Diastereoselective darzens condensations of α-haloamides: Influence of aryl substituents on diastereoselectivity

Letters in Organic Chemistry

Volumn 6, Issue 7, 2009, Pages 552-556

  North, Michael ^a   Pizzato, Francesca ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Aldehyde; Darzens condensation; Diastereoselectivity; Epoxide; Metal hydroxide; Proton acidity

Indexed keywords

EID: 73849107340     PISSN: 15701786     EISSN: None     Source Type: Journal    
DOI: 10.2174/157017809789869465     Document Type: Article

References (27)

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7. 1H NMR spectroscopy to determine the diastereomeric ratio. Purification by flash column chromatography (hexane/EtOAc) then gave the cis- and trans-epoxides.
8. Of compounds 3a, b to 7a, b, only compound 4a has been reported before: Wadia, M.S.; Patil, D.V. Synth. Commun., 2003, 33, 2725.
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