Retrospective analysis of clinical yeast isolates in a hospital in the centre of Portugal: Spectrum and revision of the identification procedures

Medical Mycology

Volumn 47, Issue 8, 2009, Pages 836-844

  Paulo, Cristina ^a,b   Mourão, Cristina ^a,b   Veiga, Pedro M ^c   Marques, Joana M ^a,b   Rocha, Graça ^b   Alves, Ana F ^d   Querol, Amparo ^c   Meliço Silvestre, António A ^a   Gonçalves, Isabel ^e   Flores, Orfeu ^f   Clemente, Carla ^f   Gonçalves, Teresa ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^d INSTITUTO DE AGROQUÍMICA Y TECNOLOGÍA DE ALIMENTOS CSIC   (Spain)

^e STAB Vida Lda   (Portugal)

^f STAB Vida Lda ^*  (Portugal)

Author keywords

Candida metapsilosis; Candida orthopsilosis; Molecular yeast identifi cation; Risk factor; Yeast infections

Indexed keywords

RIBOSOME RNA; FUNGAL DNA;

ADOLESCENT; ADULT; AGED; ARTICLE; CANDIDA GLABRATA; CANDIDA KRUSEI; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CHILD; CONTROLLED STUDY; FEMALE; FUNGUS IDENTIFICATION; FUNGUS ISOLATION; GENE SEQUENCE; HOSPITAL; HOSPITAL LABORATORY; HUMAN; MAJOR CLINICAL STUDY; MALE; MYCOSIS; PORTUGAL; PRESCHOOL CHILD; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RETROSPECTIVE STUDY; SCHOOL CHILD; YEAST; CANDIDA; CANDIDIASIS; CLASSIFICATION; GENETICS; INFANT; ISOLATION AND PURIFICATION; MICROBIOLOGY; MIDDLE AGED; POLYMERASE CHAIN REACTION; RISK FACTOR; STATISTICAL MODEL;

CANDIDA METAPSILOSIS; CANDIDA ORTHOPSILOSIS; CANDIDA PARAPSILOSIS;

ADOLESCENT; ADULT; AGED; CANDIDA; CANDIDIASIS; CHILD; CHILD, PRESCHOOL; DNA, FUNGAL; FEMALE; HUMANS; INFANT; LOGISTIC MODELS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PORTUGAL; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 73649102062     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.3109/13693780802709081     Document Type: Article

References (59)

1. Voss A, Hollis RJ, Pfaller MA, Wenzel RP, Doebbeling BN. Investigation of the sequence of colonization and candidemia in nonneutropenic patients. J Clin Microbiol 1994; 32: 975-980.
2. Reagan DR, Pfaller MA, Hollis RJ, Wenzel RP. Characterization of the sequence of colonization and nosocomial candidemia using DNA fingerprinting and a DNA probe. J Clin Microbiol 1990; 28: 2733-2738.
3. Burnie JP, Odds FC, Lee W, Webster C, Williams JD. Outbreak of systemic Candida albicans in an intensive care unit caused by cross infection. British Med J 1985; 290: 746-748.
4. Betremieux P, Chevrier S, Quindos G, et al. Use of DNA fingerprinting and biotyping methods to study a Candida albicans outbreak in a neonatal intensive care unit. Pediatr Infect Dis J 1994; 13: 899-905.
5. Vaudry WL, Tierney AJ, Wenman WM. Investigation of a cluster of Candida albicans in a neonatal intensive care unit. J Infect Dis 1988; 158: 1376- 1379 0.
6. Hedderwick SA, Lyons MJ, Liu M, Vazquez JA, Kauffman CA. Epidemiology of yeast colonization in the intensive care unit. Eur J Clin Microbiol Infect Dis 2000; 19: 663-670.
7. Eggimann P, Garbino J, Pittet D. Epidemiology of Candida species in critically ill non-immunosuppressed patients. Lancet Infect Dis 2003; 3: 685-702. (Pubitemid 37345347)
8. Richardson MD. Changing patterns and trends in systemic fungal infections. J Antimicrob Chemother 2005; 56 ( Suppl. 1 ): i5-i11.
9. Sendid B, Cotteau A, François N, et al. Candidaemia and antifungal therapy in a French university hospital: Rough trends over a decade and possible links. BMC Infect Dis 2006; 6: 80-89.
10. Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 2007; 20: 133-163.
11. Walsh TJ, Groll A, Hiemenz J, et al. Infections due to emerging and uncommon medically important fungal pathogens. Clin Microbiol Infec 2004; 10: 48-66.
12. Costa-de-Oliveira S, Pina-Vaz C, Mendonça D, Gonçalves- Rodrigues A. A first Portuguese epidemiological survey of fungaemia in a university hospital. Eur J Clin Microbiol Infect Dis 2008; 24: 23-30.
13. Pappas PG, Rex JH, Lee J, et al. Prospective observational study of candidemia: epidemiology, therapy, and influences on mortality in hospitalized adult and pediatric patients. Clin Infect Dis 2003; 37: 634-643.
14. Sanglard D, Odds FC. Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences. Lancet Infect Dis 2002; 2: 73-85.
15. Buchner T, Fegeler W, Bernhardt H, et al. Treatment of severe Candida infections in high-risk patients in Germany: consensus formed by a panel of interdisciplinary investigators. Eur J Clin Microbiol Infect Dis 2002; 21: 337-352.
16. Pappas PG, Rex JH, Sobel JD, et al. Guidelines for the treatment of candidiasis. Clin Infect Dis 2004; 38: 161-189.
17. Hoppe JE, Frey P. Evaluation of six commercial tests and the germ-tube test for presumptive identification of Candida albicans. Eur J Clin Microbiol 1999; 18: 188-191.
18. Borman AM, Linton CJ, Miles SJ, Johnson EM. Molecular identification of pathogenic fungi. J Antimicrob Chemother 2008; 61: i7-i12.
19. Guillamón JM, Sabaté J, Barrio E, Cano J, Querol A. Rapid identification of wine yeast species based on RFLP analysis of the ribosomal ITS regions. Arch Microbiol 1998; 169: 387-392.
20. Esteve-Zarzoso B, Belloch C, Uruburu F, Querol A. Identification of yeasts by RFLP analysis of the 5.8S rRNA gene and the two ribosomal internal transcribed spacers. Int J Syst Bacteriol 1999; 49: 329-337.
21. Llanos-Frutos R, Fernández-Espinar MT, Querol A. Identification of species of the genus Candida by analysis of the 5.8S rRNA gene and the two ribosomal internal transcribed spacers. Anton Leeuw Int J G 2004; 85: 175-185.
22. Kurtzman CP, Robnett CJ. Identification and phylogeny of ascomycetous yeasts from analysis of nuclear large subunit (26S) ribosomal DNA partial sequences. Anton Leeuw Int J G 1998; 73: 331-371.
23. Tavanti A, Davidson AD, Gow NAR, Maiden MCJ, Odds FC. Candida orthopsilosis and Candida metapsilosis spp. nov. to replace Candida parapsilosis Groups II and III. J Clin Microbiol 2005; 43: 284-292.
24. León C, Ruiz-Santana S, Saavedra P, et al. EPCAN Study Group. A bedside scoring system (" Candida score") for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization. Crit Care Med 2006; 34: 730-737.
25. Thomas DP, Bachmann SP, Lopez-Ribot JL. Proteomics for the analysis of the Candida albicans biofilm lifestyle. Proteomics 2006; 6: 5795-5804.
26. Nucci M, Marr KA. Emerging fungal diseases. Clin Infect Dis. 2005; 41: 521-526.
27. Essman M, Larsen B. Protective effect of the selective estrogen receptor modulator LY117018 on rat vaginal Candida albicans colonization. Gynecol Obstet Invest 2000; 49: 57-61.
28. Peleg AY, Weerarathna T, McCarthy JS, Davis TM. Common infections in diabetes: pathogenesis, management and relationship to glycaemic control. Diabetes Metab Res Rev 2007; 23: 3-13.
29. Ostrosky-Zeichner L, Sable C, Sobel J, et al. Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting. Eur J Clin Microbiol Infect Dis 2007; 26: 271-276.
30. Fidel PL. Candida -host interactions in HIV disease: Relationships in oropharyngeal candidiasis. Adv Dent Res 2006; 19: 80-84.
31. Aw D, Silva AB, Palmer DB. Immunosenescence: emerging challenges for an ageing population. Immunology. 2007; 120: 435-446.
32. Laube S. Skin infections and ageing. A geing Res Rev 2004; 3: 69-89.
33. Brawner DL, Cutler JE. Oral Candida albcans isolates from non-hospitalized normal carriers, immunocompetent hospitalized patients, and immunocompromised patients with or without acquired immunodeficiency syndrome. J Clin Microbiol 1989; 27: 1335-1341.
34. Kullberg BJ, Oude-Lashof AML. Epidemiology of opportunistic invasive mycoses. Eur J Med Res 2002; 7: 183-191.
35. Odds FC, Hanson MF, Davidson AD, et al. One year prospective survey of Candida bloodstream infections in Scotland. J Med Microbiol 2007; 56: 1066-1075.
36. Ellepola AN, Morrison CJ. Laboratory diagnosis of invasive candidiasis. J Microbiol 2005; 43: 65-84.
37. Horvath LL, Hospenthal DR, Murray CK, Dooley DP. Detection of simulated candidemia by the BACTEC 9240 system with Plus Aerobic/F and Anaerobic/F Blood Culture Bottles. J Clin Microbiol 2003; 41: 4714-4717.
38. MaaroufiY, De Bruyne JM, Duchateau V, Georgala A, Crokaert F. Early detection and identification of commonly encountered Candida species from simulated blood cultures by using a real-time PCR-based assay. J Molec Diagn 2004; 41: 3293-3298.
39. White PL, Barton R, Guiver M, et al. Consensus on fungal polymerase chain reaction diagnosis? A United-Kingdom-Ireland evaluation of polymerase chain reaction methods for detection of systemic fungal infections. J Mol Diagn 2006; 8: 376-384.
40. White TJ, Bruns T, Lee S, Taylor J. Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics. In Innis MA, Gelfand Dh, Sninsky JJ, White TJ, (eds.) PCR Protocols: a Guide to Methods and Applications, San Diego CA: Academic Press 1990; 315-322.
41. Trost A, Graf B, Eucker J, et al. Identification of clinically relevant yeasts by PCR/RFLP. J Microb Meth 2003; 56: 201-211.
42. Fridkin SK. The changing face of fungal infections in health care settings. Clin Infect Dis 2005; 41: 1455-1460.
43. García-Martos P, Domínguez I, Marin P, et al. Antifungal susceptibility of emerging yeast pathogens. Enferm Infec Microbiol Clin 2001; 19: 249-256.
44. Ruiz-Diez B, Martinez V, Alvarez M, Rodriguez-Tudela JL, Martinez-Suarez JV. Molecular tracking of Candida albicans in a neonatal intensive care unit: long-term colonizations versus catether related infections. J Clin Microbiol 1997; 35: 3032-3036.
45. Reef SE, Lasker BA, Butcher DS, et al. Nonperinatal nosocomial transmission of Candida albicans in a neonatal intensive care unit: prospective study. J Clin Microbiol 1998; 36: 1255-1259.
46. Waggoner-Fountain LA, Walker MW, Hollis RJ, et al. Vertical and horizontal transmission of unique Candida species to premature newborns. Clin Infect Dis 1996; 22: 803-808.
47. Rangel-Frausto MS, Houston AK, Bale MJ, Fu C, Wenzel RP. An experimental model for study of Candida survival and transmission in human volunteers. Eur J Clin Microbiol Infect Dis 1994; 13: 590-595.
48. de Llanos-Frutos R, Fernandez-Espinar MT, Querol A. A comparison of clinical and food Saccharomyces cerevisiae isolates on the basis of the potential virulence factors. Anton Leeuw Int J G 2006; 90: 221-231.
49. Meis JF, Lunel FM, Verweij PE, Voss A. One-year prevalence of Candida dubliniensis in a Dutch university hospital. J Clin Microbiol 2000; 38: 3139-3140.
50. Mosaid A, Sullivan D, Salkin IF, Shanley S, Coleman DC. Differentiation of Candida dubliniensis from Candida albicans on Staib Agar and Caffeic Acid-Ferric Citrate Agar. J Clin Microbiol 2001; 39: 323-327.
51. Jabra RM, Baqui AA, Kelley JA, et al. Identification of Candida dubliniensis in a prospective study of patients in the United States. J Clin Microbiol 1999; 37: 321-326.
52. Jabra-Rizk MA, Johnson JK, Forrest G, et al. Prevalence of Candida dubliniensis fungemia at a large teaching hospital. Clin Infect Dis 2005; 41: 1064-1067.
53. Clark TA, Morgan J, Brandt M, et al. Hospital outbreak of Candida parapsilosis bloodstream infections - Mississippi, 2001. Proceedings of the 42nd Intersci Conf Antimicrob Agents Chemother, San Diego, California. 2002 : M-880.
54. Gácser A, Schäfer W, Nosanchuk JS, Salomon S, Nosanchuk JD. Virulence of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis in reconstituted human tissue models. Fungal Genet Biol 2007; 44: 1336-1341.
55. Kocsubé S, Tóth M, Vágvölgyi C, et al. Occurrence and genetic variability of Candida parapsilosis sensu lato in Hungary. J Med Microbiol 2007; 56: 190-195.
56. Gomez-Lopez A, Alastruey-Izquierdo A, Rodriguez D, et al. Prevalence and susceptibility profile of Candida metapsilosis and Candida orthopsilosis. Results from population-based surveillance of candidemia in Spain. Antimicrob Agents Chemother 2008; 52: 1506-1509.
57. Ascioglu S, Rex JH, de Pauw B, et al. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 2002; 34: 7-14.
58. O'Donnell K. Ribosomal DNA internal transcribed spacers are highly divergent in the phytopathogenic ascomycete Fusarium sambucinum ( Gibberella pulicaris ). Curr Genet 1992; 22: 213-220.
59. Agvald-Öhman C, Klingspor L, Hjelmqvist H, Edlund C. Invasive candidiasis in long-term patients at a multidisciplinary intensive care unit: Candida colonization index, risk factors, treatment and outcome. Scand J Infect Dis 2008; 40: 145-153.