disease 1997, 12:214-219. 10.1007/s003840050092, 9272450.
14. Beynon J, Mortensen NJ, Channer JL, Rigby H. Rectal endosonography accurately predicts depth of penetration in rectal cancer. International journal of colorectal disease 1992, 7:4-7. 10.1007/BF01647651, 1588225.
15. Widder J, Herbst F, Dobrowsky W, Schmid R, Pokrajac B, Jech B, Chiari C, Stift A, Maier A, Karner-Hanusch J, et al. Preoperative short-term radiation therapy (25 Gy, 2.5 Gy twice daily) for primary resectable rectal cancer (phase II). British journal of cancer 2005, 92:1209-1214. 10.1038/sj.bjc.6602485, 2361979, 15785745.
16. Mackay SG, Pager CK, Joseph D, Stewart PJ, Solomon MJ. Assessment of the accuracy of transrectal ultrasonography in anorectal neoplasia. The British journal of surgery 2003, 90:346-350. 10.1002/bjs.4042, 12594671.
17. Goertz RS, Fein M, Sailer M. Impact of biopsy on the accuracy of endorectal ultrasound staging of rectal tumors. Diseases of the colon and rectum 2008, 51:1125-1129. 10.1007/s10350-008-9222-7, 18478299.
18. Extramural depth of tumor invasion at thin-section MR in patients with rectal cancer: results of the MERCURY study. Radiology 2007, 243:132-139. 10.1148/radiol.2431051825, 17329685.
19. Dinter DJ, Hofheinz RD, Hartel M, Kaehler GF, Neff W, Diehl SJ. Preoperative staging of rectal tumors: comparison of endorectal ultrasound, hydro-CT, and high-resolution endorectal MRI. Onkologie 2008, 31:230-235. 10.1159/000121359, 18497511.
20. Kwok H, Bissett IP, Hill GL. Preoperative staging of rectal cancer. International journal of colorectal disease 2000, 15:9-20. 10.1007/s003840050002, 10766086.
21. Initial report from a Swedish multicentre study examining the role of preoperative irradiation in the treatment of patients with resectable rectal carcinoma. Swedish Rectal Cancer Trial. The British journal of surgery 1993, 80:1333-1336. 10.1002/bjs.1800801040, 8242317.
22. Marijnen CA, Kapiteijn E, Velde CJ, Martijn H, Steup WH, Wiggers T, Kranenbarg EK, Leer JW. Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol 2002, 20:817-825. 10.1200/JCO.20.3.817, 11821466.
23. Dahlberg M, Glimelius B, Graf W, Pahlman L. Preoperative irradiation affects functional results after surgery for rectal cancer: results from a randomized study. Diseases of the colon and rectum 1998, 41:543-549. discussion 549-551., 10.1007/BF02235256, 9593234.
24. Peeters KC, Velde CJ, Leer JW, Martijn H, Junggeburt JM, Kranenbarg EK, Steup WH, Wiggers T, Rutten HJ, Marijnen CA. Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients--a Dutch colorectal cancer group study. J Clin Oncol 2005, 23:6199-6206. 10.1200/JCO.2005.14.779, 16135487.
25. Chan P, Yeo I, Perkins G, Fyles A, Milosevic M. Dosimetric comparison of intensity-modulated, conformal, and four-field pelvic radiotherapy boost plans for gynecologic cancer: a retrospective planning study. Radiat Oncol 2006, 1:13. 10.1186/1748-717X-1-13, 1471795, 16722546.
26. Guckenberger M, Baier K, Richter A, Vordermark D, Flentje M. Does Intensity Modulated Radiation Therapy (IMRT) prevent additional toxicity of treating the pelvic lymph nodes compared to treatment of the prostate only?. Radiat Oncol 2008, 3:3. 10.1186/1748-717X-3-3, 2253547, 18190681.
27. Stieler F, Wolff D, Lohr F, Steil V, Abo-Madyan Y, Lorenz F, Wenz F, Mai S. A fast radiotherapy paradigm for anal cancer with volumetric modulated arc therapy (VMAT). Radiat Oncol 2009, 4:48. 10.1186/1748-717X-4-48, 2774855, 19852856.
28. Weber DC, Wang H, Cozzi L, Dipasquale G, Khan HG, Ratib O, Rouzaud M, Vees H, Zaidi H, Miralbell R. RapidArc, intensity modulated photon and proton techniques for recurrent prostate cancer in previously irradiated patients: a treatment planning comparison study. Radiat Oncol 2009, 4:34. 10.1186/1748-717X-4-34, 2749024, 19740429.
29. Suwinski R, Wzietek I, Tarnawski R, Namysl-Kaletka A, Kryj M, Chmielarz A, Wydmanski J. Moderately low alpha/beta ratio for rectal cancer may best explain the outcome of three fractionation schedules of preoperative radiotherapy. International journal of radiation oncology, biology, physics 2007, 69:793-799.
30. Purkayastha S, Tekkis PP, Athanasiou T, Tilney HS, Darzi AW, Heriot AG. Diagnostic precision of magnetic resonance imaging for preoperative prediction of the circumferential margin involvement in patients with rectal cancer. Colorectal Dis 2007, 9:402-411. 10.1111/j.1463-1318.2006.01104.x, 17504336.