Molecular analysis of db gene-related pancreatic β cell dysfunction; evidence for a compensatory mechanism inhibiting development of diabetes in the db gene heterozygote

Endocrine Journal

Volumn 56, Issue 8, 2009, Pages 997-1008

  Kanda, Yukiko ^a   Shimoda, Masashi ^a   Tawaramoto, Kazuhito ^a   Hamamoto, Sumiko ^a   Tatsumi, Fuminori ^a   Kawasaki, Fumiko ^a   Hashiramoto, Mitsuru ^a   Nakashima, Koji ^a   Matsuki, Michihiro ^a   Kaku, Kohei ^a  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

cell dysfunction; Cell apoptosis; Cell proliferation; db gene heterozygote; Oxidative stress

Indexed keywords

GLUCAGON; GLUCOSE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 3; PANCREAS POLYPEPTIDE; PROTEIN BCL 2; SOMATOSTATIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL DAMAGE; CELL FUNCTION; CELL PROLIFERATION; CELL STRUCTURE; DB GENE; DIABETES MELLITUS; ENDOPLASMIC RETICULUM STRESS; GENE; GENE EXPRESSION PROFILING; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HETEROZYGOTE; HOMOZYGOTE; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN TOLERANCE TEST; LASER CAPTURE MICRODISSECTION; LIPID DIET; LIPID STORAGE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; UPREGULATION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE; HETEROZYGOTE; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; PANCREAS; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION;

EID: 73549105431     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.K09E-028     Document Type: Article

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