Liquid-air partition coefficients of 1,1-difluoroethane (HFC152a), 1,1,1-trifluoroethane (HFC143a), 1,1,1,2-tetrafluoroethane (HFC134a), 1,1,1,2,2-pentafluoroethane (HFC125) and 1,1,1,3,3-pentafluoropropane (HFC245fa)

Journal of Applied Toxicology

Volumn 30, Issue 1, 2010, Pages 59-62

  Ernstgård, Lena ^a   Lind, Birger ^a   Andersen, Melvin E ^a,b   Johanson, Gunnar ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

Author keywords

Blood air; HFC; Hydrofluorocarbons; Liquid air; Oil air; Partition coefficient; Tissue air

Indexed keywords

1,1 DIFLUOROETHANE; 1,1,1 TRIFLUOROETHANE; 1,1,1,2,2 PENTAFLUOROETHANE; 1,1,1,3,3 PENTAFLUOROPROPANE; FLUORINATED HYDROCARBON; NORFLURANE; OIL; UNCLASSIFIED DRUG;

ARTICLE; BLOOD SAMPLING; CONCENTRATION RESPONSE; EQUILIBRIUM CONSTANT; FEMALE; GAS CHROMATOGRAPHY; HUMAN; MALE; NORMAL HUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL;

AIR; BLOOD CHEMICAL ANALYSIS; CHROMATOGRAPHY, GAS; FLUOROCARBONS; HUMANS; HYDROCARBONS, FLUORINATED; PLANT OILS; SODIUM CHLORIDE; SOLUBILITY; WATER;

EID: 74549113607     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1473     Document Type: Article

References (22)

1. Akins JR, Waldrep K, Bernert JT Jr. 1989. The estimation of total serum lipids by a completely enzymatic 'summation' method. Clin. Chim. Acta. 184(3): 219-226; doi: 10.1016/0009-8981(89)90054-5.
2. Batterman S, Zhang L, Wang S, Franzblau A. 2002. Partition coeffi cients for the trihalomethanes among blood, urine, water, milk and air. Sci. Total. Environ. 284(1-3): 237-247; doi: 10.1016/S0048-9697 (01)00890-7.
3. Bertolucci C, Fazio F, Piccione G. 2008. Daily rhythms of serum lipids in dogs: infl uences of lighting and fasting cycles. Comp. Med. 58(5): 485-489.
4. D'Orazio P, Conant J, Cervera J. 2008. Measurement of creatinine in whole blood samples supplemented to achieve increased creatinine concentrations. Clin. Chem. 54(2): 451-452; doi: 10.1373/ clinchem.2007.096594.
5. Eger EI, 2nd. 1987. Partition coeffi cients of I-653 in human blood, saline, and olive oil. Anesth. Analg. 66(10): 971-973.
6. Eger EI, 2nd, Liu J, Koblin DD, Laster MJ, Taheri S, Halsey MJ, Ionescu P, Chortkoff BS, Hudlicky T. 1994. Molecular properties of the 'ideal' inhaled anesthetic: studies of fl uorinated methanes, ethanes, propanes, and butanes. Anesth. Analg. 79(2): 245-251.
7. Emmen HH, Hoogendijk EM, Klopping-Ketelaars WA, Muijser H, Duistermaat E, Ravensberg JC, Alexander DJ, Borkhataria D, Rusch GM, Schmit B. 2000. Human safety and pharmacokinetics of the CFC alternative propellants HFC 134a (1,1,1,2-tetrafl uoroethane) and HFC 227 (1,1,1,2,3,3, 3-heptafl uoropropane) following whole-body exposure. Regul. Toxicol. Pharmacol. 32(1): 22-35; doi: 10.1006/rtph.2000. 1402.
8. Falk A, Gullstrand E, Löf A, Wigaeus-Hjelm E. 1990. Liquid/air partition coeffi cients of four terpenes. Br. J. Ind. Med. 47(1): 62-64.
9. Fiserova-Bergenrova V. 1983. Physiological models for pulmonary administration and elimination of inert vapors and gases. In Modeling of Inhalation Exposure to Vapors: Uptake, Distribution, and Elimination, Fiserova-Bergerova V (ed.). CRC Press: Boca Raton, FL; Vol. 1, 73-100.
10. Gargas ML, Burgess RJ, Voisard DE, Cason GH, Andersen ME. 1989. Partition coeffi cients of low-molecular-weight volatile chemicals in various liquids and tissues. Toxicol. Appl. Pharmacol. 98(1): 87-99; doi: 10.1016/0041-008X(89)90137-3.
11. Gunnare S, Ernstgård L, Sjögren B, Johanson G. 2006. Toxicokinetics of 1,1,1,2-tetrafl uoroethane (HFC-134a) in male volunteers after experimental exposure. Toxicol. Lett. 167(1): 54-65; doi: 10.1016/j. toxlet.2006.08.009.
12. Gunnare S, Ernstgård L, Sjögren B, Johanson G. 2007. Experimental exposure to 1,1,1,2-tetrafluoroethane (HFC-143a): uptake, disposition and acute eff ects in male volunteers. Toxicol. Lett. 172(3): 120-130; doi: 10.1016/j.toxlet.2007.05.010.
13. Johanson G, Dynesius B. 1988. Liquid/air partition coeffi cients of six commonly used glycol ethers. Br. J. Ind. Med. 45(8): 561-564.
14. Johanson G, Filser JG. 1992. Experimental data from closed chamber gas uptake studies in rodents suggest lower uptake rate of chemical than calculated from literature values on alveolar ventilation. Arch. Toxicol. 66(4): 291-295.
15. Järnberg J, Johanson G. 1995. Liquid/air partition coeffi cients of the trimethylbenzenes. Toxiocol. Ind. Health 11(1): 81-88.
16. Lerman J, Gregory G A, Eger E I, 2nd. 1987. Eff ects of anaesthesia and surgery on the solubility of volatile anaesthetics in blood. Can. J. Anaesth. 34(1): 14-16.
17. Nihlén A, Löf A, Johanson G. 1995. Liquid/air partition coeffi cients of methyl and ethyl T-butyl ethers, T-amyl methyl ether, and T-butyl alcohol. J. Expo. Anal. Environ. Epidemiol. 5(4): 573-582.
18. Perbellini L, Brugnone F, Caretta D, Maranelli G. 1985. Partition coefficients of some industrial aliphatic hydrocarbons (C5-C7) in blood and human tissues. Br. J. Ind. Med. 42(3): 162-167.
19. Rylander L, Nilsson-Ehle, P, Hagmar L. 2006. A simplifi ed precise method for adjusting serum levels of persistent organohalogen pollutants to total serum lipids. Chemosphere 62(3): 333-336; doi: 10.1016/j. chemosphere.2005.04.107.
20. Sato A, Nakajima T. 1979. Partition coefficients of some aromatic hydrocarbons and ketones in water, blood and oil. Br. J. Ind. Med. 36(3): 231-234.
21. Ventresca GP. 1995. Clinical pharmacology of HFA134a. J. Aerosol. Med. 8(suppl 1): S35-S39.
22. Vinegar A, Jepson GW, Cisneros M, Rubenstein R, Brock WJ. 2000. Setting safe acute exposure limits for halon replacement chemicals using physiologically based pharmacokinetic modeling. Inhal. Toxicol. 12(8): 751-763; doi: 10.1080/08958370050085174.