Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts

Xenotransplantation

Volumn 16, Issue 6, 2009, Pages 472-476

  Bakri, Marwah M ^a   Sutherland, Alistair D ^a   Brown, Derek J ^b   Vesely, Pavel ^c   Crossan, Claire ^a   Scobie, Linda ^a  

^a GLASGOW CALEDONIAN UNIVERSITY   (United Kingdom)

^b STOBHILL HOSPITAL   (United Kingdom)

^c INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

C. difficile; Hospital acquired infection; Xenotransplant; Zoonoses

Indexed keywords

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM CONTAMINATION; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; CLINICAL ASSESSMENT; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; DONOR; FECES; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; INFECTION RISK; NONHUMAN; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SKIN; XENOGRAFT;

ANIMALS; ANTI-BACTERIAL AGENTS; CLOSTRIDIUM DIFFICILE; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FECES; HUMANS; MICROBIAL SENSITIVITY TESTS; RISK ASSESSMENT; RISK FACTORS; SKIN; SWINE; TRANSPLANTATION, HETEROLOGOUS; ZOONOSES;

EID: 73449100161     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2009.00538.x     Document Type: Article

References (35)

1. Mattiuzzo G, Scobie L, Takeuchi Y. Strategies to enhance the safety profile of xenotransplantation: minimizing the risk of viral zoonoses. Curr Opin Organ Transplant 2008 13 : 184 188.
2. Fishman JA. Infection in xenotransplantation: a clinical approach. Transplant Proc 1999 31 : 2225 2227.
3. Garkavenko O, Croxson MC, Irgang M, Karlas A, Denner J, Elliott RB. Monitoring for presence of potentially xenotic viruses in recipients of pig islet xenotransplantation. J Clin Microbiol 2004 42 : 5353 5356.
4. Swindle MM. Defining appropriate health status and management programs for specific-pathogen-free swine for xenotransplantation. Ann N Y Acad Sci 1998 862 : 111 120.
5. Tucker A, Belcher C, Moloo B et al. The production of transgenic pigs for potential use in clinical xenotransplantation: microbiological evaluation. Xenotransplantation 2002 9 : 191 202. (Pubitemid 36358960)
6. Denner J, Specke V, Karlas A et al. No transmission of porcine endogenous retroviruses (PERVs) in a long-term pig to rat xenotransplantation model and no infection of immunosuppressed rats. Ann Transplant 2008 13 : 20 31.
7. Garkavenko O, Dieckhoff B, Wynyard S et al. Absence of transmission of potentially xenotic viruses in a prospective pig to primate islet xenotransplantation study. J Med Virol 2008 80 : 2046 2052.
8. Paradis K, Langford G, Long Z et al. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. The XEN 111 Study Group. Science 1999 285 : 1236 1241.
9. Swindle MM. Animal husbandry for xenotransplantation. Xenotransplantation 2007 14 : 352 353.
10. Bobak D, Arfons LM, Creger RJ, Lazarus HM. Clostridium difficile-associated disease in human stem cell transplant recipients: coming epidemic or false alarm? Bone Marrow Transplant 2008 42 : 705 713.
11. Riddle DJ, Dubberke ER. Clostridium difficile infection in solid organ transplant recipients. Curr Opin Organ Transplant 2008 13 : 592 600.
12. Kuijper EJ, Coignard B, Tull P. Emergence of Clostridium difficile-associated disease in North America and Europe. Clin Microbiol Infect 2006 12 (Suppl. 6 2 18.
13. Keel MK, Songer JG. The comparative pathology of Clostridium difficile-associated disease. Vet Pathol 2006 43 : 225 240.
14. Missaghi B, Valenti AJ, Owens RC Jr. Clostridium difficile infection: a critical overview. Curr Infect Dis Rep 2008 10 : 165 173.
15. Olson MM, Shanholtzer CJ, Lee JT Jr., Gerding DN. Ten years of prospective Clostridium difficile-associated disease surveillance and treatment at the Minneapolis VA Medical Center, 1982-1991. Infect Control Hosp Epidemiol 1994 15 : 371 381.
16. Songer JG, Anderson MA. Clostridium difficile: an important pathogen of food animals. Anaerobe 2006 12 : 1 4.
17. Debast SB, van Leengoed LA, Goorhuis A, Harmanus C, Kuijper EJ, Bergwerff AA. Clostridium difficile PCR ribotype 078 toxinotype V found in diarrhoeal pigs identical to isolates from affected humans. Environ Microbiol 2009 11 : 505 511.
18. Habal MB. Pig skin over open wounds. Surg Gynecol Obstet 1979 149 : 395.
19. Matouskova E, Broz L, Stolbova V, Klein L, Konigova R, Vesely P. Human allogeneic keratinocytes cultured on acellular xenodermis: the use in healing of burns and other skin defects. Biomed Mater Eng 2006 16 : S63 S71.
20. Muller FE. Experience with deep-frozen fresh pig skin in the treatment of 100 burn injury patients. Z Plast Chir 1979 3 : 129 137.
21. Sologub VK, Dolgina MI, Donetskii DA, Morozov SS, Borisov VG. Pig skin xenotransplants in the treatment of extensive burns. Khirurgiia (Mosk) 1980 : 14 16.
22. Dvorankova B, Broz L, Pafcuga I, Kapounkova Z, Konigova R. The role of skin bank in the treatment of severely burnt patients. Acta Chir Plast 2004 46 : 51 55.
23. John R, Brazier JS. Antimicrobial susceptibility of polymerase chain reaction ribotypes of Clostridium difficile commonly isolated from symptomatic hospital patients in the UK. J Hosp Infect 2005 61 : 11 14.
24. Aspinall ST, Hutchinson DN. New selective medium for isolating Clostridium difficile from faeces. J Clin Pathol 1992 45 : 812 814.
25. Gumerlock PH, Tang YJ, Meyers FJ, Silva J Jr. Use of the polymerase chain reaction for the specific and direct detection of Clostridium difficile in human feces. Rev Infect Dis 1991 13 : 1053 1060.
26. Stubbs SL, Brazier JS, O'Neill GL, Duerden BI. PCR targeted to the 16S-23S rRNA gene intergenic spacer region of Clostridium difficile and construction of a library consisting of 116 different PCR ribotypes. J Clin Microbiol 1999 37 : 461 463.
27. Voth DE, Ballard JD. Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev 2005 18 : 247 263.
28. van den Berg RJ, Claas EC, Oyib DH et al. Characterization of toxin A-negative, toxin B-positive Clostridium difficile isolates from outbreaks in different countries by amplified fragment length polymorphism and PCR ribotyping. J Clin Microbiol 2004 42 : 1035 1041.
29. McDonald LC, Owings M, Jernigan DB. Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003. Emerg Infect Dis 2006 12 : 409 415.
30. Rupnik M. Is Clostridium difficile-associated infection a potentially zoonotic and foodborne disease? Clin Microbiol Infect 2007 13 : 457 459.
31. Kuddus RH, Metes DM, Nalesnik MA, Logar AJ, Rao AS, Fung JJ. Porcine cell microchimerism but lack of productive porcine endogenous retrovirus (PERV) infection in naive and humanized SCID-beige mice treated with porcine peripheral blood mononuclear cells. Transpl Immunol 2004 13 : 15 24.
32. Keel MK, Songer JG. The distribution and density of Clostridium difficile toxin receptors on the intestinal mucosa of neonatal pigs. Vet Pathol 2007 44 : 814 822.
33. Lyras D, O'Connor JR, Howarth PM et al. Toxin B is essential for virulence of Clostridium difficile. Nature 2009 458 : 1176 1179.
34. Alvarez-Perez S, Blanco JL, Bouza E et al. Prevalence of Clostridium difficile in diarrhoeic and non-diarrhoeic piglets. Vet Microbiol 2009 137 : 302 305.
35. Debast SB, van Kregten E, Oskam KM, van den Berg T, Van den Berg RJ, Kuijper EJ. Effect on diagnostic yield of repeated stool testing during outbreaks of Clostridium difficile-associated disease. Clin Microbiol Infect 2008 14 : 622 624.