Adeno-associated virus type 5 utilizes alternative translation initiation to encode a small Rep40-like protein

Journal of Virology

Volumn 84, Issue 2, 2010, Pages 1193-1197

  Farris, K David ^a   Pintel, David J ^a  

^a University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELICASE; ISOPROTEIN; MESSENGER RNA; REP40 LIKE PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA;

ADENO ASSOCIATED VIRUS; ADENO ASSOCIATED VIRUS TYPE 5; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; DNA PACKAGING; DNA SPLICING; GENETIC CODE; INTRON; NONHUMAN; NOTE; PRIORITY JOURNAL; START CODON; TRANSLATION INITIATION; VIRUS TRANSCRIPTION;

ALTERNATIVE SPLICING; ANIMALS; DEPENDOVIRUS; DNA HELICASES; GENE EXPRESSION REGULATION, VIRAL; HUMANS; MUTATION; PROTEIN BIOSYNTHESIS; RNA, VIRAL;

ADENO-ASSOCIATED VIRUS; ADENO-ASSOCIATED VIRUS - 2;

EID: 73849125570     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01961-09     Document Type: Note

References (15)

1. Collaco, R. F., V. Kalman-Maltese, A. D. Smith, J. D. Dignam, and J. P. Trempe. 2003. A biochemical characterization of the adeno-associated virus Rep40 helicase. J. Biol. Chem. 278:34011-34017.
2. Farris, K. D., and D. J. Pintel. 2008. Improved splicing of adeno-associated viral (AAV) capsid protein-supplying pre-mRNAs leads to increased recombinant AAV vector production. Hum. Gene Ther. 19:1421-1427.
3. Hall, M. C., and S. W. Matson. 1999. Helicase motifs: the engine that powers DNA unwinding. Mol. Microbiol. 34:867-877.
4. James, J. A., C. R. Escalante, M. Yoon-Robarts, T. A. Edwards, R. M. Linden, and A. K. Aggarwal. 2003. Crystal structure of the SF3 helicase from adeno-associated virus type 2. Structure 11:1025-1035.
5. King, J. A., R. Dubielzig, D. Grimm, and J. A. Kleinschmidt. 2001. DNA helicase-mediated packaging of adeno-associated virus type 2 genomes into preformed capsids. EMBO J. 20:3282-3291.
6. Meinnel, T., A. Serero, and C. Giglione. 2006. Impact of the N-terminal amino acid on targeted protein degradation. Biol. Chem. 387:839-851.
7. Nayak, R., K. D. Farris, and D. J. Pintel. 2008. E4Orf6-E1B-55k-dependent degradation of de novo-generated adeno-associated virus type 5 Rep52 and capsid proteins employs a cullin 5-containing E3 ligase complex. J. Virol. 82:3803-3808.
8. Nayak, R., and D. J. Pintel. 2007. Positive and negative effects of adenovirus type 5 helper functions on adeno-associated virus type 5 (AAV5) protein accumulation govern AAV5 virus production. J. Virol. 81:2205-2212.
9. Qiu, J., F. Cheng, and D. Pintel. 2007. The abundant R2 mRNA generated by Aleutian mink disease parvovirus is tricistronic, encoding NS2, VP1, and VP2. J. Virol. 81:6993-7000.
10. Qiu, J., F. Cheng, and D. Pintel. 2006. Molecular characterization of caprine adeno-associated virus (AAV-Go. 1) reveals striking similarity to human AAV5. Virology 356:208-216.
11. Qiu, J., R. Nayak, G. E. Tullis, and D. J. Pintel. 2002. Characterization of the transcription profile of adeno-associated virus type 5 reveals a number of unique features compared to previously characterized adeno-associated viruses. J. Virol. 76:12435-12447.
12. Qiu, J., and D. J. Pintel. 2004. Alternative polyadenylation of adeno-associated virus type 5 RNA within an internal intron is governed by the distance between the promoter and the intron and is inhibited by U1 small nuclear RNP binding to the intervening donor. J. Biol. Chem. 279:14889-14898.
13. Reed, S. E., E. M. Staley, J. P. Mayginnes, D. J. Pintel, and G. E. Tullis. 2006. Transfection of mammalian cells using linear polyethylenimine is a simple and effective means of producing recombinant adeno-associated virus vectors. J. Virol. Methods 138:85-98.
14. Smith, R. H., A. J. Spano, and R. M. Kotin. 1997. The Rep78 gene product of adeno-associated virus (AAV) self-associates to form a hexameric complex in the presence of AAV ori sequences. J. Virol. 71:4461-4471.
15. Tasaki, T., and Y. T. Kwon. 2007. The mammalian N-end rule pathway: new insights into its components and physiological roles. Trends Biochem. Sci. 32:520-528.