The effect of intracellular delivery of catalase and antisense oligonucleotides to NF-κB using albumin microcapsules in the endotoxic shock model

Journal of Drug Targeting

Volumn 17, Issue 9, 2009, Pages 701-709

  Siwale, Rodney C ^a   Oettinger, Carl W ^a   Addo, Richard ^b   Siddig, Aladin ^c   D'Souza, Martin J ^a  

^a MERCER UNIVERSITY   (United States)

^b SHENANDOAH UNIVERSITY   (United States)

^c Robert C Byrd Center for Pharmacy Education   (United States)

Author keywords

antisense oligonucleotides to NF B; catalase; endotoxic shock; Hydrogen peroxide; reactive oxygen species; TNF

Indexed keywords

ALBUMIN; ANTISENSE OLIGONUCLEOTIDE; CATALASE; CYTOKINE; ESCHERICHIA COLI ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR; ANTIOXIDANT; ANTISENSE OLIGODEOXYNUCLEOTIDE; BOVINE SERUM ALBUMIN; DRUG CARRIER; ENDOTOXIN; ENDOTOXIN, ESCHERICHIA COLI; MICROSPHERE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; IN VIVO STUDY; MICROCAPSULE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RAT; SEPTIC SHOCK; SURVIVAL; ANIMAL; CATTLE; CHEMISTRY; DISEASE MODEL; DRUG ANTAGONISM; METABOLISM; MULTIMODALITY CANCER THERAPY; PARTICLE SIZE; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; SURVIVAL RATE;

ANIMALS; ANTIOXIDANTS; CATALASE; CATTLE; COMBINED MODALITY THERAPY; CYTOKINES; DISEASE MODELS, ANIMAL; DRUG CARRIERS; ENDOTOXINS; MICROSPHERES; NF-KAPPA B; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN, BOVINE; SHOCK, SEPTIC; SURVIVAL RATE;

EID: 73449109206     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/10611860903062070     Document Type: Article

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