Natural oxidant balance in Parkinson disease

Archives of Neurology

Volumn 66, Issue 12, 2009, Pages 1445-

  Perry, George ^a   Moreira, Paula I ^a   Siedlak, Sandra L ^a   Nunomura, Akihiko ^a   Zhu, Xiongwei ^a   Smith, Mark A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; OXIDIZING AGENT; URATE;

BRAIN FUNCTION; BRAIN PROTECTION; CELL METABOLISM; CEREBROSPINAL FLUID; CHELATION; DISEASE COURSE; EDITORIAL; GOUT; HOMEOSTASIS; HUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; STOICHIOMETRY;

BIOLOGICAL MARKERS; HUMANS; OXIDANTS; PARKINSON DISEASE; URIC ACID;

EID: 73549092919     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneurol.2009.261     Document Type: Editorial

References (7)

1. Ascherio A, LeWitt PA, Xu K, et al; Parkinson Study Group DATATOP Investigators. Urate as a predictor of the rate of clinical decline in Parkinson disease. Arch Neurol. 2009;66(12):1460-1468.
2. Sonnen JA, Larson EB, Gray SL, et al. Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking. Ann Neurol. 2009; 65(2):226-229.
3. Perry G, Zhu X, Moreira PI, Smith MA. Altered redox balance in disease: can we change the new equilibria? Ann Neurol. 2009;65(2):121-123.
4. Martins RN, Harper CG, Stokes GB, Masters CL. Increased cerebral glucose-6-phosphate dehydrogenase activity in Alzheimer's disease may reflect oxidative stress. J Neurochem. 1986;46(4):1042-1045.
5. Russell RL, Siedlak SL, Raina AK, Bautista JM, Smith MA, Perry G. Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease. Arch Biochem Biophys. 1999;370(2):236-239.
6. Smith MA, Kutty RK, Richey PL, et al. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease. Am J Pathol. 1994;145(1):42-47.
7. Perry G, Roder H, Nunomura A, et al. Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation. Neuroreport. 1999;10(11):2411-2415.