Discovery of biaryl inhibitors of H+/K+ ATPase

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 3, 2010, Pages 1049-1054

  Garton, Neil ^a   Bailey, Nick ^a   Bamford, Mark ^a   Demont, Emmanuel ^a   Farre Gutierrez, Irene ^a   Hutley, Gail ^a   Bravi, Gianpaolo ^a   Pickering, Paula ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Acid pump antagonists; Acid secretion; APA; Biaryl imidazole; Potassium competitive acid blockers

Indexed keywords

AR HO47108; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; IMIDAZOPYRIDINE DERIVATIVE; INDOLE DERIVATIVE; PROTON PUMP INHIBITOR; UNCLASSIFIED DRUG; IMIDAZOLE DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; HYDROGEN BOND; IC 50; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; CHEMISTRY; COMPARATIVE STUDY; DRUG DEVELOPMENT; METABOLISM; PROCEDURES;

DRUG DISCOVERY; H(+)-K(+)-EXCHANGING ATPASE; IMIDAZOLES; PROTON PUMP INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 73949161357     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.040     Document Type: Article

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