메뉴 건너뛰기




Volumn 23, Issue 14, 2009, Pages

CYP2D6 testing in breast cancer: Ready for prime time?

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; AMFEBUTAMONE; AMIODARONE; ANASTROZOLE; AROMATASE INHIBITOR; CIMETIDINE; CYTOCHROME P450 2D6; DIPHENHYDRAMINE; DRUG METABOLITE; DULOXETINE; ENDOXIFEN; FLUOXETINE; PAROXETINE; PLACEBO; QUINIDINE; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TAMOXIFEN; TRAZODONE; UNCLASSIFIED DRUG;

EID: 74249113418     PISSN: 08909091     EISSN: 08909091     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (10)

References (47)
  • 1
    • 50549123220 scopus 로고
    • On the treatment of inoperable cases of carcinoma of the mammary: Suggestions for a new method of treatment, with illustrative cases
    • Beatson G: On the treatment of inoperable cases of carcinoma of the mammary: Suggestions for a new method of treatment, with illustrative cases. Lancet 2:104-107, 1896.
    • (1896) Lancet , vol.2 , pp. 104-107
    • Beatson, G.1
  • 2
    • 0032569831 scopus 로고    scopus 로고
    • Tamoxifen in the treatment of breast cancer
    • Osborne CK: Tamoxifen in the treatment of breast cancer. N Engl J Med 339:1609-1618, 1998.
    • (1998) N Engl J Med , vol.339 , pp. 1609-1618
    • Osborne, C.K.1
  • 3
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists Collaborative Group
    • Early Breast Cancer Trialists Collaborative Group: Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet 365:1687-1717, 2005.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 4
    • 0032537990 scopus 로고    scopus 로고
    • Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
    • Fisher B, Costantino JP, Wickerham DL, et al: Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 90:1371-1388, 1998.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1371-1388
    • Fisher, B.1    Costantino, J.P.2    Wickerham, D.L.3
  • 5
    • 0033549344 scopus 로고    scopus 로고
    • Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trial
    • Fisher B, Dignam J, Wolmark N, et al: Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trial. Lancet 353:1993-2000, 1999.
    • (1999) Lancet , vol.353 , pp. 1993-2000
    • Fisher, B.1    Dignam, J.2    Wolmark, N.3
  • 6
    • 0026500848 scopus 로고
    • Adjuvant tamoxifen for male breast cancer (MBC)
    • Ribeiro G, Swindell R: Adjuvant tamoxifen for male breast cancer (MBC). Br J Cancer 65:252-254, 1992.
    • (1992) Br J Cancer , vol.65 , pp. 252-254
    • Ribeiro, G.1    Swindell, R.2
  • 7
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • Paik S, Shak S, Tang G, et al: A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 351:2817-2826, 2004.
    • (2004) N Engl J Med , vol.351 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3
  • 8
    • 67649364451 scopus 로고    scopus 로고
    • Aromatase inhibitors versus tamoxifen as adjuvant therapy for postmenopausal women with estrogen receptor positive breast cancer: Meta-analyses of randomized trials of monotherapy and switching strategies (abstract 12)
    • 66s
    • Ingle JN, Dowsett M, Cuzick J, et al: Aromatase inhibitors versus tamoxifen as adjuvant therapy for postmenopausal women with estrogen receptor positive breast cancer: Meta-analyses of randomized trials of monotherapy and switching strategies (abstract 12). Cancer Res 69(suppl 2):66s, 2009.
    • (2009) Cancer Res , vol.69 , Issue.SUPPL. 2
    • Ingle, J.N.1    Dowsett, M.2    Cuzick, J.3
  • 9
    • 11444251764 scopus 로고    scopus 로고
    • Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years adjuvant treatment for breast cancer
    • Howell A, Cuzick J, Baum M, et al: Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years adjuvant treatment for breast cancer. Lancet 365:60-62, 2005.
    • (2005) Lancet , vol.365 , pp. 60-62
    • Howell, A.1    Cuzick, J.2    Baum, M.3
  • 10
    • 37449028688 scopus 로고    scopus 로고
    • Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial
    • Forbes JF, Cuzick J, Buzdar A, et al: Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncol 9:45-53, 2008.
    • (2008) Lancet Oncol , vol.9 , pp. 45-53
    • Forbes, J.F.1    Cuzick, J.2    Buzdar, A.3
  • 11
    • 29544433211 scopus 로고    scopus 로고
    • A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer
    • Thurlimann B, Keshaviah A, Coates AS, et al: A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. N Engl J Med 353:2747-2757, 2005.
    • (2005) N Engl J Med , vol.353 , pp. 2747-2757
    • Thurlimann, B.1    Keshaviah, A.2    Coates, A.S.3
  • 12
    • 0017665570 scopus 로고
    • A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity
    • Jordan VC, Collins MM, Rowsby L, et al: A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol 75:305-316, 1977.
    • (1977) J Endocrinol , vol.75 , pp. 305-316
    • Jordan, V.C.1    Collins, M.M.2    Rowsby, L.3
  • 13
    • 0017695082 scopus 로고
    • Polymorphic hydroxylation of Debrisoquine in man
    • Mahgoub A, Idle JR, Dring LG, et al: Polymorphic hydroxylation of Debrisoquine in man. Lancet 2:584-586, 1977.
    • (1977) Lancet , vol.2 , pp. 584-586
    • Mahgoub, A.1    Idle, J.R.2    Dring, L.G.3
  • 14
    • 34548650021 scopus 로고    scopus 로고
    • CYP2D6 polymorphisms and the impact on tamoxifen therapy
    • Beverage JN, Sissung TM, Sion AM, et al: CYP2D6 polymorphisms and the impact on tamoxifen therapy. J Pharm Sci 96:2224-2231, 2007.
    • (2007) J Pharm Sci , vol.96 , pp. 2224-2231
    • Beverage, J.N.1    Sissung, T.M.2    Sion, A.M.3
  • 15
    • 0031949132 scopus 로고    scopus 로고
    • Dalen P, Dahl ML, Bernal Ruiz ML, et al: 10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes. Clin Pharmacol Ther 63:444-452, 1998.
    • Dalen P, Dahl ML, Bernal Ruiz ML, et al: 10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes. Clin Pharmacol Ther 63:444-452, 1998.
  • 16
    • 0036124107 scopus 로고    scopus 로고
    • CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
    • Bradford LD: CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics 3:229-243, 2002.
    • (2002) Pharmacogenomics , vol.3 , pp. 229-243
    • Bradford, L.D.1
  • 17
    • 33644639136 scopus 로고    scopus 로고
    • Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes
    • Goetz MP, Rae JM, Suman VJ, et al: Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol 23:9312-9318, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 9312-9318
    • Goetz, M.P.1    Rae, J.M.2    Suman, V.J.3
  • 18
    • 0037087582 scopus 로고    scopus 로고
    • Phase III evaluation of fluoxetine for treatment of hot flashes
    • Loprinzi CL, Sloan JA, Perez EA, et al: Phase III evaluation of fluoxetine for treatment of hot flashes. J Clin Oncol 20:1578-1583, 2002.
    • (2002) J Clin Oncol , vol.20 , pp. 1578-1583
    • Loprinzi, C.L.1    Sloan, J.A.2    Perez, E.A.3
  • 19
    • 0037976797 scopus 로고    scopus 로고
    • Paroxetine controlled release in the treatment of menopausal hot flashes: A randomized controlled trial
    • Stearns V, Beebe KL, Iyengar M, et al: Paroxetine controlled release in the treatment of menopausal hot flashes: A randomized controlled trial. JAMA 289:2827-2834, 2003.
    • (2003) JAMA , vol.289 , pp. 2827-2834
    • Stearns, V.1    Beebe, K.L.2    Iyengar, M.3
  • 20
    • 34250687523 scopus 로고    scopus 로고
    • Clinical update: New treatments for hot flushes
    • Stearns V: Clinical update: New treatments for hot flushes. Lancet 369:2062-2064, 2007.
    • (2007) Lancet , vol.369 , pp. 2062-2064
    • Stearns, V.1
  • 21
    • 74249122766 scopus 로고    scopus 로고
    • Patterns of Care in Medical
    • Love N: Patterns of Care in Medical Oncology 2(3), 2005.
    • (2005) Oncology , vol.2 , Issue.3
    • Love, N.1
  • 22
    • 0346602691 scopus 로고    scopus 로고
    • Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine
    • Stearns V, Johnson MD, Rae JM, et al: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. J Natl Cancer Inst 95:1758-1764, 2003.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 1758-1764
    • Stearns, V.1    Johnson, M.D.2    Rae, J.M.3
  • 23
    • 19944434201 scopus 로고    scopus 로고
    • CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment
    • Jin Y, Desta Z, Stearns V, et al: CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J Natl Cancer Inst 97:30-39, 2005.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 30-39
    • Jin, Y.1    Desta, Z.2    Stearns, V.3
  • 24
    • 0025251643 scopus 로고
    • Tamoxifen metabolites in patients on long-term adjuvant therapy for breast cancer
    • Langan-Fahey SM, Tormey DC, Jordan VC: Tamoxifen metabolites in patients on long-term adjuvant therapy for breast cancer. Eur J Cancer 26:883-888, 1990.
    • (1990) Eur J Cancer , vol.26 , pp. 883-888
    • Langan-Fahey, S.M.1    Tormey, D.C.2    Jordan, V.C.3
  • 25
    • 67651177578 scopus 로고    scopus 로고
    • Genotype-guided tamoxifen therapy: Time to pause for reflection?
    • Lash TL, Lien EA, Sorensen HT, et al: Genotype-guided tamoxifen therapy: Time to pause for reflection? Lancet Oncol 10:825-833, 2009.
    • (2009) Lancet Oncol , vol.10 , pp. 825-833
    • Lash, T.L.1    Lien, E.A.2    Sorensen, H.T.3
  • 26
    • 33745926220 scopus 로고    scopus 로고
    • Randomized trial of tamoxifen alone or combined with fluoxymesterone as adjuvant therapy in postmenopausal women with resected estrogen receptor positive breast cancer. North Central Cancer Treatment Group Trial 89-30-52
    • Ingle JN, Suman VJ, Mailliard JA, et al: Randomized trial of tamoxifen alone or combined with fluoxymesterone as adjuvant therapy in postmenopausal women with resected estrogen receptor positive breast cancer. North Central Cancer Treatment Group Trial 89-30-52. Breast Cancer Res Treat 98:217-222, 2006.
    • (2006) Breast Cancer Res Treat , vol.98 , pp. 217-222
    • Ingle, J.N.1    Suman, V.J.2    Mailliard, J.A.3
  • 27
    • 33847034287 scopus 로고    scopus 로고
    • The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen
    • Goetz MP, Knox SK, Suman VJ, et al: The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Res Treat 101:113-121, 2007.
    • (2007) Breast Cancer Res Treat , vol.101 , pp. 113-121
    • Goetz, M.P.1    Knox, S.K.2    Suman, V.J.3
  • 28
    • 74249086681 scopus 로고    scopus 로고
    • Tamoxifen pharmacogenetics of CYP2D6, CYP2C19, and SULT1A1: Long term follow-up of the North Central Cancer Treatment Group 89-30-52 adjuvant trial (abstract 6037)
    • Goetz MP, Suman V, Ames M, et al: Tamoxifen pharmacogenetics of CYP2D6, CYP2C19, and SULT1A1: Long term follow-up of the North Central Cancer Treatment Group 89-30-52 adjuvant trial (abstract 6037). Cancer Res 69(suppl), 2009.
    • (2009) Cancer Res , vol.69 , Issue.SUPPL.
    • Goetz, M.P.1    Suman, V.2    Ames, M.3
  • 29
    • 36349024762 scopus 로고    scopus 로고
    • Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes
    • Schroth W, Antoniadou L, Fritz P, et al: Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes. J Clin Oncol 25:5187-5193, 2007.
    • (2007) J Clin Oncol , vol.25 , pp. 5187-5193
    • Schroth, W.1    Antoniadou, L.2    Fritz, P.3
  • 30
    • 43649090742 scopus 로고    scopus 로고
    • Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy
    • Kiyotani K, Mushiroda T, Sasa M, et al: Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy. Cancer Sci 99:995-999, 2008.
    • (2008) Cancer Sci , vol.99 , pp. 995-999
    • Kiyotani, K.1    Mushiroda, T.2    Sasa, M.3
  • 31
    • 47749105202 scopus 로고    scopus 로고
    • Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment
    • Xu Y, Sun Y, Yao L, et al: Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment. Ann Oncol 19:1423-1429, 2008.
    • (2008) Ann Oncol , vol.19 , pp. 1423-1429
    • Xu, Y.1    Sun, Y.2    Yao, L.3
  • 32
    • 74249090424 scopus 로고    scopus 로고
    • Pharmacogenetic (CYP2D6) and gene expression profiles (HOXB13/IL17BR and molecular grade index) for prediction of adjuvant endocrine therapy benefit in the ABCSG 8 trial (abstract 57)
    • Goetz MP, Ames M, Gnant M, et al: Pharmacogenetic (CYP2D6) and gene expression profiles (HOXB13/IL17BR and molecular grade index) for prediction of adjuvant endocrine therapy benefit in the ABCSG 8 trial (abstract 57). Cancer Res 69(suppl), 2009.
    • (2009) Cancer Res , vol.69 , Issue.SUPPL.
    • Goetz, M.P.1    Ames, M.2    Gnant, M.3
  • 33
    • 74249095324 scopus 로고    scopus 로고
    • Ramon y Cahal T, Altes A, Pare L, et al: Impact of CYP2D6 polymorphisms in tamoxifen adjuvant breast cancer treatment. Breast Cancer Res Treat (epub February 3, 2009).
    • Ramon y Cahal T, Altes A, Pare L, et al: Impact of CYP2D6 polymorphisms in tamoxifen adjuvant breast cancer treatment. Breast Cancer Res Treat (epub February 3, 2009).
  • 34
    • 34548532227 scopus 로고    scopus 로고
    • Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer
    • Lim HS, Ju Lee H, Seok Lee K, et al: Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer. J Clin Oncol 25:3837-3845, 2007.
    • (2007) J Clin Oncol , vol.25 , pp. 3837-3845
    • Lim, H.S.1    Ju Lee, H.2    Seok Lee, K.3
  • 35
    • 33747045564 scopus 로고    scopus 로고
    • Bonanni B, Macis D, Maisonneuve P, et al: Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: Data from the Italian Tamoxifen Trial. J Clin Oncol 24:3708-3709; author reply 3709, 2006.
    • Bonanni B, Macis D, Maisonneuve P, et al: Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: Data from the Italian Tamoxifen Trial. J Clin Oncol 24:3708-3709; author reply 3709, 2006.
  • 36
    • 29144491089 scopus 로고    scopus 로고
    • Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients
    • Wegman P, Vainikka L, Stal O, et al: Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients. Breast Cancer Res 7:R284-R290, 2005.
    • (2005) Breast Cancer Res , vol.7
    • Wegman, P.1    Vainikka, L.2    Stal, O.3
  • 37
    • 21344467511 scopus 로고    scopus 로고
    • Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
    • Nowell SA, Ahn J, Rae JM, et al: Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients. Breast Cancer Res Treat 91:249-258, 2005.
    • (2005) Breast Cancer Res Treat , vol.91 , pp. 249-258
    • Nowell, S.A.1    Ahn, J.2    Rae, J.M.3
  • 38
    • 61449171134 scopus 로고    scopus 로고
    • Genetic polymorphisms of CYP2D6 10 and CYP2C19 2, 3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen
    • Okishiro M, Taguchi T, Jin Kim S, et al: Genetic polymorphisms of CYP2D6 10 and CYP2C19 2, 3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen. Cancer 115:952-961, 2009.
    • (2009) Cancer , vol.115 , pp. 952-961
    • Okishiro, M.1    Taguchi, T.2    Jin Kim, S.3
  • 39
    • 74549184178 scopus 로고    scopus 로고
    • Risk of breast cancer recurrence in women initiating tamoxifen with CYP2D6 inhibitors (abstract CRA508)
    • Aubert RE, Stanek EJ, Yao J, et al: Risk of breast cancer recurrence in women initiating tamoxifen with CYP2D6 inhibitors (abstract CRA508). J Clin Oncol 27(18S), 2009.
    • (2009) J Clin Oncol , vol.27 , Issue.18 S
    • Aubert, R.E.1    Stanek, E.J.2    Yao, J.3
  • 40
    • 74249111710 scopus 로고    scopus 로고
    • Concomitant CYP2D6 inhibitor use and tamoxifen adherence in early stage breast cancer: A pharmaco-epidemiological study (CRA509)
    • Dezentjé V, Van Blijderveen NJ, Gelderblom H, et al: Concomitant CYP2D6 inhibitor use and tamoxifen adherence in early stage breast cancer: A pharmaco-epidemiological study (CRA509). J Clin Oncol 27(18S), 2009.
    • (2009) J Clin Oncol , vol.27 , Issue.18 S
    • Dezentjé, V.1    Van Blijderveen, N.J.2    Gelderblom, H.3
  • 41
    • 33745347897 scopus 로고    scopus 로고
    • Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment
    • Borges S, Desta Z, Li L, et al: Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment. Clin Pharmacol Ther 80:61-74, 2006.
    • (2006) Clin Pharmacol Ther , vol.80 , pp. 61-74
    • Borges, S.1    Desta, Z.2    Li, L.3
  • 42
    • 70349575970 scopus 로고    scopus 로고
    • Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort
    • Lynn Henry N, Rae JM, Li L, et al: Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort. Breast Cancer Res Treat 117:571-575, 2009.
    • (2009) Breast Cancer Res Treat , vol.117 , pp. 571-575
    • Lynn Henry, N.1    Rae, J.M.2    Li, L.3
  • 43
    • 52449134044 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 activity predicts adherence to tamoxifen therapy (abstract)
    • Rae J, Sikora MJ, Henry NL. Cytochrome P450 2D6 activity predicts adherence to tamoxifen therapy (abstract). Breast Cancer Res Treat 106(suppl 1):S21, 2007.
    • (2007) Breast Cancer Res Treat , vol.106 , Issue.SUPPL. 1
    • Rae, J.1    Sikora, M.J.2    Henry, N.L.3
  • 44
    • 44049098379 scopus 로고    scopus 로고
    • Pharmacogenomic variation of CYP2D6 and the choice of optimal adjuvant endocrine therapy for postmenopausal breast cancer: A modeling analysis
    • Punglia RS, Burstein HJ, Winer EP, et al: Pharmacogenomic variation of CYP2D6 and the choice of optimal adjuvant endocrine therapy for postmenopausal breast cancer: A modeling analysis. J Natl Cancer Inst 100:642-648, 2008.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 642-648
    • Punglia, R.S.1    Burstein, H.J.2    Winer, E.P.3
  • 45
    • 34248208754 scopus 로고    scopus 로고
    • Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer
    • Wegman P, Elingarami S, Carstensen J, et al: Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer. Breast Cancer Res 9(1):R7, 2007.
    • (2007) Breast Cancer Res , vol.9 , Issue.1
    • Wegman, P.1    Elingarami, S.2    Carstensen, J.3
  • 46
    • 53249086540 scopus 로고    scopus 로고
    • Impaired tamoxifen metabolism reduces survival in familial breast cancer patients
    • Newman WG, Hadfield KD, Latif A, et al: Impaired tamoxifen metabolism reduces survival in familial breast cancer patients. Clin Cancer Res 14:5913-5918, 2008.
    • (2008) Clin Cancer Res , vol.14 , pp. 5913-5918
    • Newman, W.G.1    Hadfield, K.D.2    Latif, A.3
  • 47
    • 4243063941 scopus 로고    scopus 로고
    • Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6
    • Desta Z, Ward BA, Soukhova NV, et al: Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther 310:1062-1075, 2004.
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 1062-1075
    • Desta, Z.1    Ward, B.A.2    Soukhova, N.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.