Zinc increases the effects of essential amino acids-whey protein supplements in frail elderly

Journal of Nutrition, Health and Aging

Volumn 13, Issue 6, 2009, Pages 491-497

  Rodondi, A ^a   Ammann, P ^a   Ghilardi Beuret, S ^a   Rizzoli, R ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Ageing; Bone remodeling; Fracture; Nutrition; Osteoporosis

Indexed keywords

CALCIUM; CALCIUM PHOSPHATE; ESSENTIAL AMINO ACID; OSTEOCALCIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; ZINC; COLLAGEN; GLUTAMYL LYSYL ALANYL HISTIDYL ASPARTYL GLYCYL GLYCYL ARGININE; GLUTAMYL-LYSYL-ALANYL-HISTIDYL-ASPARTYL-GLYCYL-GLYCYL-ARGININE; MILK PROTEIN; PEPTIDE FRAGMENT; WHEY PROTEIN;

AGED; ARTICLE; BONE REMODELING; BONE TURNOVER; CALCIUM METABOLISM; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DIET SUPPLEMENTATION; DIETARY INTAKE; DRUG EFFECT; FRAIL ELDERLY; HUMAN; MAJOR CLINICAL STUDY; NUTRITIONAL ASSESSMENT; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; WHEY; BLOOD; DIET THERAPY; DOUBLE BLIND PROCEDURE; FEMALE; MALE; METABOLISM; MULTIMODALITY CANCER THERAPY; PROTEIN CALORIE MALNUTRITION; PROTEIN INTAKE;

ACTIVITIES OF DAILY LIVING; AGED, 80 AND OVER; AMINO ACIDS, ESSENTIAL; BONE RESORPTION; COLLAGEN; COMBINED MODALITY THERAPY; DIETARY PROTEINS; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; FRAIL ELDERLY; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MILK PROTEINS; PEPTIDE FRAGMENTS; PROTEIN-ENERGY MALNUTRITION; ZINC;

EID: 73449115030     PISSN: 12797707     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12603-009-0099-5     Document Type: Article

References (46)

1. Sullivan D H, Sun S, Walls R C. Protein-energy undernutrition among elderly hospitalized patients: a prospective study. Jama 1999; 281: 2013-2019.
2. Corish C A, Kennedy N P. Protein-energy undernutrition in hospital in-patients. Br J Nutr 2000; 83: 575-591.
3. Rizzoli R, Bonjour J P. Dietary protein and bone health. J Bone Miner Res 2004; 19: 527-531.
4. Geinoz G, Rapin C H, Rizzoli R, Kraemer R, Buchs B, Slosman D, Michel J P, Bonjour J P. Relationship between bone mineral density and dietary intakes in the elderly. Osteoporos Int 1993; 3: 242-248.
5. Hannan M T, Tucker K L, Dawson-Hughes B, Cupples L A, Felson D T, Kiel D P. Effect of dietary protein on bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res 2000; 15: 2504-2512.
6. Promislow J H, Goodman-Gruen D, Slymen D J, Barrett-Connor E. Protein consumption and bone mineral density in the elderly : the Rancho Bernardo Study. Am J Epidemiol 2002; 155: 636-644.
7. Rapuri P B, Gallagher J C, Haynatzka V. Protein intake: effects on bone mineral density and the rate of bone loss in elderly women. Am J Clin Nutr 2003; 77: 1517-1525.
8. Rizzoli R, Ammann P, Chevalley T, Bonjour J P. Protein intake and bone disorders in the elderly. Joint Bone Spine 2001; 68: 383-392.
9. Thissen J P, Ketelslegers J M, Underwood L E. Nutritional regulation of the insulinlike growth factors. Endocr Rev 1994; 15: 80-101.
10. Bonjour J P, Schurch M A, Chevalley T, Ammann P, Rizzoli R. Protein intake, IGF-1 and osteoporosis. Osteoporos Int 1997; 7 (Suppl 3): S36-42.
11. Bourrin S, Toromanoff A, Ammann P, Bonjour J P, Rizzoli R. Dietary protein deficiency induces osteoporosis in aged male rats. J Bone Miner Res 2000; 15: 1555-1563.
12. Ammann P, Bourrin S, Bonjour J P, Meyer J M, Rizzoli R. Protein undernutrition-induced bone loss is associated with decreased IGF-I levels and estrogen deficiency. J Bone Miner Res 2000; 15: 683-690.
13. Ammann P, Laib A, Bonjour J P, Meyer J M, Ruegsegger P, Rizzoli R. Dietary essential amino acid supplements increase bone strength by influencing bone mass and bone microarchitecture in ovariectomized adult rats fed an isocaloric low-protein diet. J Bone Miner Res 2002; 17: 1264-1272.
14. Hengsberger S, Ammann P, Legros B, Rizzoli R, Zysset P. Intrinsic bone tissue properties in adult rat vertebrae: modulation by dietary protein. Bone 2005; 36: 134-141.
15. Ammann P, Rizzoli R. Bone strength and its determinants. Osteoporos Int 2003; 14 Suppl 3: S13-18.
16. Bourrin S, Ammann P, Bonjour J P, Rizzoli R. Dietary protein restriction lowers plasma insulin-like growth factor I (IGF-I), impairs cortical bone formation, and induces osteoblastic resistance to IGF-I in adult female rats. Endocrinology 2000; 141: 3149-3155.
17. Ammann P, Rodriguez L, Aubert M L, Bonjour J P, Rizzoli R. Growth hormone (GH) decreases bone mineral mass and bone strength in adult female rats fed a low protein diet. J Bone Miner Res 2001; 16 (Suppl. 1): S294.
18. Ammann P, Gabay C, Palmer G, Garcia I, Rizzoli R. Tumor necrosis factor alpha but not interleukine-1 is involved in protein undernutrition-induced bone resorption. J Bone Miner Res 2002; 17 (Suppl. 1): S205.
19. Delmi M, Rapin C H, Bengoa J M, Delmas P D, Vasey H, Bonjour J P. Dietary supplementation in elderly patients with fractured neck of the femur. Lancet 1990; 335: 1013-1016.
20. Tkatch L, Rapin C H, Rizzoli R, Slosman D, Nydegger V, Vasey H, Bonjour J P. Benefits of oral protein supplementation in elderly patients with fracture of the proximal femur. J Am Coll Nutr 1992; 11: 519-525.
21. Schurch M A, Rizzoli R, Slosman D, Vadas L, Vergnaud P, Bonjour J P. Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 1998; 128: 801-809.
22. Hampson G, Martin F C, Moffat K, Vaja S, Sankaralingam S, Cheung J, Blake G M, Fogelman I. Effects of dietary improvement on bone metabolism in elderly underweight women with osteoporosis: a randomised controlled trial. Osteoporos Int 2003; 14: 750-756.
23. Prasad A S. Clinical manifestations of zinc deficiency. Annu Rev Nutr 1985; 5: 341-363.
24. Devine A, Rosen C, Mohan S, Baylink D, Prince R L. Effects of zinc and other nutritional factors on insulin-like growth factor I and insulin-like growth factor binding proteins in postmenopausal women. Am J Clin Nutr 1998; 68: 200-206.
25. Imamoglu S, Bereket A, Turan S, Taga Y, Haklar G. Effect of zinc supplementation on growth hormone secretion, IGF-I, IGFBP-3, somatomedin generation, alkaline phosphatase, osteocalcin and growth in prepubertal children with idiopathic short stature. J Pediatr Endocrinol Metab 2005; 18: 69-74.
26. Ninh N X, Thissen J P, Collette L, Gerard G, Khoi H H, Ketelslegers J M. Zinc supplementation increases growth and circulating insulin-like growth factor I (IGF-I) in growth-retarded Vietnamese children. Am J Clin Nutr 1996; 63: 514-519.
27. Ninh N X, Maiter D, Verniers J, Lause P, Ketelslegers J M, Thissen J P. Failure of exogenous IGF-I to restore normal growth in rats submitted to dietary zinc deprivation. J Endocrinol 1998; 159: 211-217.
28. Ninh N X, Thissen J P, Maiter D, Adam E, Mulumba N, Ketelslegers J M. Reduced liver insulin-like growth factor-I gene expression in young zinc-deprived rats is associated with a decrease in liver growth hormone (GH) receptors and serum GH-binding protein. J Endocrinol 1995; 144: 449-456.
29. Brown K H, Peerson J M, Rivera J, Allen L H. Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2002; 75: 1062-1071.
30. Darnton-Hill I, Webb P, Harvey P W, Hunt J M, Dalmiya N, Chopra M, Ball M J, Bloem M W, de Benoist B. Micronutrient deficiencies and gender: social and economic costs. Am J Clin Nutr 2005; 81: 1198S-1205S.
31. Pepersack T, Rotsaert P, Benoit F, Willems D, Fuss M, Bourdoux P, Duchateau J. Prevalence of zinc deficiency and its clinical relevance among hospitalised elderly. Arch Gerontol Geriatr 2001; 33: 243-253.
32. Yamaguchi M, Uchiyama S. Regucalcin stimulates osteoclast-like cell formation in mouse marrow cultures. J Cell Biochem 2005; 94: 794-803.
33. Holloway W R, Collier F M, Herbst R E, Hodge J M, Nicholson G C. Osteoblast-mediated effects of zinc on isolated rat osteoclasts: inhibition of bone resorption and enhancement of osteoclast number. Bone 1996; 19: 137-142.
34. Moonga B S, Dempster D W. Zinc is a potent inhibitor of osteoclastic bone resorption in vitro. J Bone Miner Res 1995; 10: 453-457.
35. Calhoun N R, Smith J C, Jr., Becker K L. The role of zinc in bone metabolism. Clin Orthop Relat Res 1974: 212-234.
36. Ma Z J, Yamaguchi M. Alternation in bone components with increasing age of newborn rats: role of zinc in bone growth. J Bone Miner Metab 2000; 18: 264-270.
37. Vellas B, Guigoz Y, Garry P J, Nourhashemi F, Bennahum D, Lauque S, Albarede J L. The Mini Nutritional Assessment (MNA) and its use in grading the nutritional state of elderly patients. Nutrition 1999; 15: 116-122.
38. Katz S, Ford A B, Moskowitz R W, Jackson B A, Jaffe M W. Studies of Illness in the Aged. The Index of Adl: A Standardized Measure of Biological and Psychosocial Function. Jama 1963; 185: 914-919.
39. Bijvoet O L. Relation of plasma phosphate concentration to renal tubular reabsorption of phosphate. Clin Sci 1969; 37: 23-36.
40. Bonjour J P, Philippe J, Guelpa G, Bisetti A, Rizzoli R, Jung A, Rosini S, Kanis J A. Bone and renal components in hypercalcemia of malignancy and responses to a single infusion of clodronate. Bone 1988; 9: 123-130.
41. Amin S, Riggs B L, Atkinson E J, Oberg A L, Melton L J, 3rd, Khosla S. A potentially deleterious role of IGFBP-2 on bone density in aging men and women. J Bone Miner Res 2004; 19: 1075-1083.
42. Kerstetter J E, O'Brien K O, Insogna K L. Dietary protein, calcium metabolism, and skeletal homeostasis revisited. Am J Clin Nutr 2003; 78: 584S-592S.
43. Avenell A, Handoll H H. A systematic review of protein and energy supplementation for hip fracture aftercare in older people. Eur J Clin Nutr 2003; 57: 895-903.
44. Wang Y, Nishida S, Elalieh H Z, Long R K, Halloran B P, Bikle D D. Role of IGF-I signaling in regulating osteoclastogenesis. J Bone Miner Res 2006; 21: 1350-1358.
45. Gomez J M. The role of insulin-like growth factor I components in the regulation of vitamin D. Curr Pharm Biotechnol 2006; 7: 125-132.
46. Soliman A T, Al Khalaf F, Alhemaidi N, Al Ali M, Al Zyoud M, Yakoot K. Linear growth in relation to the circulating concentrations of insulin-like growth factor I, parathyroid hormone, and 25-hydroxy vitamin D in children with nutritional rickets before and after treatment: endocrine adaptation to vitamin D deficiency. Metabolism 2008; 57: 95-102.