Multivariate statistical approach to optimizing sustained-release tablet formulations containing diltiazem hydrochloride as a model highly water-soluble drug

International Journal of Pharmaceutics

Volumn 386, Issue 1-2, 2010, Pages 149-155

  Kikuchi, Shingo ^a   Takayama, Kozo ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Confidence interval; Highly water soluble drug; Hydrophilic matrix tablet; Quality by design; Simultaneous optimization; Sustained release

Indexed keywords

DEXTRAN SULFATE; DIETHYLAMINOETHYLDEXTRAN; DILTIAZEM; HYDROXYPROPYLMETHYLCELLULOSE;

ARTICLE; CONTROLLED STUDY; HYDROPHILICITY; MATRIX TABLET; MULTIVARIATE ANALYSIS; PREDICTION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RELIABILITY; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE PREPARATION;

CHEMISTRY, PHARMACEUTICAL; DEAE-DEXTRAN; DELAYED-ACTION PREPARATIONS; DEXTRAN SULFATE; DILTIAZEM; KINETICS; METHYLCELLULOSE; MODELS, CHEMICAL; MODELS, STATISTICAL; MULTIVARIATE ANALYSIS; NONLINEAR DYNAMICS; REPRODUCIBILITY OF RESULTS; SOLUBILITY; TABLETS; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 74149092348     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.11.008     Document Type: Article

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