메뉴 건너뛰기




Volumn 18, Issue 11, 2009, Pages 1667-1686

Antivascular agents for non-small-cell lung cancer: Current status and future directions

Author keywords

Angiogenesis; Antivascular drug; Clinical trial; Non small cell lung cancer

Indexed keywords

1 [4 (3 AMINO 1H INDAZOL 4 YL)PHENYL] 3 (2 FLUORO 5 METHYLPHENYL)UREA; 3 (4 BROMO 2,6 DIFLUOROBENZYLOXY) 5 [3 [4 (1 PYRROLIDINYL)BUTYL]UREIDO] 4 ISOTHIAZOLECARBOXAMIDE; 3 BENZYLIDENE 6 [(5 TERT BUTYL 1H IMIDAZOL 4 YL)METHYLENE] 2,5 PIPERAZINEDIONE; 5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; 6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; AFLIBERCEPT; AMG 386; AXITINIB; BEVACIZUMAB; BIBF 1120; BMS 690514; CARBOPLATIN; CEDIRANIB; CETUXIMAB; CILENGITIDE; CISPLATIN; DOCETAXEL; ERLOTINIB; FUMAGILLOL CHLOROACETYLCARBAMATE; GEFITINIB; GEMCITABINE; IMC 1121B; IMC 18F1; IRINOTECAN; KRN 951; LENALIDOMIDE; MATRIX METALLOPROTEINASE; MONOCLONAL ANTIBODY; MOTESANIB; N [2 [(4 HYDROXYPHENYL)AMINO] 3 PYRIDINYL] 4 METHOXYBENZENESULFONAMIDE; NAVELBINE; OSI 930; PACLITAXEL; PAZOPANIB; PEMETREXED; PROTEIN TYROSINE KINASE INHIBITOR; REBIMASTAT; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VASCULAR TARGETING AGENT; VATALANIB; VOLOCIXIMAB; XL 647; XL 999; ZYBERSTAT;

EID: 73849135676     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543780903336050     Document Type: Review
Times cited : (7)

References (138)
  • 1
    • 44649159153 scopus 로고    scopus 로고
    • Recent trends of cancer in Europe: A combined approach of incidence, survival and mortality for 17 cancer sites since the 1990s
    • Karim-Kos HE, de Vries E, Soerjomataram I, et al. Recent trends of cancer in Europe: a combined approach of incidence, survival and mortality for 17 cancer sites since the 1990s. Eur J Cancer 2008;44:1345-1389
    • (2008) Eur J Cancer , vol.44 , pp. 1345-1389
    • Karim-Kos, H.E.1    De Vries, E.2    Soerjomataram, I.3
  • 3
    • 0037050352 scopus 로고    scopus 로고
    • Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
    • Eastern Cooperative Oncology Group
    • Schiller JH, Harrington D, Belani CP, et al.; Eastern Cooperative Oncology Group. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 2002;346:92-98
    • (2002) N Engl J Med , vol.346 , pp. 92-98
    • Schiller, J.H.1    Harrington, D.2    Belani, C.P.3
  • 4
    • 0042010018 scopus 로고    scopus 로고
    • Second-line chemotherapy for non-small cell lung cancer
    • Shepherd FA. Second-line chemotherapy for non-small cell lung cancer. Expert Rev Anticancer Ther 2003;3:435-442
    • (2003) Expert Rev Anticancer Ther , vol.3 , pp. 435-442
    • Shepherd, F.A.1
  • 5
    • 3042673101 scopus 로고    scopus 로고
    • Cytotoxic chemotherapy in advanced non-small cell lung cancer: A review of standard treatment paradigms
    • Socinski MA. Cytotoxic chemotherapy in advanced non-small cell lung cancer: a review of standard treatment paradigms. Clin Cancer Res 2004;10:4210-14s
    • (2004) Clin Cancer Res , vol.10
    • Socinski, M.A.1
  • 6
    • 12244292196 scopus 로고    scopus 로고
    • Differentiation and definition of vascular-targeted therapies
    • Siemann DW, Bibby MC, Dark GG, et al. Differentiation and definition of vascular-targeted therapies. Clin Cancer Res 2005;11:416-420
    • (2005) Clin Cancer Res , vol.11 , pp. 416-420
    • Siemann, D.W.1    Bibby, M.C.2    Dark, G.G.3
  • 7
    • 33847048710 scopus 로고    scopus 로고
    • Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications
    • Döme B, Hendrix MJ, Paku S, et al. Alternative vascularization mechanisms in cancer: pathology and therapeutic implications. Am J Pathol 2007;170:1-15
    • (2007) Am J Pathol , vol.170 , pp. 1-15
    • Döme, B.1    Hendrix, M.J.2    Paku, S.3
  • 8
    • 40049087424 scopus 로고    scopus 로고
    • Circulating bone marrow-derived endothelial progenitor cells: Characterization, mobilization, and therapeutic considerations in malignant disease
    • Dome B, Dobos J, Tovari J, et al. Circulating bone marrow-derived endothelial progenitor cells: characterization, mobilization, and therapeutic considerations in malignant disease. Cytometry A 2008;73:186-193
    • (2008) Cytometry A , vol.73 , pp. 186-193
    • Dome, B.1    Dobos, J.2    Tovari, J.3
  • 9
    • 31344474845 scopus 로고    scopus 로고
    • Angiogenesis in non-small cell lung cancer: The prognostic impact of neo angiogenesis and the cytokines VEGF and bFGF in tumours and blood
    • Bremnes RM, Camps C, Sirera R. Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood. Lung Cancer 2006;51:143-158
    • (2006) Lung Cancer , vol.51 , pp. 143-158
    • Bremnes, R.M.1    Camps, C.2    Sirera, R.3
  • 10
    • 33947370773 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) signaling in tumor progression
    • Roskoski R Jr. Vascular endothelial growth factor (VEGF) signaling in tumor progression. Crit Rev Oncol Hematol 2007;62:179-213
    • (2007) Crit Rev Oncol Hematol , vol.62 , pp. 179-213
    • Roskoski Jr., R.1
  • 11
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for meta static breast cancer
    • Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007;357:2666-2676
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 12
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
    • AVOREN Trial investigators
    • Escudier B, Pluzanska A, Koralewski P, et al. AVOREN Trial investigators. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007;370:2103-2111
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 13
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-2342
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 14
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF, et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004;22:2184-2191
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 15
    • 0001385079 scopus 로고    scopus 로고
    • Identification of squamous cell histology and central, cavitary tumors as possible risk factors for pulmonary hemorrhage (PH) in patients with advanced NSCLC receiving bevacizumab (BV)
    • Novotny WF, Holmgren E, Griffing S, et al. Identification of squamous cell histology and central, cavitary tumors as possible risk factors for pulmonary hemorrhage (PH) in patients with advanced NSCLC receiving bevacizumab (BV). Proc Am Soc Clin Oncol 2001;20:abstract 1318
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Novotny, W.F.1    Holmgren, E.2    Griffing, S.3
  • 17
    • 70349722247 scopus 로고    scopus 로고
    • Treatment outcomes by tumor histology in Eastern Cooperative Group (ECOG) study E4599 of bevacizumab (BV) with paclitaxel/carboplatin (PC) for advanced non-small cell lung cancer (NSCLC)
    • Sandler A, Kong G, Strickland D, Johnson HD. Treatment outcomes by tumor histology in Eastern Cooperative Group (ECOG) study E4599 of bevacizumab (BV) with paclitaxel/carboplatin (PC) for advanced non-small cell lung cancer (NSCLC). J Thorac Oncol 2008;3:S283
    • (2008) J Thorac Oncol , vol.3
    • Sandler, A.1    Kong, G.2    Strickland, D.3    Johnson, H.D.4
  • 18
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAIL
    • Reck M, von Pawel J, Zatloukal P, et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAIL. J Clin Oncol 2009;27:1227-1234
    • (2009) J Clin Oncol , vol.27 , pp. 1227-1234
    • Reck, M.1    Von Pawel, J.2    Zatloukal, P.3
  • 19
    • 73849145920 scopus 로고    scopus 로고
    • First-line bevacizumab combined with cisplatin/gemcitabine (CG) in patients (PTS) with advanced or recurrent non-squamous non-small-cell lung cancer (NSCLC) AVAIL (BO17704), a phase III randomized study
    • Reck M, von Pawel J, Zatloukal P, et al. First-line bevacizumab combined with cisplatin/gemcitabine (CG) in patients (PTS) with advanced or recurrent non-squamous non-small-cell lung cancer (NSCLC) AVAIL (BO17704), a phase III randomized study. J Thorac Oncol 2008;3:S302
    • (2008) J Thorac Oncol , vol.3
    • Reck, M.1    Von Pawel, J.2    Zatloukal, P.3
  • 20
    • 63849219230 scopus 로고    scopus 로고
    • Pemetrexed and carboplatin plus bevacizumab with maintenance pemetrexed and bevacizumab as first-line therapy for advanced non-squamous non-small cell lung cancer (NSCLC)
    • Patel JD, Hensing TA, Rademaker F, et al. Pemetrexed and carboplatin plus bevacizumab with maintenance pemetrexed and bevacizumab as first-line therapy for advanced non-squamous non-small cell lung cancer (NSCLC). J Clin Oncol 2008;26(Suppl):abstract 8044
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Patel, J.D.1    Hensing, T.A.2    Rademaker, F.3
  • 21
    • 43049127188 scopus 로고    scopus 로고
    • Efficacy and safety of oxaliplatin and gemcitabine with bevacizumab in advanced non-small cell lung cancer
    • Lilenbaum R, Raez L, Tseng J, et al. Efficacy and safety of oxaliplatin and gemcitabine with bevacizumab in advanced non-small cell lung cancer. J Thorac Oncol 2008;3:511-515
    • (2008) J Thorac Oncol , vol.3 , pp. 511-515
    • Lilenbaum, R.1    Raez, L.2    Tseng, J.3
  • 22
    • 84868057331 scopus 로고    scopus 로고
    • Available from: Last accessed 30 April 2009
    • SAKK 19/05 trial. Available from: http://clinicaltrials.gov/ct2/show/ NCT00354549 [Last accessed 30 April 2009]
    • SAKK 19/05 Trial
  • 23
    • 84868071232 scopus 로고    scopus 로고
    • Available from: Last accessed 30 April 2009
    • INNOVATIONS study. Available from: http://clinicaltrials.gov/ct2/show/ NCT00536640?term= bevacizumab+and+erlotinib+gemcitabin%2C+cisplatin+and+bevacizumab&rank=1 [Last accessed 30 April 2009]
    • INNOVATIONS Study
  • 24
    • 65349111301 scopus 로고    scopus 로고
    • Phase II trial of sequential bevacizumab (B), erlotinib (E) and chemotherapy for first line treatment of clinical stage IIIB or IV non-small cell lung cancer (NSCLC)
    • Faoro L, Cohen EE, Govindan R, et al. Phase II trial of sequential bevacizumab (B), erlotinib (E) and chemotherapy for first line treatment of clinical stage IIIB or IV non-small cell lung cancer (NSCLC). J Clin Oncol 2008;26(Suppl):abstract 19130
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Faoro, L.1    Cohen, E.E.2    Govindan, R.3
  • 25
    • 66249112918 scopus 로고    scopus 로고
    • S0536: SWOG phase II trial of carboplatin (C), paclitaxel (P), cetuximab (CX) and bevacizumab (B) followed by cetuximab and bevacizumab in advanced non-small cell lung cancer (NSCLC)
    • Kim ES, Herbst RS, Moon J, et al. S0536: SWOG phase II trial of carboplatin (C), paclitaxel (P), cetuximab (CX) and bevacizumab (B) followed by cetuximab and bevacizumab in advanced non-small cell lung cancer (NSCLC). J Thorac Oncol 2008;3:S266
    • (2008) J Thorac Oncol , vol.3
    • Kim, E.S.1    Herbst, R.S.2    Moon, J.3
  • 27
    • 36048982143 scopus 로고    scopus 로고
    • Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer
    • Herbst RS, O'Neill VJ, Fehrenbacher L, et al. Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer. J Clin Oncol 2007;25:4743-4750
    • (2007) J Clin Oncol , vol.25 , pp. 4743-4750
    • Herbst, R.S.1    O'Neill, V.J.2    Fehrenbacher, L.3
  • 28
    • 65649132497 scopus 로고    scopus 로고
    • A phase III, multicenter, placebo-controlled, double-blind, randomized, clinical trial to evaluate the efficacy of bevacizumab (Avastin® ) in combination with erlotinib (Tarceva®) compared with erlotinib alone for treatment of advanced non-small cell lung cancer (NSCLC) after failure of standard first line chemotherapy (BETA)
    • Hainsworth J, Herbst R. A phase III, multicenter, placebo-controlled, double-blind, randomized, clinical trial to evaluate the efficacy of bevacizumab (Avastin® ) in combination with erlotinib (Tarceva® ) compared with erlotinib alone for treatment of advanced non-small cell lung cancer (NSCLC) after failure of standard first line chemotherapy (BETA). J Thorac Oncol 2008;3:S302
    • (2008) J Thorac Oncol , vol.3
    • Hainsworth, J.1    Herbst, R.2
  • 30
    • 84868080984 scopus 로고    scopus 로고
    • Available from: Last accessed 30 April 2009
    • BEACON study. Available from: http://www.clinicaltrials.gov/ct2/show/ NCT00130780?term=beacon&rank=2 [Last accessed 30 April 2009]
    • BEACON Study
  • 32
    • 49749096080 scopus 로고    scopus 로고
    • Safety of bevacizumab-based therapy as first-line treatment of patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): MO19390 (SAiL)
    • Dansin E, Mezger J, Isla D, et al. Safety of bevacizumab-based therapy as first-line treatment of patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): MO19390 (SAiL). J Clin Oncol 2008;26(Suppl):abstract 8085
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Dansin, E.1    Mezger, J.2    Isla, D.3
  • 33
    • 77952118055 scopus 로고    scopus 로고
    • Available from: Last accessed 06 October 2009
    • Bevacizumab summary of product characteristics. Available from: http://www.emea.europa.eu/humandocs/PDFs/EPAR/avastin/emea-combined-h582en.pdf [Last accessed 06 October 2009]
    • Bevacizumab Summary of Product Characteristics
  • 34
    • 70350126021 scopus 로고    scopus 로고
    • BRIDGE: An open-label phase ii trial evaluating the safety of bevacizumab (BV) + paclitaxel/carboplatin (PC) as 1st-line treatment for patients (pts) with advanced, previously untreated, squamous non-small cell lung cancer (NSCLC)
    • Hainsworth J, Compton P, Strickland D, Azzoli CG. BRIDGE: an open-label phase ii trial evaluating the safety of bevacizumab (BV) + paclitaxel/ carboplatin (PC) as 1st-line treatment for patients (pts) with advanced, previously untreated, squamous non-small cell lung cancer (NSCLC). J Thorac Oncol 2008;3:S281
    • (2008) J Thorac Oncol , vol.3
    • Hainsworth, J.1    Compton, P.2    Strickland, D.3    Azzoli, C.G.4
  • 35
    • 49749127690 scopus 로고    scopus 로고
    • Acceptable safety of bevacizumab therapy in patients with brain metastases due to non-small cell lung cancer
    • Akerley WL, Langer CJ, Oh Y, et al. Acceptable safety of bevacizumab therapy in patients with brain metastases due to non-small cell lung cancer. J Clin Oncol 2008;26(Suppl):abstract 8043
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Akerley, W.L.1    Langer, C.J.2    Oh, Y.3
  • 38
    • 54849433672 scopus 로고    scopus 로고
    • Phase II study of the efficacy and safety of intravenous (IV) AVE0005 (VEGF Trap) given every 2 weeks in patients (Pts) with platinum- and erlotinib-resistant adenocarcinoma of the lung (NSCLA)
    • Massarelli E, Miller VA, Leighl NB, et al. Phase II study of the efficacy and safety of intravenous (IV) AVE0005 (VEGF Trap) given every 2 weeks in patients (Pts) with platinum- and erlotinib-resistant adenocarcinoma of the lung (NSCLA). J Clin Oncol 2007;25:abstract 7627
    • (2007) J Clin Oncol , vol.25
    • Massarelli, E.1    Miller, V.A.2    Leighl, N.B.3
  • 40
    • 66349087009 scopus 로고    scopus 로고
    • Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: Results from a two-part, double-blind, randomized phase II study
    • Natale RB, Bodkin D, Govindan R, et al. Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: results from a two-part, double-blind, randomized phase II study. J Clin Oncol 2009;27:2523-2529
    • (2009) J Clin Oncol , vol.27 , pp. 2523-2529
    • Natale, R.B.1    Bodkin, D.2    Govindan, R.3
  • 41
    • 34948838898 scopus 로고    scopus 로고
    • Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer
    • Heymach JV, Johnson BE, Prager D, et al. Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer. J Clin Oncol 2007;25:4270-4277
    • (2007) J Clin Oncol , vol.25 , pp. 4270-4277
    • Heymach, J.V.1    Johnson, B.E.2    Prager, D.3
  • 42
    • 56749102822 scopus 로고    scopus 로고
    • Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer
    • Heymach JV, Paz-Ares L, De Braud F, et al. Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol 2008;26:5407-5415
    • (2008) J Clin Oncol , vol.26 , pp. 5407-5415
    • Heymach, J.V.1    Paz-Ares, L.2    De Braud, F.3
  • 46
    • 84868086033 scopus 로고    scopus 로고
    • Available from: Last accessed 30 April 2009
    • Radiation therapy (XRT) and ZD6474 in NSCLC. Available from: http://www.clinicaltrials.gov/ct2/show/record/NCT00745732?term= radiation&cond=nsclc&intr=vandetanib&rank=2 [Last accessed 30 April 2009]
    • Radiation Therapy (XRT) and ZD6474 in NSCLC
  • 47
    • 42949105645 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: The National Cancer Institute of Canada clinical trials group
    • Laurie SA, Gauthier I, Arnold A, et al. Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: the National Cancer Institute of Canada clinical trials group. J Clin Oncol 2008;26:1871-1878
    • (2008) J Clin Oncol , vol.26 , pp. 1871-1878
    • Laurie, S.A.1    Gauthier, I.2    Arnold, A.3
  • 48
    • 35948990764 scopus 로고    scopus 로고
    • IND. 175: Phase i study ofdaily oral AZD2171, a vascular endothelial growth factor receptor inhibitor (VEGFRI), in combination with gemcitabine and cisplatin (G/C) in patients with advanced non-small cell lung cancer (ANSCLC): A study of the NCIC Clinical Trials Group
    • Goss GD, Laurie S, Shepherd FA, et al. IND. 175: phase I study ofdaily oral AZD2171, a vascular endothelial growth factor receptor inhibitor (VEGFRI), in combination with gemcitabine and cisplatin (G/C) in patients with advanced non-small cell lung cancer (ANSCLC): a study of the NCIC Clinical Trials Group. J Clin Oncol 2007;25:abstract 7649
    • (2007) J Clin Oncol , vol.25
    • Goss, G.D.1    Laurie, S.2    Shepherd, F.A.3
  • 52
    • 36349033172 scopus 로고    scopus 로고
    • Efficacy and safety of axitinib (AG-013736; AG) in patients (pts) with advanced non-small cell lung cancer (NSCLC): A phase II trial
    • Schiller JH, Larson T, Ou SI, et al. Efficacy and safety of axitinib (AG-013736; AG) in patients (pts) with advanced non-small cell lung cancer (NSCLC): a phase II trial. J Clin Oncol 2007;25:abstract 7507
    • (2007) J Clin Oncol , vol.25
    • Schiller, J.H.1    Larson, T.2    Ou, S.I.3
  • 55
    • 33748913369 scopus 로고    scopus 로고
    • A Phase II trial of single-agent sorafenib in patients with advanced non-small cell lung carcinoma
    • Gatzemeier U, Blumenschein G, Fosella F, et al. A Phase II trial of single-agent sorafenib in patients with advanced non-small cell lung carcinoma. J Clin Oncol 2006;24:abstract 7002
    • (2006) J Clin Oncol , vol.24
    • Gatzemeier, U.1    Blumenschein, G.2    Fosella, F.3
  • 56
    • 33845321649 scopus 로고    scopus 로고
    • A phase II study of BAY 43-9006 (Sorafenib) in patients with relapsed non-small cell lung cancer (NSCLC)
    • Liu B, Barrett T, Choyke P, et al. A phase II study of BAY 43-9006 (Sorafenib) in patients with relapsed non-small cell lung cancer (NSCLC).J Clin Oncol 2006;24:abstract 17119
    • (2006) J Clin Oncol , vol.24
    • Liu, B.1    Barrett, T.2    Choyke, P.3
  • 57
    • 84868076149 scopus 로고    scopus 로고
    • Available from: Last accessed 30 April 2009
    • Phase III trial of nexavar in patients with NSCLC. Available from: http://www.onyxgrant.com/view.cfm/392/Bayer-and-Onyx-Provide-Update-on-Phase-3- Trial-of-Nexavar-in-Patients-With-Non-Small-Cell-Lung-Cancer-Onyx- Pharmaceuticals [Last accessed 30 April 2009]
    • Phase III Trial of Nexavar in Patients with NSCLC
  • 59
    • 34249093653 scopus 로고    scopus 로고
    • Phase i trial of sorafenib in combination with gefitinib in patients with refractory or recurrent non-small cell lung cancer
    • Adjei AA, Molina JR, Mandrekar SJ, et al. Phase I trial of sorafenib in combination with gefitinib in patients with refractory or recurrent non-small cell lung cancer. Clin Cancer Res 2007;13:2684-2691
    • (2007) Clin Cancer Res , vol.13 , pp. 2684-2691
    • Adjei, A.A.1    Molina, J.R.2    Mandrekar, S.J.3
  • 60
    • 84868068098 scopus 로고    scopus 로고
    • Available from: Last accessed 30 April 2009
    • Sorafenib and thoracic radiation for patients with NSCLC. Available from: www.clinicaltrials.gov/ct2/show/NCT00543335?cond=nsclc&intr= sorafenib&rank=14 [Last accessed 30 April 2009]
    • Sorafenib and Thoracic Radiation for Patients with NSCLC
  • 61
    • 67649397517 scopus 로고    scopus 로고
    • Sabre-l: A randomized phase ii trial evaluating the safety and efficacy of combining sunitinib (S) with bevacizumab (BV) + paclitaxel/carboplatin (PC) as first-line treatment for metastatic nonsquamous non-small cell lung cancer (NSCLC)
    • Socinski MA, Samant M, Strickland D, Kozloff M. Sabre-l: a randomized phase ii trial evaluating the safety and efficacy of combining sunitinib (S) with bevacizumab (BV) + paclitaxel/carboplatin (PC) as first-line treatment for metastatic nonsquamous non-small cell lung cancer (NSCLC). J Thorac Oncol 2008;3:S281
    • (2008) J Thorac Oncol , vol.3
    • Socinski, M.A.1    Samant, M.2    Strickland, D.3    Kozloff, M.4
  • 62
    • 73849150849 scopus 로고    scopus 로고
    • Phase II study of sunitinib as maintenance therapy in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
    • Blais N, Page RD, Hainsworth JD, et al. Phase II study of sunitinib as maintenance therapy in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). J Thorac Oncol 2008;3:S283
    • (2008) J Thorac Oncol , vol.3
    • Blais, N.1    Page, R.D.2    Hainsworth, J.D.3
  • 63
    • 36749052079 scopus 로고    scopus 로고
    • Efficacy and safety of continuous daily sunitinib dosing in previously treated advanced non-small cell lung cancer (NSCLC): Results from a phase II study
    • ASCO Annual Meeting Proceedings (Post-Meeting Edition)
    • Brahmer JR, Govindan R, Novello S, et al. Efficacy and safety of continuous daily sunitinib dosing in previously treated advanced non-small cell lung cancer (NSCLC): results from a phase II study. ASCO Annual Meeting Proceedings (Post-Meeting Edition). J Clin Oncol 2007;25:S7542
    • (2007) J Clin Oncol , vol.25
    • Brahmer, J.R.1    Govindan, R.2    Novello, S.3
  • 64
    • 73849103735 scopus 로고    scopus 로고
    • Sunitinib (SU) plus erlotinib (E) for metastatic non-small cell lung cancer (NSCLC): A novel VEGFR-EGFR combination treatment strategy
    • Govindan R, Blumenschein G, Groen HJM, et al. Sunitinib (SU) plus erlotinib (E) for metastatic non-small cell lung cancer (NSCLC): a novel VEGFR-EGFR combination treatment strategy. J Thorac Oncol 2008;3:S289
    • (2008) J Thorac Oncol , vol.3
    • Govindan, R.1    Blumenschein, G.2    Groen, H.J.M.3
  • 65
    • 33750940321 scopus 로고    scopus 로고
    • Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and carboplatin/paclitaxel (CP) for the treatment of patients (pts) with advanced non-small cell lung cancer (NSCLC)
    • Blumenschein G Jr, Sandler A, O'Rourke T, et al. Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and carboplatin/paclitaxel (CP) for the treatment of patients (pts) with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2006;24(18 Suppl):abstract 7119
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Blumenschein Jr., G.1    Sandler, A.2    O'Rourke, T.3
  • 69
    • 64249099126 scopus 로고    scopus 로고
    • Phase II open-label study to investigate efficacy and safety of PTK787/ZK 222584 (PTK/ZK) orally administered once daily or twice daily at 1,250 mg as second-line monotherapy in patients (pts) with stage IIIB/IV non-small cell lung cancer (NSCLC)
    • Gauler TC, Besse B, Meric JB, et al. Phase II open-label study to investigate efficacy and safety of PTK787/ZK 222584 (PTK/ZK) orally administered once daily or twice daily at 1,250 mg as second-line monotherapy in patients (pts) with stage IIIB/IV non-small cell lung cancer (NSCLC). J Clin Oncol 2007;25(Suppl 18s):7541
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 18 , pp. 7541
    • Gauler, T.C.1    Besse, B.2    Meric, J.B.3
  • 70
    • 73849150372 scopus 로고    scopus 로고
    • Phase II study of pazopanib (GW786034) given preoperatively in stage I-II NSCLC: A proof-of-concept study
    • Altorki NK, Heymach JV, Guarino MJ, et al. Phase II study of pazopanib (GW786034) given preoperatively in stage I-II NSCLC: a proof-of-concept study. J Thorac Oncol 2008;3:S263
    • (2008) J Thorac Oncol , vol.3
    • Altorki, N.K.1    Heymach, J.V.2    Guarino, M.J.3
  • 71
    • 84868076997 scopus 로고    scopus 로고
    • Available from: Last accessed 30 April 2009
    • Adjuvant pazopanib in stage I NSCLC. Available from: http://www. clinicaltrials.gov/ct2/show/NCT00775307?cond=nsclc&intr=pazopanib&rank= 3 [Last accessed 30 April 2009]
    • Adjuvant Pazopanib in Stage i NSCLC
  • 72
    • 84868079845 scopus 로고    scopus 로고
    • Available from: Last accessed 30 April 2009
    • Monotherapy pazopanib in subjects with advanced NSCLC. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00549328?cond=nsclc&intr= pazopanib&rank=2 [Last accessed 30 April 2009]
    • Monotherapy Pazopanib in Subjects with Advanced NSCLC
  • 73
    • 33645090144 scopus 로고    scopus 로고
    • A phase i study of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) in patients with advanced solid malignancies
    • Lee CP, Attard G, Poupard L, et al. A phase I study of BIBF 1120, an orally active triple angiokinase inhibitor (VEGFR, PDGFR, FGFR) in patients with advanced solid malignancies. Proc Am Soc Clin Oncol 2005;23:205s
    • (2005) Proc Am Soc Clin Oncol , vol.23
    • Lee, C.P.1    Attard, G.2    Poupard, L.3
  • 74
    • 37549024347 scopus 로고    scopus 로고
    • A double blind phase II study of BIBF 1,120 in patients suffering from relapsed advanced non-small cell lung cancer (NSCLC)
    • Von Pawel J, Kaiser R, Eschbach C, et al. A double blind phase II study of BIBF 1,120 in patients suffering from relapsed advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2007;25:abstract 7635
    • (2007) J Clin Oncol , vol.25
    • Von Pawel, J.1    Kaiser, R.2    Eschbach, C.3
  • 77
    • 84868065394 scopus 로고    scopus 로고
    • Available from: Last accessed 30 April 2009
    • Study of ABT-869 in subjects with advanced NSCLC. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00517790?term=NCT00517790&rank=1 [Last accessed 30 April 2009]
    • Study of ABT-869 in Subjects with Advanced NSCLC
  • 81
    • 34447136111 scopus 로고    scopus 로고
    • A novel epidermal growth factor receptor inhibitor promotes apoptosis in nonsmall cell lung cancer cells resistant to erlotinib
    • de La Motte Rouge T, Galluzzi L, Olaussen KA, et al. A novel epidermal growth factor receptor inhibitor promotes apoptosis in nonsmall cell lung cancer cells resistant to erlotinib. Cancer Res 2007;67:6253-6262
    • (2007) Cancer Res , vol.67 , pp. 6253-6262
    • De La Motte Rouge, T.1    Galluzzi, L.2    Olaussen, K.A.3
  • 82
    • 73849119058 scopus 로고    scopus 로고
    • Antitumor efficacy of OSI-930 and the molecular targeted agent erlotinib in preclinical xenograft models
    • Rosenfeld-Franklin M, Silva S, Pirritt C, et al. Antitumor efficacy of OSI-930 and the molecular targeted agent erlotinib in preclinical xenograft models. J Clin Oncol 2008;26(15 Suppl):14596
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL. , pp. 14596
    • Rosenfeld-Franklin, M.1    Silva, S.2    Pirritt, C.3
  • 83
    • 73849128297 scopus 로고    scopus 로고
    • A phase I, dose escalation (DE), pharmacokinetic (PK), and pharmacodynamic (PD) study of two schedules of OSI-930, an oral tyrosine kinase inhibitor (TKI), in patients (pts) with advanced solid tumors
    • Lal R, Camidge DR, George S, et al. A phase I, dose escalation (DE), pharmacokinetic (PK), and pharmacodynamic (PD) study of two schedules of OSI-930, an oral tyrosine kinase inhibitor (TKI), in patients (pts) with advanced solid tumors. J Clin Oncol 2008;26(15 Suppl):3553
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL. , pp. 3553
    • Lal, R.1    Camidge, D.R.2    George, S.3
  • 84
    • 84868078307 scopus 로고    scopus 로고
    • Available from: Last accessed 30 April 2009
    • Phase I study of OSI-930 and erlotinib in cancer tumors. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00603356?term=osi-930&rank=2 [Last accessed 30 April 2009]
    • Phase i Study of OSI-930 and Erlotinib in Cancer Tumors
  • 85
    • 34147158876 scopus 로고    scopus 로고
    • Enhanced growth inhibition of human NSCLC cell resistant to gefitinib (ZD1839) by a dual tyrosine kinase inhibitor of EGFR/VEGFR2 (AEE788) in combination with a mTOR inhibitor (RAD001)
    • Nakachi I, Naoki K, Soejima K, et al. Enhanced growth inhibition of human NSCLC cell resistant to gefitinib (ZD1839) by a dual tyrosine kinase inhibitor of EGFR/VEGFR2 (AEE788) in combination with a mTOR inhibitor (RAD001). Proc Am Assoc Cancer Res 2006;47:abstract 5081
    • (2006) Proc Am Assoc Cancer Res , vol.47
    • Nakachi, I.1    Naoki, K.2    Soejima, K.3
  • 86
    • 30044449518 scopus 로고    scopus 로고
    • Phase i study of AEE788, a novel multitargeted inhibitor of ErbB and VEGF receptor family tyrosine kinases: A pharmacokinetic (PK)-pharmacodynamic (PD) study to identify the optimal therapeutic dose regimen
    • Baselga J, Rojo F, Dumez H, et al. Phase I study of AEE788, a novel multitargeted inhibitor of ErbB and VEGF receptor family tyrosine kinases: a pharmacokinetic (PK)-pharmacodynamic (PD) study to identify the optimal therapeutic dose regimen. J Clin Oncol 2005;23:abstract 3028
    • (2005) J Clin Oncol , vol.23
    • Baselga, J.1    Rojo, F.2    Dumez, H.3
  • 87
    • 28044459118 scopus 로고    scopus 로고
    • AEE788, a novel multitargeted inhibitor of ErbB and VEGF receptor family tyrosine kinases: Preliminary phase 1 results
    • Martinelli E, Takimoto C, Van Oosterom A, et al. AEE788, a novel multitargeted inhibitor of ErbB and VEGF receptor family tyrosine kinases: preliminary phase 1 results. J Clin Oncol 2005;23:abstract 3039
    • (2005) J Clin Oncol , vol.23
    • Martinelli, E.1    Takimoto, C.2    Van Oosterom, A.3
  • 88
    • 84868069961 scopus 로고    scopus 로고
    • Available from: Last accessed 30 April 2009
    • Study of oral AEE788 in adults with advanced cancer. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00118456?term=aee788&rank=1 [Last accessed 30 April 2009]
    • Study of Oral AEE788 in Adults with Advanced Cancer
  • 89
    • 36049026182 scopus 로고    scopus 로고
    • Role of anti-angiogenesis agents in treating NSCLC: Focus on bevacizumab and VEGFR tyrosine kinase inhibitors
    • Cabebe E, Wakelee H. Role of anti-angiogenesis agents in treating NSCLC: focus on bevacizumab and VEGFR tyrosine kinase inhibitors. Curr Treat Options Oncol 2007;8:15-27
    • (2007) Curr Treat Options Oncol , vol.8 , pp. 15-27
    • Cabebe, E.1    Wakelee, H.2
  • 90
    • 44649125425 scopus 로고    scopus 로고
    • A phase i dose-escalation and pharmacokinetic (PK) study of a novel spectrum selective kinase inhibitor, XL647, in patients with advanced solid malignancies
    • Wakelee H, Adjei AA, Halsey J, et al. A phase I dose-escalation and pharmacokinetic (PK) study of a novel spectrum selective kinase inhibitor, XL647, in patients with advanced solid malignancies. J Clin Oncol 2006;24:3044
    • (2006) J Clin Oncol , vol.24 , pp. 3044
    • Wakelee, H.1    Adjei, A.A.2    Halsey, J.3
  • 91
    • 67449084164 scopus 로고    scopus 로고
    • Combined inhibition of vascular endothelial growth factor and epidermal growth factor signaling in non-small-cell lung cancer therapy
    • Pakkala S, Ramalingam SS. Combined inhibition of vascular endothelial growth factor and epidermal growth factor signaling in non-small-cell lung cancer therapy. Clin Lung Cancer 2009;10:S17-23
    • (2009) Clin Lung Cancer , vol.10
    • Pakkala, S.1    Ramalingam, S.S.2
  • 93
    • 36549004113 scopus 로고    scopus 로고
    • A phase II study of XL999 in patients (pts) with NSCLC
    • March RJ, Mirtsching B, Modi S, et al. A phase II study of XL999 in patients (pts) with NSCLC. J Clin Oncol 2007;25(18 Suppl):abstract 18112
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • March, R.J.1    Mirtsching, B.2    Modi, S.3
  • 94
    • 34247326880 scopus 로고    scopus 로고
    • A phase I/randomized phase II, non-comparative, multicenter, open label trial of CP-547,632 in combination with paclitaxel and carboplatin or paclitaxel and carboplatin alone as first-line treatment for advanced non-small cell lung cancer (NSCLC)
    • Cohen RB, Langer CJ, Simon GR, et al. A phase I/randomized phase II, non-comparative, multicenter, open label trial of CP-547,632 in combination with paclitaxel and carboplatin or paclitaxel and carboplatin alone as first-line treatment for advanced non-small cell lung cancer (NSCLC). Cancer Chemother Pharmacol 2007;60:81-89
    • (2007) Cancer Chemother Pharmacol , vol.60 , pp. 81-89
    • Cohen, R.B.1    Langer, C.J.2    Simon, G.R.3
  • 95
    • 84868050585 scopus 로고    scopus 로고
    • Available from: Last accessed 30 April 2009
    • Phase I and II data of AV-951. Available from: http://www.aveopharma.com/ content/rd/products/av-951.jsp [Last accessed 30 April 2009]
    • Phase I and II Data of AV-951
  • 98
    • 33746316839 scopus 로고    scopus 로고
    • Phase II study of carboplatin, irinotecan and thalidomide in patients with advanced nonsmall cell lung cancer (NSCLC) [abstract]
    • Miller AA, Case D, Atkins J, Giguere J. Phase II study of carboplatin, irinotecan and thalidomide in patients with advanced nonsmall cell lung cancer (NSCLC) [abstract]. J Clin Oncol 2004;22:7132
    • (2004) J Clin Oncol , vol.22 , pp. 7132
    • Miller, A.A.1    Case, D.2    Atkins, J.3    Giguere, J.4
  • 99
    • 84860596909 scopus 로고    scopus 로고
    • A phase II trial of thalidomide (T), irinotecan (I) and gemcitabine (G) in chemonaive patients (pts) with advanced nonsmall cell lung cancer (NSCLC) [abstract]
    • Flora DB, Kleykamp B, Knapp M, et al. A phase II trial of thalidomide (T), irinotecan (I) and gemcitabine (G) in chemonaive patients (pts) with advanced nonsmall cell lung cancer (NSCLC) [abstract]. J Clin Oncol 2004;22:7258
    • (2004) J Clin Oncol , vol.22 , pp. 7258
    • Flora, D.B.1    Kleykamp, B.2    Knapp, M.3
  • 103
    • 33748114137 scopus 로고    scopus 로고
    • Toxicity profile of the immunomodulatory thalidomide analogue, lenalidomide: Phase i clinical trial of three dosing schedules in patients with solid malignancies
    • Sharma RA, Steward WP, Daines CA, et al. Toxicity profile of the immunomodulatory thalidomide analogue, lenalidomide: phase I clinical trial of three dosing schedules in patients with solid malignancies. Eur J Cancer 2006;42:2318-2325
    • (2006) Eur J Cancer , vol.42 , pp. 2318-2325
    • Sharma, R.A.1    Steward, W.P.2    Daines, C.A.3
  • 105
    • 21044453902 scopus 로고    scopus 로고
    • Randomized phase III study of matrix metalloproteinase inhibitor BMS-275291 in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR.18
    • Leighl NB, Paz-Ares L, Douillard JY, et al. Randomized phase III study of matrix metalloproteinase inhibitor BMS-275291 in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR.18. J Clin Oncol 2005;23:2831-2839
    • (2005) J Clin Oncol , vol.23 , pp. 2831-2839
    • Leighl, N.B.1    Paz-Ares, L.2    Douillard, J.Y.3
  • 106
    • 0347155579 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of continuous twice weekly intravenous administration of cilengitide (EMD 121974), a novel inhibitor of the integrins alphavbeta3 and alphavbeta5 in patients with advanced solid tumours
    • Eskens FA, Dumez H, Hoekstra R, et al. Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of cilengitide (EMD 121974), a novel inhibitor of the integrins alphavbeta3 and alphavbeta5 in patients with advanced solid tumours. Eur J Cancer 2003;39:917-926
    • (2003) Eur J Cancer , vol.39 , pp. 917-926
    • Eskens, F.A.1    Dumez, H.2    Hoekstra, R.3
  • 107
    • 73849115445 scopus 로고    scopus 로고
    • A phase i and pharmacokinetic study of continuous infusion EMD 121974 (EMD), an antiangiogenic alphavbeta3 and alphavbeta5 integrin antagonist, in patients with advanced solid malignancy
    • Undevia SD, Janisch L, Stadler WM, et al. A phase I and pharmacokinetic study of continuous infusion EMD 121974 (EMD), an antiangiogenic alphavbeta3 and alphavbeta5 integrin antagonist, in patients with advanced solid malignancy. J Clin Oncol 2006;24:abstract 3052
    • (2006) J Clin Oncol , vol.24
    • Undevia, S.D.1    Janisch, L.2    Stadler, W.M.3
  • 109
    • 59449094255 scopus 로고    scopus 로고
    • Volociximab, a chimeric monoclonal antibody that specifically binds alpha5beta1 integrin: A phase I, pharmacokinetic, and biological correlative study
    • Ricart AD, Tolcher AW, Liu G, et al. Volociximab, a chimeric monoclonal antibody that specifically binds alpha5beta1 integrin: a phase I, pharmacokinetic, and biological correlative study. Clin Cancer Res 2008;14:7924-7929
    • (2008) Clin Cancer Res , vol.14 , pp. 7924-7929
    • Ricart, A.D.1    Tolcher, A.W.2    Liu, G.3
  • 113
    • 0037112010 scopus 로고    scopus 로고
    • Safety and pharmacokinetic effects of TNP-470, an angiogenesis inhibitor, combined with paclitaxel in patients with solid tumors: Evidence for activity in non-small-cell lung cancer
    • Herbst RS, Madden TL, Tran HT, et al. Safety and pharmacokinetic effects of TNP-470, an angiogenesis inhibitor, combined with paclitaxel in patients with solid tumors: evidence for activity in non-small-cell lung cancer. J Clin Oncol 2002;20:4440-4447
    • (2002) J Clin Oncol , vol.20 , pp. 4440-4447
    • Herbst, R.S.1    Madden, T.L.2    Tran, H.T.3
  • 114
    • 41149171034 scopus 로고    scopus 로고
    • First-in-human study of AMG 386, a selective angiopoietin1/2-neutralizing peptibody, in adult patients with advanced solid tumors
    • Rosen LS, Hong D, Chap L, et al. First-in-human study of AMG 386, a selective angiopoietin1/2-neutralizing peptibody, in adult patients with advanced solid tumors. J Clin Oncol 2007;25:abstract 3522
    • (2007) J Clin Oncol , vol.25
    • Rosen, L.S.1    Hong, D.2    Chap, L.3
  • 115
    • 70349307342 scopus 로고    scopus 로고
    • AMG 386, a selective angiopoietin 1/2-neutralizing peptibody, in combination with chemotherapy in adult patients with advanced solid tumors
    • Mita AC, Wang D, Takimoto CH, et al. AMG 386, a selective angiopoietin 1/2-neutralizing peptibody, in combination with chemotherapy in adult patients with advanced solid tumors. J Clin Oncol 2007;25:abstract 14033
    • (2007) J Clin Oncol , vol.25
    • Mita, A.C.1    Wang, D.2    Takimoto, C.H.3
  • 116
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin LE, Golijanin D, Itin A, et al. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 1999;103:159-165
    • (1999) J Clin Invest , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3
  • 118
    • 57449103348 scopus 로고    scopus 로고
    • Randomized phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
    • McKeage MJ, Von Pawel J, Reck M, et al. Randomized phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. Br J Cancer 2008;99:2006-2012
    • (2008) Br J Cancer , vol.99 , pp. 2006-2012
    • McKeage, M.J.1    Von Pawel, J.2    Reck, M.3
  • 122
    • 68049100832 scopus 로고    scopus 로고
    • Phase i study of NPI-2358 (a novel vascular disrupting agent) in patients with solid tumors and lymphomas
    • Mita C, Yee LK, Papadopoulos KP, et al. Phase I study of NPI-2358 (a novel vascular disrupting agent) in patients with solid tumors and lymphomas. J Clin Oncol 2008;26:3525
    • (2008) J Clin Oncol , vol.26 , pp. 3525
    • Mita, C.1    Yee, L.K.2    Papadopoulos, K.P.3
  • 124
    • 33646741205 scopus 로고    scopus 로고
    • The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: Results of a phase 1 study
    • Hande KR, Hagey A, Berlin J, et al. The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: results of a phase 1 study. Clin Cancer Res 2006;12:2834-2840
    • (2006) Clin Cancer Res , vol.12 , pp. 2834-2840
    • Hande, K.R.1    Hagey, A.2    Berlin, J.3
  • 125
    • 33748372759 scopus 로고    scopus 로고
    • A phase 1 study of ABT-751, an orally bioavailable tubulin inhibitor, administered daily for 7 days every 21 days in pediatric patients with solid tumors
    • Fox E, Maris JM, Widemann BC, et al. A phase 1 study of ABT-751, an orally bioavailable tubulin inhibitor, administered daily for 7 days every 21 days in pediatric patients with solid tumors. Clin Cancer Res 2006;12:4882-4887
    • (2006) Clin Cancer Res , vol.12 , pp. 4882-4887
    • Fox, E.1    Maris, J.M.2    Widemann, B.C.3
  • 126
    • 25144483821 scopus 로고    scopus 로고
    • Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies
    • Yee KW, Hagey A, Verstovsek S, et al. Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies. Clin Cancer Res 2005;11:6615-6624
    • (2005) Clin Cancer Res , vol.11 , pp. 6615-6624
    • Yee, K.W.1    Hagey, A.2    Verstovsek, S.3
  • 129
    • 84868081323 scopus 로고    scopus 로고
    • Available from: Last accessed 30 April 2009
    • A study of ABT-751 in patients with NSCLC. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00073151?cond=nsclc&intr= abt+751&rank=3 [Last accessed 30 April 2009]
    • A Study of ABT-751 in Patients with NSCLC
  • 131
    • 58149151390 scopus 로고    scopus 로고
    • Circulating endothelial cells, bone marrow-derived endothelial progenitor cells and proangiogenic hematopoietic cells in cancer: From biology to therapy
    • Dome B, Timar J, Ladanyi A, et al. Circulating endothelial cells, bone marrow-derived endothelial progenitor cells and proangiogenic hematopoietic cells in cancer: from biology to therapy. Crit Rev Oncol Hematol 2009;69:108-124
    • (2009) Crit Rev Oncol Hematol , vol.69 , pp. 108-124
    • Dome, B.1    Timar, J.2    Ladanyi, A.3
  • 134
    • 84868055128 scopus 로고    scopus 로고
    • Available from: Last accessed 30 April 2009
    • Malignant pleural effusion with ZD6474. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00402896?term=NCT00402896&rank=1 [Last accessed 30 April 2009]
    • Malignant Pleural Effusion with ZD6474
  • 138
    • 46749108882 scopus 로고    scopus 로고
    • Multimodality molecular imaging of tumor angiogenesis
    • Cai W, Chen X. Multimodality molecular imaging of tumor angiogenesis. J Nucl Med 2008;49(Suppl 2):113-28S
    • (2008) J Nucl Med , vol.49 , Issue.SUPPL. 2
    • Cai, W.1    Chen, X.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.