Gammaaminobutyric acid a receptor alpha 3 subunit is overexpressed in lung cancer

Pathology and Oncology Research

Volumn 15, Issue 3, 2009, Pages 351-358

  Liu, Yan ^a   Guo, Fengjie ^a   Dai, Miao ^b   Wang, Di ^c   Tong, Yongqing ^a   Huang, Jian ^a   Hu, Jinyue ^a   Li, Guancheng ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b Medical College   (China)

^c Fist Hospital of Changsha   (China)

Author keywords

Cancer; GABRA3; Immunohistochemistry; In silico; RT PCR

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA 3 SUBUNIT; MESSENGER RNA; TUMOR ANTIGEN; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; FEMALE; GABRA 3 GENE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR DIFFERENTIATION; TUMOR GENE;

GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; RECEPTORS, GABA-A; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL;

EID: 73449127990     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12253-008-9128-7     Document Type: Article

References (23)

1. Toronto, Canada, Canadian Cancer Society/National Cancer Institute of Canada (2006) Canadian Cancer Statistics
2. DP Carbone 1997 The biology of lung cancer Semin Oncol 24 4 388 401 1:STN:280:DyaK2svisVaqtA%3D%3D 9280218
3. Y Chen C Miller R Mosher, et al. 2003 Identification of cervical cancer markers by cDNA and tissue microarrays Cancer Res 63 8 1927 1935 1:CAS:528:DC%2BD3sXivFynsb8%3D 12702585
4. M Takahashi XJ Yang J Sugimura, et al. 2003 Molecular subclassification of kidney tumors and the discovery of new diagnostic markers Oncogene 22 43 6810 6818 10.1038/sj.onc.1206869 1:CAS:528:DC%2BD3sXotVWntr8%3D 14555994
5. EM Reis EP Ojopi FL Alberto, et al. 2005 Large-scale transcriptome analyses reveal new genetic marker candidates of head, neck, and thyroid cancer Cancer Res 65 5 1693 1699 10.1158/0008-5472.CAN-04-3506 15753364 (Pubitemid 40478594)
6. C Vinals S Gaulis T Coche 2001 Using in silico transcriptomics to search for tumor-associated antigens for immunotherapy Vaccine 19 17-19 2607 2614 10.1016/S0264-410X(00)00500-4 1:CAS:528:DC%2BD3MXitVOitr4%3D 11257399 (Pubitemid 32234279)
7. S Jin Y Wanjun S Ie-Ming, et al. 2006 Identification of BCOX1, a novel gene overexpressed in breast cancer Biochimica Biophysica Acta 1760 1 62 69
8. MA Rieger R Ebner DR Bell, et al. 2004 Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma Cancer Res 64 7 2357 2364 10.1158/0008-5472.CAN-03-0849 1:CAS:528:DC%2BD2cXis1yjtL4%3D 15059886 (Pubitemid 38528668)
9. AO Schmitt T Specht G Beckmann, et al. 1999 Exhaustive mining of EST libraries for genes differentially expressed in normal and tumour tissues Nucleic Acids Res 27 21 4251 4260 10.1093/nar/27.21.4251 1:CAS:528: DyaK1MXnt1Gkurg%3D 10518618 (Pubitemid 29500260)
10. EN Imyanitov AV Togo KP Hanson 2004 Searching for cancer-associated gene polymorphisms: promises and obstacles Cancer Lett 204 1 3 14 10.1016/j.canlet.2003.09.026 1:CAS:528:DC%2BD2cXntVyqsw%3D%3D 14744529 (Pubitemid 38120375)
11. A Abdel N Vincent B Audrey, et al. 2006 Bioinformatic screening of human ESTs for differentially expressed genes in normal and tumor tissues BMC Genomics 7 94 10.1186/1471-2164-7-94
12. TR Neelands J Zhang RL Macdonald 1999 GABAA receptors expressed in undifferentiated human teratocarcinoma NT2 cells differ from those expressed by differentiated NT2-N cells J Neurosci 19 16 7057 7065 1:CAS:528: DyaK1MXlt1Chtro%3D 10436060
13. A Rasola LJ Galietta DC Gruenert, et al. 1994 Volume-sensitive chloride currents in four epithelial cell lines are not directly correlated to the expression of the MDR-1 gene J Biol Chem 269 2 1432 1436 1:CAS:528: DyaK2cXhtlSkurw%3D 7904600
14. CY Chou MR Shen SN Wu 1995 Volume-sensitive chloride channels associated with human cervical carcinogenesis Cancer Res 55 24 6077 6083 1:CAS:528:DyaK2MXhtVShtL%2FK 8521396
15. - currents and regulatory volume decrease in the cell cycle and proliferation in nasopharyngeal carcinoma cells Cell Prolif 40 2 253 267 10.1111/j.1365-2184.2007.00432.x 1:CAS:528:DC%2BD2sXkvFelt74%3D 17472731 (Pubitemid 46398821)
16. MR Shen G Droogmans J Eggermont, et al. 2000 Differential expression of volume-regulated anion channels during cell cycle progression of human cervical cancer cells J Physiol 529 385 394 10.1111/j.1469-7793.2000.00385.x 1:CAS:528:DC%2BD3MXhs1Whsg%3D%3D 11101648 (Pubitemid 32042106)
17. J Mao L Wang A Fan, et al. 2007 Blockage of volume-activated chloride channels inhibits migration of nasopharyngeal carcinoma cells Cell Physiol Biochem 19 5-6 249 258 10.1159/000102388 1:CAS:528:DC%2BD2sXkvVantLk%3D 17495465 (Pubitemid 46701500)
18. KJ Sarah SH Randy 2005 The gamma-aminobutyric acid A receptor π subunit is overexpressed in pancreatic adenocarcinomas JOP 6 2 136 142
19. T Akio H Masayo E Hidetoshi, et al. 2007 γ-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor π subunit Cancer Res 67 20 9704 9712 10.1158/0008-5472.CAN-07-2099 (Pubitemid 47621217)
20. WF Symmans DJ Fiterman SK Anderson, et al. 2005 A single-gene biomarker identifies breast cancers associated with immature cell type and short duration of prior breastfeeding Endocr Relat Cancer 12 4 1059 1069 10.1677/erc.1.01051 1:CAS:528:DC%2BD28XnvVyhsw%3D%3D 16322343
21. F Giammarco M Luca G Shannon 2005 γ-aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway Cancer Res 65 24 11437 1146 10.1158/0008-5472.CAN-05-1470 (Pubitemid 41821701)
22. J Joseph B Niggemann K Zaenker, et al. 2002 The neurotransmitter g-aminobutyric acid is an inhibitory regulator for the migration of SW480 colon carcinoma cells Cancer Res 62 22 6467 6479 1:CAS:528:DC%2BD38XovFOlu7g%3D 12438237
23. H Azuma T Inamoto T Sakamoto, et al. 2003 γ-Aminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism Cancer Res 63 23 8090 8096 1:CAS:528:DC%2BD3sXpvVagsLc%3D 14678958