Design, synthesis, and antiviral activity of certain 3-substituted 2,5,6-trichloroindole nucleosides

Journal of Medicinal Chemistry

Volumn 47, Issue 23, 2004, Pages 5753-5765

  Williams, John D ^a   Chen, Jiong J ^a   Drach, John C ^a   Townsend, Leroy B ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMO 5,6 DICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)BENZIMIDAZOLE; 2,3,5,6 TETRACHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)BENZIMIDAZOLE; 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 (2 FURYL) 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 (3 THIENYL) 2,5,6 TRICHLORO 1 BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 ACETYL 2,5,6 TRICHLORO 1 (5 O ACETYL BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 ACETYL 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 CYANO 2,5,6 TRICHLORO 1 (5 O ACETYL BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 CYANO 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 FORMYL 2 BROMO 5,6 DICHLORO 1 (5 O ACETYL BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 FORMYL 2 BROMO 5,6 DICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 FORMYL 2,5,6 TRICHLORO 1 (5 O ACETYL BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 FORMYL 2,5,6 TRICHLORO 1 (5 O BUTYRYL BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 FORMYL 2,5,6 TRICHLORO 1 (5 O METHOXYCARBONYL BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 FORMYL 2,5,6 TRICHLORO 1 (5 O PROPIONYL BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 FORMYL 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 FORMYLMETHYL 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 IODO 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 METHYL 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 MTHYL 2,5,6 TRICHLORO 1 3,5 DI O (P TOLUOYL) 2 DEOXY BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 PROPIONYL 2,5,6 TRICHLORO 1 (5 O ACETYL BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 PROPIONYL 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; 3 TRIFLUOROACETYL 2,5,6 TRICHLORO 1 (BETA DEXTRO RIBOFURANOSYL)INDOLE; BENZIMIDAZOLE DERIVATIVE; GANCICLOVIR; INDOLE DERIVATIVE; SUGAR; UNCLASSIFIED DRUG;

ADDITION REACTION; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CHEMICAL MODIFICATION; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GLYCOSYLATION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; HYDROGEN BOND; IC 50; OPTIMAL DRUG DOSE; VIRUS INHIBITION;

ANTIVIRAL AGENTS; CELL LINE; CYTOMEGALOVIRUS; DRUG DESIGN; HERPESVIRUS 1, HUMAN; HUMANS; INDOLES; MOLECULAR CONFORMATION; NUCLEOSIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 7444233117     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0400146     Document Type: Article

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