Effects of baclofen on motor units paralysed by chronic cervical spinal cord injury

Brain

Volumn 133, Issue 1, 2010, Pages 117-125

  Thomas, Christine K ^a   Häger Ross, Charlotte K ^b   Klein, Cliff S ^c  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UMEÅ UNIVERSITY   (Sweden)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Axon conduction velocity; Baclofen; Intraneural motor axon stimulation; Muscle paralysis; Muscle weakness; Spinal cord injury

Indexed keywords

BACLOFEN;

ARTICLE; CERVICAL SPINE INJURY; CHRONIC DISEASE; DISEASE DURATION; DRUG EFFECT; ELECTROMYOGRAPHY; ELECTROSTIMULATION; EVOKED MUSCLE RESPONSE; FORCE; HUMAN; HYPERREFLEXIA; MOTOR UNIT; MUSCLE FORCE; MUSCLE SPASM; MUSCLE STRENGTH; MUSCLE TONE; MUSCLE WEAKNESS; NERVE CONDUCTION; PARALYSIS; PRIORITY JOURNAL; SPASTICITY; SPINAL CORD INJURY; TETANY; THENAR; TREATMENT DURATION;

EID: 74249115619     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awp285     Document Type: Article

References (61)

1. Adams MM, Hicks AL. Spasticity after spinal cord injury. Spinal Cord 2005; 43: 577-586
2. Alaimo MA, Smith JL, Roy RR, Edgerton VR. EMG activity of slow and fast ankle extensors following spinal cord transection. J Appl Physiol 1984; 56: 1608-1613
3. Burke D, Andrews CJ, Knowles L. The action of a GABA derivative in human spasticity. J Neurol Sci 1971; 14: 199-208.
4. Burke RE, Levine DN, Tsairis P, Zajac FE III. Physiological types and histochemical profiles in motor units of the cat gastrocnemius. J Physiol 1973; 234: 723-748
5. Carp JS, Wolpaw JR. Motoneuron plasticity underlying operantly conditioned decrease in primate H-reflex. J Neurophysiol 1994; 72: 431-442
6. Carp JS, Chen XY, Sheikh H, Wolpaw JR. Operant conditioning of rat H-reflex affects motoneuron axonal conduction velocity. Exp Brain Res 2001; 136: 269-273
7. Celichowski J, Mrowczynski W, Krutki P, Gorska T, Majczynski H, Slawinska U. Changes in contractile properties of motor units of the rat medial gastrocnemius muscle after spinal cord transection. Exp Physiol 2006; 91: 887-895 (Pubitemid 44266585)
8. Cope TC, Bodine SC, Fournier M, Edgerton VR. Soleus motor units in chronic spinal transected cats: physiological and morphological alterations. J Neurophysiol 1986; 55: 1202-1220
9. Curtis DR, Gynther BD, Lacey G, Beattie DT. Baclofen: reduction of presynaptic calcium influx in the cat spinal cord in vivo. Exp Brain Res 1997; 113: 520-533
10. Dario A, Tomei G. A benefit-risk assessment of baclofen in severe spinal spasticity. Drug Saf 2004; 27: 799-818.
11. Davis CJ, Montgomery A. The effect of prolonged inactivity upon the contraction characteristics of fast and slow mammalian twitch muscle. J Physiol 1977; 270: 581-594
12. Dressnandt J, Auer C, Conrad B. Influence of baclofen upon the alpha-motoneuron in spasticity by means of F-wave analysis. Muscle Nerve 1995; 18: 103-107
13. Duchateau J, Hainaut K. Electrical and mechanical changes in immobilized human muscle. J Appl Physiol 1987; 62: 2168-2173
14. Gordon T, Tyreman N, Rafuse VF, Munson JB. Fast-to-slow conversion following chronic low-frequency activation of medial gastrocnemius muscle in cats. I. Muscle and motor unit properties. J Neurophysiol 1997; 77: 2585-2604 (Pubitemid 27209224)
15. Häger-Ross CK, Klein CS, Thomas CK. Twitch and tetanic properties of human thenar motor units paralyzed by chronic spinal cord injury. J Neurophysiol 2006; 96: 165-174
16. Halter JA, Carp JS, Wolpaw JR. Operantly conditioned motoneuron plasticity: possible role of sodium channels. J Neurophysiol 1995; 73: 867-871
17. Harris RL, Bobet J, Sanelli L, Bennett DJ. Tail muscles become slow but fatigable in chronic sacral spinal rats with spasticity. J Neurophysiol 2006; 95: 1124-1133
18. Hiersemenzel LP, Curt A, Dietz V. From spinal shock to spasticity: neuronal adaptations to a spinal cord injury. Neurology 2000; 54: 1574-1582
19. Hugenholtz H, Nelson RF, Dehoux E, Bickerton R. Intrathecal baclofen for intractable spinal spasticity-a double-blind cross-over comparison with placebo in 6 patients. Can J Neurol Sci 1992; 19: 188-195
20. Johansson RS, Vallbo AB. Tactile sensory coding in the glabrous skin of the human hand. Trends Neurosci 1983; 6: 27-32.
21. Kernell D, Donselaar Y, Eerbeek O. Effects of physiological amounts of high-and low-rate chronic stimulation on fast-twitch muscle of the cat hindlimb. II. Endurance-related properties. J Neurophysiol 1987a; 58: 614-627 (Pubitemid 17142668)
22. Kernell D, Eerbeek O, Verhey BA, Donselaar Y. Effects of physiological amounts of high-and low-rate chronic stimulation on fast-twitch muscle of the cat hindlimb. I. Speed-and force-related properties. J Neurophysiol 1987b; 58: 598-613. (Pubitemid 17142667)
23. Klein CS, Hä ger-Ross CK, Thomas CK. Fatigue properties of human thenar motor units paralysed by chronic spinal cord injury. J Physiol 2006; 573: 161-171
24. Kravitz HM, Corcos DM, Hansen G, Penn RD, Cartwright RD, Gianino J. Intrathecal baclofen. Effects on nocturnal leg muscle spasticity. Am J Phys Med Rehabil 1992; 71: 48-52.
25. Lewis KS, Mueller WM. Intrathecal baclofen for severe spasticity secondary to spinal cord injury. Ann Pharmacother 1993; 27: 767-774
26. Li Y, Li X, Harvey PJ, Bennett DJ. Effects of baclofen on spinal reflexes and persistent inward currents in motoneurons of chronic spinal rats with spasticity. J Neurophysiol 2004; 92: 2694-2703 (Pubitemid 40340482)
27. Lieber RL, Johansson CB, Vahlsing HL, Hargens AR, Feringa ER. Long-term effects of spinal cord transection on fast and slow rat skeletal muscle. I. Contractile properties. Exp Neurol 1986; 91: 423-434
28. Little JW, Micklesen P, Umlauf R, Britell C. Lower extremity manifestations of spasticity in chronic spinal cord injury. Am J Phys Med Rehabil 1989; 68: 32-36
29. Macintosh BR, Smith MJ, Rassier DE. Staircase but not posttetanic potentiation in rat muscle after spinal cord hemisection. Muscle Nerve 2008; 38: 1455-1465
30. Magnaghi V, Ballabio M, Cavarretta IT, Froestl W, Lambert JJ, Zucchi I, et al. GABAB receptors in Schwann cells influence proliferation and myelin protein expression. Eur J Neurosci 2004; 19: 2641-2649
31. Malisoux L, Jamart C, Delplace K, Nielens H, Francaux M, Theisen D. Effect of long-term muscle paralysis on human single fiber mechanics. J Appl Physiol 2007; 102: 340-349
32. Maynard FM Jr, Bracken MB, Creasey G, Ditunno JF Jr, Donovan WH, Ducker TB, et al. International Standards for Neurological and Functional Classification of Spinal Cord Injury. American Spinal Injury Association. Spinal Cord 1997; 35: 266-274
33. Munson JB, Foehring RC, Lofton SA, Zengel JE, Sypert GW. Plasticity of medial gastrocnemius motor units following cordotomy in the cat. J Neurophysiol 1986; 55: 619-634
34. Munson JB, Foehring RC, Mendell LM, Gordon T. Fast-to-slow conversion following chronic low-frequency activation of medial gas-trocnemius muscle in cats. II. Motoneuron properties. J Neurophysiol 1997; 77: 2605-2615 (Pubitemid 27209225)
35. Nielsen JF, Sinkjær T. Peripheral and central effect of baclofen on ankle joint stiffness in multiple sclerosis. Muscle Nerve 2000; 23: 98-105.
36. Ohira Y, Yoshinaga T, Ohara M, Kawano F, Wang XD, Higo Y, et al. The role of neural and mechanical influences in maintaining normal fast and slow muscle properties. Cells Tissues Organs 2006; 182: 129-142
37. Pedersen E, Arlien-Søborg P, Grynderup V, Henriksen O. Gaba derivative in spasticity. (Beta-(4-chlorophenyl)-gamma-aminobutyric acid, Ciba 34.647-Ba). Acta Neurol Scand 1970; 46: 257-266
38. Penn RD, Savoy SM, Corcos D, Latash M, Gottlieb G, Parke B, et al. Intrathecal baclofen for severe spinal spasticity. N Engl J Med 1989; 320: 1517-1521 (Pubitemid 19145803)
39. Price GW, Wilkin GP, Turnbull MJ, Bowery NG. Are baclofen-sensitive GABAB receptors present on primary afferent terminals of the spinal cord? Nature 1984; 307: 71-74
40. Roy RR, Zhong H, Monti RJ, Vallance KA, Edgerton VR. Mechanical properties of the electrically silent adult rat soleus muscle. Muscle Nerve 2002; 26: 404-412
41. Roy RR, Zhong H, Khalili N, Kim SJ, Higuchi N, Monti RJ, et al. Is spinal cord isolation a good model of muscle disuse? Muscle Nerve 2007; 35: 312-321
42. Shields RK, Dudley-Javoroski S. Musculoskeletal plasticity after acute spinal cord injury: effects of long-term neuromuscular electrical stimulation training. J Neurophysiol 2006; 95: 2380-2390
43. Skö ld C. Spasticity in spinal cord injury: self-and clinically rated intrinsic fluctuations and intervention-induced changes. Arch Phys Med Rehabil 2000; 81: 144-149
44. Smith MB, Brar SP, Nelson LM, Franklin GM, Cobble ND. Baclofen effect on quadriceps strength in multiple sclerosis. Arch Phys Med Rehabil 1992; 73: 237-240
45. Talmadge RJ, Roy RR, Caiozzo VJ, Edgerton VR. Mechanical properties of rat soleus after long-term spinal cord transection. J Appl Physiol 2002; 93: 1487-1497
46. Taricco M, Pagliacci MC, Telaro E, Adone R. Pharmacological interventions for spasticity following spinal cord injury: results of a Cochrane systematic review. Europa Medicophysica 2006; 42: 5-15.
47. Thomas CK, Johansson RS, Westling G, Bigland-Ritchie B. Twitch properties of human thenar motor units measured in response to intraneural motor-axon stimulation. J Neurophysiol 1990; 64: 1339-1346 (Pubitemid 20338974)
48. Thomas CK, Johansson RS, Bigland-Ritchie B. Attempts to physiologically classify human thenar motor units. J Neurophysiol 1991a; 65: 1501-1508
49. Thomas CK, Bigland-Ritchie B, Johansson RS. Force-frequency relationships of human thenar motor units. J Neurophysiol 1991b; 65: 1509-1516
50. Thomas CK, Ross BH. Distinct patterns of motor unit behavior during muscle spasms in spinal cord injured subjects. J Neurophysiol 1997; 77: 2847-2850
51. Thomas CK, Nelson G, Than L, Zijdewind I. Motor unit activation order during electrically evoked contractions of paralyzed or partially paralyzed muscles. Muscle Nerve 2002; 25: 797-804.
52. Thomas CK, Griffin L, Godfrey S, Ribot-Ciscar E, Butler JE. Fatigue of paralyzed and control thenar muscles induced by variable or constant frequency stimulation. J Neurophysiol 2003; 89: 2055-2064
53. Thomas CK, Peterson LB, Klein CS, Ferrell S, Winslow J, Tepavac D. Daily use of human thenar muscles. Soc Neurosci Abs 2005; 31: 397.7.
54. Thomas CK, Zijdewind I. Fatigue of muscles weakened by death of motoneurons. Muscle Nerve 2006; 33: 21-41.
55. Thomas CK, Johansson RS, Bigland-Ritchie B. EMG changes in human thenar motor units with force potentiation and fatigue. J Neurophysiol 2006; 95: 1518-1526
56. Tubman LA, Rassier DE, Macintosh BR. Attenuation of myosin light chain phosphorylation and posttetanic potentiation in atrophied skeletal muscle. Pflugers Archiv Eur J Physiol 1997; 434: 848-851
57. Westgaard RH, Lomo T. Control of contractile properties within adaptive ranges by patterns of impulse activity in the rat. J Neurosci 1988; 8: 4415-4426
58. Westling G, Johansson RS, Thomas CK, Bigland-Ritchie B. Measurement of contractile and electrical properties of single human thenar motor units in response to intraneural motor-axon stimulation. J Neurophysiol 1990; 64: 1331-1338 (Pubitemid 20338973)
59. Yang JF, Stein RB, Jhamandas J, Gordon T. Motor unit numbers and contractile properties after spinal cord injury. Ann Neurol 1990; 28: 496-502.
60. Yang K, Wang D, Li YQ. Distribution and depression of the GABA(B) receptor in the spinal dorsal horn of adult rat. Brain Res Bull 2001; 55: 479-485
61. Zijdewind I, Thomas CK. Spontaneous motor unit behavior in human thenar muscles after spinal cord injury. Muscle Nerve 2001; 24: 952-62.