SLC/CCR7 stimulates the proliferation of BMDCs by the pNF-κB p65 pathway

Anatomical Record

Volumn 293, Issue 1, 2010, Pages 48-54

  Zhou, Shuang ^a   Li, Rilun ^a   Qin, Jie ^a   Zhong, Cuiping ^a   Liang, Chunmin ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

BMDCs; CCR7; pNF Bp65; Secondary lymphoid tissue chemokine

Indexed keywords

CHEMOKINE RECEPTOR CCR7; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; PYRROLIDINE DITHIOCARBAMATE; SECONDARY LYMPHOID TISSUE CHEMOKINE; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ARTICLE; BONE MARROW CELL; CELL PROLIFERATION; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; BONE MARROW CELLS; CELL PROLIFERATION; DENDRITIC CELLS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; MICE; MICE, INBRED C57BL; PROLINE; RECEPTORS, CCR7; SIGNAL TRANSDUCTION; THIOCARBAMATES; TRANSCRIPTION FACTOR RELA;

EID: 74249107248     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.21015     Document Type: Article

References (19)

1. Forster R, Davalos-Misslitz AC, Rot A. 2008. CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol 8:362-371.
2. Forster R, Schubel A, Breitfeld D, Kremmer E, Renner-Müller I, Wolf E, Lipp M. 1999. CCR7 coordinates the primary immune response by establishing functional micro-environments in secondary lymphoid organs. Cell 99:23-33.
3. Gunn MD, Kyuwa S, Tam C, Kakiuchi T, Matsuzawa A, Williams LT, Nakano H. 1999. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J Exp Med 189:451-460.
4. Liang CM, Ye SL, Zhong CP, Zheng N, Bian W, Sun RX, Chen J, Li RL, Zhou S, Liu YK. 2007. More than chemotaxis: a new anti-tumor DC vaccine modified by rAAV2-SLC. Mol Immunol 44:3797-3804.
5. Marsland BJ, Bättig P, Bauer M, Ruedl C, Lässing U, Beerli RR, Dietmeier K, Ivanova L, Pfister T, Vogt L, Nakano H, Nembrini C, Saudan P, Kopf M, Bachmann MF. 2005. CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells. Immunity 22:493-505.
6. Mellado M, Rodríguez-Frade JM, Mañes S, Martinez- AC. 2001. Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation. Annu Rev Immunol 19:397-421.
7. Nagira M, Imai T, Yoshida R, Takagi S, Iwasaki M, Baba M, Tabira Y, Akagi J, Nomiyama H, Yoshie O. 1998. A lymphocyte-specific CC chemokine, secondary lymphoid tissue chemokine (SLC), is a highly efficient chemoattractant for B cells and activated T cells. Eur J Immunol 28:1516-1523.
8. Nakano H, Gunn MD. 2001. Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. J Immunol 166:361-369.
9. Riol-Blanco L, Sánchez-Sánchez N, Torres A, Tejedor A, Narumiya S, Corbí AL, Sánchez-Mateos P, Rodríguez- Fernández JL. 2005. The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed. J Immunol 174:4070-4080.
10. Rot A, von Andrian UH. 2004. Chemokines in innate and adaptive host defense: basic chemokinese grammar for Immune cells. Annu Rev Immunol 22:891-928.
11. Sánchez-Sánchez N, Riol-Blanco L, de la Rosa G, Puig-Kröger A, García-Bordas J, Martín D, Longo N, Cuadrado A, Cabañas C, Corbí AL, Sánchez-Mateos P, Rodríguez-Fernández JL. 2004. Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells. Blood 104:619-625.
12. Sánchez-Sánchez N, Riol-Blanco L, Rodríguez- Fernández JL. 2006. The multiple personalities of the chemokine receptor CCR7 in dendritic cells. J Immunol 176:5153-5159.
13. Tangemann K, Gunn MD, Giblin P, Rosen SD. 1998. A high endothelial cell-derived chemokine induces rapid, efficient, and subset-selective arrest of rolling T lymphocytes on a reconstituted endothelial substrate. J Immunol 161:6330-6337.
14. Ueno T, Hara K, Willis MS, Malin MA, Höpken UE, Gray DH, Matsushima K, Lipp M, Springer TA, Boyd RL, Yoshie O, Takahama Y. 2002. Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus. Immunity 16:205-218.
15. Von Andrian UH, Mackay CR. 2000. T-cell function and migration - two sides of the same coin. N Engl J Med 343:1020-1034.
16. Willimann K, Legler DF, Loetscher M, Roos RS, Delgado MB, Clark-Lewis I, Baggiolini M, Moser B. 1998. The chemokine SLC is expressed in Tcell areas of lymph nodes andmucosal lymphoid tissues and attracts activated Tcells via CCR7. Eur J Immunol 28:2025-2034.
17. Yang SC, Hillinger S, Riedl K, Zhang L, Zhu L, Huang M, Atianzar K, Kuo BY, Gardner B, Batra RK, Strieter RM, Dubinett SM, Sharma S. 2004. Intratumoral administration of dendritic cells overexpressing CCL21 generates systemic antitumor responses and confers tumor immunity. Clin Cancer Res 10:2891-2901.
18. Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O. 1998. Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7. J Biol Chem 273:7118-7122.
19. Zlotnik A, Yoshie O. 2000. Chemokines: a new classification system and their role in immunity. Immunity 12:121-127.