Growth and development of tadpoles (Xenopus laevis) exposed to selective serotonin reuptake inhibitors, fluoxetine and sertraline, throughout metamorphosis

Environmental Toxicology and Chemistry

Volumn 28, Issue 12, 2009, Pages 2671-2676

  Conners, Deanna E ^a   Rogers, Emily D ^a   Armbrust, Kevin L ^b   Kwon, Jeong Wook ^b   Black, Marsha C ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

Anurans; Endocrine disruption; Fluoxetine; Pharmaceuticals; Sertraline

Indexed keywords

AFRICAN CLAWED FROG; DEVELOPMENTAL TOXICITY; ENDOCRINE DISRUPTION; FEEDING RATE; FLUOXETINE; FOOD INTAKE; GROWTH AND DEVELOPMENT; HUMAN HEALTH; NEUROENDOCRINE SYSTEMS; SELECTIVE SEROTONIN REUPTAKE INHIBITOR; SERTRALINE; SEWAGE EFFLUENTS; VIA EFFECT; XENOPUS LAEVIS;

HEALTH RISKS; PERSONNEL; SEWAGE;

DRUG PRODUCTS;

FLUOXETINE; SERTRALINE;

BIOLOGICAL UPTAKE; CONCENTRATION (COMPOSITION); ENDOCRINE DISRUPTOR; FROG; GROWTH RATE; HEALTH RISK; LARVAL DEVELOPMENT; METAMORPHOSIS; ORGANIC COMPOUND; POLLUTION EFFECT; POLLUTION EXPOSURE; PUBLIC HEALTH; SEWAGE DISPOSAL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY MASS; CONTROLLED STUDY; DEFORMITY; ENVIRONMENTAL EXPOSURE; FEEDING BEHAVIOR; FEMALE; FOOD INTAKE; GROWTH; MALE; METAMORPHOSIS; MORTALITY; NEUROENDOCRINE SYSTEM; NONHUMAN; NUTRITIONAL STATUS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; TADPOLE; XENOPUS LAEVIS;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOXETINE; LARVA; METAMORPHOSIS, BIOLOGICAL; SEROTONIN UPTAKE INHIBITORS; SERTRALINE; WATER POLLUTANTS, CHEMICAL; XENOPUS LAEVIS;

AMPHIBIA; ANURA; XENOPUS LAEVIS;

EID: 73449108078     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/08-493.1     Document Type: Article

References (40)

1. Daughton CG, Ternes TA. 1999. Pharmaceuticals and personal care products in the environment: Agents of subtle change? Environ Health Perspect 107(Suppl. 6):907-938.
2. Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT. 2002. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: A national reconnaissance. Environ Sci Technol 36:1202-1211.
3. Metcalfe CD, Miao XS, Koenig BG, Struger J. 2003. Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower Great Lakes, Canada. Environ Toxicol Chem 22:2881-2889.
4. Johnson DJ, Sanderson H, Brain RA, Wilson CJ, Bestari KT, Solomon KR. 2005. Exposure assessment and microcosm fate of selected selective serotonin reuptake inhibitors. Regul Toxicol Pharmacol 42:313-323.
5. Brooks BW, Chambliss CK, Stanley JK, Ramirez A, Banks KE, Johnson RD, Lewis RJ. 2005. Determination of select antidepressants in fish from an effluent-dominated stream. Environ Toxicol Chem 24:464-469.
6. Hines RN, Adams J, Buck GM, Faber W, Holson JF, Jacobson SE, Keszler M, McMartin K, Segraves RT, Singer LT, Sipes IG, Williams PL. 2004. NTP-CERHR expert panel report on the reproductive and developmental toxicity of fluoxetine. Birth Defects Res B Dev Reprod Toxicol 71:193-280.
7. Weissman AM, Levy BT, Hartz AJ, Bentler S, Donohue M, Ellingrod VL, Wisner KL. 2004. Pooled analysis of antidepressant levels in lactating mothers, breast milk, and nursing infants. Am J Psychiatry 161:1066-1078.
8. Foran CM, Weston J, Slattery M, Brooks BW, Huggett DB. 2004. Reproductive assessment of Japanese medaka (Oryzias latipes) following a four-week fluoxetine (SSRI) exposure. Arch Environ Contam Toxicol 46:511-517.
9. Vorhees C, Acuff-Smith K, Schilling M, Fisher J, Moran M, Buelle-Sam J. 1994. A developmental neurotoxicity evaluation of the effects of prenatal exposure to fluoxetine in rats. Fundam Appl Toxicol 23:194-205.
10. Deiro TCBJ, Manhaes-De-Castro R, Cabral JE, Barreto-Medeiros JM, Souza SL, Maririo SMOC, Castro FMM, Toscano AE, Jesus-Deiro RA, Banos KMFT. 2006. Sertraline delays the somatic growth and reflex ontogeny in neonate rats. Physiol Behav 87:338-344.
11. Oberlander TF, Warburton W, Misri S, Aghajanian J, Hertzman C. 2006. Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health data. Arch Gen Psychiatry 63:898-906.
12. American Society for Testing and Materials. 2004. Standard guide for conducting the frog embryo teratogenesis assay-Xenopus (FETAX). E 1439-98. InAnnual Book of ASTM Standards, Vol 11.05. West Conshohocken, PA, pp 1-16.
13. Opitz R, Braunbeck T, Bögi C, Pickford DB, Nentwig G, Oehlmann J, Tooi O, Lutz I, Kloas W. 2005. Description and initial evaluation of a Xenopus metamorphosis assay for detection of thyroid system - Disrupting activities of environmental compounds. Environ Toxicol Chem 24:653-664.
14. Burkhart JG, Ankley G, Bell H, Carpenter H, Fort D, Gardiner D, Gardner H, Hale R, Helgen JC, Jepson P, Johnson D, Lannoo M, Lee D, Lary J, Levey R, Magner J, Meteyer C, Shelby MD, Lucier G. 2000. Strategies for assessing the implications of malformed frogs for environmental health. Environ Health Perspect 108:83-90.
15. Hayes TB, Collins A, Lee M, Mendoza M, Noriega N, Stuart AA, Vonk A. 2002. Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses. Proc Natl Acad Sci USA 99:5476-5480.
16. Shi YB. 2000. Amphibian Metamorphosis: From Morphology to Molecular Biology. Wiley-Liss, New York, NY, USA.
17. Brown V. 2003. Disrupting a delicate balance: Environmental effects on the thyroid. Environ Health Perspect 111:A642-A649.
18. DeVito M, Biegel L, Brouwer A, Brown S, Brucker-Davis F, Oliver Cheek A, Christensen R, Colborn T, Cooke P, Crissman J, Crofton K, Doerge D, Gray E, Hauser P, Hurley P, Kohn M, Lazar J, McMaster S, McClain M, McConnell E, Meler C, Miller R, Tietge J, Tyl R. 1999. Screening methods for thyroid hormone disruptors. Environ Health Perspect 107:407-415.
19. Kirkegaard C, Faber J. 1998. The role of thyroid hormones in depression. Eur J Endocrinol 138:1-9.
20. Eravci M, Pinna G, Meinhold H, Baumgartner A. 2000. Effects of pharmacological and nonpharmacological treatments on thyroid hormone metabolism and concentrations in rat brain. Endocrinology 141:1027-1040.
21. Lowry CA, Moore FL. 2006. Regulation of behavioral responses by corticotropin-releasing factor. Gen Comp Endocrinol 146:19-27.
22. Denver RJ. 1997. Proximate mechanisms of phenotypic plasticity in amphibian metamorphosis. Am Zool 37:172-184.
23. Fukumoto T, Blakely R, Levin M. 2005. Serotonin transporter function is an early step in left-right patterning in chick and frog embryos. Dev Neurosci 27:349-363.
24. Meguid MM, Fetissov SO, Varma M, Sato T, Zhang L, Laviano A, Rossi-Fanelli F. 2000. Hypothalamic dopamine and serotonin in the regulation of food intake. Nutrition 16:843-857.
25. Olsson C, Homgren S. 2001. The control of gut motility. Comp Biochem Physiol A Comp Physiol 128:481-503.
26. Nieuwkoop PD, Faber J. 1994. Normal Table of Xenopus laevis (Daudin): A Systematical and Chronological Survey of Development from the Fertilized Egg till the End of Metamorphosis, 3rd ed. Garland, New York, NY, USA.
27. Alwan S, Reefhuis J, Rasmussen SA, Olney RS, Friedman JM. 2007. Use of selective serotonin-reuptake inhibitors in pregnancy and the risk of birth defects. N Engl J Med 356:2684-2692.
28. Louik C, Lin AE, Werler MM, Hernández-Diaz S, Mitchell AA. 2007. First-trimester use of selective serotonin-reuptake inhibitors and the risk of birth defects. N Engl J Med 356:2675-2683.
29. Crespi EJ, Denver RJ. 2004. Ontogeny of corticotropin-releasing factor effects on locomotion and foraging in the Western spadefoot toad (Spea hammondii). Horm Behav 46:399-410.
30. Chelgren ND, Rosenberg DK, Heppell SS, Gitelman AI. 2006. Carryover aquatic effects on survival of metamorphic frogs during pond emigration. Ecol Appl 16:250-261.
31. Relyea RA. 2007. Getting out alive: How predators affect the decision to metamorphose. Oecologia 152:389-400.
32. Hack M, Flannery DJ, Schluchter M, Cartar L, Borawski E, Klein N. 2002. Outcomes in young adulthood for very-low-birth-weight infants. N Engl J Med 346:149-157.
33. Semlitsch RD. 1988. Time and size at metamorphosis related to adult fitness in Ambystoma talpoideum. Ecology 69:184-192.
34. Nicieza AG. 2000. Interacting effects of predation risk and food availability on larval anuran behavior and development. Oecologia 123:497-505.
35. Calabrese EJ. 2008. Hormesis: Why it is important to toxicology and toxicologists. Environ Toxicol Chem 27:1451-1474.
36. Brodeur JC, Svartz G, Perez-Coll CS, Marino DJG, Herkovits J. 2009. Comparative susceptibility to atrazine of three developmental stages of Rhinella arenarum and influence on metamorphosis: Non-monotonous acceleration of the time to climax and delayed tail resorption. Aquat Toxicol 91:161-170.
37. Littleton J. 2001. Receptor regulation as a unitary mechanism for drug tolerance and physical dependence - Not quite as simple as it seemed! Addiction 96:87-101.
38. Henry TB, Kwon JW, Armbrust KL, Black MC. 2004. Acute and chronic toxicity of five selective serotonin reuptake inhibitors in Ceriodaphnia dubia. Environ Toxicol Chem 23:2229-2233.
39. Edwards CJ, Yamamoto K, Kikuyama S, Kelley DB. 1999. Prolactin opens the sensitive period for androgen regulation of a larynx-specific myosin heavy chain gene. J Neurobiol 41:443-451.
40. Huang H, Brown DD. 2000. Prolactin is not juvenile hormone in Xenopus laevis metamorphosis. Proc Natl Acad Sci USA 97:195-199.