Synthesis and antiviral activity of 3-formyl- and 3-cyano-2,5,6- trichloroindole nucleoside derivatives

Journal of Medicinal Chemistry

Volumn 47, Issue 23, 2004, Pages 5766-5772

  Williams, John D ^a   Chen, Jiong J ^a   Drach, John C ^a   Townsend, Leroy B ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE 3 CARBOXAMIDE OXIME; 3 [(4 SEMICARBAZONO)METHYLIDENE] 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 [(4 THIOSEMICARBAZONO)METHYLIDENE] 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 [N (ACETYLAMINO)IMINOMETHYLIDENE] 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 [N (METHOXYCARBONYLAMINO)IMINOMETHYLIDENE] 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 CYANO 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 FORMYL 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; AMIDE; GANCICLOVIR; HYDRAZINE DERIVATIVE; HYDRAZONE DERIVATIVE; HYDROXYLAMINE; IMIDATE; IMIDOESTER; INDOLE DERIVATIVE; METHANOL; NUCLEOSIDE DERIVATIVE; OXIME; OXIME DERIVATIVE; UNCLASSIFIED DRUG;

ADDITION REACTION; ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IC 50; VIRUS INHIBITION;

ANTIVIRAL AGENTS; CELL LINE; CYTOMEGALOVIRUS; HERPESVIRUS 1, HUMAN; HUMANS; INDOLES; MOLECULAR CONFORMATION; NUCLEOSIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 7444229249     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040032n     Document Type: Article

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