Analysis of streptonigrin-induced incomplete chromosome elements and interstitial fragments in chinese hamster cells using a telomeric PNA probe

Environmental and Molecular Mutagenesis

Volumn 44, Issue 4, 2004, Pages 277-282

  Bolzán, Alejandro D ^a   Bianchi, Martha S ^a  

^a Instituto Multidisciplinario de Biologia Celular   (Argentina)

Author keywords

Chromosome aberrations; Incomplete chromosome elements; Interstitial fragments; Streptonigrin; Telomeric probe

Indexed keywords

PEPTIDE NUCLEIC ACID; RUFOCROMOMYCIN;

ANIMAL CELL; ARTICLE; CENTROMERE; CHINESE HAMSTER; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME STRUCTURE; CONTROLLED STUDY; DICENTRIC CHROMOSOME; DOSE RESPONSE; DRUG EFFECT; FLUORESCENCE IN SITU HYBRIDIZATION; INTERSTITIAL CHROMOSOME DELETION; METAPHASE; MITOSIS; NONHUMAN; NUCLEIC ACID PROBE; RING CHROMOSOME; TELOMERE;

ANIMALS; CHROMOSOME ABERRATIONS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; IN SITU HYBRIDIZATION, FLUORESCENCE; NUCLEIC ACID PROBES; PEPTIDE NUCLEIC ACIDS; STREPTONIGRIN; TELOMERE;

CRICETINAE; CRICETULUS GRISEUS;

EID: 7444222929     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.20051     Document Type: Article

References (24)

1. Balajee AS, Oh HJ, Natarajan AT. 1994. Analysis of restriction enzyme-induced chromosome aberrations in the interstitial telomeric repeat sequences of CHO and CHE cells by FISH. Mutat Res 307:307-313.
2. Balajee AS, Dominguez I, Bohr VA, Natarajan AT. 1996. Immunofluorescent analysis of the organization of telomeric DNA sequences and their involvement in chromosomal aberrations in hamster cells. Mutat Res 372:163-172.
3. Boei JJWA, Natarajan AT. 1998. Combined use of chromosome painting and telomere detection to analyse radiation induced chromosomal aberrations in mouse splenocytes. Int J Radiat Biol 73:125-133.
4. Boei JJWA, Vermeulen S, Fomina J, Natarajan AT. 1998. Detection of incomplete exchanges and interstitial fragments in X-irradiated human lymphocytes using a telomeric PNA probe. Int J Radiat Biol 73:599-603.
5. Boei JJWA, Vermeulen S, Natarajan AT. 2000. Analysis of radiation-induced chromosomal aberrations using telomeric and centromeric PNA probes. Int J Radiat Biol 76:163-167.
6. Boei JJWA, Vermeulen S, Mullenders LHF, Natarajan AT. 2001. Impact of radiation quality on the spectrum of induced chromosome exchange aberrations. Int J Radiat Biol 77:847-857.
7. Bolzán AD, Bianchi NO, Bianchi MS. 1998. Chromosomal response of insect and mammalian cells to sireptonigrin: a comparative study. Environ Mol Mutagen 32:331-335.
8. Bolzán AD, Bianchi MS. 2001. Genotoxicity of streptonigrin: a review. Mutat Res 488:25-37.
9. Bolzán AD, Páez GL, Bianchi MS. 2001a. FISH analysis of telomeric repeat sequences and their involvement in chromosomal aberrations induced by radiomimetic compounds in hamster cells. Mutat Res 479:187-196.
10. Bolzán AD, Bianchi MS, Correa MV. 2001b. Modulation of streplonigrin's clastogenic effects in CHO cells by the metal-chelating agent 1,10-phenanthroline. Environ Mol Mutagen 38:306-310.
11. Bolzán AD, Bianchi MS. 2004. Detection of incomplete chromosome elements and interstitial fragments induced by bleomycin in hamster cells using a telomeric PNA probe. Mutat Res 554:1-8.
12. De Lange T. 1992. Human telomeres are attached to the nuclear matrix. EMBO J 11:717-724.
13. Ellard S, Parry EM, Parry JM. 1995. Use of multicolour chromosome painting to identify chromosomal rearrangements in human lymphocytes exposed to bleomycin: a comparison with conventional cytogenetic analysis of Giemsa-stained chromosomes. Environ Mol Mutagen 26:44-54.
14. Fomina J, Darroudi F, Boei JJWA, Natarajan AT. 2000. Discrimination between complete and incomplete chromosome exchanges in X-irradiated human lymphocytes using FISH with pan-centromeric and chromosome specific DNA probes in combination with telomeric PNA probe. Int J Radiat Biol 76:807-813.
15. Fomina J, Darroudi F, Natarajan AT. 2001. Accurate detection of true incomplete exchanges in human lymphocytes exposed to neutron radiation using chromosome painting in combination with a telomeric PNA probe. Int J Radiat Biol 77:1175-1183.
16. Fomina J, Darroudi F, Natarajan AT. 2002. Incomplete chromosome exchanges are not fingerprints of high LET neutrons. Radiat Prot Dosimetry 99:215-216.
17. Hlatky LR, Sachs RK, Hahndfeldt P. 1992. The ratio of dicentrics to centric rings produced in human lymphocytes by acute low-LET radiation. Radiat Res 129:304-308.
18. López-Larraza DM, De Luca JC, Bianchi NO. 1990. The kinetics of DNA damage by bleomycin in mammalian cells. Mutat Res 232:57-61.
19. Natarajan AT, Boei JJWA. 2003. Formation of chromosome aberrations: insights form FISH. Mutat Res 544:299-304.
20. Perry PE, Wolff P. 1974. New Giemsa method for differential staining of sister chromatids. Nature 251:156-158.
21. Puerto S, Surrallés J, Ramírez MJ, Carbonell E, Creus A, Marcos R. 1999. Análisis of bleomycin- and cytosine arabinoside-induced chromosome aberrations involving chromosomes 1 and 4 by painting FISH. Mutat Res 439:3-11.
22. Sachs RK, Chen AM, Brenner DJ. 1997. Review: proximity effects in the production of chromosome aberrations by ionizing radiation. Int J Radiat Biol 71:1-19.
23. Slijepcevic P, Hande MP. 1999. Chinese hamster telomeres are comparable in size to mouse telomeres. Cytogenet Cell Genet 85:196-199.
24. Wu H, George K, Yang TC. 1998. Estimate of true incomplete exchanges using fluorescence in situ hybridization with telomere probes. Int J Radiat Biol 73:521-527.