The capsaicin cough reflex in patients with symptoms elicited by odorous chemicals

International Journal of Hygiene and Environmental Health

Volumn 213, Issue 1, 2010, Pages 66-71

  Holst, H ^a   Arendt Nielsen, L ^b   Mosbech, H ^c   Vesterhauge, S ^d   Elberling, J ^a  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b Center for Sensory Motor Interaction (SMI)   (Denmark)

^c Rigshospitalet   (Denmark)

^d Hamlet Hospital   (Denmark)

Author keywords

Airway hyperresponsiveness; Capsaicin; Cough; Eczema; Multiple chemical sensitivity; TRPV1

Indexed keywords

CAPSAICIN; DIAGNOSTIC AGENT; PLANT EXTRACT; VOLATILE ORGANIC COMPOUND;

ADULT; AIR POLLUTANT; ARTICLE; CASE CONTROL STUDY; CHEMISTRY; COUGHING; DOSE RESPONSE; ECZEMA; EXPOSURE; FEMALE; HUMAN; INHALATION TEST; MIDDLE AGED; MULTIPLE CHEMICAL SENSITIVITY; ODOR; PATHOPHYSIOLOGY; PEPPER; STATISTICAL MODEL;

ADULT; AIR POLLUTANTS; BRONCHIAL PROVOCATION TESTS; CAPSAICIN; CAPSICUM; CASE-CONTROL STUDIES; COUGH; DOSE-RESPONSE RELATIONSHIP, DRUG; ECZEMA; FEMALE; HUMANS; INHALATION EXPOSURE; LOGISTIC MODELS; MIDDLE AGED; MULTIPLE CHEMICAL SENSITIVITY; ODORS; PLANT EXTRACTS; VOLATILE ORGANIC COMPOUNDS;

EID: 74149084771     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2009.08.005     Document Type: Article

References (33)

1. Berg N.D., Linneberg A., Dirksen A., and Elberling J. Prevalence of self-reported symptoms and consequences related to inhalation of airborne chemicals in a Danish general population. Int. Arch. Occup. Environ. Health 81 (2008) 881-887
2. Choudry N.B., and Fuller R.W. Sensitivity of the cough reflex in patients with chronic cough. Eur. Respir. J. 5 (1992) 296-300
3. Chung K. Review series: chronic cough: future directions in chronic cough: mechanisms and antitussives. Chron. Respir. Dis. 4 (2007) 159-165
4. Cullen M.R. The worker with multiple chemical sensitivities: an overview. Ocupational Medicine: State of the Art Reviews 2 4 (1987) 655-661
5. Davidoff A.L., and Keyl P.M. Symptoms and health status in individuals with multiple chemical sensitivities syndrome from four reported sensitizing exposures and a general population comparison group. Arch. Environ. Health 51 (1996) 201-213
6. Dicpinigaitis P.V. Short- and long-term reproducibility of capsaicin cough challenge testing. Pulm. Pharmacol. Ther. 16 (2003) 61-65
7. Dicpinigaitis P.V. Experimentally induced cough. Pulm. Pharmacol. Ther. 20 (2007) 319-324
8. Dicpinigaitis P.V., Allusson V.R., Baldanti A., and Nalamati J.R. Ethnic and gender differences in cough reflex sensitivity. Respiration 68 (2001) 480-482
9. Doherty M.J., Mister R., Pearson M.G., and Calverley P.M. Capsaicin induced cough in cryptogenic fibrosing alveolitis. Thorax 55 (2000) 1028-1032
10. Elberling J., Dirksen A., Johansen J.D., and Mosbech H. The capsaicin cough reflex in eczema patients with respiratory symptoms elicited by perfume. Contact Dermatitis 54 (2006) 158-164
11. Elberling J., Linneberg A., Dirksen A., Johansen J.D., Frolund L., Madsen F., Nielsen N.H., and Mosbech H. Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivity. Clin. Exp. Allergy 35 (2005) 75-81
12. Elberling J., Skov P.S., Mosbech H., Holst H., Dirksen A., and Johansen J.D. Increased release of histamine in patients with respiratory symptoms related to perfume. Clin. Exp. Allergy 37 (2007) 1676-1680
13. Fujimura M., Kasahara K., Kamio Y., Naruse M., Hashimoto T., and Matsuda T. Female gender as a determinant of cough threshold to inhaled capsaicin. Eur. Respir. J. 9 (1996) 1624-1626
14. Gazerani P., Andersen O.K., and Arendt-Nielsen L. A human experimental capsaicin model for trigeminal sensitization. Gender-specific differences. Pain 118 (2005) 155-163
15. Graveling R.A., Pilkington A., George J.P., Butler M.P., and Tannahill S.N. A review of multiple chemical sensitivity. Occup. Environ. Med. 56 (1999) 73-85
16. Groneberg D.A., Niimi A., Dinh Q.T., Cosio B., Hew M., Fischer A., and Chung K.F. Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am. J. Respir. Crit. Care Med. 170 (2004) 1276-1280
17. Irwin S.R. Assesing cough serverity and efficacy of therapy in clinical research: ACCP evidence-based clinical practice guidelines. Chest 129 (2006) 232-237 (Ref Type: Generic)
18. Johansson A., Lowhagen O., Millqvist E., and Bende M. Capsaicin inhalation test for identification of sensory hyperreactivity. Respir. Med. 96 (2002) 731-735
19. McGarvey L., McKeagney P., Polley L., Macmahon J., and Costello R.W. Are there clinical features of a sensitized cough reflex?. Pulm. Pharmacol. Ther. 22 (2009) 59-64
20. Midgren B., Hansson L., Karlsson J.A., Simonsson B.G., and Persson C.G. Capsaicin-induced cough in humans. Am. Rev. Respir. Dis. 146 (1992) 347-351
21. Millqvist E. Cough provocation with capsaicin is an objective way to test sensory hyperreactivity in patients with asthma-like symptoms. Allergy 55 (2000) 546-550
22. Millqvist E. Mechanisms of increased airway sensitivity to occupational chemicals and odors. Curr. Opin. Allergy Clin. Immunol. 8 (2008) 135-139
23. Millqvist E., Bende M., and Lowhagen O. Sensory hyperreactivity - a possible mechanism underlying cough and asthma-like symptoms. Allergy 53 (1998) 1208-1212
24. Morice A.H., Fontana G.A., Belvisi M.G., Birring S.S., Chung K.F., Dicpinigaitis P.V., Kastelik J.A., McGarvey L.P., Smith J.A., Tatar M., and Widdicombe J. ERS guidelines on the assessment of cough. Eur. Respir. J. 29 (2007) 1256-1276
25. Morice A.H., Fontana G.A., Sovijarvi A.R., Pistolesi M., Chung K.F., Widdicombe J., O'Connell F., Geppetti P., Gronke L., De J.J., Belvisi M., Dicpinigaitis P., Fischer A., McGarvey L., Fokkens W.J., and Kastelik J. The diagnosis and management of chronic cough. Eur. Respir. J. 24 (2004) 481-492
26. Morice A.H., Higgins K.S., and Yeo W.W. Adaptation of cough reflex with different types of stimulation. Eur. Respir. J. 5 (1992) 841-847
27. Morice A.H., Kastelik J.A., and Thompson R. Cough challenge in the assessment of cough reflex. Brit. J. Clin. Pharmacol. 52 (2001) 365-375
28. Nejla S., Fujimura M., and Kamio Y. Comparison between tidal breathing and dosimeter methods in assessing cough receptor sensitivity to capsaicin. Respirology 5 4 (2000) 337-342
29. O'Connell F., Thomas V.E., Pride N.B., and Fuller R.W. Capsaicin cough sensitivity decreases with successful treatment of chronic cough. Am. J. Respir. Crit. Care Med. 150 (1994) 374-380
30. Prudon B., Birring S.S., Vara D.D., Hall A.P., Thompson J.P., and Pavord I.D. Cough and glottic-stop reflex sensitivity in health and disease. Chest 127 (2005) 550-557
31. Quanjer, P.H., Tammeling, G.J., Cotes, J.E., Pedersen, O.F., Peslin, R., Yernault, J.C., 1993. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur. Respir. J. Suppl. 16, 5-40.
32. Ternesten-Hasseus E., Bende M., and Millqvist E. Increased capsaicin cough sensitivity in patients with multiple chemical sensitivity. J. Occup. Environ. Med. 44 (2002) 1012-1017
33. Ternesten-Hasseus E., Johansson K., Lowhagen O., and Millqvist E. Inhalation method determines outcome of capsaicin inhalation in patients with chronic cough due to sensory hyperreactivity. Pulm. Pharmacol. Ther. 19 (2006) 172-178