Evaluation of in vivo antitrypanosomal activity of selected medicinal plant extracts

Journal of Medicinal Plants Research

Volumn 3, Issue 11, 2009, Pages 849-854

  Peter, Ogoti ^a   Magiri, Esther ^a   Auma, Joanna ^b   Magoma, Gabriel ^a   Imbuga, Mabel ^a   Murilla, Grace ^b  

^a JOMO KENYATTA UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Kenya)

^b KENYA AGRICULTURAL RESEARCH INSTITUTE   (Kenya)

Author keywords

Antitrypanosomal activity; Human African tryponosomiasis; Kigelia africana; Packed cell volume

Indexed keywords

ARTEMESIA ANNUA EXTRACT; AZADIRACHTA INDICA EXTRACT; BIDENS PILOSA EXTRACT; DICHLOROMETHANE; KIGELIA AFRICANA EXTRACT; MELARSOPROL; METHANOL; PLANT EXTRACT; SURAMIN; UNCLASSIFIED DRUG; WATER;

AFRICAN TRYPANOSOMIASIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTEMESIA ANNUA; ARTICLE; AZADIRACHTA INDICA; BIDENS PILOSA; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFICACY; DRUG ISOLATION; DRUG SCREENING; EXPERIMENTAL MODEL; FRUIT; HEMATOCRIT; IN VIVO STUDY; KIGELIA AFRICANA; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; PARASITEMIA; SURVIVAL TIME; TRYPANOSOMA BRUCEI;

ANIMALIA; ARTEMESIA; AZADIRACHTA INDICA; BIDENS PILOSA; KIGELIA AFRICANA; MUS; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 73649118527     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Barrett MP (1999). The fall and rise of sleeping sickness. Lancet 353: 1113-1114
2. Camacho MDR, Croft SL, Phillipson JD (2000a). Natural products as source of antiprotozoal drugs. Curr. Opin. Anti-infect. Investig. Drugs 2: 47-62.
3. Freiburghaus F, Kaminsky R, Brun R (1996). Evaluation of Africa medicinal plants for their in vitro trypanocidal activity; J. Ethnopharmacol. 55: 1-11.
4. Grace OM, Light MF, Lindiscy KI, Moholland DA, Staden JV, Jager AK (2002). Antibacterial activity and isolation of antibacterial compounds from the fruit of the traditional African medicinal plant Kigali africana. S. Afr. J. Bot. 68: 220-222.
5. Kirby GC (1996). Medicinal plants and the control of parasites: medicinal plants and control of protozoal disease with particular reference to malaria. Trans. R. Soc. Trop. Med. Hyg. 90: 605-609.
6. Legros D, Ollivier G, Gastellu-Etchegorry M (2002). Treatment of human African trypanosomiasis- present situation and needs for research and development. Lancet Infect. Dis. 20: 437-440.
7. Neuwinger HD (2000). African Traditional Medicine: A Dictionary of plants Use and Application. Medpharm, Stuttgart.
8. Owolabi OJ, Amaechina FC, Eledan AB (2008). Central nervous system stimulant effect of the ethanolic extract of Kigeria africana. J. Med Plant Res. 2(1): 20-23.
9. Owolabi OJ, Omogbai FKI (2007). Analgesic and anti-inflammatory activities of the ethanolic stem bark extract of Kigelia africana . Afr. J. Biotechnol. 6: 582-585.
10. Tagboto S, Townson S (2001). Antiparasitic properties of medicinal plants and other naturally occurring products. Adv. Parasitol. 50: 199-295.
11. Youan BBC, Coulibaly S, Miezen TB, Doua F, Bamba M (1997). In vivo evaluation of 16 plant extracts on mice inoculated with T.b. gambiense. Bull. WHO. 75: 343-348.