Synthesis, antitumor activity and molecular docking study of novel Sulfonamide-Schiff's bases, thiazolidinones, benzothiazinones and their C-nucleoside derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2010, Pages 572-580

  Kamel, Mohsen M ^a   Ali, Hamed I ^b   Anwar, Manal M ^a   Mohamed, Neama A ^a   Soliman, AbdelMohsen M ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b Helwan   (Egypt)

Author keywords

Antitumor activity; Autodock; Benzothiazin 4 one; Protein tyrosine kinase; Sugar Schiff's base; Thiazolidin 4 one

Indexed keywords

(3,4 DIMETHOXYPHENYL) 3 [4 [(PYRIDIN 2 YLAMINO)SULFONYL] PHENYL] THIAZOLIDIN 4 ONE; 2 (2 HYDROXY 4 METHOXYPHENYL) 3 [4 (PYRIDIN 2 YLAMINO) SULFONYL] PHENYL]THIAZOLIDIN 4 ONE; 2 (2 HYDROXY 4 METHOXYPHENYL) 3 [4 [(PYRIDIN 2 YLAMINO)SULFONYL] PHENYL] 2,4 DIHYDROBENZO[E][1,3]THIAZIN 4 ONE; 2 (3 INDOLYL) 3 [4 (PYRIDIN 2 YLAMINO)SULFONYL]PHENYL]THIAZOLIDIN 4 ONE; 2 (3 INDOLYL) 3 [4 [(PYRIDIN 2 YLAMINO)SULFONYL]PHENYL] 2,4 DIHYDROBENZO[E] [1,3 THIAZIN 4 ONE; 2 (3,4 DIMETHOXYPHENYL) 3 [4 [(PYRIDIN 2 YLAMINO)SULFONYL]PHENYL] 2,4 DIHYDRO BENZO[E][1,3]THIAZIN 4 ONE; 2 (3,4,5 TRIMETHOXYPHENYL) 3 [4 (PYRIDIN 2 YLAMINO)SULFONYL]PHENYL]THIAZOLIDIN 4 ONE; 2 (3,4,5 TRIMETHOXYPHENYL) 3 [4 [(PYRIDIN 2 YLAMINO)SULFONYL]PHENYL] 2,4 DIHYD ROBENZO[E][1,3]THIAZIN 4 ONE; 2 (P METHOXYPHENYL) 3 [4 [(PRYRIDIN 2 YLAMINO)SULFONYL]PHENYL] THIAZOLIDIN 4 ONE; 2 (P METHOXYPHENYL) 3 [4 [(PYRIDIN 2 YLAMINO)SULFONYL] PHENYL] 2,4DIHYDROBENZO [E][1,3]THIAZIN 4 ONE; 2 [1 (1,2,3,4 TETRAHYDROXYBUTYL)] [4 [(PYRIDIN 2 YLAMINO)SULFONYL]PHENYL]THIAZO LIDIN 4 ONE; ALDEHYDE; BENZOTHIADIAZINE DERIVATIVE; C NUCLEOSIDE; DOXORUBICIN; FLUOROURACIL; MONOSACCHARIDE; N (2 HYDROXYL 4 METHOXYPHENYLIDENE) IMINO 4 [(PYRIDIN 2 YLAMINO)SULFONYL] BENZENE; N (3 INDOLMETHYLIDENE) IMINO 4 [(PYRIDIN 2 YLAMINO) SULFONYL] BENZENE; N (3,4 DIMETHOXYPHENYLIDENE) IMINO 4 [(PYRIDIN 2 YLAMINO) SULFONYL] BENZENE; N (3,4,5 TRIMETHOXYPHENYLIDENE) IMINO 4 [(PYRIDIN 2 YLAMINO) SULFONYL]BENZENE; N (P METHOXYPHENYLIDENE) IMINO 4 [(PYRIDIN 2 YLAMINO)SULFONYL] BENZENE; PROTEIN TYROSINE KINASE INHIBITOR; SCHIFF BASE; SULFONAMIDE; THIAZOLIDINE DERIVATIVE; THIOGLYCOLIC ACID DERIVATIVE; THIOSALICYLIC ACID; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CYTOTOXICITY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; MOLECULAR DOCKING; POLYMERIZATION; UTERINE CERVIX CARCINOMA;

ANTINEOPLASTIC AGENTS; BENZOTHIAZOLES; CELL LINE, TUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; NUCLEOSIDES; PROTO-ONCOGENE PROTEINS C-KIT; REPRODUCIBILITY OF RESULTS; SULFONAMIDES; THIAZOLIDINES;

EID: 73549105462     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.10.044     Document Type: Article

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