Efficacy of High-Dose Clopidogrel Treatment (600 mg) Less Than Two Hours Before Percutaneous Coronary Intervention in Patients With Non-ST-Segment Elevation Acute Coronary Syndromes

American Journal of Cardiology

Volumn 105, Issue 3, 2010, Pages 323-332

  Feldman, Dmitriy N ^a   Fakorede, Foluso ^a   Minutello, Robert M ^a   Bergman, Geoffrey ^a   Moussa, Issam ^a   Wong, S Chiu ^a  

^a NEW YORK PRESBYTERIAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; CLOPIDOGREL; EPTIFIBATIDE; HEPARIN; HIRULOG; PACLITAXEL; RAPAMYCIN;

ACUTE CORONARY SYNDROME; ADULT; ADVERSE OUTCOME; AGED; ANGIOCARDIOGRAPHY; ANTICOAGULATION; ARTICLE; BLEEDING; CORONARY ARTERY DISEASE; CORONARY STENT; DEATH; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG ELUTING STENT; DRUG MEGADOSE; FEMALE; HEART INFARCTION; HIGH RISK PATIENT; HOSPITAL PATIENT; HUMAN; INCIDENCE; KAPLAN MEIER METHOD; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIVARIATE ANALYSIS; OUTCOMES RESEARCH; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; SURVIVAL RATE; TREATMENT OUTCOME;

ACUTE CORONARY SYNDROME; AGED; ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HOSPITAL MORTALITY; HUMANS; INCIDENCE; MALE; MEDICAL RECORDS; MIDDLE AGED; MYOCARDIAL INFARCTION; NEW YORK CITY; PLATELET AGGREGATION INHIBITORS; PREOPERATIVE CARE; RETROSPECTIVE STUDIES; SURVIVAL RATE; TICLOPIDINE;

EID: 74249086287     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2009.09.034     Document Type: Article

References (27)

1. Schömig A., Neumann F.J., Kastrati A., Schühlen H., Blasini R., Hadamitzky M., Walter H., Zitzmann-Roth E.M., Richardt G., Alt E., Schmitt C., and Ulm K. A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N Engl J Med 334 (1996) 1084-1089
2. Leon M.B., Baim D.S., Popma J.J., Gordon P.C., Cutlip D.E., Ho K.K., Giambartolomei A., Diver D.J., Lasorda D.M., Williams D.O., Pocock S.J., and Kuntz R.E.S.A.R.S.Investigators. A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. N Engl J Med 339 (1998) 1665-1671
3. Ault K.A., Cannon C.P., Mitchell J., McCahan J., Tracy R.P., Novotny W.F., Reimann J.D., and Braunwald E. Platelet activation in patients after an acute coronary syndrome: results from the TIMI-12 trial. Thrombolysis In Myocardial Infarction. J Am Coll Cardiol 33 (1999) 634-639
4. Soffer D., Moussa I., Harjai K.J., Boura J.A., Dixon S.R., Grines C.L., O'Neill W.W., Roubin G.S., and Moses J.W. Impact of angina class on inhibition of platelet aggregation following clopidogrel loading in patients undergoing coronary intervention: do we need more aggressive dosing regimens in unstable angina?. Catheter Cardiovasc Interv 59 (2003) 21-25
5. Mehta S.R., Yusuf S., Peters R.J., Bertrand M.E., Lewis B.S., Natarajan M.K., Malmberg K., Rupprecht H., Zhao F., Chrolavicius S., Copland I., and Fox K.A. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 345 (2001) 494-502
6. Yusuf S., Mehta S.R., Zhao F., Gersh B.J., Commerford P.J., Blumenthal M., Budaj A., Wittlinger T., and Fox K.A. Clopidogrel in unstable angina to prevent Recurrent Events Trial Investigators. Early and late effects of clopidogrel in patients with acute coronary syndromes. Circulation 107 (2003) 966-972
7. Mehta S.R., Yusuf S., Peters R.J., Bertrand M.E., Lewis B.S., Natarajan M.K., Malmberg K., Rupprecht H., Zhao F., Chrolavicius S., Copland I., Fox K.A., and Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators. Effects of pre-treatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 358 (2001) 527-533
8. Steinhubl S.R., Berger P.B., Mann III J.T., Fry E.T., DeLago A., Wilmer C., Topol E.J., and CREDO Investigators. Clopidogrel for the reduction of events during observation. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA 288 (2002) 2411-2420
9. Steinhubl S.R., Berger P.B., Brennan D.M., Topol E.J., and CREDO Investigators. Optimal timing for the initiation of pre-treatment with 300 mg clopidogrel before percutaneous coronary intervention. J Am Coll Cardiol 47 (2006) 939-943
10. Gurbel P.A., Bliden K.P., Zaman K.A., Yoho J.A., Hayes K.M., and Tantry U.S. Clopidogrel loading with eptifibatide to arrest the reactivity of platelets: results of the Clopidogrel Loading With Eptifibatide to Arrest the Reactivity of Platelets (CLEAR PLATELETS) study. Circulation 111 (2005) 1153-1159
11. Von Beckerath N., Taubert D., Pogatsa-Murray G., Schömig E., Kastrati A., and Schömig A. Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect) trial. Circulation 112 (2005) 2946-2950
12. Montalescot G., Sideris G., Meuleman C., Bal-dit-Sollier C., Lellouche N., Steg P.G., Slama M., Milleron O., Collet J.P., Henry P., Beygui F., Drouet L., and ALBION Trial investigators. A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes: the ALBION (Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis) trial. J Am Coll Cardiol 48 (2006) 931-938
13. Hochholzer W., Trenk D., Frundi D., Blanke P., Fischer B., Andris K., Bestehorn H.P., Büttner H.J., and Neumann F.J. Time dependence of platelet inhibition after a 600-mg loading dose of clopidogrel in a large, unselected cohort of candidates for percutaneous coronary intervention. Circulation 111 (2005) 2560-2564
14. Kandzari D.E., Berger P.B., Kastrati A., Steinhubl S.R., Mehilli J., Dotzer F., Ten B.J.M., Neumann F.J., Bollwein H., Dirschinger J., Schömig A., and ISAR-REACT Study Investigators. Influence of treatment duration with a 600-mg dose of clopidogrel before percutaneous coronary revascularization. J Am Coll Cardiol 44 (2004) 2133-2136
15. Patti G., Colonna G., Pasceri V., Pepe L.L., Montinaro A., and Di Sciascio G. A randomized trial of high loading dose of clopidogrel for reduction of peri-procedural myocardial infarction in patients undergoing coronary intervention results from the ARMYDA-2 (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) study. Circulation 111 (2005) 2099-2106
16. King III S.B., Smith Jr. S.C., Hirshfeld Jr. J.W., Jacobs A.K., Morrison D.A., Williams D.O., Feldman T.E., Kern M.J., O'Neill W.W., Schaff H.V., Whitlow P.L., ACC/AHA/SCAI, Adams C.D., Anderson J.L., Buller C.E., Creager M.A., Ettinger S.M., Halperin J.L., Hunt S.A., Krumholz H.M., Kushner F.G., Lytle B.W., Nishimura R., Page R.L., Riegel B., Tarkington L.G., and Yancy C.W. 2007 Focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention. J Am Coll Cardiol 51 (2008) 172-209
17. Sesso H.D., Paffenbarger R.S., and Lee I.M. Comparison of National Death Index and World Wide Web death searches. Am J Epidemiol 152 (2000) 107-111
18. Stone G.W., White H.D., Ohman E.M., Bertrand M.E., Lincoff A.M., McLaurin B.T., Cox D.A., Pocock S.J., Ware J.H., Feit F., Colombo A., Manoukian S.V., Lansky A.J., Mehran R., and Moses J.W.A.C.I.T.s.(A.C.U.I.T.Y.) T.Investigators. Bivalirudin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a subgroup analysis from the Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) trial. Lancet 369 (2007) 907-919
19. Stone G.W., Ware J.H., Bertrand M.E., Lincoff A.M., Moses J.W., Ohman E.M., White H.D., Feit F., Colombo A., McLaurin B.T., Cox D.A., Manoukian S.V., Fahy M., Clayton T.C., Mehran R., Pocock S.J., and ACUITY Investigators. Antithrombotic strategies in patients with acute coronary syndromes undergoing early invasive management: one-year results from the ACUITY trial. JAMA 298 (2007) 2497-2506
20. Patti G., Pasceri V., and Di Sciascio G. Optimal antiplatelet therapy in patients undergoing percutaneous coronary intervention: new insights from the randomized ARMYDA-2 (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) study. Vasc Dis Manag 2 (2005) 60-62
21. Cuisset T., Frere C., Quilici J., Morange P.E., Nait-Saidi L., Carvajal J., Lehmann A., Lambert M., Bonnet J.L., and Alessi M.C. Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting. J Am Coll Cardiol 48 (2006) 1339-1345
22. Manoukian S.V., Feit F., Mehran R., Voeltz M.D., Ebrahimi R., Hamon M., Dangas G.D., Lincoff A.M., White H.D., Moses J.W., King III S.B., Ohman E.M., and Stone G.W. Impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes: an analysis from the ACUITY trial. J Am Coll Cardiol 49 (2007) 1362-1368
23. Ndrepepa G., Berger P.B., Mehilli J., Seyfarth M., Neumann F.J., Schömig A., and Kastrati A. Periprocedural bleeding and 1-year outcome after percutaneous coronary interventions: appropriateness of including bleeding as a component of a quadruple end point. J Am Coll Cardiol 51 (2008) 690-697
24. Fox K.A., Mehta S.R., Peters R., Zhao F., Lakkis N., Gersh B.J., and Yusuf S. Clopidogrel in Unstable angina to prevent Recurrent ischemic Events Trial. Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) trial. Circulation 110 (2004) 1202-1208
25. Widimsky P., Motovská Z., Simek S., Kala P., Pudil R., Holm F., Petr R., Bílková D., Skalická H., Kuchynka P., Poloczek M., Miklík R., Maly M., Aschermann M., and PRAGUE-8 Trial Investigators. Clopidogrel pre-treatment in stable angina: for all patients >6 h before elective coronary angiography or only for angiographically selected patients a few minutes before PCI? A randomized multicentre trial PRAGUE-8. Eur Heart J 29 (2008) 1495-1503
26. Patti G., Pasceri V., and Colonna G. Is 600 mg in-lab clopidogrel loading equivalent to "upstream" pre-treatment in patients undergoing percutaneous coronary intervention? Results of the ARMYDA-5 (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty) randomized trial. Late breaking clinical trials, TCT sessions (October 2007). www.cardiosource.com/img/armyda501.ppt Accessed October 26, 2009
27. Lincoff A.M., Steinhubl S.R., Manoukian S.V., Chew D., Pollack Jr. C.V., Feit F., Ware J.H., Bertrand M.E., Ohman E.M., Desmet W., Cox D.A., Mehran R., Stone G.W., and Acute Catheterization and Urgent Intervention Triage strategY of Trial Investigators. Influence of timing of clopidogrel treatment on the efficacy and safety of bivalirudin in patients with non-ST-elevation acute coronary syndromes undergoing percutaneous coronary intervention. An analysis of the ACUITY Trial. J Am Coll Cardiol Interv 1 (2008) 639-648