CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila

Human Molecular Genetics

Volumn 10, Issue 24, 2001, Pages 2767-2773

  Den Hollander, Anneke I ^a,c   Johnson, Kevin ^b   De Kok, Yvette J M ^a   Klebes, Ansgar ^a   Brunner, Han G ^a   Knust, Elisabeth ^a   Cremers, Frans P M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CELL PROTEIN; MEMBRANE PROTEIN;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL EMBRYO; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; BASEMENT MEMBRANE; BRAIN; CELL DEATH; CELL MEMBRANE; CELL POLARITY; CONTROLLED STUDY; CYTOPLASM; DROSOPHILA; EPIDERMIS CELL; EPITHELIUM CELL; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC CODE; GENETIC CONSERVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LEBER CONGENITAL AMAUROSIS; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; RETINA; RETINA DYSTROPHY; RETINITIS PIGMENTOSA; SPECIES;

ANIMALIA;

EID: 0035891865     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.24.2767     Document Type: Article

References (22)

1. Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12)
2. Leber congenital amaurosis and retinitis pigmentosa with Coats-like exudative vasculopathy are associated with mutations in the crumbs homologue 1 (CRB1) gene
3. Mutations in the CRB1 gene cause Leber congenital amaurosis
4. Preserved para-arteriole retinal pigment epithelium (PPRPE) in retinitis pigmentosa
5. Crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia
6. Phenotypic and developmental analysis of mutations at the crumbs locus, a gene required for the development of epithelia in Drosophila melanogaster
7. Crumbs, a component of the apical membrane, is required for zonula adherens formation in primary epithelia of Drosophila
8. The Drosophila genes crumbs and stardust are involved in the biogenesis of adherens junctions
9. CRUMBS is involved in the control of apical protein targeting during Drosophila epithelial development
10. Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila
11. A conserved motif in Crumbs is required for E-cadherin localisation and zonula adherens formation in Drosophila
12. Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain
13. EAT-20, a novel transmembrane protein with EGF motifs, is required for efficient feeding in Caenorhabditis elegans
14. Zonula adherens formation in Caenorhabditis elegans requires dlg-1, the homologue of the Drosophila gene discs large
15. Discs lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity
16. Stardust, a novel Drosophila MAGUK protein, acts as a partner of Crumbs in the control of epithelial cell polarity
17. Cell polarity: Nailing Crumbs to the scaffold
18. Isolation and mapping of novel candidate genes for retinal disorders using suppression subtractive hybridization
19. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
20. P-element mediated transformation
21. Looking at embryos
22. Characterization and cloning of fasciclin III: A glycoprotein expressed on a subset of neurons and axon pathways in Drosophila