Oxygen uptake kinetics: Historical perspective and future directions

Applied Physiology, Nutrition and Metabolism

Volumn 34, Issue 5, 2009, Pages 840-850

  Hughson, Richard L ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Intracellular PO2; Linear system; Onset of exercise; Oxidative metabolism; Principle of superposition

Indexed keywords

ANIMAL; ANIMAL EXPERIMENT; EXERCISE; HUMAN; OXYGEN CONSUMPTION; PHYSIOLOGY; REST; REVIEW;

ANIMALS; EXERCISE; HUMANS; OXYGEN CONSUMPTION; PHYSICAL CONDITIONING, ANIMAL; REST;

EID: 73649126862     PISSN: 17155312     EISSN: None     Source Type: Journal    
DOI: 10.1139/H09-088     Document Type: Review

References (73)

1. Arthur, P.G., Hogan, M.C., Bebout, D.E., Wagner, P.D., and Hochachka, P.W. 1992. Modeling the effects of hypoxia on ATP turnover in exercising muscle. J. Appl. Physiol. 73(2): 737-742. PMID:1400004.
2. Bangsbo, J., Krustrup, P., González-Alonso, J., Boushel, R., and Saltin, B. 2000. Muscle oxygen kinetics at onset of intense dynamic exercise in humans. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279(3): R899-R906. PMID:10956247.
3. Bangsbo, J., Gibala, M.J., Krustrup, P., González-Alonso, J., and Saltin, B. 2002. Enhanced pyruvate dehydrogenase activity does not affect muscle O2 uptake at onset of intense exercise in humans. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282(1): R273-R280. PMID:11742848.
4. Brittain, C.J., Rossiter, H.B., Kowalchuk, J.M., and Whipp, B.J. 2001. Effect of prior metabolic rate on the kinetics of oxygen uptake during moderate-intensity exercise. Eur. J. Appl. Physiol. 86(2): 125-134. doi:10.1007/s004210100514. PMID:11822471.
5. Brown, G.C. 2001. Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase. Biochim. Biophys. Acta, 1504(1): 46-57. doi:10.1016/S0005-2728(00)00238-3. PMID:11239484.
6. Cerretelli, P., Sikand, R., and Farhi, L.E. 1966. Readjustments in cardiac output and gas exchange during onset of exercise and recovery. J. Appl. Physiol. 21(4): 1345-1350. PMID:5916673.
7. 2. J. Appl. Physiol. 68(3): 833-842. PMID:2187852.
8. Davies, C.T.M., Di Prampero, P.E., and Cerretelli, P. 1972. Kinetics of cardiac output and respiratory gas exchange during exercise and recovery. J. Appl. Physiol. 32(5): 618-625. PMID: 5038849.
9. Di Prampero, P.E., Davies, C.T.M., Cerretelli, P., and Margaria, R. 1970. An analysis of O2 debt contracted in submaximal exercise. J. Appl. Physiol. 29(5): 547-551. PMID:5474842.
10. Erecinska, M., and Wilson, D.F. 1982. Regulation of cellular energy metabolism. J. Membr. Biol. 70(1): 1-14. doi:10.1007/BF01871584. PMID:6226798.
11. Faisal, A., Beavers, K.R., Robertson, A.D., and Hughson, R.L. 2009. Prior moderate and heavy exercise accelerate oxygen up-take and cardiac output kinetics in endurance athletes. J. Appl. Physiol. 106(5): 1553-1563. doi:10.1152/japplphysiol.91550. 2008. PMID:19246653.
12. Frandsenn, U., Bangsbo, J., Sander, M., Höffner, L., Betak, A., Saltin, B., and Hellsten, Y. 2001. Exercise-induced hyperaemia and leg oxygen uptake are not altered during effective inhibition of nitric oxide synthase with N(G)-nitro-L-arginine methyl ester in humans. J. Physiol. 531(Pt 1): 257-264. doi:10.1111/j.1469-7793.2001.0257j.x. PMID:11179408.
13. Graham, T.E., and Saltin, B. 1989. Estimation of the mitochondrial redox state in human skeletal muscle during exercise. J. Appl. Physiol. 66(2): 561-566. PMID:2565330.
14. Grassi, B. 2001. Regulation of oxygen consumption at exercise onset: is it really controversial? Exerc. Sport Sci. Rev. 29(3): 134-138. doi:10.1097/00003677-200107000-00009. PMID:11474962.
15. Grassi, B. 2003. Oxygen uptake kinetics: old and recent lessons from experiments on isolated muscle in situ. Eur. J. Appl. Physiol. 90(3-4): 242-249. doi:10.1007/s00421-003-0994-0. PMID: 14556076.
16. 2) on-kinetics in isolated in situ canine muscle. J. Appl. Physiol. 85(4): 1394-1403. PMID:9760333.
17. Grassi, B., Hogan, M.C., Greenhaff, P.L., Hamann, J.J., Kelley, K.M., Aschenbach, W.G., et al. 2002. Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate. J. Physiol. 538(Pt 1): 195-207. doi:10.1113/jphysiol.2001.012984. PMID:11773328.
18. Green, H.J., Cadefau, J., Cussó, R., Ball-Burnett, M., and Jamieson, G. 1995. Metabolic adaptations to short-term training are expressed early in submaximal exercise. Can. J. Physiol. Pharmacol. 73(4): 474-482. PMID:7671190.
19. 2 kinetics during moderate-intensity exercise in young adults. J. Appl. Physiol. 98(4): 1371-1378. doi:10.1152/japplphysiol.01028. 2004. PMID:15579570.
20. 2 uptake kinetics, pyruvate dehydrogenase activity, and muscle deoxygenation in young and older adults during the transition to moderate-intensity exercise. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294(2): R577-R584. PMID:18032470.
21. Haseler, L.J., Richardson, R.S., Videen, J.S., and Hogan, M.C. 1998. Phosphocreatine hydrolysis during submaximal exercise: the effect of FIO2. J. Appl. Physiol. 85(4): 1457-1463. PMID: 9760341.
22. 22 availability. J. Appl. Physiol. 86(6): 2013-2018. PMID:10368368.
23. Haseler, L.J., Lin, A., Hoff, J., and Richardson, R.S. 2007. Oxygen availability and PCr recovery rate in untrained human calf muscle: evidence of metabolic limitation in normoxia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293(5): R2046-R2051. PMID:17715186.
24. Henry, F.M. 1951. Aerobic oxygen consumption and alactic debt in muscular work. J. Appl. Physiol. 3(7): 427-438. PMID: 14803395.
25. Henry, F.M., and De Moor, J.C. 1956. Lactic and alactic oxygen consumption in moderate exercise of graded intensity. J. Appl. Physiol. 8(6): 608-614. PMID:13331844.
26. Hill, A.V., Long, C.N.H., and Lupton, H. 1924. Muscular exercise, lactic acid, and supply and utilization of oxygen. Proc. R. Soc. Lond. [Biol.], 97: 84-96.
27. 2 in regulating tissue respiration in dog muscle working in situ. J. Appl. Physiol. 73(2): 728-736. PMID:1400003.
28. 2-debt at severe work. Arbeitsphysiologie, 14(3): 251-254. PMID:14783387.
29. Hughson, R.L. 1984. Alterations in the oxygen deficit-oxygen debt relationships with beta-adrenergic receptor blockade in man. J. Physiol. 349: 375-387. PMID:6429319.
30. Hughson, R.L., and Morrissey, M.A. 1982. Delayed kinetics of respiratory gas exchange in the transition from prior exercise. J. Appl. Physiol. 52(4): 921-929. PMID:6806226.
31. 2 kinetics: a review. Int. J. Sports Med. 4(1): 31-39. PMID:6341268.
32. Hughson, R.L., Rouleau, M., and Jones, N.L. 1978. Oxygen uptake kinetics at onset of exercise in man with and without beta-blockade. Fed. Proc. 37: 580. [Abstract.]
33. Hughson, R.L., Shoemaker, J.K., Tschakovsky, M.E., and Kowalchuk, J.M. 1996. Dependence of muscle VO2 on blood flow dynamics at onset of forearm exercise. J. Appl. Physiol. 81(4): 1619-1626. PMID:8904578.
34. Hughson, R.L., O'Leary, D.D., Betik, A.C., and Hebestreit, H. 2000. Kinetics of oxygen uptake at the onset of exercise near or above peak oxygen uptake. J. Appl. Physiol. 88(5): 1812-1819. PMID:10797146.
35. Hughson, R.L., Tschakovsky, M.E., and Houston, M.E. 2001. Regulation of oxygen consumption at the onset of exercise. Exerc. Sport Sci. Rev. 29(3): 129-133. doi:10.1097/00003677-200107000-00008. PMID:11474961.
36. 2 kinetics in the transition to moderate-intensity exercise in man. J. Physiol. 552(Pt.): 265-272. doi:10.1113/jphysiol.2003.045799. PMID: 12897178.
37. Krogh, A., and Lindhard, J. 1913. The regulation of respiration and circulation during the initial stages of muscular work. J. Physiol. 47(1-2): 112-136. PMID:16993229.
38. Krustrup, P., Secher, N.H., Relu, M.U., Hellsten, Y., Söderlund, K., and Bangsbo, J. 2008. Neuromuscular blockade of slow twitch muscle fibres elevates muscle oxygen uptake and energy turnover during submaximal exercise in humans. J. Physiol. 586(Pt. 24): 6037-6048. doi:10.1113/jphysiol.2008.158162. PMID:18955384.
39. Lai, N., Nasca, M.M., Silva, M.A., Silva, F.T., Whipp, B.J., and Cabrera, M.E. 2008. Influence of exercise intensity on pulmonary oxygen uptake kinetics at the onset of exercise and recovery in male adolescents. Appl. Physiol. Nutr. Metab. 33(1): 107-117. doi:10.1139/H07-154. PMID:18347660.
40. Linnarsson, D. 1974. Dynamics of pulmonary gas exchange and heart rate changes at start and end of exercise. Acta Physiol. Scand. Suppl. 415: 1-68. PMID:4621315.
41. Linnarsson, D., Karlsson, J., Fagraeus, L., and Saltin, B. 1974. Muscle metabolites and oxygen deficit with exercise in hypoxia and hyperoxia. J. Appl. Physiol. 36(4): 399-402. PMID: 4820319.
42. MacDonald, M.J., Shoemaker, J.K., Tschakovsky, M.E., and Hughson, R.L. 1998. Alveolar oxygen uptake and femoral artery blood flow dynamics in upright and supine leg exercise in humans. J. Appl. Physiol. 85(5): 1622-1628. PMID:9804561.
43. MacDonald, M.J., Tarnopolsky, M.A., and Hughson, R.L. 2000. Effect of hyperoxia and hypoxia on leg blood flow and pulmonary and leg oxygen uptake at the onset of kicking exercise. Can. J. Physiol. Pharmacol. 78(1): 67-74. doi:10.1139/cjpp-78-1-67. PMID:10741762.
44. MacDonald, M.J., Naylor, H.L., Tschakovsky, M.E., and Hughson, R.L. 2001. Peripheral circulatory factors limit rate of increase in muscle O(2) uptake at onset of heavy exercise. J. Appl. Physiol. 90(1): 83-89. PMID:11133896.
45. 2 and phosphorylcreatine level. Implications for the control of respiration. J. Gen. Physiol. 86(1): 135-165. doi:10.1085/jgp.86.1.135. PMID:4031824.
46. Marcinek, D.J., Ciesielski, W.A., Conley, K.E., and Schenkman, K.A. 2003. Oxygen regulation and limitation to cellular respiration in mouse skeletal muscle in vivo. Am. J. Physiol. Heart Circ. Physiol. 285(5): H1900-H1908. PMID:12775561.
47. Margaria, R., Edwards, H.T., and Dill, D.B. 1933. The possible mechanisms of contracting and paying the oxygen debt and the role of lactic acid in muscular contraction. Am. J. Physiol. 106(3): 689-715.
48. Margaria, R., Mangili, F., Cuttica, F., and Cerretelli, P. 1965. The kinetics of the oxygen consumption at the onset of muscular exercise in man. Ergonomics, 8(1): 49-54. doi:10.1080/00140136508930773.
49. Murphy, P.C., Cuervo, L.A., and Hughson, R.L. 1989. A study of cardiorespiratory dynamics with step and ramp exercise tests in normoxia and hypoxia Cardiovasc. Res. 23(10):825-832. doi:10. 1093/cvr/23.10.825. PMID:2620311.
50. Ozyener, F., Rossiter, H.B., Ward, S.A., and Whipp, B.J. 2001. Influence of exercise intensity on the onand off-transient kinetics of pulmonary oxygen uptake in humans. J. Physiol. 533(Pt. 3): 891-902. doi:10.1111/j.1469-7793.2001.t01-1-00891.x. PMID: 11410644.
51. 2 uptake at exercise onset in nonischemic human forearm. J. Appl. Physiol. 91(5): 2010-2016. PMID:11641338.
52. 2 kinetics at the onset of submaximal exercise. J. Appl. Physiol. 79(6): 1914-1920. PMID:8847253.
53. Phillips, S.M., Green, H.J., Tarnopolsky, M.A., Heigenhauser, G.J., and Grant, S.M. 1996. Progressive effect of endurance training on metabolic adaptations in working skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 270(2 Pt. 1): E265-E272. PMID: 8779948.
54. Poole, D.C., Schaffartzik, W., Knight, D.R., Derion, T., Kennedy, B., Guy, H.J., et al. 1991. Contribution of exercising legs to the slow component of oxygen uptake kinetics in humans. J. Appl. Physiol. 71(4): 1245-1260. PMID:1757346.
55. Poole, D.C., Barstow, T.J., McDonough, P., and Jones, A.M. 2008. Control of oxygen uptake during exercise. Med. Sci. Sports Exerc. 40(3): 462-474. doi:10.1249/MSS.0b013e31815ef29b. PMID:18379208.
56. Pringle, J.S., Doust, J.H., Carter, H., Tolfrey, K., Campbell, I.T., Sakkas, G.K., and Jones, A.M. 2003. Oxygen uptake kinetics during moderate, heavy and severe intensity "submaximal" exercise in humans: the influence of muscle fibre type and capillarisation. Eur. J. Appl. Physiol. 89(3-4): 289-300. doi:10.1007/s00421-003-0799-1. PMID:12736837.
57. 2 transport. J. Clin. Invest. 96(4): 1916-1926. doi:10.1172/JCI118237. PMID:7560083.
58. 2. J. Appl. Physiol. 85(2): 627-634. PMID:9688741.
59. Richardson, R.S., Noyszewski, E.A., Haseler, L.J., Bluml, S., and Frank, L.R. 2002. Evolving techniques for the investigation of muscle bioenergetics and oxygenation. Biochem. Soc. Trans. 30(2): 232-237. doi:10.1042/BST0300232. PMID:12023857.
60. 2 up-take with respect to intramuscular [phosphocreatine] kinetics during moderate exercise in humans. J. Physiol. 518(Pt. 3): 921-932. doi:10.1111/j.1469-7793.1999.0921p.x. PMID: 10421675.
61. Rossiter, H.B., Ward, S.A., Kowalchuk, J.M., Howe, F.A., Griffiths, J.R., and Whipp, B.J. 2001. Effects of prior exercise on oxygen uptake and phosphocreatine kinetics during high-intensity knee-extension exercise in humans. J. Physiol. 537(Pt. 1): 291-303. doi:10.1111/j.1469-7793.2001.0291k.x. PMID:11711581.
62. Rossiter, H.B., Ward, S.A., Howe, F.A., Wood, D.M., Kowalchuk, J.M., Griffiths, J.R., and Whipp, B.J. 2003. Effects of dichloroacetate on VO2 and intramuscular 31P metabolite kinetics during high-intensity exercise in humans. J. Appl. Physiol. 95(3): 1105-1115. PMID:12754181.
63. 2) uptake is not accompanied by changes in muscle EMG during repeated bouts of heavy exercise in humans. J. Physiol. 531(Pt 1): 245-256. doi:10.1111/j.1469-7793.2001.0245j.x. PMID:11179407.
64. Shinohara, M., and Moritani, T. 1992. Increase in neuromuscular activity and oxygen uptake during heavy exercise. Ann. Physiol. Anthropol. 11(3): 257-262. PMID:1642722.
65. Shoemaker, J.K., Phillips, S.M., Green, H.J., and Hughson, R.L. 1996. Faster femoral artery blood velocity kinetics at the onset of exercise following short-term training. Cardiovasc. Res. 31(2): 278-286. PMID:8730405.
66. Sietsema, K.E., Ben-Dov, I., Zhang, Y.Y., Sullivan, C., and Wasserman, K. 1994. Dynamics of oxygen uptake for submaximal exercise and recovery in patients with chronic heart failure. Chest, 105(6): 1693-1700. doi:10.1378/chest.105.6.1693. PMID: 8205862.
67. Tordi, N., Perrey, S., Harvey, A., and Hughson, R.L. 2003. Oxygen uptake kinetics during two bouts of heavy cycling separated by fatiguing sprint exercise in humans. J. Appl. Physiol. 94(2): 533-541. PMID:12391053.
68. Tschakovsky, M.E., and Hughson, R.L. 1999. Interaction of factors determining oxygen uptake at the onset of exercise. J. Appl. Physiol. 86(4): 1101-1113. PMID:10194190.
69. 2 uptake kinetics during heavy exercise. Med. Sci. Sports Exerc. 26(11): 1319-1326. PMID:7741865.
70. Whipp, B.J., and Mahler, M. 1980. Dynamics of pulmonary gas exchange during exercise. In Pulmonary gas exchange. Vol. II. Edited by J.B. West. Academic Press Inc., New York, N.Y. pp. 33-96.
71. Whipp, B.J., and Wasserman, K. 1972. Oxygen uptake kinetics for various intensities of constant-load work. J. Appl. Physiol. 33(3): 351-356. PMID:5056210.
72. Whipp, B.J., Rossiter, H.B., and Ward, S.A. 2002. Exertional oxygen uptake kinetics: a stamen of stamina? Biochem. Soc. Trans. 30(2): 237-247. doi:10.1042/BST0300237. PMID:12023858.
73. Wilson, D.F., and Rumsey, W.L. 1988. Factors modulating the oxygen dependence of mitochondrial oxidative phosphorylation. Adv. Exp. Med. Biol. 222: 121-131. PMID:2834920.