Renal tubular epithelial cell injury and oxidative stress induce calcium oxalate crystal formation in mouse kidney: Original Article: Laboratory Investigation

International Journal of Urology

Volumn 17, Issue 1, 2010, Pages 83-92

  Hirose, Masahito ^a   Yasui, Takahiro ^a   Okada, Atsushi ^a   Hamamoto, Shuzo ^a   Shimizu, Hideo ^a   Itoh, Yasunori ^a   Tozawa, Keiichi ^a   Kohri, Kenjiro ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

Calcium oxalate crystal; Cell injury; Electron microscopy; Green tea; Oxidative stress

Indexed keywords

4 HYDROXYNONENAL; CALCIUM OXALATE; GLYOXYLIC ACID; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULE CELL; KIDNEY TUBULE DISORDER; LIPID PEROXIDATION; MICROSCOPY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; STAINING; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ANIMALS; CALCIUM OXALATE; CRYSTALLIZATION; EPITHELIAL CELLS; KIDNEY TUBULES; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, TRANSMISSION; OXIDATIVE STRESS;

EID: 74049157052     PISSN: 09198172     EISSN: 14422042     Source Type: Journal    
DOI: 10.1111/j.1442-2042.2009.02410.x     Document Type: Article

References (30)

1. Khan SR, Glenton PA, Backov R et al. Presence of lipids in urine, crystals and stones: implications for the formation of kidney stones. Kidney Int. 2002 62 : 2062 2072.
2. Asselman M, Verhulst A, De Broe ME et al. Calcium oxalate crystal adherence to hyaluronan-, osteopontin-, and CD44-expressing injured/regenerating tubular epithelial cells in rat kidneys. J. Am. Soc. Nephrol. 2003 14 : 3155 3166.
3. Thamilselvan S, Hackett RL, Khan SR. Lipid peroxidation in ethylene glycol induced hyperoxaluria and calcium oxalate nephrolithiasis. J. Urol. 1997 157 : 1059 1063.
4. Koul HK, Koul S, Fu S et al. Oxalate: from crystal formation to crystal retention. J. Am. Soc. Nephrol. 1999 14 : 417 421.
5. Thamilselvan S, Byer KJ, Hackett RL et al. Free radical scavengers, catalase and superoxide dismutase provide protection from oxalate-associated injury to LLC-PK1 and MDCK cells. J. Urol. 2000 164 : 224 229.
6. Muthukumar A, Selvam R. Role of glutathione on renal mitochondrial status in hyperoxaluria. Mol. Cell. Biochem. 1998 185 : 77 84.
7. 2 in the cytotoxic effects of oxalate in cultured renal epithelial cells. Kidney Int. 1999 56 : 1432 1441.
8. Khand FD, Gordge MP, Robertson WG et al. Mitochondrial superoxide production during oxalate-mediated oxidative stress in renal epithelial cells. Free Radic. Biol. Med. 2002 32 : 1339 1350.
9. Byer K, Khan SR. Citrate provides protection against oxalate and calcium oxalate crystal induced oxidative damage to renal epithelium. J. Urol. 2005 173 : 640 646.
10. Itoh Y, Yasui T, Okada A et al. Examination of the anti-oxidative effect in renal tubular cells and apoptosis by oxidative stress. Urol. Res. 2005 33 : 261 266.
11. Moriyama MT, Suga K, Miyazawa K et al. Inhibitions of urinary oxidative stress and renal calcium level by an extract of Quercus salicina Blume/Quercus stenophylla Makino in a rat calcium oxalate urolithiasis model. Int J Urol. 2009 16 : 397 401.
12. Lieske JC, Swift H, Martin T et al. Renal epithelial cells rapidly bind and internalize calcium oxalate monohydrate crystals. Proc. Natl. Acad. Sci. USA 1994 19 : 6987 6991.
13. Okada A, Nomura S, Higashibata Y et al. Successful formation of calcium oxalate crystal deposition in mouse kidney by intraabdominal glyoxylate injection. Urol. Res. 2007 35 : 89 99.
14. Pizzolato P. Histochemical recognition of calcium oxalate. J. Histochem. Cytochem. 1964 12 : 333 336.
15. Hirose M, Tozawa K, Okada A et al. Glyoxylate induces renal tubular cell injury and microstructural changes in experimental mouse. Urol. Res. 2008 36 : 139 147.
16. Thamilselvan S, Khan SR, Menon M. Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: effect of antioxidants. Urol. Res. 2003 31 : 3 9.
17. Khan SR, Byer KJ, Thamilselvan S et al. Crystal-cell interaction and apoptosis in oxalate-associated injury of renal epithelial cells. J. Am. Soc. Nephrol. 1999 10 : 457 463.
18. Uchigata Y, Yamamoto H, Kawamura A et al. Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J. Biol. Chem. 1982 257 : 6084 6088.
19. Grases F, García-Ferragut L, Costa-Bauzá A. Development of calcium oxalate crystals on urothelium: effect of free radicals. Nephron 1998 78 : 296 301.
20. Tungsanga K, Sriboonlue P, Futrakul P et al. Renal tubular cell damage and oxidative stress in renal stone patients and the effect of potassium citrate treatment. Urol. Res. 2005 33 : 65 9.
21. Huang HS, Ma MC, Chen CF et al. Lipid peroxidation and its correlations with urinary levels of oxalate, citric acid, and osteopontin in patients with renal calcium oxalate stones. Urology 2003 62 : 1123 1128.
22. Green ML, Freel RW, Hatch M. Lipid peroxidation is not the underlying cause of renal injury in hyperoxaluric rats. Kidney Int. 2005 68 : 2629 2638.
23. Orozco-Ibarra M, Medina-Campos ON, Sánchez-González DJ et al. Evaluation of oxidative stress in D-serine induced nephrotoxicity. Toxicology 2007 229 : 123 135.
24. Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am. J. Physiol. Lung Cell. Mol. Physiol. 2000 279 : 1005 1028.
25. Zamzami N, Marchetti P, Castedo M et al. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J. Exp. Med. 1995 182 : 367 377.
26. Fleury C, Mignotte B, Vayssiere JL. Mitochondrial reactive oxygen species in cell death signaling. Biochimie 2002 84 : 131 141.
27. Cao LC, Honeyman TW, Cooney R et al. Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity. Kidney Int. 2004 66 : 1890 1900.
28. Korff S, Riechert N, Schoensiegel F et al. Calcification of myocardial necrosis is common in mice. Virchows Arch. 2006 448 : 630 638.
29. Tanaka N, Ichinose S, Adachi Y et al. Ultrastructural analysis of salivary calculus in combination with X-ray microanalysis. Med. Electron Microsc. 2003 36 : 120 126.
30. Umekawa T, Byer K, Uemura H et al. Diphenyleneiodium (DPI) reduces oxalate ion- and calcium oxalate monohydrate and brushite crystal-induced upregulation of MCP-1 in NRK 52E cells. Nephrol. Dial. Transplant. 2005 20 : 870 878.