Multimerization of hepatitis delta antigen is a critical determinant of RNA binding specificity

Journal of Virology

Volumn 84, Issue 3, 2010, Pages 1406-1413

  Lin, Brian C ^a   Defenbaugh, Dawn A ^a   Casey, John L ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS DELTA ANTIGEN; MUTANT PROTEIN; RNA;

ARTICLE; GEL MOBILITY SHIFT ASSAY; GENE MUTATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RNA BINDING; SITE DIRECTED MUTAGENESIS; TEMPERATURE DEPENDENCE;

BINDING SITES; BIOPOLYMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HEPATITIS DELTA ANTIGENS; HEPATITIS DELTA VIRUS; RIBONUCLEOPROTEINS; RNA, VIRAL; ULTRACENTRIFUGATION;

HEPATITIS DELTA VIRUS;

EID: 73949110743     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01723-09     Document Type: Article

References (36)

1. Antson, A. A., E. J. Dodson, G. Dodson, R. B. Greaves, X. Chen, and P. Gollnick. 1999. Structure of the trp RNA-binding attenuation protein, TRAP, bound to RNA. Nature 401:235-242.
2. Baumann, C., J. Otridge, and P. Gollnick. 1996. Kinetic and thermodynamic analysis of the interaction between TRAP (trp RNA-binding attenuation protein) of Bacillus subtilis and trp leader RNA. J. Biol. Chem. 271:12269-12274.
3. Bichko, V. V., S. M. Lemon, J. G. Wang, S. Hwang, M. M. Lai, and J. M. Taylor. 1996. Epitopes exposed on hepatitis delta virus ribonucleoproteins. J. Virol. 70:5807-5811.
4. Casey, J. L., and J. L. Gerin. 1998. Genotype-specific complementation of hepatitis delta virus RNA replication by hepatitis delta antigen. J. Virol. 72:2806-2814.
5. Chang, J., X. Nie, H. E. Chang, Z. Han, and J. Taylor. 2008. Transcription of hepatitis delta virus RNA by RNA polymerase II. J. Virol. 82:1118-1127.
6. Chang, M. F., C. H. Chen, S. L. Lin, C. J. Chen, and S. C. Chang. 1995. Functional domains of delta antigens and viral RNA required for RNA packaging of hepatitis delta virus. J. Virol. 69:2508-2514.
7. Cornillez-Ty, C. T., and D. W. Lazinski. 2003. Determination of the multimerization state of the hepatitis delta virus antigens in vivo. J. Virol. 77:10314-10326.
8. Defenbaugh, D. A., M. Johnson, R. Chen, Y. Y. Zheng, and J. L. Casey. 2009. Hepatitis delta antigen requires a minimum length of the hepatitis delta virus unbranched rod RNA structure for binding. J. Virol. 83:4548-4556.
9. Gudima, S., J. Chang, G. Moraleda, A. Azvolinsky, and J. Taylor. 2002. Parameters of human hepatitis delta virus genome replication: the quantity, quality, and intracellular distribution of viral proteins and RNA. J. Virol. 76:3709-3719.
10. Kos, A., R. Dijkema, A. C. Arnberg, P. H. van der Meide, and H. Schellekens. 1986. The hepatitis delta (delta) virus possesses a circular RNA. Nature 323:558-560.
11. Kuo, M. Y., J. Goldberg, L. Coates, W. Mason, J. Gerin, and J. Taylor. 1988. Molecular cloning of hepatitis delta virus RNA from an infected woodchuck liver: sequence, structure, and applications. J. Virol. 62:1855-1861.
12. Lazinski, D. W., and J. M. Taylor. 1993. Relating structure to function in the hepatitis delta virus antigen. J. Virol. 67:2672-2680.
13. Lee, C. Z., J. H. Lin, M. Chao, K. McKnight, and M. M. Lai. 1993. RNAbinding activity of hepatitis delta antigen involves two arginine-rich motifs and is required for hepatitis delta virus RNA replication. J. Virol. 67:2221-2227.
14. Macnaughton, T. B., E. J. Gowans, B. Reinboth, A. R. Jilbert, and C. J. Burrell. 1990. Stable expression of hepatitis delta virus antigen in a eukaryotic cell line. J. Gen. Virol. 71:1339-1345.
15. Macnaughton, T. B., and M. M. Lai. 2006. HDV RNA replication: ancient relic or primer? Curr. Top. Microbiol. Immunol. 307:25-45.
16. Mathews, D. H., J. Sabina, M. Zuker, and D. H. Turner. 1999. Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J. Mol. Biol. 288:911-940.
17. Mir, M. A., and A. T. Panganiban. 2004. Trimeric hantavirus nucleocapsid protein binds specifically to the viral RNA panhandle. J. Virol. 78:8281-8288.
18. Moraleda, G., K. Dingle, P. Biswas, J. Chang, H. Zuccola, J. Hogle, and J. Taylor. 2000. Interactions between hepatitis delta virus proteins. J. Virol. 74:5509-5515.
19. Pohl, C., B. M. Baroudy, K. F. Bergmann, P. J. Cote, R. H. Purcell, J. Hoofnagle, and J. L. Gerin. 1987. A human monoclonal antibody that recognizes viral polypeptides and in vitro translation products of the genome of the hepatitis D virus. J. Infect. Dis. 156:622-629.
20. Poisson, F., P. Roingeard, and A. Goudeau. 1995. Direct Investig. of protein RNA-binding domains using digoxigenin-labeled RNAs and synthetic peptides: application to the hepatitis delta antigen. J. Virol. Methods 55:381-389.
21. Polson, A. G., H. L. Ley III, B. L. Bass, and J. L. Casey. 1998. Hepatitis delta virus RNA editing is highly specific for the amber/W site and is suppressed by hepatitis delta antigen. Mol. Cell. Biol. 18:1919-1926.
22. Powers, T., and H. F. Noller. 1995. A temperature-dependent conformational rearrangement in the ribosomal protein S4.16 S rRNA complex. J. Biol. Chem. 270:1238-1242.
23. Rizzetto, M. 1983. The delta agent. Hepatology 3:729-737.
24. Rozzelle, J. E., Jr., J. G. Wang, D. S. Wagner, B. W. Erickson, and S. M. Lemon. 1995. Self-association of a synthetic peptide from the N terminus of the hepatitis delta virus protein into an immunoreactive alpha-helical multimer. Proc. Natl. Acad. Sci. U. S. A. 92:382-386.
25. Ryu, W. S., H. J. Netter, M. Bayer, and J. Taylor. 1993. Ribonucleoprotein complexes of hepatitis delta virus. J. Virol. 67:3281-3287.
26. Taraporewala, Z., D. Chen, and J. T. Patton. 1999. Multimers formed by the rotavirus nonstructural protein NSP2 bind to RNA and have nucleoside triphosphatase activity. J. Virol. 73:9934-9943.
27. Taraporewala, Z. F., D. Chen, and J. T. Patton. 2001. Multimers of the bluetongue virus nonstructural protein, NS2, possess nucleotidyl phosphatase activity: similarities between NS2 and rotavirus NSP2. Virology 280:221-231.
28. Taylor, J. M. 2006. Structure and replication of hepatitis delta virus RNA. Curr. Top. Microbiol. Immunol. 307:1-23.
29. Wang, H. W., P. J. Chen, C. Z. Lee, H. L. Wu, and D. S. Chen. 1994. Packaging of hepatitis delta virus RNA via the RNA-binding domain of hepatitis delta antigens: different roles for the small and large delta antigens. J. Virol. 68:6363-6371.
30. Wang, J. G., and S. M. Lemon. 1993. Hepatitis delta virus antigen forms dimers and multimeric complexes in vivo. J. Virol. 67:446-454.
31. Wang, K. S., Q. L. Choo, A. J. Weiner, J. H. Ou, R. C. Najarian, R. M. Thayer, G. T. Mullenbach, K. J. Denniston, J. L. Gerin, and M. Houghton. 1986. Structure, sequence, and expression of the hepatitis delta (delta) viral genome. Nature 323:508-514.
32. Xia, Y. P., and M. M. Lai. 1992. Oligomerization of hepatitis delta antigen is required for both the trans-activating and trans-dominant inhibitory activities of the delta antigen. J. Virol. 66:6641-6648.
33. Yang, L., and Z. R. Liu. 2004. Bacterially expressed recombinant p68 RNA helicase is phosphorylated on serine, threonine, and tyrosine residues. Protein Expr. Purif. 35:327-333.
34. Ye, Q., R. M. Krug, and Y. J. Tao. 2006. The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA. Nature 444:1078-1082.
35. Zuccola, H. J., J. E. Rozzelle, S. M. Lemon, B. W. Erickson, and J. M. Hogle. 1998. Structural basis of the oligomerization of hepatitis delta antigen. Structure 6:821-830.
36. Zuker, M. 2003. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 31:3406-3415.