A novel method to quantify contribution of channels and transporters to membrane potential dynamics

Biophysical Journal

Volumn 97, Issue 12, 2009, Pages 3086-3094

  Cha, Chae Young ^a   Himeno, Yukiko ^b   Shimayoshi, Takao ^c   Amano, Akira ^a   Noma, Akinori ^a  

^a RITSUMEIKAN UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Sakyo 606   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 73449148734     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2009.08.060     Document Type: Article

References (13)

1. Cannon, S. C., R. H. Brown, Jr., and D. P. Corey. 1993. Theoretical reconstruction of myotonia and paralysis caused by incomplete inactivation of sodium channels. Biophys. J. 65:270-288.
2. Chay, T. R., and Y. S. Lee. 1992. Studies on re-entrant arrhythmias and ectopic beats in excitable tissues by bifurcation analyses. J. Theor. Biol. 155:137-171.
3. + currents in sinoatrial node pacemaking: insights from stability and bifurcation analyses of a mathematical model. Am. J. Physiol. Heart Circ. Physiol. 285:H2804-H2819.
4. Kurata, Y., I. Hisatome, H. Matsuda, and T. Shibamoto. 2005. Dynamical mechanisms of pacemaker generation in IK1-downregulated human ventricular myocytes: insights from bifurcation analyses of a mathematical model. Biophys. J. 89:2865-2887.
5. Kim, T. H., S. Y. Shin, S. M. Choo, and K. H. Cho. 2008. Dynamical analysis of the calcium signaling pathway in cardiac myocytes based on logarithmic sensitivity analysis. Biotechnol. J. 3:639-647.
6. Weaver, C. M., and S. L. Wearne. 2008. Neuronal firing sensitivity to morphologic and active membrane parameters. PLOS Comput. Biol. 4:e11.
7. Himeno, Y., N. Sarai, S. Matsuoka, and A. Noma. 2008. Ionic mechanisms underlying the positive chronotropy induced by β1-adrenergic stimulation in guinea pig sinoatrial node cells: a simulation study. J. Physiol. Sci. 58:53-65.
8. + pump as revealed by experiments and simulation. J. Gen. Physiol. 128:495-507.
9. Dokos, S., B. Celler, and N. Lovell. 1996. Ion currents underlying sinoatrial node pacemaker activity: a new single cell mathematical model. J. Theor. Biol. 181:245-272.
10. Demir, S. S., J. W. Clark, C. R. Murphey, and W. R. Giles. 1994. A mathematical model of a rabbit sinoatrial node cell. Am. J. Physiol. 266:C832-C852.
11. Zhang, H., A. V. Holden, I. Kodama, H. Honjo, M. Lei, et al. 2000. Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node. Am. J. Physiol. Heart Circ. Physiol. 279:H397-H421.
12. Sarai, N., S. Matsuoka, S. Kuratomi, K. Ono, and A. Noma. 2003. Role of individual ionic current systems in the SA node hypothesized by a model study. Jpn. J. Physiol. 53:125-134.
13. Rice, J. J., M. S. Jafri, and R. L. Winslow. 2000. Modeling short-term interval-force relations in cardiac muscle. Am. J. Physiol. Heart Circ. Physiol. 278:H913-H931.