Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteria

Neurobiology of Aging

Volumn 31, Issue 3, 2010, Pages 368-377

  Chao, L L ^a,b,c   Mueller, S G ^a,b   Buckley, S T ^a   Peek, K ^a   Raptentsetseng, S ^a   Elman, J ^a   Yaffe, K ^c   Miller, B L ^c   Kramer, J H ^c   Madison, C ^d   Mungas, D ^e   Schuff, N ^a,b   Weiner, M W ^a,b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AD; Aging; MCI; MRS; Structural MRI

Indexed keywords

INOSITOL; N ACETYLASPARTIC ACID;

ADULT; AGED; ARTICLE; BRAIN DEGENERATION; BRAIN METABOLISM; BRAIN SIZE; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; ENTORHINAL CORTEX; FEMALE; GRAY MATTER; HIPPOCAMPUS; HUMAN; MALE; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; SUBICULUM; TEMPORAL LOBE;

AGED; AGED, 80 AND OVER; BRAIN; COGNITION DISORDERS; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; NERVE DEGENERATION; NEUROPSYCHOLOGICAL TESTS; PROTONS; PSYCHIATRIC STATUS RATING SCALES;

EID: 74149094154     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2008.05.004     Document Type: Article

References (82)

1. Albert M.S., Moss M.B., Tanzi R., and Jones K. Preclinical prediction of AD using neuropsychological tests. J. Int. Neuropsychol. Soc. 7 (2001) 631-639
2. Ashburner J., Csernansky J.G., Davatzikos C., Fox N.C., Frisoni G.B., and Thompson P. Computer-assisted imaging to assess brain structure in healthy and diseased brains. Lancet Neurol. 2 (2003) 79-88
3. Baker F.B. The Basics of Item Response Theory (1985), Heinemann, Portsmouth, NH
4. Baron J.C., Chételat G., Desgranges B., Perchey G., Landeau B., de la Sayette V., and Eustache F. In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer's disease. Neuroimage 14 (2001) 298-309
5. Bartzokis G., Beckson M., Lu P.H., Nuechterlein K.H., Edwards N., and Mintz J. Age-related changes in frontal and temporal volume in men: a magnetic resonance imaging study. Arch. Gen. Psychiatry 60 (2001) 393-398
6. Bell-McGinty S., Lopez O.L., Meltzer C.C., Scanlon J.M., Whyte E.M., Dekosky S.T., and Becker J.T. Differential cortical atrophy in subgroups of mild cognitive impairment. Arch. Neurol. 62 (2005) 1393-1397
7. Braak H., and Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol. 82 (1991) 239-259
8. Busatto G.F., Garrido G.E., Almeida O.P., Castro C.C., Camargo C.H., Cid C.G., Buchpiguel C.A., Furuie S., and Bottino C.M. A voxel-based morphometry study of temporal lobe gray matter reductions in Alzheimer's disease. Neurobiol. Aging 24 (2003) 221-231
9. Catani M., Cherubini A., Howard R., Tarducci R., Pelliccioli G.P., Piccirilli M., Gobbi G., Senin U., and Mecocci P. (1)H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging. Neuroreport 12 (2001) 2315-2317
10. Chao L.L., Schuff N., Clevenger E.M., Mueller S.G., Rosen H.J., Gorno-Tempini M.L., Kramer J.H., Miller B.L., and Weiner M.W. Patterns of white matter atrophy in frontotemporal lobar degeneration. Arch. Neurol. 64 (2007) 1-7
11. Chetelat G., Landeau B., Eustache F., Mezenge F., Viader F., de la Sayette V., Desgranges B., and Baron J.C. Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study. Neuroimage 27 (2005) 934-946
12. Convit A., de Asis J., de Leon M.J., Tarshish C.Y., De Santi S., and Rusinek H. Atrophy of the medial occipitotemporal, inferior, and middle temporal gyri in non-demented elderly predict decline to Alzheimer's disease. Neurobiol. Aging 21 (2000) 19-26
13. Convit A., de Leon M.J., Tarshish C., De Santi S., Tsui W., Rusinek H., and George A.E. Specific hippocampal volume reductions in individuals at risk for Alzheimer's disease. Neurobiol. Aging 18 (1997) 131-138
14. de Leon M.J., Convit A., Wolf O.T., Tarshish C.Y., DeSanti S., Rusinek H., Tsui W., Kandil E., Scherer A.J., Roche A., Imossi A., Thorn E., Bobinski M., Caraos C., Lesbre P., Schlyer D., Poirier J., Reisberg B., and Fowler J. Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-d-glucose/poitron-emission tomography (FDG/PET). Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 10966-10971
15. de Leon M.J., George A.E., Golomb J., Tarshish C., Convit A., Kluger A., De Santi S., McRae T., Ferris S.H., Reisberg B., Ince C., Rusinek H., Bobinski M., Quinn B., Miller D.C., and Wisniewski H.M. Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease. Neurobiol. Aging 18 (1997) 1-11
16. de Toledo-Morrell L., Goncharova I., Dickerson B., Wilson R.S., and Bennett D.A. From healthy aging to early Alzheimer's disease: in vivo detection of entorhinal cortex atrophy. Ann. NY Acad. Sci. 911 (2000) 240-253
17. Delis, D.C., Kaplan, E., Kramer, J.H., 2001. Delis-Kaplan Executive Function System.
18. Delis, DC, Kramer, JH, Kaplan E, Ober BA. California Verbal Learning Test-2nd edition. Adult version. Manual, Psychological Corporation, San Antonio, TX (2000).
19. den Heijer T., Geerlings M.I., Hoebeek F.E., Hofman A., Koudstaal P.J., and Breteler M.M. Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people. Arch. Gen. Psychiatry 63 (2006) 57-62
20. Dickerson B.C., Goncharova I., Sullivan M.P., Forchetti C., Wilson R.S., Bennett D.A., Beckett L.A., and deToledo-Morrell L. MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease. Neurobiol. Aging 22 (2001) 747-754
21. Du A.T., Schuff N., Amend D., Laakso M.P., Hsu Y.Y., Jagust W.J., Yaffe K., Kramer J.H., Reed B., Norman D., Chui H.C., and Weiner M.W. Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 71 (2001) 441-447
22. Du A.T., Schuff N., Kramer J.H., Ganzer S., Zhu X.P., Jagust W.J., Miller B.L., Reed B.R., Mungas D., Yaffe K., Chui H.C., and Weiner M.W. Higher atrophy rate of entorhinal cortex than hippocampus in AD. Neurology 62 (2004) 422-427
23. Duarte A., Hayasaka S., Du A., Schuff N., Jahng G.H., Kramer J., Miller B., and Weiner M. Volumetric correlates of memory and executive function in normal elderly, mild cognitive impairment and Alzheimer's disease. Neurosci. Lett. 406 (2006) 60-65
24. Fischl B., and Dale A.M. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 11050-11055
25. Frisoni G.B., Testa C., Zorzan A., Sabattoli F., Beltramello A., Soininen H., and Laakso M.P. Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry. J. Neurol. Neurosurg. Psychiatry 73 (2002) 657-664
26. Hambleton R.K., and Swaminathan H. Item Response Theory Principles and Applications (1985), Kluwer Nijhoff Publishing, Dordrecht
27. Hambleton R.K., Swaminathan H., and Rogers H.A. Fundamentals of Item Response Theory (1991), Sage Publications Inc., London
28. Hedden T., and Gabrieli J.D. Healthy and pathological processes in adult development: new evidence from neuroimaging of the aging brain. Curr. Opin. Neurol. 18 (2005) 740-747
29. Hsu Y.Y., Du A.T., Schuff N., and Weiner M.W. Magnetic resonance imaging and magnetic resonance spectroscopy in dementias. J. Geriatr. Psychiatry Neurol. 14 (2001) 145-166
30. Hsu Y.Y., Schuff N., Du A.T., Mark K., Zhu X., Hardin D., and Weiner M.W. Comparison of automated and manual MRI volumetry of hippocampus in normal aging and dementia. J. Magn. Reson. Imaging 16 (2002) 305-310
31. Hughes C.P., Berg L., Danizer W.L., Coben L.A., and Martin R.L. A new clinical scale for the staging of dementia. Br. J. Psychiatry 140 (1982) 566-572
32. Jack Jr. C.R., Shiung M.M., Gunter J.L., O'Brien P.C., Weigand S.D., Knopman D.S., Boeve B.F., Ivnik R.J., Smith G.E., Cha R.H., Tangalos E.G., and Petersen R.C. Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD. Neurology 62 (2004) 591-600
33. Jack C.R., Petersen R.C., Xu Y.C., O'Brien P.C., Smith G.E., Ivnik R.J., Boeve B.F., Waring S.C., Tangalos E.G., and Kokmen E. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology 52 (1999) 1397-1403
34. Jack C.R.J., Petersen R.C., Xu Y., O'Brien P.C., Smith G.E., Ivnik R.J., Boeve B.F., Tangalos E.G., and Kokmen E. Rates of hippocampal atrophy correlate with change in clinical status in aging and AD. Neurology 55 (2000) 484-490
35. Jernigan T.L., Archibald S.L., Fenema-Notestine C., Gamst A.C., Stout J., Bonner J., and Hesselink J.R. Effects of age on tissues and regions of the cerebrum and cerebellum. Neurobiol. Aging 22 (2001) 581-594
36. Jorm A.F., and Jacomb P.A. An informant questionnaire on cognitive decline in the elderly (IQCODE): socio-demographic correlates reliability, validity and some norms. Psychol. Med. 18 (1989) 1015-1022
37. Kantarci K., and Jack Jr. C.R. Neuroimaging in Alzheimer disease: an evidence-based review. Neuroimaging Clin. N. Am. 13 (2003) 197-209
38. Kantarci K., Jack C.R., Xu Y.C., Campeau N.G., O'Brien P.C., Smith G.E., Ivnik R.J., Boeve B.F., Kokmen E., Tangalos E.G., and Petersen R.C. Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: a 1H MRS study. Neurology 55 (2000) 210-217
39. Kantarci K., Smith G.E., Ivnik R.J., Petersen R.C., Boeve B.F., Knopman D.S., Tangalos E.G., and Jack Jr. C.R. 1H magnetic resonance spectroscopy, cognitive function, and apolipoprotein E genotype in normal aging, mild cognitive impairment and Alzheimer's disease. J. Int. Neuropsychol. Soc. 8 (2002) 934-942
40. Karas G.B., Scheltens P., Rombouts S.A.R.B., Visser P.J., van Schijndel R.A., Fox N.C., and Barkhof F. Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease. Neuroimage 23 (2004) 708-716
41. Kidron D., Black S.E., Stanchev P., Buck B., Szalai J., Parker J., Szekely C., and Bronskill M.J. Quantitative MR volumetry in Alzheimer's disease. Topographic markers and the effects of sex and education. Neurology 49 (1997) 1504-1512
42. Killiany R.J., Gomez-Isla T., Moss M., Kikinis R., Sandor T., Jolesz F., Tanzi R., Jones K., Hyman B.T., and Albert M.S. Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease. Ann. Neurol. 47 (2000) 430-439
43. Klunk W.E., Engler H., Nordberg A., Wang Y., Blomqvist G., Holt D.P., Bergström M., Savitcheva I., Huang G.F., Estrada S., Ausén B., Debnath M.L., Barletta J., Price J.C., Sandell J., Lopresti B.J., Wall A., Koivisto P., Antoni G., Mathis C.A., and Långström B. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann. Neurol. 55 (2004) 306-319
44. Kordower J.H., Chu Y., Stebbins G.T., DeKosky S.T., Cochran E.J., Bennett D., and Mufson E.J. Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment. Ann. Neurol. 49 (2001) 202-213
45. Matson G.B. An integrated program for amplitude-modulated RF pulse generation and re-mapping with shaped gradients. Magn. Reson. Imaging 12 (1994) 1205-1225
46. Morris J.C. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 43 (1993) 2412-2414
47. Morris J.C., and Price A.L. Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease. J. Mol. Neurosci. 17 (2001) 101-118
48. Morris J.C., Storandt M., Miller J.P., McKeel D.W., Price J.L., Rubin E.H., and Berg L. Mild cognitive impairment represents early-stage Alzheimer disease. Arch. Neurol. 58 (2001) 397-405
49. Mungas D., Harvey D., Reed B.R., Jagust W.J., DeCarli C., Beckett L., Mack W.J., Kramer J.H., Weiner W.W., Schuff N., and Chui H.C. Longitudinal volumetric MRI change and rate of cognitive decline. Neurology 65 (2005) 565-571
50. Mungas D., Reed B.R., and Kramer J.H. Psychometrically matched measures of global cognition, memory, and executive function for assessment of cognitive decline in older persons. Neuropsychology 17 (2003) 380-392
51. Pennanen C., Kivipelto M., Tuomainen S., Hartikainen P., Hänninen T., Laakso M.P., Hallikainen M., Vanhanen M., Nissinen A., Helkala E.L., Vainio P., Vanninen R., Partanen K., and Soininen H. Hippocampus and entorhinal cortex in mild cognitive impairment and early AD. Neurobiol. Aging 25 (2004) 303-310
52. Pennanen C., Testa C., Laakso M.P., Hallikainen M., Helkala E.L., Hänninen T., Kivipelto M., Könönen M., Nissinen A., Tervo S., Vanhanen M., Vanninen R., Frisoni G.B., and Soininen H. A voxel based morphometry study on mild cognitive impairment. J. Neurol. Neurosurg. Psychiatry 76 (2005) 11-14
53. Petersen R.C., Jack Jr. C.R., Xu Y.C., Waring S.C., O'Brien P.C., Smith G.E., Ivnik R.J., Tangalos E.G., Boeve B.F., and Kokmen E. Memory and MRI-based hippocampal volumes in aging and AD. Neurology 54 (2000) 581-587
54. Petersen R.C., Smith G.E., Waring S.C., Ivnik R.J., Tangalos E.G., and Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch. Neurol. 56 (1999) 303-308
55. Petersen R.C., Stevens J.C., Ganguli M., Tangalos E.G., Cummings J.L., and DeKosky S.T. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review) Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 56 (2001) 1133-1142
56. Pfeffer R.I., Kurosaki T.T., Hurrah C.H.J., Chance J.M., and Filos S. Measurement of functional activities in older adults in the community. J. Gerontol. 37 (1982) 323-329
57. Pfefferbaum A., Sullivan E.V., Rosenbloom M.J., Mathalon D.H., and Lim K.O. A controlled study of cortical gray matter and ventricular changes in alcoholic men over a 5-year interval. Arch. Gen. Psychiatry 55 (1998) 905-912
58. Price J.L., and Morris J.C. Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease. Ann. Neurol. 45 (1999) 358-368
59. Rabin L.A., Saykin A.J., Wishart H.A., Copenhaver B.R., Flashman L.A., and Santulli R.B. Telephone-based screening for MCI and cognitive complaints: preliminary validation by comprehensive assessment. Paper presented at the International Neuropsychological Society Meeting (2004)
60. Raz N., Gunning-Dixon F., Head D., Rodrigue K.M., Williamson A., and Acker J.D. Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: replicability of regional differences in volume. Neurobiol. Aging 25 (2004) 377-396
61. Raz N., Lindenberger U., Rodrigue K.M., Kennedy K.M., Head D., WIlliamson A., Dahle C., Gerstorf D., and Acker J.D. Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb. Cortex 15 (2005) 1676-1689
62. Resnick S.M., Pham D.L., Kraut M.A., Zonderman A.B., and Davatzikos C. Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. J. Neurosci. 23 (2003) 3295-3301
63. Rockwood K., Strang D., MacKnight C., Downer R., and Morris J.C. Interrater reliability of the Clinical Dementia Rating in a multicenter trial. J. Am. Geriatr. Soc. 48 (2000) 558-559
64. Saykin A.J. Neurobehavioral Function and Activities of Daily Living Rating Scale (NBFADL-63 item version) (1992), Darthmouth Medical School, Hanover
65. Saykin A.J., Janssen R., Sprehn G., Spira T., Kaplan J., and O'Connor B. Longitudinal evaluation of neuropsychological function in homosexual men with HIV-1 infection; 18 month follow-up. J. Neuropsychiatry Clin. Neurosci. 3 (1991) 286-298
66. Saykin A.J., Wishart H.A., Rabin L.A., Santulli R.B., Flashman L.A., West J.D., McHugh T.L., and Mamourian A.C. Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology 67 (2006) 834-842
67. Scahill R.I., Frost C., Jenkins R., Whitwell J.L., Rossor M.N., and Fox N.C. A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging. Arch. Neurol. 60 (2003) 989-994
68. Scahill R.I., Schott J.M., Stevens J.M., Rossor M.N., and Fox N.C. Mapping the evolution of regional atrophy in Alzheimer's disease: unbiased analysis of fluid-registered serial MRI. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 4703-4707
69. Schafer K.A., Tractenberg R.E., Sano M., Mackell J.A., Thomas R.G., Gamst A., Thal L.J., Morris J.C., and Study A.s.D.C. Reliability of monitoring the clinical dementia rating in multicenter clinical trials. Alzheimer Dis. Assoc. Disord. 18 (2004) 219-222
70. Schmand B., Smit J.H., Geerlings M.I., and Lindeboom J. The effects of intelligence and education on the development of dementia A test of the brain reserve hypothesis. Psychol. Med. 27 (1997) 1337-1344
71. Squire L.R., Wetzel C.D., and Slater P.C. Memory complaint after electroconvulsive therapy: assessment with a new self-rating instrument. Biol. Psychiatry 14 (1979) 791-801
72. Stern Y. What is cognitive reserve? Theory and research application of the reserve concept. J. Int. Neuropsychol. Soc. 8 (2002) 448-460
73. Storandt M., Grant E.A., Miller J.P., and Morris J.C. Longitudinal course and neuropathologic outcomes in original vs. revised MCI and in pre-MCI. Neurology 67 (2006) 467-473
74. Studholme C., Cardenas V., Song I., Ezekiel F., Maudsley A., and Weiner M. Accurate template-based correction of brain MRI intensity disorder with application to dementia and aging. IEEE Trans. Med. Imaging 23 (2004) 99-110
75. Van Leemput K., Maes F., Vandermeulen D., Colchester A., and Suetens P. Automated segmentation of multiple sclerosis lesions by model outlier detection. IEEE Trans. Med. Imaging 20 (2001) 677-688
76. Van Leemput K., Maes F., Vandermeulen D., and Suetens P. Automated model-based tissue classification of MR images of the brain. IEEE Trans. Med. Imaging 18 (1999) 897-908
77. Van Leemput K., Maes F., Vandermeulen D., and Suetens P. A unifying framework for partial volume segmentation of brain MR images. IEEE Trans. Med. Imaging 22 (2003) 105-109
78. Visser P., Scheltens P., Verhey F.R., Schmand B., Launer L.J., Jolles J., and Jonker C. Medial temporal lobe atrophy and memory dysfunction as predictors for dementia in subjects with mild cognitive impairment. J. Neurol. 246 (1999) 477-485
79. Wolf H., Jelic V., Gertz H.J., Nordberg A., Julin P., and Wahlund L.O. A critical discussion of the role of neuroimaging in mild cognitive impairment. Acta Neurol. Scand. Suppl. 179 (2003) 52-76
80. Xu Y., Jack Jr. C.R., O'Brien P.C., Kokmen E., Smith G.E., Ivnik R.J., Boeve B.F., Tangalos R.G., and Petersen R.C. Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD. Neurology 54 (2000) 1760-1767
81. Yesavage J.A., Brink T.L., Rose T.L., Lum O., Huang V., Adey M., and Leirer V.O. Development and validation of Geriatric Depression Rating Scale: a preliminary report. J. Psychiatr. Res. 17 (1982) 37-49
82. Zakzanis K.K., Graham S.J., and Campbell Z. A meta-analysis of structural and functional brain imaging in dementia of the Alzheimer's type: a neuroimaging profile. Neuropsychol. Rev. 13 (2003) 1-18