Pharmacokinetics and safety of bromotetrandrine (BrTet, W198) after single-dose intravenous administration in healthy Chinese volunteers

Journal of Clinical Pharmacy and Therapeutics

Volumn 35, Issue 1, 2010, Pages 113-119

  Zheng, L ^a   Qing, Y P ^a   Xu, N ^a   Yu, Q ^a   Wang, Y ^a   Wang, F P ^b   Li, Z Y ^c  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c Kang Hong Pharmaceutical Group   (China)

Author keywords

Bromotetrandrine; Inhibitor; P glucoprotein; Pharmacokinetics; Phase I

Indexed keywords

BROMOTETRANDRINE; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; UNCLASSIFIED DRUG; W 198;

ADULT; AREA UNDER THE CURVE; ARTICLE; CHINESE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE ESCALATION; DRUG HALF LIFE; DRUG URINE LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; OPEN STUDY; PHASE 1 CLINICAL TRIAL; PHLEBITIS; RANDOMIZED CONTROLLED TRIAL; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADULT; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZYLISOQUINOLINES; CHINA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HALF-LIFE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; METABOLIC CLEARANCE RATE; P-GLYCOPROTEIN; SEX CHARACTERISTICS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 74349118726     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2009.01075.x     Document Type: Article

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