Proinflammatory phenotype with imbalance of KLF2 and RelA: Risk of childhood stroke with sickle cell anemia

American Journal of Hematology

Volumn 85, Issue 1, 2010, Pages 18-23

  Enenstein, Judy ^a   Milbauer, Liming ^a   Domingo, Evidio ^b   Wells, Alexandra ^c   Roney, Mark ^a   Kiley, Jim ^a   Wei, Peng ^d   Hebbel, Robert P ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b MAYO CLINIC   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 2; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; KLF2 PROTEIN, HUMAN; RELA PROTEIN, HUMAN; TRANSCRIPTION FACTOR RELA;

AFRICAN AMERICAN; ARTICLE; BRAIN CIRCULUS ARTERIOSUS; CHILDHOOD DISEASE; CONTROLLED STUDY; DIFFERENTIAL DISPLAY; ENDOTHELIUM CELL; FLOW CYTOMETRY; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; INFLAMMATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR; SICKLE CELL ANEMIA; STROKE; WESTERN BLOTTING; ADOLESCENT; ADULT; CASE CONTROL STUDY; CHILD; CLASSIFICATION; METABOLISM; PATHOLOGY; PRESCHOOL CHILD;

ADOLESCENT; ANEMIA, SICKLE CELL; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CIRCLE OF WILLIS; ENDOTHELIAL CELLS; FLOW CYTOMETRY; HUMANS; INFLAMMATION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; RISK FACTORS; STROKE; TRANSCRIPTION FACTOR RELA; YOUNG ADULT;

EID: 74049157063     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.21558     Document Type: Article

References (25)

1. Adams RJ. Big strokes in small persons. Arch Neurol 2007;64:1567-1574.
2. Stockman JA, Nigro MA, Mishkin MM, Oski FA. Occlusion of large cerebral vessels in sickle-cell anemia. N Engl J Med 1972;287:846-849.
3. Milbauer LC, Wei P, Enenstein J, et al. Genetic endothelial systems biology of sickle stroke risk. Blood 2008;111:3872-3879.
4. Atkins GB, Jain MK. Role of Krüppel-like transcription factors in endothelial biology. Circ Res 2007;100:1686-1695.
5. Viatour P, Merville MP, Bours V, Chariot A. Phosphorylation of NF-kappaB and IkappaB proteins: Implications in cancer and inflammation. Trends Biochem Sci 2005;30:43-52.
6. Zhang W, Potrovita I, Tarabin V, et al. Neuronal activation of NF-kappaB contributes to cell death in cerebral ischemia. J Cereb Blood Flow Metab 2005;25:30-40.
7. Nurmi A, Lindsberg PJ, Koistinaho M, et al. Nuclear factor-kappaB contributes to infarction after permanent focal ischemia. Stroke 2004;35:987-991.
8. Dekker RJ, Boon RA, Rondaij MG, et al. KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium. Blood 2006;107:4354-4363.
9. Kawanami D, Mahabeleshwar GH, Lin Z, et al. Kruppel-like factor 2 inhibits hypoxia-inducible factor 1α expression and function in the endothelium. J Biol Chem 2009;284:20522-20530.
10. Xu Y, Sengupta PK, Seto E, Smith BD. Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen α2(I) gene (COL1A2) expression. J Biol Chem 2006;281:9260-9270.
11. Lawrance IC, Wu F, Leite AZ, et al. A murine model of chronic inflammationinduced intestinal fibrosis down-regulated by antisense NF-kappa B. Gastroenterology 2003;125:1750-1761.
12. Yoneyama T, Kasuya H, Onda H, et al. Collagen type I α2 (COL1A2) is the susceptible gene for intracranial aneurysms. Stroke 2004;35:443-448.
13. Chen L, Smith L, Johnson MR, et al. Activation of protein kinase C induces nuclear translocation of RFX1 and down-regulates c-myc via an intron 1 X box in undifferentiated leukemia HL-60 cells. J Biol Chem 2000;275:32227-32233.
14. Lin Y, Weisdorf DJ, Solovey A, Hebbel RP. Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest 2000;105:71-77.
15. Frith MC, Fu Y, Yu L, et al. Detection of functional DNA motifs via statistical over-representation. Nucleic Acids Res 2004;32:1372-1381.
16. Matys V, Fricke E, Geffers R, et al. TRANSFAC: Transcriptional regulation, from patterns to profiles. Nucleic Acids Res 2003;31:374-378.
17. Davis CS. Statistical Methods for the Analysis of Repeated Measurements. New York: Springer-Verlag; 2002.
18. SAS Institute. SAS OnlineDoc, Version 8. Cary, NC: SAS Institute; 2000.
19. Province MA. Sequential methods of analysis for genome scans. Adv Genet 2001;42:499-514.
20. de Launoit Y, Audette M, Pelczar H, et al. The transcription of the intercellular adhesion molecule-1 is regulated by Ets transcription factors. Oncogene 1998;16:2065-2073.
21. Hajra L, Evans AI, Chen M, et al. The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation. Proc Natl Acad Sci USA 2000;97:9052-9057.
22. Wallinder J, Bergqvist D, Henriksson AE. Proinflammatory and anti-inflammatory cytokine balance in patients with abdominal aortic aneurysm and the impact of aneurysm size. Vasc Endovasc Surg 2009;43:258-261.
23. Zoli A, Ferlisi EM, Lizzio M, et al. Prolactin/cortixol ratio in rheumatoid arthritis. Ann N Y Acad Sci 2002;966:508-512.
24. Liu M, Kluger M, D'Alessio A, et al. Regulation of arterial-venous differences in tumor necrosis factor responsiveness of endothelial cells by anatomic context. Am J Pathol 2008;172:1088-1099.
25. Kumar A, Lin Z, SenBanerjee S, Jain MK. Tumor necrosis factor α-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases. Mol Cell Biol 2005;25:5893-5903.