The natriuretic peptide uroguanylin elicits physiologic actions through 2 distinct topoisomers

Hypertension

Volumn 53, Issue 5, 2009, Pages 867-876

  Moss, Nicholas G ^a   Riguera, Dorothy A ^a   Solinga, Robert M ^b   Kessler, Marco M ^b   Zimmer, Daniel P ^b   Arendshorst, William J ^a   Currie, Mark G ^b   Goy, Michael F ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b Ironwood Pharmaceuticals   (United States)

Author keywords

Electrolyte homeostasis; Hypertension; Natriuretic peptide; Peptide isomerization; Sodium excretion; Uroguanylin

Indexed keywords

DNA TOPOISOMERASE; NATRIURETIC PEPTIDE RECEPTOR C; UROGUANYLIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIURETIC ACTIVITY; ELECTROLYTE TRANSPORT; HUMAN; HUMAN CELL; HYPERTENSION; ISOMERISM; ISOMERIZATION; KALIURESIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NATRIURESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION; RAT; RECEPTOR BINDING; SALURESIS; SODIUM EXCRETION;

ANIMALS; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLOMERULAR FILTRATION RATE; GUANYLATE CYCLASE; HUMANS; MALE; NATRIURETIC PEPTIDES; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; RENAL CIRCULATION; SODIUM;

EID: 73549093854     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.108.128264     Document Type: Article

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