How important are S100A8/S100A9 calcium binding proteins for the activation of phagocyte NADPH oxidase, Nox2

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry

Volumn 8, Issue 4, 2009, Pages 282-289

  Berthier, Sylvie ^a   Baillet, Athan ^a,b   Paclet, Marie Hélène ^a   Gaudin, Philippe ^a,b   Morel, Françoise ^a  

^a LABORATOIRE TIMC IMAG   (France)

^b Grenoble Teaching Hospital CHU Hôpital Sud   (France)

Author keywords

NADPH oxidase; Neutrophils; S100A8 protein; S100A9 protein

Indexed keywords

ARACHIDONIC ACID; CALGRANULIN A; CALGRANULIN B; CASEIN KINASE II; CYTOCHROME B558; PROTEIN E7; PROTEIN P22; PROTEIN P40; PROTEIN P47; PROTEIN P67; RAC1 PROTEIN; RAC2 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2;

B LYMPHOCYTE; CHRONIC GRANULOMATOUS DISEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; INFLAMMATION; LEUKOCYTE ACTIVATION; MICROBIAL IMMUNITY; NONHUMAN; PHAGOCYTE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; REVIEW; RHEUMATOID ARTHRITIS; TUMOR IMMUNITY;

EID: 73649139256     PISSN: 18715230     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152309789839000     Document Type: Review

References (36)

1. Ehrchen, J. M.; Sunderkotter, C.; Foell, D.; Vogl, T.; Roth, J. The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J. Leukoc. Biol., 2009, 86, 557-566.
2. Morel, F. Molecular aspects of chronic granulomatous disease. "the NADPH oxidase complex". Bull. Acad. Natl. Med., 2007, 191, 377-392.
3. Nacken, W.; Roth, J.; Sorg, C.; Kerkhoff, C. S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity. Microsc. Res. Tech., 2003, 60, 569-580.
4. Gebhardt, C.; Nemeth, J.; Angel, P.; Hess, J. S100A8 and S100A9 in inflammation and cancer. Biochem. Pharmacol., 2006, 72, 1622-1631.
5. Foell, D.; Wittkowski, H.; Vogl, T.; Roth, J. S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J. Leukoc. Biol., 2007, 81, 28-37.
6. Benedyk, M.; Sopalla, C.; Nacken, W.; Bode, G.; Melkonyan, H.; Banfi, B.; Kerkhoff, C. HaCaT keratinocytes overexpressing the S100 proteins S100A8 and S100A9 show increased NADPH oxidase and NF-kappaB activities. J. Invest. Dermatol., 2007, 127, 2001-2011.
7. Bouzidi, F.; Doussiere, J. Binding of arachidonic acid to myeloidrelated proteins (S100A8/A9) enhances phagocytic NADPH oxidase activation. Biochem. Biophys. Res. Commun., 2004, 325, 1060-1065.
8. Doussiere, J.; Bouzidi, F.; Vignais, P. V. The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils. Eur. J. Biochem., 2002, 269, 3246-3255.
9. Berthier, S.; Paclet, M. H.; Lerouge, S.; Roux, F.; Vergnaud, S.; Coleman, A. W.; Morel, F. Changing the conformation state of cytochrome b558 initiates NADPH oxidase activation: MRP8/MRP14 regulation. J. Biol. Chem., 2003, 278, 25499-25508.
10. Vogl, T.; Tenbrock, K.; Ludwig, S.; Leukert, N.; Ehrhardt, C.; van Zoelen, M. A.; Nacken, W.; Foell, D.; van der Poll, T.; Sorg, C.; Roth, J. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat. Med., 2007, 13, 1042-1049.
11. Bedard, K.; Lardy, B.; Krause, K. H. NOX family NADPH oxidases: not just in mammals. Biochimie, 2007, 89, 1107-1112.
12. Bedard, K.; Krause, K. H. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol. Rev., 2007, 87, 245-313.
13. Batot, G.; Paclet, M. H.; Doussiere, J.; Vergnaud, S.; Martel, C.; Vignais, P. V.; Morel, F. Biochemical and immunochemical properties of B lymphocyte cytochrome b558. Biochim. Biophys. Acta, 1998, 1406, 188-202.
14. Paclet, M. H.; Coleman, A. W.; Burritt, J.; Morel, F. NADPH oxidase of Epstein-Barr-virus immortalized B lymphocytes. Effect of cytochrome b(558) glycosylation. Eur. J. Biochem., 2001, 268, 5197-5208.
15. Paclet, M. H.; Coleman, A. W.; Vergnaud, S.; Morel, F. P67-phoxmediated NADPH oxidase assembly: imaging of cytochrome b558 liposomes by atomic force microscopy. Biochemistry, 2000, 39, 9302-9310.
16. Roth, J.; Vogl, T.; Sorg, C.; Sunderkotter, C. Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules. Trends Immunol., 2003, 24, 155-158.
17. Kerkhoff, C.; Hofmann, H. A.; Vormoor, J.; Melkonyan, H.; Roth, J.; Sorg, C.; Klempt, M. Binding of two nuclear complexes to a novel regulatory element within the human S100A9 promoter drives the S100A9 gene expression. J. Biol. Chem., 2002, 277, 41879-41887.
18. Sopalla, C.; Leukert, N.; Sorg, C.; Kerkhoff, C. Evidence for the involvement of the unique C-tail of S100A9 in the binding of arachidonic acid to the heterocomplex S100A8/A9. Biol. Chem., 2002, 383, 1895-1905.
19. Korndorfer, I. P.; Brueckner, F.; Skerra, A. The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins. J. Mol. Biol., 2007, 370, 887-898.
20. Leukert, N.; Vogl, T.; Strupat, K.; Reichelt, R.; Sorg, C.; Roth, J. Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activity. J. Mol. Biol., 2006, 359, 961-972.
21. Morel, F.; Dewald, B.; Berthier, S.; Zaoui, P.; Dianoux, A. C.; Vignais, P. V.; Baggiolini, M. Further characterization of the gelatinase-containing particles of human neutrophils. Biochim. Biophys. Acta, 1994, 1201, 373-380.
22. Stroncek, D. F.; Shankar, R. A.; Skubitz, K. M. The subcellular distribution of myeloid-related protein 8 (MRP8) and MRP14 in human neutrophils. J. Transl. Med., 2005, 3, 36.
23. Baillet, A.; Trocmé, C.; Berthier, S.; Arlotto, M.; Grange, L.; Quétant, S.; Sève, M.; Berger, F.; Juvin, R.; Morel, F.; Gaudin, P. Synovial fluid proteomic fingerprint: S100A8, S100A9 and S100A12 proteins discriminate rheumatoid arthritis from other inflammatory joint diseases. Rheumatology (Oxford), 2009, [under revision].
24. Passey, R. J.; Xu, K.; Hume, D. A.; Geczy, C. L. S100A8: emerging functions and regulation. J. Leukoc. Biol., 1999, 66, 549-556.
25. Vandal, K.; Rouleau, P.; Boivin, A.; Ryckman, C.; Talbot, M.; Tessier, P. A. Blockade of S100A8 and S100A9 suppresses neutrophil migration in response to lipopolysaccharide. J. Immunol., 2003, 171, 2602-2609.
26. Hiratsuka, S.; Watanabe, A.; Aburatani, H.; Maru, Y. Tumourmediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat. Cell. Biol., 2006, 8, 1369-1375.
27. Tugizov, S.; Berline, J.; Herrera, R.; Penaranda, M. E.; Nakagawa, M.; Palefsky, J. Inhibition of human papillomavirus type 16 E7 phosphorylation by the S100 MRP-8/14 protein complex. J. Virol., 2005, 79, 1099-1112.
28. Kerkhoff, C.; Nacken, W.; Benedyk, M.; Dagher, M. C.; Sopalla, C.; Doussiere, J. The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2. FASEB J., 2005, 19, 467-469.
29. Foubert, T. R.; Burritt, J. B.; Taylor, R. M.; Jesaitis, A. J. Structural changes are induced in human neutrophil cytochrome b by NADPH oxidase activators, LDS, SDS, and arachidonate: intermolecular resonance energy transfer between trisulfopyrenyl-wheat germ agglutinin and cytochrome b(558). Biochim. Biophys. Acta, 2002, 1567, 221-231.
30. Doussiere, J.; Gaillard, J.; Vignais, P. V. Electron transfer across the O2- generating flavocytochrome b of neutrophils: evidence for a transition from a low-spin state to a high-spin state of the heme iron component. Biochemistry, 1996, 35, 13400-13410.
31. Doussiere, J.; Bouzidi, F.; Poinas, A.; Gaillard, J.; Vignais, P. V. Kinetic study of the activation of the neutrophil NADPH oxidase by arachidonic acid. Antagonistic effects of arachidonic acid and phenylarsine oxide. Biochemistry, 1999, 38, 16394-16406.
32. Dana, R.; Leto, T. L.; Malech, H. L.; Levy, R. Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase. J. Biol. Chem., 1998, 273, 441-445.
33. Brash, A. R. Arachidonic acid as a bioactive molecule. J. Clin. Invest., 2001, 107, 1339-1345.
34. Paclet, M. H.; Berthier, S.; Kuhn, L.; Garin, J.; Morel, F. Regulation of phagocyte NADPH oxidase activity: identification of two cytochrome b558 activation states. FASEB J., 2007, 21, 1244-1255.
35. van den Bos, C.; Roth, J.; Koch, H. G.; Hartmann, M.; Sorg, C. Phosphorylation of MRP14, an S100 protein expressed during monocytic differentiation, modulates Ca(2+)-dependent translocation from cytoplasm to membranes and cytoskeleton. J. Immunol., 1996, 156, 1247-1254.
36. Guignard, F.; Mauel, J.; Markert, M. Phosphorylation of myeloidrelated proteins MRP-14 and MRP-8 during human neutrophil activation. Eur. J. Biochem., 1996, 241, 265-271.