The Effects of Absent or Reversed End-diastolic Umbilical Artery Doppler Flow Velocity

Taiwanese Journal of Obstetrics and Gynecology

Volumn 48, Issue 3, 2009, Pages 225-231

  Wang, Kuo Gon ^a,b   Chen, Chen Yu ^a,c   Chen, Yi Yung ^a  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NURSING AND MANAGEMENT COLLEGE   (Taiwan)

Author keywords

absent or reversed end diastolic velocity; fetal growth retardation; perinatal mortality; placental insufficiency; preeclampsia; pregnancy complications

Indexed keywords

BRAIN HEMORRHAGE; DISEASE ASSOCIATION; DOPPLER ECHOGRAPHY; HIGH RISK PREGNANCY; HUMAN; INTRAUTERINE GROWTH RETARDATION; LUNG DYSPLASIA; MATERNAL HYPERTENSION; NECROTIZING ENTEROCOLITIS; NERVE CELL DIFFERENTIATION; PERINATAL MORBIDITY; PERINATAL MORTALITY; PREECLAMPSIA; RESPIRATORY DISTRESS SYNDROME; REVIEW; UMBILICAL ARTERY; UMBILICAL CORD BLOOD FLOW; BLOOD FLOW VELOCITY; DOPPLER FLOWMETRY; ECHOGRAPHY; FEMALE; FETUS ECHOGRAPHY; PHYSIOLOGY; PLACENTA INSUFFICIENCY; PREGNANCY; PREGNANCY COMPLICATION;

BLOOD FLOW VELOCITY; FEMALE; FETAL GROWTH RETARDATION; HUMANS; PLACENTAL INSUFFICIENCY; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; ULTRASONOGRAPHY, DOPPLER; ULTRASONOGRAPHY, PRENATAL; UMBILICAL ARTERIES;

EID: 73449141155     PISSN: None     EISSN: 10284559     Source Type: Journal    
DOI: 10.1016/S1028-4559(09)60294-1     Document Type: Review

References (71)

1. Fleischer A., Schulman H., Farmakides G., Bracero L., Blattner P., and Randolph G. Umbilical artery velocity waveforms and intrauterine growth retardation. Am J Obstet Gynecol 151 (1985) 502-506
2. Rochelson B.L., Schulman H., Fleischer A., et al. The clinical significance of Doppler umbilical artery velocimetry in the small for gestational age fetus. Am J Obstet Gynecol 156 (1987) 1223-1226
3. Trudinger B.J., Cook C.M., and Giles W.B. Fetal umbilical artery velocity waveforms and subsequent neonatal outcome. Br J Obstet Gynaecol 98 (1991) 378-384
4. Devoe L.D., Gardner P., Dear C., and Faircloth D. The significance of increasing umbilical artery systolic-diastolic ratios in third-trimester pregnancy. Obstet Gynecol 80 (1992) 684-687
5. Hecher K., Campbell S., Doyle P., Harrington K., and Nicolaides K. Assessment of fetal compromise by Doppler ultrasound investigation of the fetal circulation: arterial, intracardiac, and venous blood flow velocity studies. Circulation 91 (1995) 129-138
6. Baschat A.A., Gembruch U., Reiss I., Gortner L., Weiner C.P., and Harman C.R. Relationship between arterial and venous Doppler and perinatal outcome in fetal growth restriction. Ultrasound Obstet Gynecol 16 (2000) 407-413
7. Ferrazzi E., Bozzo M., Rigano S., et al. Temporal sequence of abnormal Doppler changes in the peripheral and central circulatory systems of the severely growth-restricted fetus. Ultrasound Obstet Gynecol 19 (2002) 140-146
8. Giles W.B., Trudinger B.J., and Baird P.J. Fetal umbilical artery flow velocity waveforms and placental resistance: pathological correlation. Br J Obstet Gynaecol 92 (1985) 31-38
9. Kingdom J.C., Burrell S.J., and Kaufmann P. Pathology and clinical implications of abnormal umbilical artery Doppler waveforms. Ultrasound Obstet Gynecol 9 (1997) 271-286
10. Gudmundsson S., and Marsal K. Umbilical and uteroplacental blood flow velocity waveforms in pregnancies with fetal growth retardation. Eur J Obstet Gynecol Reprod Biol 27 (1988) 187-196
11. Wang K.G., Chen C.P., Yang J.M., and Su T.H. Impact of reverse end-diastolic flow velocity in umbilical artery on pregnancy outcome after the 28th gestational week. Acta Obstet Gynecol Scand 77 (1998) 527-531
12. Berkowitz G.S., Mehalek K.E., Chitkara U., Rosenberg J., Cogswell C., and Berkowitz R.L. Doppler umbilical velocimetry in the prediction of adverse outcome in pregnancies at risk for intrauterine growth retardation. Obstet Gynecol 71 (1988) 742-746
13. Burke G., Stuart B., Crowley P., Scanaill S.N., and Drumm J. Is intrauterine growth retardation with normal umbilical artery blood flow a benign condition?. BMJ 300 (1990) 1044-1045
14. Trudinger B.J., Cook C.M., Giles W.B., Ng S., Fong E., Connelly A., and Wilcox W. Fetal umbilical artery velocity waveforms and subsequent neonatal outcome. Br J Obstet Gynaecol 98 (1991) 378-384
15. Yoon B.H., Oh I.H., Lee P.R., Kim W.J., Syn H.C., and Kim S.W. Is an abnormal Doppler umbilical artery waveform ratio a risk factor for poor perinatal outcome in the non-small for gestational age fetus?. Am J Perinatol 10 (1993) 245-249
16. Soregaroli M., Bonera R., Danti L., Dinolfo D., Taddei F., Valcamonico A., and Frusca T. Prognostic role of umbilical artery Doppler velocimetry in growth-restricted fetuses. J Matern Fetal Neonatal Med 11 (2002) 199-203
17. Hartung J., Kalache K.D., Heyna C., et al. Outcome of 60 neonates who had ARED flow prenatally compared with a matched control group of appropriate-for-gestational age preterm neonates. Ultrasound Obstet Gynecol 25 (2005) 566-572
18. Alfirevic Z., and Neilson J.P. Doppler ultrasonography in high-risk pregnancies: systematic review with meta-analysis. Am J Obstet Gynecol 172 (1995) 1379-1387
19. Vergani P., Locatelli A., Doria V., Assi F., Paterlini G., Pezzullo J.C., and Ghidini A. Intraventricular hemorrhage and periventricular leukomalacia in preterm infants. Obstet Gynecol 104 (2004) 225-231
20. Al-Ghazali W., Chita S.K., Chapman M.G., and Allan L.D. Evidence of redistribution of cardiac output in asymmetrical growth retardation. Br J Obstet Gynaecol 96 (1989) 697-704
21. Volpe J.J. Intraventricular hemorrhage in the premature infant-current concepts, part I. Ann Neurol 25 (1989) 3-11
22. Wilcox G.R., and Trudinger B.J. Fetal platelet consumption: a feature of placental insufficiency. Obstet Gynecol 77 (1991) 616-621
23. Steiner H., Staudach A., Spitzer D., Schaffer K.H., Gregg A., and Weiner C.P. Growth deficient fetuses with absent or reversed umbilical artery end-diastolic flow are metabolically compromised. Early Hum Dev 41 (1995) 1-9
24. Phelan J.P., Korst L.M., Ahn M.O., and Martin G.I. Neonatal nucleated red blood cell and lymphocyte counts in fetal brain injury. Obstet Gynecol 91 (1998) 485-489
25. Viscardi R.M., and Sun C.C. Placental lesion multiplicity: risk factor for IUGR and neonatal cranial ultrasound abnormalities. Early Hum Dev 62 (2001) 1-10
26. Eronen M., Kari A., Pesonen E., Kaaja R., Wallgren E.I., and Hallman M. Value of absent or retrograde end-diastolic flow in fetal aorta and umbilical artery as a predictor of perinatal outcome in pregnancy-induced hypertension. Acta Paediatr 82 (1993) 919-924
27. Gaziano E.P., Knox H., Ferrera B., Brandt D.G., Calvin S.E., and Knox G.E. Is it time to reassess the risk for the growth-retarded fetus with normal Doppler velocimetry of the umbilical artery?. Am J Obstet Gynecol 170 (1994) 1734-1741
28. Yoon B.H., Lee C.M., and Kim S.W. An abnormal umbilical artery waveform: a strong and independent predictor of adverse perinatal outcome in patients with preeclampsia. Am J Obstet Gynecol 171 (1994) 713-721
29. Karsdorp V.H., van Vugt J.M., van Geijn H.P., Kostense P.J., Arduini D., Montenegro N., and Todros T. Clinical significance of absent or reversed end diastolic velocity waveforms in umbilical artery. Lancet 344 (1994) 1664-1668
30. Baschat A.A., Gembruch U., Viscardi R.M., Gortner L., and Harman C.R. Antenatal prediction of intraventricular hemorrhage in fetal growth restriction: what is the role of Doppler?. Ultrasound Obstet Gynecol 19 (2002) 334-339
31. Adiotomre P.N., Johnstone F.D., and Laing I.A. Effect of absent end diastolic flow velocity in the fetal umbilical artery on subsequent outcome. Arch Dis Child Fetal Neonatal Ed 76 (1997) 35-38
32. Spinillo A., Montanari L., Bergante C., Gaia G., Chiara A., and Fazzi E. Prognostic value of umbilical artery Doppler studies in unselected preterm deliveries. Obstet Gynecol 105 (2005) 613-620
33. Graziani L.J., Pasto M., Stanley C., et al. Neonatal neurosono-graphic correlates of cerebral palsy in preterm infants. Pediatrics 78 (1986) 88-95
34. Graham M., Levene M.I., Trounce J.Q., and Rutter N. Prediction of cerebral palsy in very low birthweight infants: prospective ultrasound study. Lancet 2 (1987) 593-596
35. Low J.A., Froese A.F., Galbraith R.S., Sauerbrei E.E., McKinven J.P., and Karchmar E.J. The association of fetal and newborn metabolic acidosis with severe periventricular leukomalacia in the preterm newborn. Am J Obstet Gynecol 162 (1990) 977-981
36. Groneck P., and Speer C. Inflammatory mediators and bronchopulmonary dysplasia. Arch Dis Child Fetal Neonatal Ed 73 (1995) 1F-3F
37. Van Marter L.J., Allred E.N., Pagano M., et al. Do clinical markers of barotraumas and oxygen toxicity explain interhospital variation in rates of chronic lung disease?. Pediatrics 105 (2000) 1194-1201
38. Jobe A.H., and Ikegami M. Prevention of bronchopulmonary dysplasia. Curr Opin Pediatr 13 (2001) 124-129
39. Hack M., Wilson-Costello D., Friedman H., Taylor G.H., Schluchter M., and Fanaroff A.A. Neurodevelopment and predictors of outcomes of children with birth weights of less than 1000 g: 1992-1995. Arch Pediatr Adolesc Med 154 (2000) 725-731
40. Walsh M.C., Morris B.H., Wrage L.A., et al. Extremely low birthweight neonates with protracted ventilation: mortality and 18-month neurodevelopmental outcomes. J Pediatr 146 (2005) 798-804
41. Gonzalez J.M., Stamilio D.M., Ural S., Macones G.A., and Odibo A.O. Relationship between abnormal fetal testing and adverse perinatal outcomes in intrauterine growth restriction. Am J Obstet Gynecol 196 (2007) 48-51
42. Torrance H.L., Mulder E.J., Brouwers H.A., van Bel F., and Visser G.H. Respiratory outcome in preterm small for gestational age fetuses with or without abnormal umbilical artery Doppler and/or maternal hypertension. J Matern Fetal Neonatal Med 20 (2007) 613-621
43. Santulli T.V., Schullinger J.N., Heird W.C., et al. Acute necrotizing enterocolitis in infancy: a review of 64 cases. Pediatrics 55 (1975) 376-387
44. Caplan M.S., and MacKendrick W. Necrotizing enterocolitis: a review of pathogenetic mechanisms and implications for prevention. Pediatr Pathol 13 (1993) 357-369
45. Beeby P.J., and Jeffrey H. Risk factors for necrotising enterocolitis: the influence of gestational age. Arch Dis Child 67 (1992) 432-435
46. McDonnell M., and Wilkinson A.R. Necrotising enterocolitis: perinatal approach to prevention, early diagnosis and management. Semin Neonatol 2 (1997) 291-296
47. Bernstein I.M., Horbar J.D., Badger G.J., Ohlsson A., and Golan A. Morbidity and mortality among very-low-birth weight neonates with intrauterine growth restriction. Am J Obstet Gynecol 182 (2000) 198-206
48. Dorling J., Kempley S., and Leaf A. Feeding growth restricted preterm infants with abnormal antenatal Doppler results. Arch Dis Child Fetal Neonatal Ed 90 (2005) F359-F363
49. Manogura A.C., Turan O., Kush M.L., et al. Predictors of necrotizing enterocolitis in preterm growth-restricted neonates. Am J Obstet Gynecol 198 (2008) 638.e1-638.e5
50. Valcamonico A., Danti L., Frusca T., Soregaroli M., Zucca S., Abrami F., and Tiberti A. Absent end-diastolic velocity in umbilical artery: risk of neonatal morbidity and brain damage. Am J Obstet Gynecol 170 (1994) 796-801
51. Wilson D.C., Harper A., McClure G., Halliday H.L., and Reid M. Long term predictive value of Doppler studies in high risk fetuses. Br J Obstet Gynaecol 99 (1992) 575-578
52. Kirsten G.F., Van Zyl J.I., Van Zijl F., Maritz J.S., and Odendaal H.J. Infants of women with severe early pre-eclampsia: the effect of absent end-diastolic umbilical artery Doppler flow velocities on neurodevelopmental outcome. Acta Paediatr 89 (2000) 566-570
53. Weiss E., Stefan U., and Berle P. Blood flow velocity waveforms of the middle cerebral artery and abnormal neurological evaluations in live-born fetuses with absent or reverse enddiastolic flow velocities of the umbilical arteries. Eur J Obstet Gynecol Reprod Biol 45 (1992) 93-100
54. Vossbeck S., de Camargo O.K., Grab D., Bode H., and Pohlandt F. Neonatal and neurodevelopmental outcome in infants born before 30 weeks of gestation with absent or reversed enddiastolic flow velocities in the umbilical artery. Eur J Pediatr 160 (2001) 128-134
55. Schreuder A.M., McDonnell M., Gaffney G., Johnson A., and Hope P.L. Outcome at school age following antenatal detection of absent or reversed end diastolic flow velocity in the umbilical artery. Arch Dis Child Fetal Neonatal Ed 86 (2002) 108-114
56. Valcamonico A., Accorsi P., Battaglia S., Soregaroli M., Beretta D., and Frusca T. Absent or reverse end-diastolic flow in the umbilical artery: intellectual development at school age. Eur J Obstet Gynecol Reprod Biol 114 (2004) 23-28
57. Dobbing J. Undernutrition and the developing brain: the use of animal models to elucidate the human problem. Psychiatr Neurol Neurochir 74 (1971) 433-442
58. Smart J.L., and Dobbing J. Vulnerability of developing brain, II: effects of early nutritional deprivation on reflex ontogeny and development of behavior in the rat. Brain Res 28 (1971) 85-95
59. Rees S., Bocking A.D., and Harding R. Structure of the fetal sheep brain in experimental growth retardation. J Dev Physiol 10 (1988) 211-225
60. Tolsa C.B., Zimine S., Warfield S.K., et al. Early alteration of structural and functional brain development in premature infants born with intrauterine growth restriction. Pediatr Res 56 (2004) 132-138
61. Ducey J., Schulman H., Farmakides G., et al. A classification of hypertension in pregnancy based on Doppler velocimetry. Am J Obstet Gynecol 157 (1987) 680-685
62. Brosens I.A., Robertson W.B., and Dixon H.G. The role of the spiral arteries in the pathogenesis of pre-eclampsia. Obstet Gynecol Annu 1 (1972) 177-191
63. Sibai B.M., Taslimi M., Abdella T.N., Brooks T.F., Spinnato J.A., and Anderson G.D. Maternal perinatal outcome of conservative management of severe preeclampsia in midtrimester. Am J Obstet Gynecol 152 (1985) 32-37
64. Fairlie F.M., Moretti M., Walker J.J., and Sibai B.M. Determinants of perinatal outcome in pregnancy-induced hypertension with absence of umbilical artery end-diastolic frequencies. Am J Obstet Gynecol 164 (1991) 1084-1089
65. Thornton J.G., Hornbuckle J., Vail A., Spiegelhalter D.J., Levene M., and GRIT study group. Infant wellbeing at 2 years of age in the Growth Restriction Intervention Trial (GRIT): multicentred randomised controlled trial. Lancet 364 (2004) 513-520
66. Giles W.B., and Bisits A. Clinical use of Doppler in pregnancy: information from six randomized trials. Fetal Diagn Ther 8 (1993) 247-255
67. Divon M.Y. Randomized controlled trials of umbilical artery Doppler velocimetry: how many are too many?. Ultrasound Obstet Gynecol 6 (1995) 377-379
68. Neilson J.P., and Alfirevic Z. Doppler ultrasound for fetal assessment in high risk pregnancies. Cochrane Database Syst Rev 2 (2000) CD000073.
69. Goffinet F., Paris-Llado J., Nisand I., and Bréart G. Umbilical artery Doppler velocimetry in unselected and low risk pregnancies: a review of randomised controlled trials. Br J Obstet Gynaecol 104 (1997) 425-430
70. Burrell S.J., and Kingdom J.C. The use of umbilical artery Doppler ultrasonography in modern obstetrics. Curr Opin Obstet Gynecol 9 (1997) 370-374
71. Bricker L., and Neilson J.P. Routine Doppler ultrasound in pregnancy. Cochrane Database Syst Rev 2 (2000) CD001450.