메뉴 건너뛰기




Volumn 92, Issue 1, 2010, Pages 187-195

Toxic effects of lead exposure on the brain of rats: Involvement of oxidative stress, inflammation, acetylcholinesterase, and the beneficial role of flaxseed extract

Author keywords

Acetylcholinesterase; Brain inflammation; Flaxseed; Lead toxicity; Oxidative stress

Indexed keywords

ACETYLCHOLINESTERASE; ADVERSE EFFECT; ANTIOXIDANT ENZYME; BRAIN TISSUE; CHRONIC TREATMENT; DRINKING WATER; FLAXSEED; GLUTATHIONE-S-TRANSFERASE; GLUTATHIONES; LEAD EXPOSURE; LIPID PROFILE; LOW LEVEL; NEUROTOXICITY; SPRAGUE-DAWLEY RATS; SUPEROXIDE DISMUTASES; TOXIC EFFECT;

EID: 74349091954     PISSN: 02772248     EISSN: 10290486     Source Type: Journal    
DOI: 10.1080/02772240902830631     Document Type: Article
Times cited : (29)

References (40)
  • 1
    • 0032798931 scopus 로고    scopus 로고
    • Lead intoxication: Antioxidant and oxidative damage in rat brain
    • Adonaylo, A., and P. Oteiza. 1999. Lead intoxication: Antioxidant and oxidative damage in rat brain. Toxicology 135: 77.
    • (1999) Toxicology , vol.135 , pp. 77
    • Adonaylo, A.1    Oteiza, P.2
  • 2
    • 0000069868 scopus 로고    scopus 로고
    • Tumor necrosis factor and lymphotoxin
    • ed. A. Thorpe, San Diego: Academic Press
    • Beyaert, R., and W. Fiers. 1998. Tumor necrosis factor and lymphotoxin. In Cytokines, ed. A. Thorpe, 335-60. San Diego: Academic Press.
    • (1998) Cytokines , pp. 335-360
    • Beyaert, R.1    Fiers, W.2
  • 5
    • 34447645907 scopus 로고    scopus 로고
    • Smelters and metal reclaimers
    • 2nd ed eds. M. Greenberg, R. Hamilton, S. Phillips and G. McCluskey, Philadelphia: Mosby
    • De Roos, F. 2003. Smelters and metal reclaimers. In Occupational, industrial and environmental toxicology. 2nd ed, eds. M. Greenberg, R. Hamilton, S. Phillips and G. McCluskey, 388-97. Philadelphia: Mosby.
    • (2003) Occupational, Industrial and Environmental Toxicology , pp. 388-397
    • de Roos, F.1
  • 7
    • 33644811612 scopus 로고
    • A new and rapid colorimetric determination of acetylcholinesterase activity
    • Ellman, G., D. Courtney, V. Andres, and R. Featherstone. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology 7: 88-95.
    • (1961) Biochemical Pharmacology , vol.7 , pp. 88-95
    • Ellman, G.1    Courtney, D.2    Andres, V.3    Featherstone, R.4
  • 8
    • 0019949179 scopus 로고
    • Triglyceride determination calorimetrically with an enzyme that produces hydrogen peroxide
    • Fossati, P., and L. Prencipe. 1982. Triglyceride determination calorimetrically with an enzyme that produces hydrogen peroxide. Clinical Chemistry 28: 2077-80.
    • (1982) Clinical Chemistry , vol.28 , pp. 2077-2080
    • Fossati, P.1    Prencipe, L.2
  • 9
    • 41949116160 scopus 로고    scopus 로고
    • Vanadium improves brain acetylcholinesterase activity on early stage alloxan-diabetic rats
    • Ghareeb, D., and H. Hussein. 2008. Vanadium improves brain acetylcholinesterase activity on early stage alloxan-diabetic rats. Neuroscience Letters 436: 44-7.
    • (2008) Neuroscience Letters , vol.436 , pp. 44-47
    • Ghareeb, D.1    Hussein, H.2
  • 10
    • 0016275313 scopus 로고
    • Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation
    • Habig, H., G. Pabst, and B. Jakoby. 1974. Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation. The Journal of Biological Chemistry 249: 7130-9.
    • (1974) The Journal of Biological Chemistry , vol.249 , pp. 7130-7139
    • Habig, H.1    Pabst, G.2    Jakoby, B.3
  • 11
    • 0347626945 scopus 로고    scopus 로고
    • Effects of concurrent exposure to lead and cadmium on renal function in goats
    • Haneef, S., D. Swarup, S. Dwivedi, and P. Dash. 1998. Effects of concurrent exposure to lead and cadmium on renal function in goats. Small Ruminant Research 28: 257-61.
    • (1998) Small Ruminant Research , vol.28 , pp. 257-261
    • Haneef, S.1    Swarup, D.2    Dwivedi, S.3    Dash, P.4
  • 12
    • 0037201960 scopus 로고    scopus 로고
    • Antioxidant nutrients and lead toxicity
    • Hsu, P., and Y. Guo. 2002. Antioxidant nutrients and lead toxicity. Toxicology 180: 33-44.
    • (2002) Toxicology , vol.180 , pp. 33-44
    • Hsu, P.1    Guo, Y.2
  • 13
    • 0033009016 scopus 로고    scopus 로고
    • Health aspects of partially defatted flaxseed, including effects on serum lipid, oxidative measures, and ex vivo androgen and progestin activity: A controlled crossover trial
    • Jenkins, D., C. Kendall, E. Vidgen, S. Agarwal, A. Rao, and R. Rosenberg. 1999. Health aspects of partially defatted flaxseed, including effects on serum lipid, oxidative measures, and ex vivo androgen and progestin activity: A controlled crossover trial. The American Journal of Clinical Nutrition 69: 395-462.
    • (1999) The American Journal of Clinical Nutrition , vol.69 , pp. 395-462
    • Jenkins, D.1    Kendall, C.2    Vidgen, E.3    Agarwal, S.4    Rao, A.5    Rosenberg, R.6
  • 14
    • 0016151122 scopus 로고
    • Bromobenzene induced liver necrosis: Protective role of glutathione and evidence for 3,4-bromobenzenoxide as the hepatotoxic intermediate
    • Jollow, D., J. Mitchell, N. Zampaglione, and J. Gillette. 1974. Bromobenzene induced liver necrosis: Protective role of glutathione and evidence for 3,4-bromobenzenoxide as the hepatotoxic intermediate. Pharmacology 11: 151-69.
    • (1974) Pharmacology , vol.11 , pp. 151-169
    • Jollow, D.1    Mitchell, J.2    Zampaglione, N.3    Gillette, J.4
  • 15
    • 33646758902 scopus 로고    scopus 로고
    • Dietary flaxseed supplementation ameliorates inflammation and oxidative tissue damage in experimental models of acute lung injury in mice
    • Kinniry, P., Y. Amrani, A. Vachani, C. Solamides, E. Arguiri, A. Workman, and J. Caster. 2006. Dietary flaxseed supplementation ameliorates inflammation and oxidative tissue damage in experimental models of acute lung injury in mice. The Journal of Nutrition 136: 1545.
    • (2006) The Journal of Nutrition , vol.136 , pp. 1545
    • Kinniry, P.1    Amrani, Y.2    Vachani, A.3    Solamides, C.4    Arguiri, E.5    Workman, A.6    Caster, J.7
  • 16
    • 0033400047 scopus 로고    scopus 로고
    • Antioxidant activity of the flaxseed lignin secoisoiciresnol diglycoside and its mammalian lignin metabolites enterodiol and enterolactone
    • Kitts, D., Y. Yuan, A. Wijewichreme, and L. Thompson. 1999. Antioxidant activity of the flaxseed lignin secoisoiciresnol diglycoside and its mammalian lignin metabolites enterodiol and enterolactone. Molecular and Cellular Biochemistry 202: 91-100.
    • (1999) Molecular and Cellular Biochemistry , vol.202 , pp. 91-100
    • Kitts, D.1    Yuan, Y.2    Wijewichreme, A.3    Thompson, L.4
  • 17
    • 0035008460 scopus 로고    scopus 로고
    • Method for the measurement of antioxidant activity in human fluids
    • Koracevic, D., and G. Koracevic. 2001. Method for the measurement of antioxidant activity in human fluids. Journal of Clinical Pathology 54: 356-61.
    • (2001) Journal of Clinical Pathology , vol.54 , pp. 356-361
    • Koracevic, D.1    Koracevic, G.2
  • 18
    • 34247542013 scopus 로고    scopus 로고
    • Effects of curcumin on renal oxidative stress and inflammation in diabetes
    • Kowluru, R., and M. Kanwar. 2007. Effects of curcumin on renal oxidative stress and inflammation in diabetes. Nutrition and Metabolism 16: 4.
    • (2007) Nutrition and Metabolism , vol.16 , pp. 4
    • Kowluru, R.1    Kanwar, M.2
  • 19
    • 35348851411 scopus 로고    scopus 로고
    • Curcumin attenuates diabetic encephalopathy in rat: Behavioral and biochemical evidence
    • Kuhad, A., and K. Chopra. 2007. Curcumin attenuates diabetic encephalopathy in rat: Behavioral and biochemical evidence. European Journal of Pain 576: 34.
    • (2007) European Journal of Pain , vol.576 , pp. 34
    • Kuhad, A.1    Chopra, K.2
  • 20
    • 0036144484 scopus 로고    scopus 로고
    • Modulation of carbon tetrachloride induced oxidative stress by dietary fat in rats
    • MacDonald-Wicks, L., and M. Garg. 2003. Modulation of carbon tetrachloride induced oxidative stress by dietary fat in rats. The Journal of Nutritional Biochemistry 13: 87-95.
    • (2003) The Journal of Nutritional Biochemistry , vol.13 , pp. 87-95
    • MacDonald-Wicks, L.1    Garg, M.2
  • 21
    • 0016272750 scopus 로고
    • Involvement of the superoxide anion radical in the auto oxidation of pyrogallol and a convenient assay for superoxide dismutase
    • Marklund, S., and G. Marklund. 1974. Involvement of the superoxide anion radical in the auto oxidation of pyrogallol and a convenient assay for superoxide dismutase. European Journal of Biochemistry 74: 469-74.
    • (1974) European Journal of Biochemistry , vol.74 , pp. 469-474
    • Marklund, S.1    Marklund, G.2
  • 23
    • 0000454942 scopus 로고
    • The determination of nitrite in water
    • Montgomery, H., and J. Dymock. 1961. The determination of nitrite in water. Analyst 86: 414-17.
    • (1961) Analyst , vol.86 , pp. 414-417
    • Montgomery, H.1    Dymock, J.2
  • 24
    • 0035671527 scopus 로고    scopus 로고
    • Behavior and neurotoxic consequences of lead on rat brain followed by recovery
    • Nehru, B., and P. Sidhu. 2001. Behavior and neurotoxic consequences of lead on rat brain followed by recovery. Biological Trace Element Research 84: 113-21.
    • (2001) Biological Trace Element Research , vol.84 , pp. 113-121
    • Nehru, B.1    Sidhu, P.2
  • 25
    • 33748563980 scopus 로고    scopus 로고
    • Lipid replacement and antioxidant nutritional therapy for restoring mitochondrial function and reducing fatigue in chronic fatigue syndrome and other fatiguing illnesses
    • Nicolson, G., and R. Ellithorpe. 2006. Lipid replacement and antioxidant nutritional therapy for restoring mitochondrial function and reducing fatigue in chronic fatigue syndrome and other fatiguing illnesses. Journal of Chronic Fatigue Syndrome 13: 57-68.
    • (2006) Journal of Chronic Fatigue Syndrome , vol.13 , pp. 57-68
    • Nicolson, G.1    Ellithorpe, R.2
  • 26
    • 0014108436 scopus 로고
    • Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
    • Paglia, E., and N. Valentine. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. Journal of Laboratory Medicine 70: 158-69.
    • (1967) Journal of Laboratory Medicine , vol.70 , pp. 158-169
    • Paglia, E.1    Valentine, N.2
  • 27
    • 42649116145 scopus 로고    scopus 로고
    • Effects of a flaxseed-derived lignin supplement in type 2 diabetic patients: A randomized, double-blind, cross over trial
    • Pan, A., J. Sun, Y. Chen, X. Xe, and H. Li. 2007. Effects of a flaxseed-derived lignin supplement in type 2 diabetic patients: A randomized, double-blind, cross over trial. PLoS ONE 2: 1148-54.
    • (2007) Plos One , vol.2 , pp. 1148-1154
    • Pan, A.1    Sun, J.2    Chen, Y.3    Xe, X.4    Li, H.5
  • 28
    • 0037102716 scopus 로고    scopus 로고
    • Lead induced oxidative damage and its response to combined administration of α-lipoic acid and succimers in rats
    • Pande, M., and S. Flora. 2002. Lead induced oxidative damage and its response to combined administration of α-lipoic acid and succimers in rats. Toxicology 177: 187-96.
    • (2002) Toxicology , vol.177 , pp. 187-196
    • Pande, M.1    Flora, S.2
  • 29
    • 0035843863 scopus 로고    scopus 로고
    • Antioxidant effects of α-tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver, kidney, and brain in rats
    • Patra, R., D. Swarup, and S. Dwivedi. 2001. Antioxidant effects of α-tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver, kidney, and brain in rats. Toxicology 162: 81-8.
    • (2001) Toxicology , vol.162 , pp. 81-88
    • Patra, R.1    Swarup, D.2    Dwivedi, S.3
  • 31
    • 1042294928 scopus 로고
    • Amino acids and proteins
    • ed. D. Plummer, UK: McGraw- Hill Book Co
    • Plummer, D. 1978. Amino acids and proteins. In An introduction to practical biochemistry, ed. D. Plummer, 145-6. UK: McGraw- Hill Book Co.
    • (1978) An Introduction to Practical Biochemistry , pp. 145-146
    • Plummer, D.1
  • 32
    • 0033758487 scopus 로고    scopus 로고
    • Antioxidant activity of secoisolariciresinol diglucoside-derived metabolites, secoisolariciresinol, enterodiol, and enterolactone
    • Prasad, K. 2000. Antioxidant activity of secoisolariciresinol diglucoside-derived metabolites, secoisolariciresinol, enterodiol, and enterolactone. The International Journal of Angiology 9: 220-5.
    • (2000) The International Journal of Angiology , vol.9 , pp. 220-225
    • Prasad, K.1
  • 34
    • 34249671683 scopus 로고    scopus 로고
    • Developmental lead neurotoxicity: Alterations in brain cholinergic system
    • Reddy, G., B. Devi, and C. Chetty. 2007. Developmental lead neurotoxicity: Alterations in brain cholinergic system. NeuroToxicology 28: 402.
    • (2007) Neurotoxicology , vol.28 , pp. 402
    • Reddy, G.1    Devi, B.2    Chetty, C.3
  • 35
    • 33947097339 scopus 로고    scopus 로고
    • Hypocholesterolemic and hepatoprotective effects of flaxseed chutney: Evidence from animal studies
    • Shakir, K., and B. Madhusudhan. 2007. Hypocholesterolemic and hepatoprotective effects of flaxseed chutney: Evidence from animal studies. Indian Journal of Clinical Biochemistry 22: 117-21.
    • (2007) Indian Journal of Clinical Biochemistry , vol.22 , pp. 117-121
    • Shakir, K.1    Madhusudhan, B.2
  • 36
    • 0037413189 scopus 로고    scopus 로고
    • Consumption of fish and fish oils and decreased risk of stroke
    • Sherrett, P., and C. Hennekens. 2003. Consumption of fish and fish oils and decreased risk of stroke. Preventive Cardiology 6: 38.
    • (2003) Preventive Cardiology , vol.6 , pp. 38
    • Sherrett, P.1    Hennekens, C.2
  • 37
    • 0001725778 scopus 로고
    • A simple method for the determination of serum cholesterol
    • Watson, D. 1960. A simple method for the determination of serum cholesterol. Clinica Chimica Acta 5: 637-43.
    • (1960) Clinica Chimica Acta , vol.5 , pp. 637-643
    • Watson, D.1
  • 38
    • 0013914976 scopus 로고
    • Mechanism of lipid peroxide formation in animals
    • Wills, E. 1965. Mechanism of lipid peroxide formation in animals. The Biochemical Journal 99: 667-76.
    • (1965) The Biochemical Journal , vol.99 , pp. 667-676
    • Wills, E.1
  • 39
    • 0026565227 scopus 로고
    • Antioxidant activity of two dibenzocyclooctene lignans on the aged and ischemic brain in rats
    • Xue, J., G. Liu, H. Wei, and Y. Pan. 1992. Antioxidant activity of two dibenzocyclooctene lignans on the aged and ischemic brain in rats. Free Radical Biology & Medicine 12: 127.
    • (1992) Free Radical Biology & Medicine , vol.12 , pp. 127
    • Xue, J.1    Liu, G.2    Wei, H.3    Pan, Y.4
  • 40
    • 34547944937 scopus 로고    scopus 로고
    • Optimization of ethanol-water extraction of ligands from flaxseed
    • Zhang, Z., D. Li, and L. Wang. 2007. Optimization of ethanol-water extraction of ligands from flaxseed. Separation Purification Technology 57: 17-24.
    • (2007) Separation Purification Technology , vol.57 , pp. 17-24
    • Zhang, Z.1    Li, D.2    Wang, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.