Lack of association between the -839C/T polymorphism in the SLC6A3 gene promoter and schizophrenia in the Iranian population

Journal of Genetics

Volumn 88, Issue 3, 2010, Pages 321-323

  Galehdari, Hamid ^a   Hosseini, Shiva ^a   Foroughmand, Ali Mohammad ^a   Musaviun, Mohsen ^a   Khatami, Saeedreza ^a   Pooryasin, Atefeh ^a   Ajam, Tahereh ^a   Haidari, Maryam ^a  

^a SHAHID CHAMRAN UNIVERSITY OF AHVAZ   (Iran)

Author keywords

Association study; Dopamine; Human genetics; Iranian population; Polymorphism; Schizophrenia; SLC6A3 (h DAT1)

Indexed keywords

DOPAMINE TRANSPORTER; SLC6A3 PROTEIN, HUMAN;

ADULT; ARTICLE; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; HUMAN; IRAN; MALE; PROMOTER REGION; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IRAN; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; SCHIZOPHRENIA;

EID: 73949127969     PISSN: 00221333     EISSN: 09737731     Source Type: Journal    
DOI: 10.1007/s12041-009-0046-6     Document Type: Article

References (20)

1. Amara S. G. and Kuhar M. J. 1993 Neurotransmitter transporters: recent progress. Annu. Rev. Neurosci. 16, 73-93.
2. Bannon M. J., Michelhaugh S. K., Waga J. and Scacchtti P. 2001 The human dopamine transporter gene: gene organization, transcriptional regulation and potential involvement in neuropsychiatric disorders. Eur. Neuropsychopharmacol. 11, 449-455.
3. Byerley W. F., Coon H., Holik J., Waldo M., Freedman R., Caron M. G. and Giros B. 1993 Human dopamine transporter gene not link to schizophrenia in multigenerational pedigrees. Hum. Hered. 43, 319-322.
4. Chen C. K., Chen S. L., Mill J., Hung Y. S., Lin S. K., Curran S. et al. 2003 The dopamine transporter gene is associated with attention deficit hyperactivity disorder in Taiwanese sample. Mol. Psychiatry8, 393-396.
5. Donovan D. M., Vandenbergh D. J., Perry M. P., Bird G. S., Ingersoll R., Nanthakumar E. and Uhl G. R. 1995 Human and mouse dopamine transporter gene: conservation of 5′-flanking sequence elements and structures. Mol. Brain Res. 30, 327-335.
6. Georgieva L., Dimitrova A., Nikolev I., Koleva S., Tsvetkova R., Owen M. J. et al. 2002 Dopamine transporter gene (DAT1) VNTR polymorphism in major psychiatric disorders: family-based association study in the Bulgarian population. Acta Psychiatr. Scand. 105, 396-399.
7. Greenwood T. A. and Kelsoe J. R. 2003 Promoter and intronic variants affect the transcriptional regulation of the human dopamine transporter gene. Genomics82, 511-519.
8. Hauser J., Kapelski P., Czerski P. M., Goldlewski S., Dmitrzak-Weglarz M., Twardowska K. and Rybakowski J. K. 2002 Lack of association between VNTR polymorphism of DAT gene and schizophrenia. Psychiatr. Pol. 36, 403-412.
9. Jellinger K. A. 1991 Pathology of Parkinsons disease. Changes other than the nigrostriatal pathway. Mol. Chem. Neruopthol. 14, 153-157.
10. Kapur S. 2003 Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Am. J. Psychiatry160, 13-23.
11. Kawarai T., Kawakami H., Yamamura Y. and Nakamura S. 1997 Structure and organization of the gene encoding of the gene encoding human dopamine transporter. Gene195, 11-18.
12. Khodayari N., Garshasbi M., Fadai F., Rahimi A., Hafizi L. and Ebrahimi A. 2004 Association of the dopamine transporter gene (DAT1) core promoter polymorphism-67T variant with schizophrenia. Am. J. Med. Genet. B129, 10-12.
13. Kouzemenko A. P., Pereira A. M. and Singh B. S. 1997 Intronic sequences are involved in neural targeting of human dopamine transporter gene expression. Biochem. Biophys. Res. Commun. 240, 807-811.
14. McGuffin P., Tandon K. and Corsico A. 2003 Linkage and association studies of schizophrenia. Curr. Psychiatry Rep. 5, 121-127.
15. Perisco A. M., Wang Z. W., Black D. W., Andreasen N. C., Uhl G. R. and Crow P. R. 1995 Exclusion of close linkage of the dopamine transporter gene with schizophrenia spectrum disorders. Am. J. Psychiatry152, 134-136.
16. Rubie C., Schmidt F., Knapp M., Sprandel J., Wiegand C., Meyer J. et al. 2001 The human dopamin transporter gene: the 5-flanking region reveals five diallelic polymorphic sites in a Caucasian population sample. Neurosci. Lett. 297, 125-128.
17. Seeman P. and Lee T. 1975 Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons. Science188, 1217-1219.
18. Stober G., Sprandel J., Jabs B., Pfuhlmann B., Moller-Ehrlich K. and Knapp M. 2005 Family-based study of markers at the 5′-flanking region of the human dopamine transporter gene reveals potential association with schizophrenia psychosis. Clin. Neurosci. 256, 422-427.
19. Thaker G. and Carpenter W. 2001 Advances in schizophrenia. Nat. Med. 7, 667-671.
20. Vandenbergh D. J., Persico A. M., Hawkins A. L., Geuffin C. A., Li X., Wang Z. W. and Jab E. 1992 Human dopamine transporter gene (DAT1) maps to chromosome 5p15. 3and display a VNTR. Genomics14, 1104-1106.