Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms

Modern Pathology

Volumn 23, Issue 1, 2010, Pages 105-112

  Chen, Yi Hua ^a   Gao, Juehua ^a   Fan, Guang ^b   Peterson, Loann C ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Cyclin D1; Hairy cell leukemia; Immunohistochemistry; Mantle cell lymphoma; Plasma cell myeloma; Sox11

Indexed keywords

CYCLIN D1; TRANSCRIPTION FACTOR SOX11;

ARTICLE; B CELL LYMPHOMA; CELL NUCLEUS; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; CYTOPLASM; FOLLICULAR LYMPHOMA; GENE OVEREXPRESSION; HAIRY CELL LEUKEMIA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARGE CELL LYMPHOMA; LYMPHOCYTOMA; MAJOR CLINICAL STUDY; MANTLE CELL LYMPHOMA; MARGINAL ZONE LYMPHOMA; MULTIPLE MYELOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; TUMOR CELL; UPREGULATION;

CELL NUCLEUS; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 14; CYCLIN D1; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, HAIRY CELL; LYMPHOMA, B-CELL; LYMPHOMA, MANTLE-CELL; SOXC TRANSCRIPTION FACTORS;

EID: 73949111959     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2009.140     Document Type: Article

References (29)

1. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th edn IARC: Lyon, 2008.
2. Jares P, Colomer D, Campo E. Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics. Nat Rev Cancer 2007;7:750-762.
3. Rizzatti EG, Falcao RP, Panepucci RA, et al. Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways. Br J Haematol 2005;130:516-526.
4. Ek S, Andreasson U, Hober S, et al. From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies. Mol Cell Proteomics 2006;5:1072-1081.
5. Ortega-Paino E, Fransson J, Ek S, et al. Functionally associated targets in mantle cell lymphoma as defined by DNA microarrays and RNA interference. Blood 2008;111:1617-1624.
6. Ek S, Dictor M, Jerkeman M, et al. Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma. Blood 2008; 111:800-805.
7. Wang X, Asplund AC, Porwit A, et al. The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival. Br J Haematol 2008;143:248-252.
8. Jay P, Goze C, Marsollier C, et al. The human SOX11 gene: cloning, chromosomal assignment and tissue expression. Genomics 1995;29:541-545.
9. Wegner M. From head to toes: the multiple facets of Sox proteins. Nucleic Acids Res 1999;27:1409-1420.
10. Kiefer JC. Back to basics: Sox genes. Dev Dyn 2007;236:2356-2366.
11. Sock E, Rettig SD, Enderich J, et al. Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Mol Cell Biol 2004;24:6635-6644.
12. Hargrave M, Wright E, Kun J, et al. Expression of the Sox11 gene in mouse embryos suggests roles in neuronal maturation and epithelio-mesenchymal induction. Dev Dyn 1997;210:79-86.
13. van de Wetering M, Oosterwegel M, van Norren K, et al. Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes. EMBO J 1993;12:3847-3854.
14. Schilham MW, Oosterwegel MA, Moerer P, et al. Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4. Nature 1996;380:711-714.
15. Dy P, Penzo-Mendez A, Wang H, et al. The three SoxC proteins-Sox4, Sox11 and Sox12-exhibit overlapping expression patterns and molecular properties. Nucleic Acids Res 2008;36:3101-3117.
16. Jankowski MP, Cornuet PK, McIlwrath S, et al. SRY-box containing gene 11 (Sox11) transcription factor is required for neuron survival and neurite growth. Neuroscience 2006;143:501-514.
17. Bergsland M, Werme M, Malewicz M, et al. The establishment of neuronal properties is controlled by Sox4 and Sox11. Genes Dev 2006;20:3475-3486.
18. Kim DK, Han SB, Hong ST, et al. Expression of Sox11 and Brn transcription factors during development and following transient forebrain ischemia in the rat. Neurosci Lett 2008;433:259-264.
19. Dong C, Wilhelm D, Koopman P. Sox genes and cancer. Cytogenet Genome Res 2004;105:442-447.
20. Lee CJ, Appleby VJ, Orme AT, et al. Differential expression of SOX4 and SOX11 in medulloblastoma. J Neurooncol 2002;57:201-214.
21. Weigle B, Ebner R, Temme A, et al. Highly specific overexpression of the transcription factor SOX11 in human malignant gliomas. Oncol Rep 2005;13:139-144.
22. Shin MS, Fredrickson TN, Hartley JW, et al. High-throughput retroviral tagging for identification of genes involved in initiation and progression of mouse splenic marginal zone lymphomas. Cancer Res 2004;64:4419-4427.
23. Lesage D, Troussard X, Sola B. The enigmatic role of cyclin D1 in multiple myeloma. Int J Cancer 2005;115:171-176.
24. de Boer CJ, Kluin-Nelemans JC, Dreef E, et al. Involvement of the CCND1 gene in hairy cell leukemia. Ann Oncol 1996;7:251-256.
25. Bosch F, Campo E, Jares P, et al. Increased expression of the PRAD-1/CCND1 gene in hairy cell leukaemia. Br J Haematol 1995;91:1025-1030.
26. Klein EA, Assoian RK. Transcriptional regulation of the cyclin D1 gene at a glance. J Cell Sci 2008;121:3853-3857.
27. Liang J, Slingerland JM. Multiple roles of the PI3K/ PKB (Akt) pathway in cell cycle progression. Cell Cycle 2003;2:339-345.
28. Sinner D, Kordich JJ, Spence JR, et al. Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol Cell Biol 2007;27:7802-7815.
29. Tiacci E, Liso A, Piris M, et al. Evolving concepts in the pathogenesis of hairy-cell leukaemia. Nat Rev Cancer 2006;6:437-448.