Dissociation of coronary vascular tolerance and neurohormonal adjustments during long-term nitroglycerin therapy in patients with stable coronary artery disease

Journal of the American College of Cardiology

Volumn 27, Issue 2, 1996, Pages 297-303

  Münzel, Thomas ^a,d   Heitzer, Thomas ^a   Kurz, Sabine ^a   Harrison, David G ^b   Luhman, Clemens ^a   Pape, Linda ^c   Olschewski, Manfred ^a   Just, Hanjörg ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b EMORY UNIVERSITY   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; GLYCERYL TRINITRATE; NEUROHORMONE; RENIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DRUG TOLERANCE; FEMALE; HEMATOCRIT; HUMAN; INTRAARTERIAL DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL;

EID: 17144447936     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/0735-1097(95)00475-0     Document Type: Article

References (36)

1. Abrams J. A reappraisal of nitrate therapy. JAMA 1988;259:396-401.
2. Packer M, Lee W, Kessler PD, Gottlieb SS, Medina N, Yushak M. Prevention and reversal of nitrate tolerance in patients with congestive heart failure. N Eng J Med 1987;317:799-804.
3. Parker JD, Farrell B, Fenton T, Cohanim M, Parker JO. Counter-regulatory responses to continuous and intermittent therapy with nitroglycerin. Circulation 1991;84:2336-45.
4. Zimrin D, Reichek N, Bogin KT, et al. Antianginal effects of intravenous nitroglycerin over 24 hours. Circulation 1988;77:1376-84.
5. Dupuis J, Lalonde G, Lemieux R, Rouleau J. Tolerance to intravenous nitroglycerin in patients with congestive heart failure: role of increased intravascular volume, neurohumoral activation and lack of prevention with N-acetylcysteine. J Am Coll Cardiol 1990;16:923-31.
6. Needleman P, Johnson EMJ. Mechanism of tolerance development to organic nitrates. J Pharmacol Esp Ther 1973;184:709-15.
7. Brien JF, McLaughlin BE, Breedon TH, Bennett BM, Nakatsu K, Marks GS. Biotransformation of glyceryl trinitrate occurs concurrently with relaxation of rabbit aorta. J Pharmacol Exp Ther 1986;237:608-14.
8. Rapoport RM, Waldman SA, Ginsburg R, Molina CR, Murad F. Effects of glyceryl trinitrate on endothelium-dependent and -independent relaxation and cyclic GMP levels in rat aorta and human coronary artery. J Cardiovasc Pharmacol 1987;10:82-9.
9. Münzel T, Kurz S, Holtz J, et al. Neurohormonal inhibition and hemodynamic unloading during prolonged inhibition of ANF degradation in patients with severe chronic heart failure. Circulation 1992;86:1089-98.
10. Drexler H, Zeiher AM, Wollschlager H, Meinertz T, Just H, Bonzel T. Flow-dependent coronary artery dilatation in humans. Circulation 1989;80: 466-74.
11. Wollschläger H, Lee P, Zeiher AM, Solzbach U, Bonzel T, Just H. Improvement of quantitative angiography by exact calculation of radiological magnification factors. Comput Cardiol 1986;11:483-6.
12. Hishashi K, Yamamoto H, Noma M, et al. Effects of continuous intravenous infusion of isosorbide dinitrate on development of tolerance to vasodilating action in human epicardial coronary arteries. Am Heart J 1994;128:230-6.
13. Münzel T, Mülsch A, Holtz J, Harrison DG, Bassenge E. Mechanisms of interaction between the sulfhydryl precursor L-methionine and glyceryl trinitrate. Circulation 1992;86:995-1003.
14. Moreyra AE, Kostis JB. Effect of cutaneous nitroglycerin patches on coronary artery diameter: issues concerning development of tolerance. J Am Coll Cardiol 1989;13:428-33.
15. Stewart DJ, Holtz J, Bassenge E. Long-term nitroglycerin treatment: effect on direct and endothelium-mediated large coronary artery dilation in conscious dogs. Circulation 1987;75:847-56.
16. Elkayam U, Kulick D, McIntosh N, Roth A, Hsueh W, Rahimtoola SH. Incidence of early tolerance to hemodynamic effects of continuous infusion of nitroglycerin in patients with coronary artery disease and heart failure. Circulation 1987;76:577-84.
17. Parker JO, Fung HL, Ruggirello D, Stone JA. Tolerance to isosorbide dinitrate: rate of development and reversal. Circulation 1983;68:1074-80.
18. Thadani U, Hamilton SF, Olson E, et al. Transdermal nitroglycerin patches in angina pectoris. Ann Intern Med 1986;105:485-92.
19. Parker JD, Parker JO. Effects of therapy with an angiotensin converting enzyme inhibitor on hemodynamic and counterregulatory responses during continuous therapy with nitroglycerin. J Am Coll Cardiol 1993;21:1445-53.
20. Mehra A, Ostrzega E, Shotan A, Johnson JV, Elkayam U. Persistent hemodynamic improvement with short-term nitrate therapy in patients with chronic congestive heart failure already treated with captopril. Am J Cardiol 1992;70:1310-4.
21. Muiesan ML, Boni E, Castellano M, et al. Effects of transdermal nitroglycerin in combination with an ACE-inhibitor in patients with chronic stable angina pectoris. Eur Heart J 1993;14:1701-8.
22. Katz RJ, Levy WS, Buff L, Wasserman AG. Prevention of nitrate tolerance with angiotensin-converting enzyme inhibitors. Circulation 1991;83:1271-7.
23. Feldman RL, Pepine CJ, Conti CR. Magnitude dilation of large and small coronary arteries by nitroglycerin. Circulation 1981;64:324-33.
24. Pagani M, Vatner SF, Braunwald E. Hemodynamic effects of intravenous nitroprusside in the conscious dog. Circulation 1978;57:144-51.
25. Ueda K, Sakai M, Matsuhita S, Kuwajiama I, Murakami M. Effect of orally administered hydralazine on neurohormonal factors and hemodynamic response in aged patients with chronic congestive heart failure. Jpn Heart J 1983;24:711-21.
26. Münzel T, Bassenge E. Chronic angiotensin converting enzyme inhibition with high dose enalapril retards nitrate tolerance development in large epicardial arteries and prevents coronary rebound constriction in vivo. Circulation. In press.
27. Stewart DJ, Elsner D, Sommer O, Holtz J, Bassenge E. Altered spectrum of nitroglycerin action in long-term treatment: nitroglycerin-specific venous tolerance with maintenance of arterial vasodepressor potency. Circulation 1986;74:573-82.
28. Münzel T, Holtz J, Mülsch A, Stewart D, Bassenge E. Nitrate tolerance in epicardial arteries or in the venous system is not reversed by N-acetylcysteine in vivo, but tolerance-independent interactions exist. Circulation 1989;79: 188-97.
29. Thadani U, Manyari D, Parker O, Fung HL. Tolerance to the circulatory effects of oral isosorbide dinitrate. Circulation 1980;61:526-35.
30. Khayal MA, Eng C, Franzen D, Breall JA, Kirk ES. Effects of vasopressin on the coronary circulation: reserve and regulation during ischemia. Am J Physiol 1985;248:H516-22.
31. Cohen MV, Kirk ES. Differential response of large and small coronary arteries to nitroglycerin and angiotensin. Circ Res 1973;33:445-53.
32. Sellke FW, Tomanek RJ, Harrison DG. L-Cysteine selectively potentiates nitroglycerin-induced dilation of small coronary microvessels. J Pharmacol Exp Ther 1991;258:365-9.
33. Sellke FW, Myers PR, Bates JN, Harrison DG. Influence of vessel size on the sensitivity of porcine microvessels to nitroglycerin. Am J Physiol 1990;258: H515-20.
34. Münzel T, Sayegh H, Freeman BA, Tarpey MM, Harrison DG. Evidence for enhanced vascular superoxide anion production in nitrate tolerance: a novel mechanism of tolerance and cross tolerance. J Clin Invest 1995;95:187-94.
35. Münzel T, Kurz S, Giaid A, Stewart D, Harrison DG. Evidence for a role of endothelin-1 and protein kinase C in nitrate tolerance. Proc Natl Acad Sci USA 1995;92:5244-8.
36. Seth P, Fung HL. Biochemical characterization of a membrane-bound enzyme responsible for generating nitric oxide from nitroglycerin in vascular smooth muscle cells. Biochem Pharmacol 1993;46:1481-6.