Effects of cyclic flexure on endothelial permeability and apoptosis in arterial segments perfused ex vivo

Journal of Biomechanical Engineering

Volumn 131, Issue 10, 2009, Pages

  Van Epps, J Scott ^a   Chew, Douglas W ^a   Vorp, David A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Computational fluid dynamics; Cyclic flexure; Finite element analysis; Permeability

Indexed keywords

APOPTOSIS; ATHEROGENESIS; ATHEROSCLEROTIC LESIONS; BIOLOGICAL DATA; BIOMECHANICAL STRESS; CIRCUMFERENTIAL STRESS; COMPUTATIONAL FLUID DYNAMICS TECHNIQUE; CYCLIC FLEXURE; ENDOTHELIAL PERMEABILITY; EX-VIVO; FEMORAL ARTERY; FINITE ELEMENT; FINITE ELEMENT ANALYSIS; HETEROGENEOUS DISEASE; LABELED ALBUMIN; LOCAL VARIATIONS; LONGITUDINAL PULSE; MECHANICAL STRESS; MULTIPLE LINEAR REGRESSION ANALYSIS; PERMEABILITY; POTENTIAL MECHANISM; RISK FACTORS; SHEAR STRESS DISTRIBUTION; SPATIAL DISTRIBUTION; TISSUE PROCESSING;

BIOMECHANICS; CELL DEATH; COMPUTATIONAL FLUID DYNAMICS; FLUID DYNAMICS; FLUIDS; LINEAR REGRESSION; SELF ASSEMBLY; SHEAR STRESS; SIZE DISTRIBUTION; STRESS CONCENTRATION;

FINITE ELEMENT METHOD;

APOPTOSIS; ARTICLE; ATHEROGENESIS; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; DIASTOLE; ENDOTHELIUM; EX VIVO STUDY; FEMORAL ARTERY; FINITE ELEMENT ANALYSIS; MECHANICAL STRESS; RISK FACTOR; SHEAR STRESS; SURGICAL TECHNIQUE; SYSTOLE; ANIMAL; ATHEROSCLEROSIS; BIOLOGY; CELL NUCLEUS; COMPUTER SIMULATION; CYTOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOHISTOCHEMISTRY; INTIMA; METABOLISM; METHODOLOGY; NICK END LABELING; PERFUSION; PERMEABILITY; PHYSIOLOGY; PULSATILE FLOW; SHEAR STRENGTH; STATISTICAL MODEL; SWINE; TUNICA MEDIA; VASCULAR ENDOTHELIUM;

SUS;

ALBUMINOID; BIOLOGICAL MARKER; COLORING AGENT; CYCLINE; EVANS BLUE; FLUORESCENT DYE; PIBENZIMOL;

ALBUMINS; ANIMALS; APOPTOSIS; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; BISBENZIMIDAZOLE; CELL NUCLEUS; COLORING AGENTS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; ENDOTHELIUM, VASCULAR; EVANS BLUE; FEMORAL ARTERY; FINITE ELEMENT ANALYSIS; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; FLUORESCENT DYES; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LINEAR MODELS; PERFUSION; PERMEABILITY; PROLIFERATING CELL NUCLEAR ANTIGEN; PULSATILE FLOW; SHEAR STRENGTH; STRESS, MECHANICAL; SWINE; TUNICA INTIMA; TUNICA MEDIA;

EID: 73949152239     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.3192143     Document Type: Article

References (48)

1. McGovern, P. G., Pankow, J. S., Shahar, E., Doliszny, K. M., Folsom, A. R., Blackburn, H., and Luepker, R. V., 1996, "Recent Trends in Acute Coronary Heart Disease-Mortality, Morbidity, Medical Care, and Risk Factors. The Minnesota Heart Survey Investigators," N. Engl. J. Med., 334(14), pp. 884-890.
2. Cooper, R., Cutler, J., Desvigne-Nickens, P., Fortmann, S. P., Friedman, L., Havlik, R., Hogelin, G., Marler, J., McGovern, P., Morosco, G., Mosca, L., Pearson, T., Stamler, J., Stryer, D., and Thom, T., 2000, "Trends and Disparities in Coronary Heart Disease, Stroke, and Other Cardiovascular Diseases in the United States: Findings of the National Conference on Cardiovascular Disease Prevention," Circulation, 102(25), pp. 3137-3147.
3. Wentzel, J. J., Janssen, E., Vos, J., Schuurbiers, J. C., Krams, R., Serruys, P. W., de Feyter, P. J., and Slager, C. J., 2003, "Extension of Increased Atherosclerotic Wall Thickness Into High Shear Stress Regions is Associated With Loss of Compensatory Remodeling," Circulation, 108(1), pp. 17-23. (Pubitemid 36859014)
4. VanEpps, J. S., and Vorp, D. A., 2007, "Mechanopathobiology of Atherogenesis: A Review," J. Surg. Res., 142(1), pp. 202-217.
5. Zarins, C. K., Giddens, D. P., Bharadvaj, B. K., Sottiurai, V. S., Mabon, R. F., and Glagov, S., 1983, "Carotid Bifurcation Atherosclerosis. Quantitative Correlation of Plaque Localization With Flow Velocity Profiles and Wall Shear Stress," Circ. Res., 53(4), pp. 502-514.
6. Moore, J. E., Xu, C., Glagov, S., Zarins, C. K., and Ku, D. N., 1994, "Fluid Wall Shear Stress Measurements in a Model of the Human Abdominal Aorta: Oscillatory Behavior and Relationship to Atherosclerosis," Atherosclerosis, 110(2), pp. 225-240. (Pubitemid 24312442)
7. Asakura, T., and Karino, T., 1990, "Flow Patterns and Spatial Distribution of Atherosclerotic Lesions in Human Coronary Arteries," Circ. Res., 66(4), pp. 1045-1066. (Pubitemid 20126435)
8. Stein, P. D., Hamid, M. S., Shivkumar, K., Davis, T. P., Khaja, F., and Henry, J. W., 1994, "Effects of Cyclic Flexion of Coronary Arteries on Progression of Atherosclerosis," Am. J. Cardiol., 73(7), pp. 431-437. (Pubitemid 24096203)
9. Smedby, O., 1998, "Geometrical Risk Factors for Atherosclerosis in the Femoral Artery: A Longitudinal Angiographic Study," Ann. Biomed. Eng., 26(3), pp. 391-397. (Pubitemid 128609280)
10. Robicsek, F., and Thubrikar, M. J., 1994, "The Freedom From Atherosclerosis of Intramyocardial Coronary Arteries: Reduction of Mural Stress-A Key Factor," Eur. J. Cardiothorac Surg., 8(5), pp. 228-235.
11. Ross, R., 1993, "The Pathogenesis of Atherosclerosis: A Perspective for the 1990s," Nature (London), 362(6423), pp. 801-809.
12. Friedman, M. H., Henderson, J. M., Aukerman, J. A., and Clingan, P. A., 2000, "Effect of Periodic Alterations in Shear on Vascular Macromolecular Uptake," Biorheology, 37(4), pp. 265-277.
13. Himburg, H. A., Grzybowski, D. M., Hazel, A. L., LaMack, J. A., Li, X. M., and Friedman, M. H., 2004, "Spatial Comparison Between Wall Shear Stress Measures and Porcine Arterial Endothelial Permeability," Am. J. Physiol., 286(5), pp. H1916-H1922.
14. Phelps, J. E., and DePaola, N., 2000, "Spatial Variations in Endothelial Barrier Function in Disturbed Flows In Vitro," Am. J. Physiol., 278(2), pp. H469-H476.
15. Albuquerque, M. L., Waters, C. M., Savla, U., Schnaper, H. W., and Flozak, A. S., 2000, "Shear Stress Enhances Human Endothelial Cell Wound Closure In Vitro," Am. J. Physiol., 279(1), pp. H293-H302. (Pubitemid 30616673)
16. Ando, J., Nomura, H., and Kamiya, A., 1987, "The Effect of Fluid Shear Stress on the Migration and Proliferation of Cultured Endothelial Cells," Microvasc. Res., 33(1), pp. 62-70. (Pubitemid 17006443)
17. Davies, P. F., Remuzzi, A., Gordon, E. J., Dewey, C. F., and Gimbrone, M. A., 1986, "Turbulent Fluid Shear Stress Induces Vascular Endothelial Cell Turnover In Vitro," Proc. Natl. Acad. Sci. U.S.A., 83(7), pp. 2114-2117. (Pubitemid 16020845)
18. White, C. R., Haidekker, M., Bao, X., and Frangos, J. A., 2001, "Temporal Gradients in Shear, But Not Spatial Gradients, Stimulate Endothelial Cell Proliferation," Circulation, 103(20), pp. 2508-2513. (Pubitemid 32493379)
19. Dimmeler, S., Assmus, B., Hermann, C., Haendeler, J., and Zeiher, A. M., 1998, "Fluid Shear Stress Stimulates Phosphorylation of Akt in Human Endothelial Cells: Involvement in Suppression of Apoptosis," Circ. Res., 83(3), pp. 334-341. (Pubitemid 28371324)
20. Tricot, O., Mallat, Z., Heymes, C., Belmin, J., Leseche, G., and Tedgui, A., 2000, "Relation Between Endothelial Cell Apoptosis and Blood Flow Direction in Human Atherosclerotic Plaques," Circulation, 101(21), pp. 2450-2453. (Pubitemid 30366245)
21. Liu, X. M., Ensenat, D., Wang, H., Schafer, A. I., and Durante, W., 2003, "Physiologic Cyclic Stretch Inhibits Apoptosis in Vascular Endothelium," FEBS Lett., 541(1-3), pp. 52-56. (Pubitemid 36428916)
22. Sumpio, B. E., Banes, A. J., Levin, L. G., and Johnson, G., 1987, "Mechanical Stress Stimulates Aortic Endothelial Cells to Proliferate," J. Vasc. Surg., 6(3), pp. 252-256.
23. Haga, M., Chen, A., Gortler, D., Dardik, A., and Sumpio, B. E., 2003, "Shear Stress and Cyclic Strain May Suppress Apoptosis in Endothelial Cells by Different Pathways," Endothelium, 10(3), pp. 149-157. (Pubitemid 37270742)
24. Birukov, K. G., Jacobson, J. R., Flores, A. A., Ye, S. Q., Birukova, A. A., Verin, A. D., and Garcia, J. G., 2003, "Magnitude-Dependent Regulation of Pulmonary Endothelial Cell Barrier Function by Cyclic Stretch," Am. J. Physiol., 285(4), pp. L785-L797.
25. Ding, Z., and Friedman, M. H., 2000, "Dynamics Of Human Coronary Arterial Motion and Its Potential Role in Coronary Atherogenesis," ASME J. Biomech. Eng., 122(5), pp. 488-492.
26. Gross, M. F., and Friedman, M. H., 1998, "Dynamics of Coronary Artery Curvature Obtained From Biplane Cineangiograms," J. Biomech., 31(5), pp. 479-484.
27. Pao, Y. C., Lu, J. T., and Ritman, E. L., 1992, "Bending and Twisting of an In Vivo Coronary Artery at a Bifurcation," J. Biomech., 25(3), pp. 287-295.
28. Smouse, B., Nikanorov, A., and LaFlash, D., 2005, "Biomechanical Forces in the Femororpopliteal Arterial Segment," Endovasc. Today, 4, pp. 60-66.
29. Ramaswamy, S. D., Vigmostad, S. C., Wahle, A., Lai, Y. G., Olszewski, M. E., Braddy, K. C., Brennan, T. M., Rossen, J. D., Sonka, M., and Chandran, K. B., 2004, "Fluid Dynamic Analysis in a Human Left Anterior Descending Coronary Artery With Arterial Motion," Ann. Biomed. Eng., 32(12), pp. 1628-1641. (Pubitemid 40121296)
30. Zeng, D., Ding, Z., Friedman, M. H., and Ethier, C. R., 2003, "Effects of Cardiac Motion on Right Coronary Artery Hemodynamics," Ann. Biomed. Eng., 31(4), pp. 420-429.
31. Humphrey, J. D., 2002, Cardiovascular Solid Mechanics: Cells, Tissues, and Organs, Springer, New York.
32. Berceli, S. A., Borovetz, H. S., Sheppeck, R. A., Moosa, H. H., Warty, V. S., Armany, M. A., and Herman, I. M., 1991, "Mechanisms of Vein Graft Atherosclerosis: LDL Metabolism and Endothelial Actin Reorganization," J. Vasc. Surg., 13(2), pp. 336-347.
33. VanEpps, J. S., Londono, R., Nieponice, A., and Vorp, D. A., 2008, "Design and Validation of a System to Simulate Coronary Flexure Dynamics on Arterial Segments Perfused Ex Vivo," Biomech. Model. Mechanobiol., 8, 57-66.
34. Vorp, D. A., Peters, D. G., and Webster, M. W., 1999, "Gene Expression Is Altered in Perfused Arterial Segments Exposed to Cyclic Flexure Ex Vivo," Ann. Biomed. Eng., 27(3), pp. 366-371.
35. Vorp, D. A., Severyn, D. A., Steed, D. L., and Webster, M. W., 1996, "A Device for the Application of Cyclic Twist and Extension on Perfused Vascular Segments," Am. J. Physiol., 270(2 Pt 2), pp. H787-795.
36. Muluk, S. C., Vorp, D. A., Severyn, D. A., Gleixner, S., Johnson, P. C., and Webster, M. W., 1998, "Enhancement of Tissue Factor Expression by Vein Segments Exposed to Coronary Arterial Hemodynamics," J. Vasc. Surg., 27(3), pp. 521-527. (Pubitemid 28177851)
37. Severyn, D. A., Muluk, S. C., and Vorp, D. A., 2004, "The Influence of Hemodynamics and Wall Biomechanics on the Thrombogenicity of Vein Segments Perfused In Vitro," J. Surg. Res., 121(1), pp. 31-37.
38. Lally, C., Reid, A. J., and Prendergast, P. J., 2004, "Elastic Behavior of Porcine Coronary Artery Tissue Under Uniaxial and Equibiaxial Tension," Ann. Biomed. Eng., 32(10), pp. 1355-1364.
39. ABAQUS, Inc., 2004, "ABAQUS 6.5 Documentation," ABAQUS, Inc., Beachwood, OH.
40. Friedman, M. H., Baker, P. B., Ding, Z., and Kuban, B. D., 1996, "Relationship Between the Geometry and Quantitative Morphology of the Left Anterior Descending Coronary Artery," Atherosclerosis, 125(2), pp. 183-192. (Pubitemid 26249208)
41. Vorp, D. A., Raghavan, M. L., and Webster, M. W., 1998, "Mechanical Wall Stress in Abdominal Aortic Aneurysm: Influence of Diameter and Asymmetry," J. Vasc. Surg., 27(4), pp. 632-639.
42. Thubrikar, M. J., and Robicsek, F., 1995, "Pressure-Induced Arterial Wall Stress and Atherosclerosis," Ann. Thorac. Surg., 59(6), pp. 1594-1603.
43. He, X., and Ku, D. N., 1996, "Pulsatile Flow in the Human Left Coronary Artery Bifurcation: Average Conditions," ASME J. Biomech. Eng., 118(1), pp. 74-82. (Pubitemid 26087285)
44. Iwami, T., Fujii, T., Miura, T., Otani, N., Iida, H., Kawamura, A., Yoshitake, S., Kohno, M., Hisamatsu, Y., Iwamoto, H., and Matsuzaki, M., 1998, "Importance of Left Anterior Descending Coronary Artery Curvature in Determining Cross-Sectional Plaque Distribution Assessed by Intravascular Ultrasound," Am. J. Cardiol., 82(3), pp. 381-384. (Pubitemid 28364258)
45. Ainslie, K. M., Garanich, J. S., Dull, R. O., and Tarbell, J. M., 2005, "Vascular Smooth Muscle Cell Glycocalyx Influences Shear Stress-Mediated Contractile Response," J. Appl. Physiol., 98(1), pp. 242-249.
46. Chen, K. D., Li, Y. S., Kim, M., Li, S., Yuan, S., Chien, S., and Shyy, J. Y., 1999, "Mechanotransduction in Response to Shear Stress. Roles of Receptor Tyrosine Kinases, Integrins, and Shc," J. Biol. Chem., 274(26), pp. 18393-18400.
47. Gautam, M., Gojova, A., and Barakat, A. I., 2006, "Flow-Activated Ion Channels in Vascular Endothelium," Cell Biochem. Biophys., 46(3), pp. 277-284. (Pubitemid 46202581)
48. Berceli, S. A., Warty, V. S., Sheppeck, R. A., Mandarino, W. A., Tanksale, S. K., and Borovetz, H. S., 1990, "Hemodynamics and Low Density Lipoprotein Metabolism. Rates of Low Density Lipoprotein Incorporation and Degradation Along Medial and Lateral Walls of the Rabbit Aorto-Iliac Bifurcation," Arteriosclerosis, 10(5), pp. 686-694.