Comparative evaluation of estrogen and progesterone receptor expression with connexins 26 and 43 in endometrial cancer

International Journal of Gynecological Cancer

Volumn 19, Issue 7, 2009, Pages 1253-1257

  Lesniewicz, Tomasz ^a   Kanczuga Koda, Luiza ^a   Baltaziak, Marek ^a   Jarzabek, Katarzyna ^a   Rutkowski, Ryszard ^a   Koda, Mariusz ^a   Wincewicz, Andrzej ^a   Sulkowska, Mariola ^a   Sulkowski, Stanisaaw ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Connexin 26; Connexin 43; Endometrial cancer; Estrogen receptor; Immunohistochemistry; Progesterone receptor

Indexed keywords

CONNEXIN 26; CONNEXIN 43; ESTROGEN RECEPTOR ALPHA; PROGESTERONE RECEPTOR; GAP JUNCTION PROTEIN; GJA1 PROTEIN, HUMAN;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CANCER GRADING; CARCINOGENESIS; COMPARATIVE STUDY; CONTROLLED STUDY; ENDOMETRIUM CARCINOMA; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SQUAMOUS CELL METAPLASIA; CASE CONTROL STUDY; CELL JUNCTION; ENDOMETRIOID CARCINOMA; ENDOMETRIUM TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; TISSUE DISTRIBUTION;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, ENDOMETRIOID; CASE-CONTROL STUDIES; CONNEXIN 43; CONNEXINS; ENDOMETRIAL NEOPLASMS; ESTROGEN RECEPTOR ALPHA; FEMALE; GAP JUNCTIONS; HUMANS; MIDDLE AGED; RECEPTORS, PROGESTERONE; TISSUE DISTRIBUTION;

EID: 73449130580     PISSN: 1048891X     EISSN: None     Source Type: Journal    
DOI: 10.1111/IGC.0b013e3181a40618     Document Type: Article

References (29)

1. Amant F, Moerman P, Neven P, et al. Endometrial cancer. Lancet. 2005;366:491-505.
2. Koda M, Jarzabek K, Haczynski J, et al. Differential effects of raloxifene and tamoxifen on the expression of estrogen receptors and antigen Ki-67 in human endometrial adenocarcinoma cell line. Oncol Rep. 2004;12:517-521.
3. Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol. 1983;15:10-17.
4. Shiozawa T, Konishi I. Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment. Int J Clin Oncol. 2006;11:13-21.
5. Ryan AJ, Susil B, Jobling TW, et al. Endometrial cancer. Cell Tissue Res. 2005;322:53-61.
6. Hecht JL, Mutter GL. Molecular and pathologic aspects of endometrial carcinogenesis. J Clin Oncol. 2006;24:4783-4791.
7. Rose PG. Endometrial carcinoma. N Engl J Med. 1996;335:640-649.
8. Saito T, Nishimura M, Kudo R, et al. Suppressed gap junctional intercellular communication in carcinogenesis of endometrium. Int J Cancer. 2001;93:317-323.
9. Martin PE, Evans WH. Incorporation of connexins into plasma membranes and gap junctions. Cardiovasc Res. 2004;62:378-387.
10. Kumar NM, Gilula NB. The gap junction communication channel. Cell. 1996;84:381-388.
11. Saez JC, Connor JA, Spray DC, et al. Hepatocyte gap junctions are permeable to the second messenger 1,4,5-trisphosphate, and to calcium ions. Proc Natl Acad Sci U S A. 1989;86:2708-2712.
12. Grümmer R, Chwalisz K, Mulholland J, et al. Regulation of connexin26 and connexin43 expression in rat endometrium by ovarian steroid hormones. Biol Reprod. 1994;51:1109-1116.
13. Risek B, Klier FG, Phillips A, et al. Gap junction regulation in the uterus and ovaries of immature rats by estrogen and progesterone. J Cell Sci. 1995;108:1017-1032.
14. Saito T, Oyamada M, Yamasaki H, et al. Co-ordinated expression of connexins 26 and 32 in human endometrial glandular epithelium during the reproductive cycle and the influence of hormone replacement therapy. Int J Cancer. 1997;73:479-485.
15. Jahn E, Classen-Linke I, Kusche M, et al. Expression of gap junction connexins in the human endometrium throughout the menstrual cycle. Hum Reprod. 1995;10:2666-2670.
16. Mesnil M, Asamoto M, Piccoli C, et al. Possible molecular mechanism of loss of homologous and heterologous gap junctional intercellular communication in rat liver epithelial cell lines. Cell Adhes Commun. 1994;2:377-384.
17. Krutovskikh VA, Troyanovsky SM, Piccoli C, et al. Differential effect of subcellular localization of communication impairing gap junction protein connexin43 on tumor cell growth in vivo. Oncogene. 2000;19:505-513.
18. Mennecier G, Derangeon M, Coronas V, et al. Aberrant expression and localization of connexin43 and connexin30 in a rat glioma cell line. Mol Carcinog. 2008;47:391-401.
19. Trosko JE, Ruch RJ. Gap junctions as targets for cancer chemoprevention and chemotherapy. Curr Drug Targets. 2002;3:465-482.
20. Mesnil M. Connexins and cancer. Biol Cell. 2002;94:493-500.
21. Saito T, Tanaka R, Wataba K, et al. Overexpression of estrogen receptor-alpha gene suppresses gap junctional intercellular communication in endometrial carcinoma cells. Oncogene. 2004;23: 1109-1116.
22. Koda M, Sulkowski S, Kanczuga-Koda L, et al. Expression of ERalpha, ERbeta and Ki-67 in primary tumors and lymph node metastases in breast cancer. Oncol Rep. 2004;11:753-759.
23. Kounelis S, Kapranos N, Kouri E, et al. Immunohistochemical profile of endometrial adenocarcinoma: a study of 61 cases and review of the literature. Mod Pathol. 2000;13:379-388.
24. Fukuda K, Mori M, Uchiyama M, et al. Prognostic significance of progesterone receptor immunohistochemistry in endometrial carcinoma. Gynecol Oncol. 1998;69:220-225.
25. Miyamoto T, Watanabe J, Hata H et al. Significance of progesterone receptor-A and -B expressions in endometrial adenocarcinoma. J Steroid Biochem Mol Biol. 2004;92:111-118.
26. Wilgenbus KK, Kirkpatrick CJ, Knuechel R, et al. Expression of Cx26, Cx32 and Cx43 gap junction proteins in normal and neoplastic human tissues. Int J Cancer. 1992;51:522-529.
27. Kanczuga-Koda L, Sulkowski S, Koda M, et al. Alterations in connexin 26 expression during colorectal carcinogenesis. Oncology. 2005;68: 217-222. (Pubitemid 41158979)
28. Kanczuga-Koda L, Sulkowski S, Tomaszewski J, et al. Connexins 26 and 43 correlate with Bak, but not with Bcl-2 protein in breast cancer. Oncol Rep. 2005;14:325-329.
29. Grümmer R, Traub O, Winterhager E. Gap junction connexin genes cx26 and cx43 are differentially regulated by ovarian steroid hormones in rat endometrium. Endocrinology. 1999;140:2509-2516.