Blood-brain barrier disruption by continuous-wave radio frequency radiation

Electromagnetic Biology and Medicine

Volumn 28, Issue 2, 2009, Pages 215-222

  Sirav, Bahriye ^a   Seyhan, Nesrin ^a  

^a GAZI UNIVERSITY   (Turkey)

Author keywords

Blood brain barrier; Evans Blue; Mobile phones; Radio frequency radiation; Rats

Indexed keywords

BIOLOGICAL EFFECTS; BLOOD-BRAIN BARRIER; CELLULAR PHONE; CONTINUOUS WAVE; CONTINUOUS WAVES; ELECTROMAGNETIC RADIATION; EM FIELD; EVANS BLUE; FEMALE RAT; MALE RATS; RADIO FREQUENCY RADIATION; SCIENTIFIC EVIDENCE;

BLOOD; CAPILLARITY; ELECTROMAGNETIC WAVES; ELECTRON OPTICS; MOBILE DEVICES; MOBILE PHONES; RADIO; RADIO WAVES; RATS; TELEPHONE; TELEPHONE SETS;

RADIATION EFFECTS;

RATTUS;

ANIMAL; ARTICLE; BLOOD BRAIN BARRIER; FEMALE; HUMAN; MALE; RADIATION EXPOSURE; RADIOFREQUENCY RADIATION; RAT; SEXUAL DEVELOPMENT; WISTAR RAT;

ANIMALS; BLOOD-BRAIN BARRIER; FEMALE; HUMANS; MALE; RADIO WAVES; RATS; RATS, WISTAR; SEX CHARACTERISTICS;

EID: 74049127881     PISSN: 15368378     EISSN: 15368386     Source Type: Journal    
DOI: 10.1080/15368370802608738     Document Type: Article

References (34)

1. Frey, A. H. (1998). Headaches from cellular telephones: Are they real and what are the implications? Environ. Health Perspect. 106(3):101-103.
2. Fritze, K., Sommer, C., Schmitz, B., et al. (1997). Effect of global system for mobile communication (GSM) microwave exposure on blood brain barrier permeability in rat. Acta Neuropathol. 94(5):465-470. (Pubitemid 27483211)
3. Gabriel, C. (2005). Dielectric properties of biological tissue: Variation with age. Bioelectromagnetics Suppl. 7 S:12-18.
4. Gruenau, S. P., Oscar, K. J., Folker, M. T., Rapoport, S. I. (1982). Absence of microwave effect on blood-brain barrier permeability to [14C] sucrose in the conscious rat. Exp. Neurol. 75(2):299-307.
5. Hardell, L., Mild, K. H. (2006). Mobile phone use and risk of glioma in adults: Results are difficult to interpret because of limitations. Brit. Med. J. 332(7548):1035.
6. ICNIRP (1998). Guidelines for limiting exposure to time varying electric, magnetic and electromagnetic fields (up to 300 GHz), International Commission on Non-Ionizing Radiation Protection-ICNIRP. Health Phys. 74(4):494-522.
7. Ilhan, A., Gurel, A., Armutcu, F., et al. (2004). Ginkgo biloba prevents mobile phone-induced oxidative stress in rat brain. Clin. Chim. Acta 340:153-162.
8. Kajiwara, K., Ho, H., Fukumoto, T. (1990). Lymphocyte infiltration into normal rat brain following hyper osmotic blood-brain barrier opening. J. Nueoroimmunol. 27:133.
9. Kaya, M., Cimen, V., Kalayci, R., et al. (2002). Catalase and a-Tocopherol Attenuate blood brain barrier breakdown in pentylenetetrazole- induced epileptic seizures in acute hyperglycaemic rats. Pharmacol. Res. 45:129-133.
10. Koenig, H., Goldstone, A. D., Lu, C. Y., Trout, J. J. (1989). Polyamines and Ca+2 mediate hyperosmolal opening of the blood brain barrier in vitro studies in isolated rat cerebral capillaries. J. Neurochem. 52:1135-1142.
11. Koziara, J. M., Lockman, P. R., Allen, D. D., Mumper, R. J. (2006). The blood-brain barrier and brain drug delivery. J. Nanosci. Nanotechnol. 6(9-10):2712-2735.
12. Leszcynski, D., Joenvr, S., Reivinen, J., Kuskka, R. (2002). Non-thermal activation of the hsp 27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: Molecular mechanism for cancer and blood-brain barrier related effects. Differentiation 70:120-129.
13. Lin, J. C., Yuan, P. M. K., Jung, T. D. (1998). Enhancement of anticancer drug delivery to the brain by microwave induced hyperthermia. Bioelectrochem. Bioenerg. 47:259-264.
14. Meral, I., Mert, H., Mert, N., et al. (2007). Effects of 900-MHz electromagnetic field emitted from cellular phone on brain oxidative stress and some vitamin levels of guinea pigs. Brain Res. 1169:120-124.
15. Muscat, J. E., Hinsvark, M., Malkin, M. (2006). Mobile telephones and rates of brain cancer. Neuroepidemiology 27(1):55-56.
16. Neubauer, C., Phelan, A. M., Kues, H., Lange, D. G. (1990). Microwave irradiation of rats of 2.45GHz activates pinocytotic like uptake of tracer by capillary endothelial cells of cerebral cortex. Bioelectromagnetics 11:261-268.
17. Oftedal, G., Wilén, J., Sandström, M., Mild, K. H. (2000). Symptoms experienced in connection with mobile phone use. Occup. Med. Oxf. 50:237-245.
18. Oscar, K. J., Hawkins, T. D. (1977). Microwave alteration of the blood brain barrier system of rats. Brain Res. 126:281-293.
19. Öztaş, B. (1998). Sex and blood-brain barrier. Pharmacol. Res. 37(3):165-167.
20. Öztaş, B., Akgul, S., Arslan, F. B. (2004). Influence of surgical pain stress on the blood-brain barrier permeability in rats. Life Sci. 74:1973-1979.
21. Öztaş, B., Akgul, S., Seker, F. B. (2007). Gender difference in the influence of antioxidants on the blood brain barrier permeability during pentylenetetrazol-induced seizures in hyperthermic rat pups. 118:77-83.
22. Öztaş, B., Koçak, H., Öner, P., Küçük, M. (2000). Sex-dependent changes in blood brain barrier permeability and brain Na+, K+ ATPase activity in rats following acute water intoxication. J. Neurosci. Res. 62:750-753.
23. Prato, F. S., Frappier, R. H., Shivers, R. R., et al. (1990). Magnetic resonance imaging increases the blood brain barrier permeability to 153-Gadolinium Diethylenetriaminepentaacedic acid in rats. Brain Res. 523:301-304.
24. Salford, L. G. (1993). Experimental studies of brain tumor development during exposure to continuous and pulsed 915MHz radiofrequency radiation. Bioelectrochem. Bioenerg. 30:313-318.
25. Salford, L. G., Brun, A., Sturesson, K., et al. (1994). Permeability of the blood brain barrier induced by 915MHz electromagnetic radiation, continuous wave and modulated at 8, 16, 50 and 200 Hz. Microscopy Res. Techniq. 27:535-542.
26. Salford, L. G., Brun, A. E., Eberhardt, J. L., et al. (2003). Nerve cell damage in mammalian brain after exposure to microwaves from GSM mobile phones. Environ. Health Perspect. 7:881-883.
27. Sandstrom, M., Wilen, J., Oftedal, G., Hansson Mild, K. (2001). Mobile phone use and subjective symptoms, comparison of symptoms experienced by users of analogue and digital mobile phones. Occup. Med. (Lond.) 51(1):25-35.
28. Schirmacher, A., Winters, S., Fischer, S., et al. (2000). Electromagnetic fields (1.8GHz) increases the permeability to sucrose of the blood brain barrier in vitro. Bioelectromagnetics 21:338-345.
29. Seyhan, N., Canseven, A. G. (2006). In vivo effects of ELF MFs on collagen synthesis, free radical processes, natural antioxidant system, respiratory burst system, immune system activities and electrolytes in the skin, plasma, spleen, lung, kidney and brain tissues. Electromagn. Biol. Med. 25:291-305.
30. Seyhan, N., Güler, G. (2006). Review of in vivo static and ELF electric fields studies performed at Gazi Biophysics Department. Electromagn. Biol. Med. 25:307-323.
31. Shivers, R. R., Kavaliers, M., Teskey, G. C., et al. (1987). Magnetic Resonance Imaging temporarily alters blood brain barrier permeability in the rat. Neurosci. Lett. 76:25-31.
32. Shivers, R. R., Pollock, M., Bowman, P. D., Atkinson, B. G. (1988). The effects of heat shock on primary cultures of brain capillary endothelium: Inhibition of assembly of zonulae occludentes and the synthesis of heat shock proteins. Eur. J. Cell Biol. 46(1):181-195.
33. Vecchio, F., Babiloni, C., Ferreri, F., et al. (2007). Mobile phone emission modulates interhemispheric functional coupling of EEG alpha rhythms. Eur. J. Neurosci. 25:1908-1913.
34. Wijsman, J. A., Shivers, R. R. (1993). Heat stress affects blood brain barrier permeability to horseradish peroxidase in mice. Acta Neuropathol. (Berl). 86(1):49-54.