-
1
-
-
0033981738
-
Determinants of passive drug entry into the central nervous system
-
Habgood, M.D., Begley, D.J., and Abbott, N.J. (2000) Determinants of passive drug entry into the central nervous system. Cell Mol Neurobiol 20, 231-253.
-
(2000)
Cell Mol Neurobiol
, vol.20
, pp. 231-253
-
-
Habgood, M.D.1
Begley, D.J.2
Abbott, N.J.3
-
2
-
-
33644788804
-
CNS drug delivery: Opioid peptides and the blood-brain barrier
-
Witt, K.A. and Davis, T.P. (2006) CNS drug delivery: opioid peptides and the blood-brain barrier. AAPS J 8, E76-E88.
-
(2006)
AAPS J
, vol.8
-
-
Witt, K.A.1
Davis, T.P.2
-
3
-
-
0035748363
-
Peptide drug modifications to enhance bioavailability and blood-brain barrier permeability
-
Witt, K.A., Gillespie, T.J., Huber, J.D., Egleton, R.D., and Davis, T.P. (2001) Peptide drug modifications to enhance bioavailability and blood-brain barrier permeability. Peptides 22, 2329-2343.
-
(2001)
Peptides
, vol.22
, pp. 2329-2343
-
-
Witt, K.A.1
Gillespie, T.J.2
Huber, J.D.3
Egleton, R.D.4
Davis, T.P.5
-
4
-
-
57449121882
-
Getting into the brain: Approaches to enhance brain drug delivery
-
Patel, M.M., Goyal, B.R., Bhadada, S.V., Bhatt, J.S., and Amin, A.F. (2009) Getting into the brain: approaches to enhance brain drug delivery. CNS Drugs 23, 35-58.
-
(2009)
CNS Drugs
, vol.23
, pp. 35-58
-
-
Patel, M.M.1
Goyal, B.R.2
Bhadada, S.V.3
Bhatt, J.S.4
Amin, A.F.5
-
5
-
-
50449097993
-
Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2
-
del Amo, E.M., Urtti, A., and Yliperttula, M. (2008) Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2. Eur J Pharm Sci 35, 161-174.
-
(2008)
Eur J Pharm Sci
, vol.35
, pp. 161-174
-
-
Del Amo, E.M.1
Urtti, A.2
Yliperttula, M.3
-
6
-
-
0030111315
-
Blood-to-central nervous system entry and stability of biphalin, a unique double-enkephalin analog, and its halogenated derivatives
-
Abbruscato, T.J.,Williams, S.A., Misicka, A., Lipkowski, A.W., Hruby, V.J., and Davis, T.P. (1996) Blood-to-central nervous system entry and stability of biphalin, a unique double-enkephalin analog, and its halogenated derivatives. J Pharm Exp Ther 276, 1049-1057.
-
(1996)
J Pharm Exp Ther
, vol.276
, pp. 1049-1057
-
-
Abbruscato, T.J.1
Williams, S.A.2
Misicka, A.3
Lipkowski, A.W.4
Hruby, V.J.5
Davis, T.P.6
-
7
-
-
23044500398
-
Drug resistance in brain diseases and the role of drug efflux transporters
-
Loscher, W. and Potschka, H. (2005) Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev 6, 591-602.
-
(2005)
Nat Rev
, vol.6
, pp. 591-602
-
-
Loscher, W.1
Potschka, H.2
-
8
-
-
17544368685
-
Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
-
Leslie, E.M., Deeley, R.G., and Cole, S.P. (2005) Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol 204, 216-237.
-
(2005)
Toxicol Appl Pharmacol
, vol.204
, pp. 216-237
-
-
Leslie, E.M.1
Deeley, R.G.2
Cole, S.P.3
-
9
-
-
0032456218
-
Altered disposition and antinociception of [D-penicillamine( 2,5)] enkephalin in mdr1a-genedeficient mice
-
Chen, C. and Pollack, G.M. (1998) Altered disposition and antinociception of [D-penicillamine( 2,5)] enkephalin in mdr1a-genedeficient mice. J Pharm Exp Ther 16, 545-552.
-
(1998)
J Pharm Exp Ther
, vol.16
, pp. 545-552
-
-
Chen, C.1
Pollack, G.M.2
-
10
-
-
0036182134
-
Endomorphins, Met-enkephalin, Tyr-MIF-1, and the P-glycoprotein efflux system
-
Kastin, A.J., Fasold, M.B., and Zadina, J.E. (2002) Endomorphins, Met-enkephalin, Tyr-MIF-1, and the P-glycoprotein efflux system. Drug Metab Dispos Biol Fate Chem 30, 231-234.
-
(2002)
Drug Metab Dispos Biol Fate Chem
, vol.30
, pp. 231-234
-
-
Kastin, A.J.1
Fasold, M.B.2
Zadina, J.E.3
-
11
-
-
67049114267
-
A comparison of the effects of p-glycoprotein inhibitors on the blood-brain barrier permeation of cyclic prodrugs of an opioid peptide (DADLE)
-
Ouyang, H., Andersen, T.E., Chen, W., Nofsinger, R., Steffansen, B., and Borchardt, R.T. (2009) A comparison of the effects of p-glycoprotein inhibitors on the blood-brain barrier permeation of cyclic prodrugs of an opioid peptide (DADLE). J Pharm Sci 98, 2227-2236.
-
(2009)
J Pharm Sci
, vol.98
, pp. 2227-2236
-
-
Ouyang, H.1
Andersen, T.E.2
Chen, W.3
Nofsinger, R.4
Steffansen, B.5
Borchardt, R.T.6
-
12
-
-
30144440842
-
Multidrug resistance protein 1-mediated export of glutathione and glutathione disulfide from brain astrocytes
-
Hirrlinger, J. and Dringen, R. (2005) Multidrug resistance protein 1-mediated export of glutathione and glutathione disulfide from brain astrocytes. Methods Enzymol 400, 395-409.
-
(2005)
Methods Enzymol
, vol.400
, pp. 395-409
-
-
Hirrlinger, J.1
Dringen, R.2
-
13
-
-
0033104810
-
Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione
-
Paulusma, C.C., van Geer, M.A., Evers, R., Heijn, M., Ottenhoff, R., Borst, P., and Oude Elferink, R.P. (1999) Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione. Biochem J 338, 393-401.
-
(1999)
Biochem J
, vol.338
, pp. 393-401
-
-
Paulusma, C.C.1
Van Geer, M.A.2
Evers, R.3
Heijn, M.4
Ottenhoff, R.5
Borst, P.6
Oude Elferink, R.P.7
-
14
-
-
33645825217
-
Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione
-
Rius, M., Hummel-Eisenbeiss, J., Hofmann, A.F., and Keppler, D. (2006) Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione. Am J Physiol Gastrointest Liver Physiol 290, G640-G649.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Rius, M.1
Hummel-Eisenbeiss, J.2
Hofmann, A.F.3
Keppler, D.4
-
15
-
-
13444288036
-
Breast cancer resistance protein (BCRP/ABCG2)
-
Staud, F. and Pavek, P. (2005) Breast cancer resistance protein (BCRP/ABCG2). Int J Biochem Cell Biol 37, 720-725.
-
(2005)
Int J Biochem Cell Biol
, vol.37
, pp. 720-725
-
-
Staud, F.1
Pavek, P.2
-
16
-
-
0033932502
-
Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier
-
Gao, B.,Hagenbuch, B.,Kullak-Ublick,G.A., Benke, D., Aguzzi, A., and Meier, P.J. (2000) Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. J Pharm Exp Ther 294, 73-79.
-
(2000)
J Pharm Exp Ther
, vol.294
, pp. 73-79
-
-
Gao, B.1
Hagenbuch, B.2
Kullak-Ublick, G.A.3
Benke, D.4
Aguzzi, A.5
Meier, P.J.6
-
17
-
-
1242272736
-
Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
-
Hagenbuch, B. and Meier, P.J. (2004) Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch 477, 653-665.
-
(2004)
Pflugers Arch
, vol.477
, pp. 653-665
-
-
Hagenbuch, B.1
Meier, P.J.2
-
18
-
-
35148850214
-
Role of rat organic anion transporter 3 (Oat3) in the renal basolateral transport of glutathione
-
Lash, L.H., Putt, D.A., Xu, F., and Matherly, L.H. (2007) Role of rat organic anion transporter 3 (Oat3) in the renal basolateral transport of glutathione. Chem Biol Interact 170, 124-134.
-
(2007)
Chem Biol Interact
, vol.170
, pp. 124-134
-
-
Lash, L.H.1
Putt, D.A.2
Xu, F.3
Matherly, L.H.4
-
19
-
-
4644239463
-
Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain
-
Shen, H., Smith, D.E., Keep, R.F., and Brosius, F.C. III (2004) Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain. Mol Pharm 1, 248-256.
-
(2004)
Mol Pharm
, vol.1
, pp. 248-256
-
-
Shen, H.1
Smith, D.E.2
Keep, R.F.3
Brosius Iii, F.C.4
-
20
-
-
0030892082
-
Cloning and functional expression of a brain peptide/histidine transporter
-
Yamashita, T., Shimada, S., Guo, W., Sato, K., Kohmura, E., Hayakawa, T., Takagi, T., and Tohyama, M. (1997) Cloning and functional expression of a brain peptide/histidine transporter. J Biol Chem272, 10205-10211.
-
(1997)
J Biol Chem
, vol.272
, pp. 10205-10211
-
-
Yamashita, T.1
Shimada, S.2
Guo, W.3
Sato, K.4
Kohmura, E.5
Hayakawa, T.6
Takagi, T.7
Tohyama, M.8
-
21
-
-
0000545811
-
An in situ brain perfusion technique to study cerebrovascular transport in the rat
-
Takasato, Y., Rapoport, S.I., and Smith, Q.R. (1984) An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am J Physiol 247, H484-H493.
-
(1984)
Am J Physiol
, vol.247
-
-
Takasato, Y.1
Rapoport, S.I.2
Smith, Q.R.3
-
22
-
-
0014888279
-
Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard
-
Oldendorf, W.H. (1970) Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard. Brain Res 24, 372-376.
-
(1970)
Brain Res
, vol.24
, pp. 372-376
-
-
Oldendorf, W.H.1
-
23
-
-
0029024640
-
Permeability of the developing blood-brain barrier to 14C-mannitol using the rat in situ brain perfusion technique
-
Preston, J.E., al Sarraf, H., and Segal, M.B. (1995) Permeability of the developing blood-brain barrier to 14C-mannitol using the rat in situ brain perfusion technique. Brain Res Dev Brain Res 87, 69-76.
-
(1995)
Brain Res Dev Brain Res
, vol.87
, pp. 69-76
-
-
Preston, J.E.1
Sarraf, H.2
Segal, M.B.3
-
24
-
-
0025295847
-
Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins
-
Triguero, D., Buciak, J., and Pardridge,W.M. (1990) Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins. J Neurochem 54, 1882-1888.
-
(1990)
J Neurochem
, vol.54
, pp. 1882-1888
-
-
Triguero, D.1
Buciak, J.2
Pardridge, W.M.3
-
25
-
-
0026784456
-
Transport, uptake, and metabolism of blood-borne vasopressin by the blood-brain barrier
-
Zlokovic, B.V., Banks, W.A., el Kadi, H., Erchegyi, J., Mackic, J.B., McComb, J.G., and Kastin, A.J. (1992) Transport, uptake, and metabolism of blood-borne vasopressin by the blood-brain barrier. Brain Res 590, 213-218.
-
(1992)
Brain Res
, vol.590
, pp. 213-218
-
-
Zlokovic, B.V.1
Banks, W.A.2
Kadi, H.3
Erchegyi, J.4
MacKic, J.B.5
McComb, J.G.6
Kastin, A.J.7
-
26
-
-
0023521093
-
Phenylalanine transport across the blood-brain barrier as studied with the in situ brain perfusion technique
-
Momma, S., Aoyagi, M., Rapoport, S.I., and Smith, Q.R. (1987) Phenylalanine transport across the blood-brain barrier as studied with the in situ brain perfusion technique. J Neurochem 48, 1291-1300.
-
(1987)
J Neurochem
, vol.48
, pp. 1291-1300
-
-
Momma, S.1
Aoyagi, M.2
Rapoport, S.I.3
Smith, Q.R.4
-
27
-
-
0000379333
-
Quantitation of bloodbrain barrier permeability
-
(Neuwelt E.A., Ed.), Plenum Press, New York
-
Smith, Q.R. (1989) Quantitation of bloodbrain barrier permeability, in Implications of the Blood-Brain Barrier and its Manipulation (Neuwelt E.A., Ed.) pp. 85-118, Plenum Press, New York.
-
(1989)
Implications of the Blood-Brain Barrier and Its Manipulation
, pp. 85-118
-
-
Smith, Q.R.1
-
28
-
-
0022250241
-
Kinetic analysis of cerebrovascular isoleucine transport from saline and plasma
-
Takasato, Y., Momma, S., and Smith, Q.R. (1985) Kinetic analysis of cerebrovascular isoleucine transport from saline and plasma. J Neurochem 45, 1013-1020.
-
(1985)
J Neurochem
, vol.45
, pp. 1013-1020
-
-
Takasato, Y.1
Momma, S.2
Smith, Q.R.3
-
29
-
-
0020956774
-
Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data
-
Patlak, C.S., Blasberg, R.G., and Fenstermacher, J.D. (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3, 1-7.
-
(1983)
J Cereb Blood Flow Metab
, vol.3
, pp. 1-7
-
-
Patlak, C.S.1
Blasberg, R.G.2
Fenstermacher, J.D.3
-
30
-
-
0022564983
-
Comparative methods for the radiolabeling of peptides
-
Bolton, A.E. (1986) Comparative methods for the radiolabeling of peptides. Methods Enzymol 124, 18-29.
-
(1986)
Methods Enzymol
, vol.124
, pp. 18-29
-
-
Bolton, A.E.1
-
31
-
-
0035951653
-
Effect of reduced flow on blood-brain barrier transport systems
-
Hom, S., Egleton, R.D., Huber, J.D., and Davis, T.P. (2001) Effect of reduced flow on blood-brain barrier transport systems. Brain Res 890, 38-48.
-
(2001)
Brain Res
, vol.890
, pp. 38-48
-
-
Hom, S.1
Egleton, R.D.2
Huber, J.D.3
Davis, T.P.4
|