Impact of combinatory growth factor application on rabbit Achilles tendon injury with operative versus conservative treatment: A pilot study

International Journal of Molecular Medicine

Volumn 25, Issue 2, 2010, Pages 217-224

  Konerding, Moritz A ^a   Arlt, Friederike ^a   Wellmann, Axel ^b   Li, Vincent ^c   Li, William ^d  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b Institute of Pathology   (Germany)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d The Angiogenesis Foundation   (United States)

Author keywords

Achilles tendon injury; Conservative treatment; Growth factors; Operative treatment; Rabbit

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; FIBROBLAST GROWTH FACTOR RECEPTOR 2; GROWTH FACTOR; RECOMBINANT PLATELET DERIVED GROWTH FACTOR; VASCULOTROPIN 165;

ACHILLES TENDON RUPTURE; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONSERVATIVE TREATMENT; CONTROLLED STUDY; DRUG EFFICACY; EXPERIMENTAL RABBIT; FEMALE; INTERMETHOD COMPARISON; NONHUMAN; PILOT STUDY; PRIORITY JOURNAL; TENSILE STRENGTH; TREATMENT RESPONSE;

ACHILLES TENDON; ANALYSIS OF VARIANCE; ANIMALS; COLLAGEN; FEMALE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; RABBITS; RUPTURE; SUTURES; TENSILE STRENGTH;

EID: 73649130245     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000333     Document Type: Article

References (31)

1. Leppilahti J, Puranen J and Orava S: Incidence of Achilles tendon rupture. Acta Orthop Scand 67: 277-279, 1996.
2. Khan RJK, Fick D, Keogh A, Crawford J, Brammar T and Parker M: Treatment of acute Achilles tendon ruptures. A meta-analysis of randomized, controlled trials. J Bone Joint Surg Am 87: 2202-2210, 2005.
3. Metz R, Verleisdonk EJ, van der Heijden GJ, Clevers GJ, Hammacher ER, Verhofstad MH and van der Werken C: Acute Achilles tendon rupture: minimally invasive surgery versus nonoperative treatment with immediate full weightbearing - a randomized controlled trial. Am J Sports Med 36: 1688-1694, 2008.
4. Aspenberg P: Stimulation of tendon repair: mechanical loading, GDFs and platelets. A mini-review. Int Orthop 31: 783-789, 2007.
5. Bolt P, Clerk AN, Luu HH, Kang Q, Kummer JL, Deng ZL, Olson K, Primus F, Montag AG, He TC, Haydon RC and Toolan BC: BMP-14 gene therapy increases tendon tensile strength in a rat model of Achilles tendon injury. J Bone Joint Surg Am 89: 1315-1320, 2007.
6. Forslund C and Aspenberg P: Improved healing of transected rabbit Achilles tendon after a single injection of cartilage-derived morphogenetic protein-2. Am J Sports Med 31: 555-559, 2003.
7. Zhang F, Liu H, Stile F, Lei MP, Pang Y, Oswald TM, Beck J, Dorsett-Martin W and Lineaweaver WC: Effect of vascular endothelial growth factor on rat Achilles tendon healing. Plast Reconstr Surg 112: 1613-1669, 2003.
8. Batten ML, Hansen JC and Dahners LE: Influence of dosage and timing of application of platelet-derived growth factor on early healing of the rat medial collateral ligament. J Orthop Res 14: 736-741, 1996.
9. Wolloscheck T, Gaumann A, Terzic A, Heintz A, Junginger T and Konerding MA: Inguinal hernia: measurement of the biomechanics of the lower abdominal wall and the inguinal canal. Hernia 8: 233-241, 2004.
10. Weibel ER. Stereological Methods. I. Practical Methods for Biological Morphometry. Academic Press, London, 1979.
11. Junqueira LCU, Bignolas G and Brentani RR: Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J 11: 447-455, 1979.
12. Whittaker P, Kloner RA, Boughner DR and Pickering JG: Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light. Basic Res Cardiol 89: 397-410, 1994.
13. Lohrer H, Arentz S, Nauck T, Dorn-Lange NV and Konerding MA: The Achilles tendon insertion is crescent-shaped: an in vitro anatomic investigation. Clin Orthop Relat Res 466: 2230-2237, 2008.
14. Tallon C, Maffulli N and Ewen SW: Ruptured Achilles tendons are significantly more degenerated than tendinopathic tendons. Med Sci Sports Exerc 33: 1983-1990, 2001.
15. Schlosser MJ, Kapeghian JC and Verlangieri AJ: Selected physical and biochemical parameters in the streptozotocin treated guinea pig: insights into the diabetic guinea pig model. Life Sci 41: 1345-1353, 1987.
16. Ilhami K, Gokhan M, Ulukan I, Eray BM, Levent A and Cigdem T: Biomechanical and histologic comparison of Achilles tendon ruptures reinforced with intratendinous and peritendinous plantaris tendon grafts in rabbits: an experimental study. Arch Orthop Trauma Surg 124: 608-613, 2004.
17. Reddy GK, Stehno-Bittel L and Enwemeka CS: Matrix remodeling in healing rabbit Achilles tendon. Wound Repair Regen 7: 518-527, 1999.
18. Kurtz CA, Loebig TG, Anderson DD, DeMeo PJ and Campbell PG: Insulin-like growth factor I accelerates functional recovery from Achilles tendon injury in a rat model. Am J Sports Med 27: 363-369, 1999.
19. Hildebrand KA, Woo SL, Smith DW, Allen CR, Deie M, Taylor BJ and Schmidt CC: The effects of platelet-derived growth factor-BB on healing of the rabbit medial collateral ligament. An in vivo study. Am J Sports Med 26: 549-554, 1998.
20. Pierce GF, Mustoe TA, Senior RM, Reed J, Griffin GL, Thomason A and Deuel TA: In vivo incisional wound healing augmented by platelet-derived growth factor and recombinant c-sis gene homodimeric proteins. J Exp Med 167: 974-987, 1988.
21. Broughton G II, Janis JE and Attinger CE: Wound healing: an overview. Plast Reconstr Surg 117: 1e-S-32e-S, 2006.
22. Liu PY, Liu K, Wang XT, Badiavas E, Rieger-Christ KM, Tang JB and Summerhayes IC: Efficacy of combination gene therapy with multiple growth factor cDNAs to enhance skin flap survival in a rat model. DNA Cell Biol 24: 751-757, 2005.
23. Pierce GF, Berg JV, Rudolph R, Tarpley J and Mustoe TA: Platelet-derived growth factor BB and transforming growth factor beta 1 selectively modulate glycosamnoglycans, collagen, and myofibroblasts in excisional wounds. Am J Pathol 138: 629-646, 1991.
24. Greenhalgh DG, Sprugel KH, Murray MJ and Ross R: PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am J Pathol 136: 1235-1246, 1990.
25. Bishop JR, Schiksz M and Esko JD: Heparan sulphate proteoglycans fine-tune mammalian physiology. Nature 446: 1030-1037, 2007.
26. Lindahl U: Heparan sulfate-protein interactions - a concept for drug design? Thromb Haemost 98: 109-115, 2007.
27. Stepp MA, Gibson HE, Gala PH, Iglesia DD, Pajoohesh-Ganji A, Pal-Ghosh S, Brown M, Aquino C, Schwartz AM, Goldberger O, Hinkes MT and Bernfield M: Defects in keratinocyte activation during wound healing in the syndecan-1-deficient mouse. J Cell Sci 115: 4517-4531, 2002.
28. Cornelison DD, Wilcox-Adelman SA, Goetinck PF, Rauvala H, Rapraeger AC and Olwin BB: Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration. Genes Dev 18: 2231-2236, 2004.
29. Zhou Z, Wang J, Cao R, Morita H, Soininen R, Chan KM, Liu B, Cao Y and Tryggvason K: Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice. Cancer Res 64: 4699-4702, 2004.
30. Geer DJ, Swartz DD and Andreadis ST: Biomimetic delivery of keratinocyte growth factor upon cellular demand for accelerated wound healing in vitro and in vivo. Am J Pathol 167: 1575-1586, 2005.
31. Zhao Y, Shimizu T, Nishihira J, Koyama Y, Kushibiki T, Honda A, Watanabe H, Abe R, Tabata Y and Shimizu H: Tissue regeneration using macrophage migration inhibitory factor-impregnated gelatin microbeads in cutaneous wounds. Am J Pathol 167: 1519-1529, 2005.