Continuous therapy with nitroglycerin impairs endothelium-dependent vasodilation but does not cause tolerance in conductance arteries: A human in vivo study

Journal of Cardiovascular Pharmacology

Volumn 44, Issue 5, 2004, Pages 601-606

  Gori, Tommaso ^a,b   Harvey, Paula ^a   Floras, John S ^a   Parker, John D ^a,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF SIENA   (Italy)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Endothelial function; Nitrate tolerance; Nitroglycerin

Indexed keywords

GLYCERYL TRINITRATE; ORGANIC NITRATE;

ADULT; ARTICLE; BRACHIAL ARTERY; CLINICAL TRIAL; CONDUCTANCE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG TOLERANCE; ENDOTHELIUM; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; VASODILATATION;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, SUBLINGUAL; ADULT; BLOOD PRESSURE; BRACHIAL ARTERY; DRUG ADMINISTRATION SCHEDULE; DRUG TOLERANCE; ENDOTHELIUM, VASCULAR; HUMANS; LASER-DOPPLER FLOWMETRY; MALE; NITROGLYCERIN; REGIONAL BLOOD FLOW; RESEARCH DESIGN; SINGLE-BLIND METHOD; TIME FACTORS; VASODILATION;

EID: 7444241325     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200411000-00014     Document Type: Article

References (27)

1. Parker JD, Parker JO. Nitrate therapy for stable angina pectoris. N Engl J Med. 1998;338:520-531.
2. Fink B, Bassenge E. Unexpected tolerance-devoid vasomotor and platelet actions of pentaerythrity 1 tetranitrate. J Cardiovasc Pharmacol. 1997;30: 831-836.
3. Munzel T, Holtz J, Mulsch A, et al. Nitrate tolerance in epicardial arteries or in the venous system is not reversed by N-acetylcysteine in vivo, but tolerance-independent interactions exist. Circulation. 1989;79:188-197.
4. Sage PR, de la Lande I, Stafford I, et al. Nitroglycerin tolerance in human vessels: evidence for impaired nitroelycerin bioconversion. Circulation. 2000;102:2810-2815.
5. Schulz E, Tsilimingas N, Rinze R, et al. Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment. Circulation. 2002;105:1170-1175.
6. Jeserich M, Munzel T, Pape L, et al. Absence of vascular tolerance in conductance vessels after 48 hours of intravenous nitroglycerin in patients with coronary artery disease. J Am Coll Cardiol. 1995;26:50-56.
7. Munzel T, Heitzer T, Kurz S, et al. Dissociation of coronary vascular tolerance and neurohormonal adjustments during long-term nitroglycerin therapy in patients with stable coronary artery disease. J Am Coll Cardiol. 1996;27:297-303.
8. Munk KM, Mortensen UM, Nielsen-Kudsk JE, et al. Noninvasive assessment of nitrate tolerance using mitral Doppler and brachial artery ultrasonography. Am J Cardiol. 2003;91:111-113.
9. Gruhn N, Aldershvile J, Boesgaard S. Tetrahydrobiopterin improves endothelium-dependent vasodilation in nitroglycerin-tolerant rats. Eur J Pharmacol. 2001;416:245-249.
10. Gori T, Mak SS, Kelly S, et al. Evidence supporting abnormalities in nitric oxide synthase function induced by nitroglycerin in humans. J Am Coll Cardiol. 2001;38:1096-1101.
11. Munzel T, Li H, Mollnau H, et al. Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS III) gene expression, NOS III-mediated superoxide production, and vascular NO bioavailability. Circ Res. 2000;86:E7-E12.
12. Gori T, Parker JD. Nitrate tolerance: a unifying hypothesis. Circulation. 2002;106:2510-2513.
13. Munzel T, Sayegh H, Freeman BA, et al. Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance. J Clin Invest. 1995;95:187-194.
14. Caramori PR, Adelman AG, Azevedo ER, et al. Therapy with nitroglycerin increases coronary vasoconstriction in response to acetylcholine. J Am Coll Cardiol. 1998;32:1969-1974.
15. Chan CT, Harvey PJ, Picton P, et al. Short-term blood pressure, noradrenergic, and vascular effects of nocturnal home hemodialysis. Hypertension. 2003;42:925-931.
16. Gori T, Saunders L, Ahmed S, et al. Effect of folic acid on nitrate tolerance in healthy volunteers: differences between arterial and venous circulation. J Cardiovasc Pharmacol. 2003;41:185-190.
17. Gori T, Parker JD. The puzzle of nitrate tolerance: pieces smaller than we thought? Circulation. 2002;106:2404-2408.
18. Giannattasio C, Piperno A, Failla M, et al. Effects of hematocrit changes on flow-mediated and metabolic vasodilation in humans. Hypertension. 2002;40:74-77.
19. Parker JD, Farrell B, Fenton T, et al. Counter-regulatory responses to continuous and intermittent therapy with nitroglycerin. Circulation. 1991; 84:2336-2345.
20. Dupuis J, Lalonde G, Lemieux R, et al. Tolerance to intravenous nitroglycerin in patients with congestive heart failure: role of increased intravascular volume, neurohumoral activation and lack of prevention with N-acetylcysteine. J Am Coll Cardiol. 1990;16:923-931.
21. Gori T, Floras JS, Parker JD. Nitroglycerin blunts the gain of the baroreceptor-heart rate reflex. Circulation. 2001;104:11-331.
22. James MA, Papouchado M, Jones JV. Attenuation of nitrate effect during an intermittent treatment regimen and the time course of nitrate tolerance. Eur Heart J. 1991;12:1266-1272.
23. Figueras J, Lidon R, Cortadellas J. Rebound myocardial ischaemia following abrupt interruption of intravenous nitroglycerin infusion in patients with unstable angina at rest. Eur Heart J. 1991;12:405-411.
24. Corretti MC, Anderson TJ, Benjamin EJ, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002;39:257-265.
25. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation. 2000;101:1899-1906.
26. Heitzer T, Schlinzig T, Krohn K, et al. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation. 2001;104:2673-2678.
27. Parker JD. Potential problems with intermittent nitrate therapy. Can J Cardiol. 1996;12(Suppl C):22C-24C.