Particle size, magnetic field, and blood velocity effects on particle retention in magnetic drug targeting

Medical Physics

Volumn 37, Issue 1, 2010, Pages 175-182

  Cherry, Erica M ^a   Maxim, Peter G ^b   Eaton, John K ^a  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Cancer; Drug delivery; Electromagnet; Helmoltz coils; Magnetic drug targeting; Magnetic field gradient; Particle retention; Tumor

Indexed keywords

BLOOD; CONTROLLED DRUG DELIVERY; DRAG; DRUG DELIVERY; ELECTROMAGNETS; FLOW VELOCITY; HEMODYNAMICS; MAGNETIC FIELD EFFECTS; PARTICLE SIZE; TUMORS;

CANCER; HELMOLTZ COILS; MAGNETIC DRUG TARGETING; MAGNETIC FIELD GRADIENT; PARTICLE RETENTION;

MAGNETIC BUBBLES;

EID: 73649135396     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.3271344     Document Type: Article

References (32)

1. M. Arruebo, R. Fernandez-Pacheco, M. R. Ibarra, and J. Santamaria, " Magnetic nanoparticles for drug delivery.," Nanotoday 1748-0132 2, 22-32 (2007). 10.1016/S1748-0132(07)70084-1 (Pubitemid 46695431)
2. M. Johannsen, U. Gneveckow, L. Eckelt, A. Feussner, N. Waldofner, R. Scholz, S. Deger, P. Wust, S. A. Loening, and A. Jordan, " Clinical hyperthermia of prostate cancer using magnetic nanoparticles: Presentation of a new interstitial technique.," Int. J. Hyperthermia 0265-6736 21, 637-647 (2005). 10.1080/02656730500158360 (Pubitemid 41684238)
3. C. Alexiou, R. Jurgons, C. Seliger, O. Brunke, H. Iro, and S. Odenbach, " Delivery of superparamagnetic nanoparticles for local chemotherapy after intraarterial infusion and magnetic drug targeting.," Anticancer Res. 0250-7005 27, 2019-2022 (2007).
4. R. Jurgons, C. Seliger, A. Hilpert, L. Trahms, S. Odenbach, and C. Alexiou, " Drug loaded magnetic nanoparticles for cancer therapy.," J. Phys.: Condens. Matter 0953-8984 18, S2893-S2902 (2006). 10.1088/0953-8984/18/ 38/S24 (Pubitemid 44523008)
5. C. H. Cunningham, T. Arai, P. C. Yang, M. V. McConnell, J. M. Pauly, and S. M. Conolly, " Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles.," Magn. Reson. Med. 0740-3194 53, 999-1005 (2005). 10.1002/mrm.20477 (Pubitemid 40627773)
6. A. Ito, K. Ino, M. Hayashida, T. Kobayashi, H. Matsunuma, H. Kagami, M. Ueda, and H. Honda, " Novel methodology for fabrication of tissue-engineered tubular constructs using magnetite nanoparticles and magnetic force.," Tissue Eng. 1076-3279 11, 1553-1561 (2005). 10.1089/ten.2005.11. 1553 (Pubitemid 41636440)
7. A. Ito, Y. Takizawa, H. Honda, K. I. Hata, H. Kagami, M. Ueda, and T. Kobayashi, " Tissue engineering using magnetite nanoparticles and magnetic force: Heterotypic layers of cocultured hepatocytes and endothelial cells.," Tissue Eng. 1076-3279 10, 833-840 (2004). 10.1089/1076327041348301 (Pubitemid 38880402)
8. C. Alexiou, W. Arnold, R. J. Klein, F. G. Parak, P. Hulin, C. Bergemann, W. Erhardt, S. Wagenpfeil, and A. S. Lubbe, " Locoregional cancer treatment with magnetic drug targeting.," Cancer Res. 0008-5472 60, 6641-6648 (2000).
9. U. O. Häfeli, " Magnetically modulated therapeutic systems.," Int. J. Pharm. 0378-5173 277, 19-24 (2004). 10.1016/j.ijpharm. 2003.03.002 (Pubitemid 38670417)
10. A. M. Derfus, G. von Maltzahn, T. J. Harris, T. Duza, K. S. Vecchio, E. Ruoslahti, and S. N. Bhatia, " Remotely triggered release from magnetic nanoparticles.," Adv. Mater. 0935-9648 19, 3932-3936 (2007). 10.1002/adma.200700091 (Pubitemid 350190441)
11. S. H. Hu, T. Y. Liu, D. M. Liu, and S. Y. Chen, " Controlled pulsatile drug release from a ferrogel by a high-frequency magnetic field.," Macromolecules 0024-9297 40, 6786-6788 (2007). 10.1021/ma0707584 (Pubitemid 47522656)
12. D. H. Kim, D. E. Nikles, D. T. Johnson, and C. S. Brazel, " Heat generation of aqueously dispersed CoFe2O4 nanoparticles as heating agents for magnetically activated drug delivery and hyperthermia.," J. Magn. Magn. Mater. 0304-8853 320, 2390-2396 (2008). 10.1016/j.jmmm.2008.05.023
13. C. Alexiou, R. Jurgons, R. J. Schmid, C. Bergemann, J. Henke, W. Erhardt, E. Huenges, and F. Parak, " Magnetic drug targeting: Biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment.," J. Drug Target. 1061-186X 11, 139-149 (2003). 10.1080/1061186031000150791 (Pubitemid 37236327)
14. C. Alexiou, A. Schmidt, R. Klein, P. Hulin, C. Bergemann, and W. Arnold, " Magnetic drug targeting: Biodistribution and dependency on magnetic field strength.," J. Magn. Magn. Mater. 0304-8853 252, 363-366 (2002). 10.1016/S0304-8853(02)00605-4
15. A. Senyei, K. Widder, and G. Czerlinski, " Magnetic guidance of drug-carrying microspheres.," J. Appl. Phys. 0021-8979 49, 3578-3583 (1978). 10.1063/1.325219 (Pubitemid 8620423)
16. C. Alexiou, R. Jurgons, R. Schmid, A. Hilpert, C. Bergemann, F. Parak, and H. Iro, " In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles.," J. Magn. Magn. Mater. 0304-8853 293, 389-393 (2005). 10.1016/j.jmmm.2005.02.036 (Pubitemid 40608956)
17. A. S. Lübbe, " Clinical experiences with magnetic drag targeting: A phase I study with 4′ -epidoxorubicin in 14 patients with advanced solid tumors.," Cancer Res. 0008-5472 56, 4686-4693 (1996).
18. E. K. Ruuge and A. N. Rusetski, " Magnetic fluids as drug carriers-Targeted transport of drugs by a magnetic-field.," J. Magn. Magn. Mater. 0304-8853 122, 335-339 (1993). 10.1016/0304-8853(93)91104-F (Pubitemid 23649021)
19. J. B. Mathieu and S. Martel, " Magnetic microparticle steering within the constraints of an MRI system: Proof of concept of a novel targeting approach.," Biomed. Microdevices 1387-2176 9, 801-808 (2007). 10.1007/s10544-007-9092-0 (Pubitemid 350020674)
20. C. Alexiou, D. Diehl, P. Henninger, H. Iro, R. Rockelein, W. Schmidt, and H. Weber, " A high field gradient magnet for magnetic drug targeting.," IEEE Trans. Appl. Supercond. 1051-8223 16, 1527-1530 (2006). 10.1109/TASC.2005.864457 (Pubitemid 44150135)
21. C. G. Caro, The Mechanics of the Circulation (Oxford University Press, Oxford, New York, 1978).
22. C. T. Crowe, M. Sommerfeld, and Y. Tsuji, Multiphase Flows with Droplets and Particles (CRC, Boca Raton, 1998).
23. P. G. Saffman, " Lift on a small sphere in a slow shear flow.," J. Fluid Mech. 0022-1120 22, 385-400 (1965). 10.1017/S0022112065000824
24. M. O. Aviles, A. D. Ebner, and J. A. Ritter, " In vitro study of magnetic particle seeding for implant assisted-magnetic drug targeting.," J. Magn. Magn. Mater. 0304-8853 320, 2640-2646 (2008). 10.1016/j.jmmm.2008.05. 022
25. P. J. Cregg, K. Murphy, and A. Madinoglu, " Inclusion of magnetic dipole-dipole and hydrodynamic interactions in implant-assisted magnetic drug targeting.," J. Magn. Magn. Mater. 0304-8853 321, 3893-3898 (2009). 10.1016/j.jmmm.2009.07.056
26. C. Mikkelsen, M. F. Hansen, and H. Bruns, " Theoretical comparison of magnetic and hydrodynamic interactions between magnetically tagged particles in microfluidic systems.," J. Magn. Magn. Mater. 0304-8853 293, 578-583 (2005). 10.1016/j.jmmm.2005.01.076 (Pubitemid 40608983)
27. P. B. L. Kar, W. Yung, and D. D. Villani, " An analytic solution for the force between two magnetic dipoles.," Magn. Electr. Sep. 1055-6915 9, 39-52 (1998).
28. M. Babincová, P. Babinec, and C. Bergemann, " High-gradient magnetic capture of ferrofluids: Implications for drug targeting and tumor embolization.," Z. Naturforsch [C] 56, 909-911 (2001).
29. M. Babincová, V. Altanerova, M. Lampert, C. Altaner, E. Machova, M. Sramka, and P. Babinec, " Site-specific in vivo targeting of magnetoliposomes using externally applied magnetic field.," Z. Naturforsch [C] 55, 278-281 (2000).
30. U. O. Häfeli and G. J. Pauer, " In vitro and in vivo toxicity of magnetic microspheres.," J. Magn. Magn. Mater. 0304-8853 194, 76-82 (1999). 10.1016/S0304-8853(98)00560-5
31. J. Kreuter, " Evaluation of nanoparticles as drug-delivery systems.1. Preparation methods.," Pharm. Acta Helv. 0031-6865 58, 196-209 (1983).
32. S. M. Moghimi, A. C. Hunter, and J. C. Murray, " Long-circulating and target-specific nanoparticles: Theory to practice.," Pharmacol. Rev. 0031-6997 53, 283-318 (2001).