A genome screen of successful aging without cognitive decline identifies LRP1B by haplotype analysis

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 153, Issue 1, 2010, Pages 114-119

  Poduslo, S E ^a,b   Huang, R ^b   Spiro III, A ^c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Alzheimer's disease; SNP microarrays; Successful cognitive aging

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 1B; UNCLASSIFIED DRUG;

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; GENETIC ANALYSIS; GENETIC SCREENING; GENOME ANALYSIS; GENOTYPE; HAPLOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; MINI MENTAL STATE EXAMINATION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

AGING; ALZHEIMER DISEASE; COGNITION; GENOME; HAPLOTYPES; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, LDL;

EID: 73949128943     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30963     Document Type: Article

References (14)

1. Atzmon G, Rincon M, Schechter CB, Shuldiner AR, Lipton RB, Bergman A, Barzilai N. 2006. Lipoprotein genotype and conserved pathway for exceptional longevity in humans. PLOS Biol 4(4):e113.
2. Barzilai N, Atzmon G, Derby CA, Bauman JM, Lipton RB. 2006.Agenotype pf exceptional longevity is associated with preservation of cognitive function. Neurology 67:2170-2175.
3. Brady CB, Spiro A, McGlinchey-Berroth R, Milberg W, Gaziano JM. 2001. Stroke risk predicts verbal fluency decline in healthy older men: Evidence from the normative aging study. J Gerontology Series B 56:340-346.
4. Bu G, Cam J, Zerbinatti C. 2006. LRP in amyloid-β production and metabolism. Ann NY Acad Sci 1086:35-53.
5. Cam JA, Zerbinatti CV, Knisely JM, Hecimovic S, Li Y, Bu G. 2004. The low density lipoprotein receptor-related protein at the cell surface and reduces amyloid-β peptide production. J Biol Chem 279:29639-29646.
6. Falush D, Stephens M, Pritchard JK. 2003. Inference of population structure using multilocus genotype data: Linked loci and correlated allele frequencies. Genetics 164:1567-1587.
7. Folstein MF, Folstein SE, McHugh PR. 1975. Mini-mental state. Apractical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198.
8. Huang R, Poduslo SE. 2006.CYP19haplotypes increase risk for Alzheimer's disease. J Med Genet 43:e42.
9. Liu C-X, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G. 2001. The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. J Biol Chem 276:28889-28896.
10. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlen E. 1984. Clinical diagnoses of Alzheimer's disease: Report of the NINCDSADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34: 939-944.
11. Perls T,Wilmoth J, Levenson R,Drinkwater M, Cohen M, Bogan H, Joyce E, Brewster S,Kunkel L,Puca A. 2002.Life-long sustained mortality advantage of siblings of centenarians. Proc Natl Acad Sci USA 99:8442-8447.
12. Puca AA, Daly MJ, Brewster SJ, Matise TC, Barrett J, Shea-Drinkwater M, Kang S, Joyce E, Nicoli J, Benson E, Kunkel LM, Perls T. 2001. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proc Natl Acad Sci USA 98:10505-10508.
13. Purcell S, Cherny SS, Sham PC. 2003. Genetic power calculator: Design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19:149-150.
14. Zubenko GS, Hughes HB, Zubenko WN, Maher BS. 2007. Genome survey for loci that influence successful aging: Results at 10-cM resolution.AmJ Geriat Psychiat 15:184-193.